Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers

Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of traits and diseases by calculating the weighted sum of allele dosages for genetic variants associated with the trait or disease in question. Present approaches for calculating PGS from genotypes are often inef...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 52; no. W1; pp. W70 - W77
Main Authors:	Forer, Lukas, Taliun, Daniel, LeFaive, Jonathon, Smith, Albert V, Boughton, Andrew P, Coassin, Stefan, Lamina, Claudia, Kronenberg, Florian, Fuchsberger, Christian, Schönherr, Sebastian
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 05.07.2024
Subjects:	Alleles Genetic Predisposition to Disease Genetic Risk Score Genome-Wide Association Study - methods Genotype Humans Internet Multifactorial Inheritance - genetics Polymorphism, Single Nucleotide Software Web Server Issue
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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