Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article i...

Celý popis

Uložené v:
Podrobná bibliografia
Vydané v:Phytotherapy research Ročník 36; číslo 5; s. 1854 - 1883
Hlavní autori: Banik, Kishore, Khatoon, Elina, Harsha, Choudhary, Rana, Varsha, Parama, Dey, Thakur, Krishan Kumar, Bishayee, Anupam, Kunnumakkara, Ajaikumar B.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Chichester, UK John Wiley & Sons, Ltd 01.05.2022
Wiley Subscription Services, Inc
Predmet:
antineoplastic agents
Antitumor agents
Baicalin
Bioactive compounds
Biocompatibility
Biomedical materials
Bladder cancer
Bone cancer
Breast cancer
breast neoplasms
Cancer
Cell signaling
Cervical cancer
chemoprevention
Chemotherapy
Cholangiocarcinoma
Clinical trials
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
drug therapy
Drugs, Chinese Herbal - pharmacology
Flavanones - pharmacology
Flavanones - therapeutic use
Flavonoids
gall bladder
Gallbladder
Gallbladder cancer
Gastric cancer
Glioblastoma
Head & neck cancer
head and neck neoplasms
Herbal medicine
Humans
in vitro
in vivo
In vivo methods and tests
Kidney cancer
kidney neoplasms
Leukemia
Liver cancer
liver neoplasms
Lung cancer
lung neoplasms
Lymphoma
Male
margin of safety
Medicinal plants
Melanoma
molecular targets
Multiple myeloma
myeloma
Neoplasms - drug therapy
Neoplasms - prevention & control
Neuroblastoma
Osteosarcoma
Ovarian cancer
ovarian neoplasms
Pancreatic cancer
pancreatic neoplasms
phytotherapy
Plant Extracts - pharmacology
Prevention
Prostate cancer
prostatic neoplasms
Sarcoma
Scutellaria
Scutellaria baicalensis
Side effects
stomach neoplasms
systematic review
therapy
Toxicity
Traditional medicine
urinary bladder neoplasms
uterine cervical neoplasms
Wogonin
chemoprevention
Wogonin
therapy
in vitro
cancer
in vivo
molecular targets
ISSN:0951-418X, 1099-1573, 1099-1573
On-line prístup:Získať plný text
Tagy: Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
Abstract The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high‐quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.
AbstractList The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high‐quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.
The medicinal plant Scutellaria baicalensis , commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high‐quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.
The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang-Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high-quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang-Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high-quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.
Author Parama, Dey
Khatoon, Elina
Rana, Varsha
Kunnumakkara, Ajaikumar B.
Harsha, Choudhary
Banik, Kishore
Thakur, Krishan Kumar
Bishayee, Anupam
Author_xml – sequence: 1
  givenname: Kishore
  orcidid: 0000-0003-2497-8313
  surname: Banik
  fullname: Banik, Kishore
  email: kishore.banik@iitg.ac.in
  organization: Indian Institute of Technology‐Guwahati
– sequence: 2
  givenname: Elina
  orcidid: 0000-0001-8190-3110
  surname: Khatoon
  fullname: Khatoon, Elina
  organization: Indian Institute of Technology‐Guwahati
– sequence: 3
  givenname: Choudhary
  orcidid: 0000-0001-7854-2406
  surname: Harsha
  fullname: Harsha, Choudhary
  organization: Indian Institute of Technology‐Guwahati
– sequence: 4
  givenname: Varsha
  orcidid: 0000-0002-1050-3934
  surname: Rana
  fullname: Rana, Varsha
  email: ranavarsha21@gmail.com
  organization: Indian Institute of Technology‐Guwahati
– sequence: 5
  givenname: Dey
  orcidid: 0000-0003-3529-7062
  surname: Parama
  fullname: Parama, Dey
  organization: Indian Institute of Technology‐Guwahati
– sequence: 6
  givenname: Krishan Kumar
  orcidid: 0000-0001-5882-6022
  surname: Thakur
  fullname: Thakur, Krishan Kumar
  organization: Indian Institute of Technology‐Guwahati
– sequence: 7
  givenname: Anupam
  orcidid: 0000-0001-9159-960X
  surname: Bishayee
  fullname: Bishayee, Anupam
  email: abishayee@lecom.edu, abishayee@gmail.com
  organization: Lake Erie College of Osteopathic Medicine
– sequence: 8
  givenname: Ajaikumar B.
