Kinetics of M1 muscarinic receptor and G protein signaling to phospholipase C in living cells

G protein-coupled receptors (GPCRs) mediate responses to external stimuli in various cell types. Early events, such as the binding of ligand and G proteins to the receptor, nucleotide exchange (NX), and GTPase activity at the Galpha subunit, are common for many different GPCRs. For G(q)-coupled M(1)...

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Bibliographic Details
Published in:	The Journal of general physiology Vol. 135; no. 2; p. 81
Main Authors:	Falkenburger, Björn H, Jensen, Jill B, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	United States 01.02.2010
Subjects:	Animals Cell Line Fluorescence Resonance Energy Transfer - methods GTP-Binding Proteins - metabolism GTP-Binding Proteins - physiology Humans Potassium Channels - metabolism Potassium Channels - physiology Rats Receptor, Muscarinic M1 - metabolism Receptor, Muscarinic M1 - physiology Receptors, G-Protein-Coupled - metabolism Receptors, G-Protein-Coupled - physiology Signal Transduction - physiology Type C Phospholipases - metabolism Type C Phospholipases - physiology
ISSN:	1540-7748, 1540-7748
Online Access:	Get more information
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