Implementation of an integrating sphere for the enhancement of noninvasive glucose detection using quantum cascade laser spectroscopy

An integrating sphere is used to enhance the collection of backscattered light in a noninvasive glucose sensor based on quantum cascade laser spectroscopy. The sphere enhances signal stability by roughly an order of magnitude, allowing us to use a thermoelectrically (TE) cooled detector while mainta...

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Veröffentlicht in:Applied physics. B, Lasers and optics Jg. 124; H. 5; S. 1 - 7
Hauptverfasser: Werth, Alexandra, Liakat, Sabbir, Dong, Anqi, Woods, Callie M., Gmachl, Claire F.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Berlin/Heidelberg Springer Berlin Heidelberg 01.05.2018
Springer Nature B.V
Schlagworte:
Applied physics
Backscattering
Engineering
Form factors
Glucose
Integrating spheres
Laser spectroscopy
Lasers
Mid-infrared and THz Laser Sources and Applications
Optical Devices
Optics
Photonics
Physical Chemistry
Physics
Physics and Astronomy
Predictions
Principal components analysis
Quantum cascade lasers
Quantum Optics
Regression analysis
Spectrum analysis
ISSN:0946-2171, 1432-0649
Online-Zugang:Volltext
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Zusammenfassung:An integrating sphere is used to enhance the collection of backscattered light in a noninvasive glucose sensor based on quantum cascade laser spectroscopy. The sphere enhances signal stability by roughly an order of magnitude, allowing us to use a thermoelectrically (TE) cooled detector while maintaining comparable glucose prediction accuracy levels. Using a smaller TE-cooled detector reduces form factor, creating a mobile sensor. Principal component analysis has predicted principal components of spectra taken from human subjects that closely match the absorption peaks of glucose. These principal components are used as regressors in a linear regression algorithm to make glucose concentration predictions, over 75% of which are clinically accurate.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 14
ISSN:0946-2171
1432-0649
DOI:10.1007/s00340-018-6946-5