Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies

Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associate...

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Published in:Clinical pharmacology and therapeutics Vol. 101; no. 4; p. 491
Main Authors: Lanvers-Kaminsky, C, Zehnhoff-Dinnesen, Ag Am, Parfitt, R, Ciarimboli, G
Format: Journal Article
Language:English
Published: United States 01.04.2017
Subjects:
Aminoglycosides - adverse effects
Animals
Antineoplastic Agents - adverse effects
Child
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - genetics
Drug-Related Side Effects and Adverse Reactions - prevention & control
Ear - physiopathology
Hearing Loss - chemically induced
Hearing Loss - epidemiology
Hearing Loss - genetics
Hearing Loss - physiopathology
Hearing Loss - prevention & control
Humans
Pharmacogenetics
ISSN:1532-6535, 1532-6535
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Abstract Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.
AbstractList Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.
Drug ototoxicity limits the quality of life of patients after treatment, having serious consequences, especially for psychosocial development of children. Although the ototoxicity of many drugs resolves after treatment discontinuation, the use of platinum derivatives and aminoglycosides is associated with permanent hearing loss. In this review, we have listed ototoxic drugs and the mechanisms by which they damage the ears. Moreover, possible protective strategies and important methods for early detection of ototoxic effects are discussed.
Author Zehnhoff-Dinnesen, Ag Am
Ciarimboli, G
Parfitt, R
Lanvers-Kaminsky, C
Author_xml – sequence: 1
  givenname: C
  surname: Lanvers-Kaminsky
  fullname: Lanvers-Kaminsky, C
  organization: Department of Pediatric Hematology and Oncology, University Children's Hospital of Muenster, Muenster, Germany
– sequence: 2
  givenname: Ag Am
  surname: Zehnhoff-Dinnesen
  fullname: Zehnhoff-Dinnesen, Ag Am
  organization: Department of Phoniatrics and Pedaudiology, University Hospital of Muenster, Muenster, Germany
– sequence: 3
  givenname: R
  surname: Parfitt
  fullname: Parfitt, R
  organization: Department of Phoniatrics and Pedaudiology, University Hospital of Muenster, Muenster, Germany
– sequence: 4
  givenname: G
  surname: Ciarimboli
  fullname: Ciarimboli, G
  organization: Experimental Nephrology, Department of Internal Medicine D, University Hospital of Muenster, Muenster, Germany
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28002638$$D View this record in MEDLINE/PubMed
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SubjectTerms Aminoglycosides - adverse effects
Animals
Antineoplastic Agents - adverse effects
Child
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - genetics
Drug-Related Side Effects and Adverse Reactions - prevention & control
Ear - physiopathology
Hearing Loss - chemically induced
Hearing Loss - epidemiology
Hearing Loss - genetics
Hearing Loss - physiopathology
Hearing Loss - prevention & control
Humans
Pharmacogenetics
Title Drug-induced ototoxicity: Mechanisms, Pharmacogenetics, and protective strategies
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