Application of solid-phase microextraction to in vitro skin permeation experiments: example using diethyl phthalate

The application of automated solid-phase microextraction (SPME) as a sample preparation technique for in vitro studies of skin permeation is described, using diethyl phthalate (DEP) as an example. In vitro diffusion cell experiments and skin–vehicle partition coefficient determinations require quant...

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Bibliographic Details
Published in:	Toxicology in vitro Vol. 19; no. 2; pp. 253 - 259
Main Authors:	Frasch, H. Fred, Barbero, Ana M.
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.03.2005
Subjects:	Animals Chromatography, Gas Diffusion Environmental Pollutants - metabolism Gas chromatography methods Guinea Pigs Male Membrane vehicle partition coefficient Microchemistry - methods Organ Culture Techniques Permeability Phthalic acid diesters Phthalic Acids - metabolism Reproducibility of Results Sensitivity and Specificity Skin Absorption - physiology Specimen Handling - methods Time lag Membrane vehicle partition coefficient Gas chromatography methods Permeability Phthalic acid diesters Time lag
ISSN:	0887-2333, 1879-3177
Online Access:	Get full text
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