Remineralization of Enamel Subsurface Lesions by Sugar-free Chewing Gum Containing Casein Phosphopeptide-Amorphous Calcium Phosphate

Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal, and human in situ experiments. The aim of this study was to determine the ability of CPP-ACP in sugar-free chewing gum to remineralize enamel subsurface lesions in a huma...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of dental research Jg. 80; H. 12; S. 2066 - 2070
Hauptverfasser: Shen, P., Cai, F., Nowicki, A., Vincent, J., Reynolds, E.C.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Los Angeles, CA SAGE Publications 01.12.2001
SAGE PUBLICATIONS, INC
Schlagworte:
Adult
Analysis of Variance
Calcium Phosphates - therapeutic use
Cariostatic Agents - therapeutic use
casein phosphopeptide-amorphous calcium phosphate
Caseins - therapeutic use
Chewing Gum
Cross-Over Studies
Densitometry
Double-Blind Method
Drug Combinations
enamel remineralization
Humans
Peptide Fragments - therapeutic use
sugar-free chewing gum
Tooth Remineralization - methods
casein phosphopeptide-amorphous calcium phosphate
enamel remineralization
sugar-free chewing gum
ISSN:0022-0345, 1544-0591
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP) exhibit anticariogenic potential in laboratory, animal, and human in situ experiments. The aim of this study was to determine the ability of CPP-ACP in sugar-free chewing gum to remineralize enamel subsurface lesions in a human in situ model. Thirty subjects in randomized, cross-over, double-blind studies wore removable palatal appliances with six human-enamel half-slabs inset containing subsurface demineralized lesions. The appliances were inserted immediately before gum-chewing for 20 min and then retained for another 20 min. This was performed four times per day for 14 days. At the completion of each treatment, the enamel half-slabs were paired with their respective demineralized control half-slabs, embedded, sectioned, and subjected to microradiography and densitometric image analysis, for measurement of the level of remineralization. The addition of CPP-ACP to either sorbitol- or xylitol-based gum resulted in a dose-related increase in enamel remineralization, with 0.19, 10.0, 18.8, and 56.4 mg of CPP-ACP producing an increase in enamel remineralization of 9, 63, 102, and 152%, respectively, relative to the control gum, independent of gum weight or type.
Bibliographie:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
content type line 23
ObjectType-Undefined-3
ISSN:0022-0345
1544-0591
DOI:10.1177/00220345010800120801