Cyclic stretch decreases TRPC4 protein and capacitative calcium entry in rat vascular smooth muscle cells

We investigated whether cyclic stretch affects TRPC4 or TRPC6 expression and calcium mobilization in cultured vascular smooth muscle cells. In aortic and mesenteric smooth muscle cells isolated from male Sprague–Dawley rats, TRPC4 expression was decreased after 5 h stretch and remained suppressed th...

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Bibliographic Details
Published in:	Life sciences (1973) Vol. 83; no. 1; pp. 29 - 34
Main Authors:	Lindsey, S.H., Tribe, R.M., Songu-Mize, E.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 04.07.2008
Subjects:	Animals Calcium Calcium - metabolism Capacitative calcium entry Cells, Cultured Cyclic stretch Down-Regulation Male Mechanical strain Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - metabolism Proteasomal degradation Rats Rats, Sprague-Dawley Receptor-operated calcium entry Store-operated Stress, Mechanical TRPC TRPC Cation Channels - metabolism Proteasomal degradation Calcium Mechanical strain TRPC Cyclic stretch Store-operated Capacitative calcium entry Receptor-operated calcium entry
ISSN:	0024-3205, 1879-0631
Online Access:	Get full text
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