Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review

Both human and animal skin in vitro models are used to predict percutaneous penetration in humans. The objective of this review is a quantitative comparison of permeability and lag time measurements between human and animal skin, including an evaluation of the intra and inter species variability. We...

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Bibliographic Details
Published in:	Toxicology in vitro Vol. 23; no. 1; pp. 1 - 13
Main Authors:	Barbero, Ana M., Frasch, H. Frederick
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.02.2009
Subjects:	Administration, Cutaneous Animal model Animals Dermal penetration Guinea pig Guinea Pigs Human Humans In vitro model In Vitro Techniques Lag time Models, Animal Permeability Pig Skin - metabolism Skin Absorption Species Specificity Swine Xenobiotics - pharmacokinetics Human Animal model Guinea pig Skin absorption In vitro model Lag time Dermal penetration Permeability Pig
ISSN:	0887-2333
Online Access:	Get full text
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