Defective cortical drive to muscle in Parkinson's disease and its improvement with levodopa

We recorded whole-scalp magnetoencephalographic (MEG) signals simultaneously with surface electromyographic (EMG) activity from eight patients with Parkinson's disease after withdrawal and reinstatement of treatment with levodopa. Variations were seen in the coherence between the forearm extens...

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Vydáno v:	Brain (London, England : 1878) Ročník 125; číslo Pt 3; s. 491
Hlavní autoři:	Salenius, Stephan, Avikainen, Sari, Kaakkola, Seppo, Hari, Riitta, Brown, Peter
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England 01.03.2002
Témata:	Adult Aged Anterior Horn Cells - drug effects Anterior Horn Cells - physiology Antiparkinson Agents - therapeutic use Basal Ganglia - drug effects Basal Ganglia - physiopathology Biological Clocks - drug effects Biological Clocks - physiology Cortical Synchronization - drug effects Efferent Pathways - drug effects Efferent Pathways - physiopathology Electromyography Female Humans Levodopa - therapeutic use Magnetoencephalography Male Middle Aged Motor Cortex - drug effects Motor Cortex - physiopathology Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Skeletal - drug effects Muscle, Skeletal - physiopathology Parkinson Disease - drug therapy Parkinson Disease - pathology Parkinson Disease - physiopathology Recovery of Function - drug effects Recovery of Function - physiology Treatment Outcome
ISSN:	0006-8950
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Popis
Shrnutí:	We recorded whole-scalp magnetoencephalographic (MEG) signals simultaneously with surface electromyographic (EMG) activity from eight patients with Parkinson's disease after withdrawal and reinstatement of treatment with levodopa. Variations were seen in the coherence between the forearm extensor EMG and the MEG signal originating near or in the hand region of the primary motor cortex. As a group, the parkinsonian patients withdrawn from levodopa showed a reduction in the coherence at 15-30 Hz and 35-60 Hz, and a further three untreated patients had abnormally strong MEG-EMG coherence at 5-12 Hz compared with when medicated or with eight healthy age-matched control subjects. We conclude that the basal ganglia have a specific effect on the temporal organization of motor cortical activity during voluntary tonic contraction. Abnormalities in this aspect of basal ganglia function may directly contribute to bradykinesia and weakness in Parkinson's disease.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0006-8950
DOI:	10.1093/brain/awf042