Imputation Server PGS: an automated approach to calculate polygenic risk scores on imputation servers

Polygenic scores (PGS) enable the prediction of genetic predisposition for a wide range of traits and diseases by calculating the weighted sum of allele dosages for genetic variants associated with the trait or disease in question. Present approaches for calculating PGS from genotypes are often inef...

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Veröffentlicht in:	Nucleic acids research Jg. 52; H. W1; S. W70 - W77
Hauptverfasser:	Forer, Lukas, Taliun, Daniel, LeFaive, Jonathon, Smith, Albert V, Boughton, Andrew P, Coassin, Stefan, Lamina, Claudia, Kronenberg, Florian, Fuchsberger, Christian, Schönherr, Sebastian
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 05.07.2024
Schlagworte:	Alleles Genetic Predisposition to Disease Genetic Risk Score Genome-Wide Association Study - methods Genotype Humans Internet Multifactorial Inheritance - genetics Polymorphism, Single Nucleotide Software Web Server Issue
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
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