  orcidid: 0000-0001-9121-6816
  surname: Kunnumakkara
  fullname: Kunnumakkara, Ajaikumar B.
  email: kunnumakkara@iitg.ac.in
  organization: Indian Institute of Technology‐Guwahati
BackLink https://www.ncbi.nlm.nih.gov/pubmed/35102626$$D View this record in MEDLINE/PubMed
BookMark eNqN0V9LHDEQAPAgSj214CeQgC992TN_Nsmmb3K0WhAs5cS-LTE30cju5kxyyn37ZnvXCmKhTwPDb2aYmQO0O4QBEDqmZEoJYWfLHKeKN3IHTSjRuqJC8V00IVrQqqbNz310kNIjIUQzUn9A-1xQwiSTE3R7G-7D4AdshgX2OZVounCfsAsR5wfAywjPMGQfNiRHMLkvCRwctmawED_jc5zWKUNvsre4eA8vR2jPmS7Bx208RDdfv8xnl9XV9cW32flVZXnDZCWVoFy4mknQztacKiMdGEKZo5I3xJbtSMO0VqC5ZaquTVnCCSplsyC04Yfo06bvMoanFaTc9j5Z6DozQFillpUJohGMqf-grJZCMS0KPX1DH8MqlsuMSiopheajOtmq1V0Pi3YZfW_iuv1z3deJNoaUIri_hJJ2fFxbHteOjyt0-oZan8149hyN794rqDYFL76D9T8bt9_nP377X3QUpaI
CitedBy_id crossref_primary_10_1515_oncologie_2024_0340
crossref_primary_10_1007_s12010_023_04849_4
crossref_primary_10_1016_j_abb_2024_109965
crossref_primary_10_3389_fphar_2023_1129662
crossref_primary_10_1002_ptr_8149
crossref_primary_10_1007_s11101_025_10167_w
crossref_primary_10_1016_j_bcp_2025_116828
crossref_primary_10_1590_acb399224
crossref_primary_10_1002_jgm_3669
crossref_primary_10_3390_ijms242115906
crossref_primary_10_1038_s41401_025_01547_1
crossref_primary_10_1111_bcpt_70027
crossref_primary_10_1007_s10555_023_10119_w
crossref_primary_10_3389_fphar_2024_1296588
crossref_primary_10_1142_S0192415X25500296
crossref_primary_10_3389_fnut_2024_1477140
crossref_primary_10_1002_ptr_8131
crossref_primary_10_1002_ptr_8376
crossref_primary_10_1016_j_prmcm_2024_100381
crossref_primary_10_1371_journal_pone_0286467
crossref_primary_10_1016_j_compbiomed_2023_107293
crossref_primary_10_1002_qua_70048
crossref_primary_10_1016_j_jep_2024_118364
crossref_primary_10_3390_molecules27041432
crossref_primary_10_1007_s12672_025_03190_y
crossref_primary_10_1016_j_drudis_2022_07_001
crossref_primary_10_3389_fphar_2022_946030
crossref_primary_10_1016_j_supflu_2025_106692
crossref_primary_10_1016_j_taap_2024_117103
crossref_primary_10_3390_ncrna9050063
crossref_primary_10_3389_fonc_2024_1383939
crossref_primary_10_1007_s11655_024_4203_9
crossref_primary_10_3390_biomedicines13081830
crossref_primary_10_1016_j_jchromb_2023_123720
crossref_primary_10_1177_2515690X241291381
crossref_primary_10_12677_BR_2023_123023
crossref_primary_10_1016_j_jfutfo_2023_07_009
crossref_primary_10_1016_j_fct_2025_115577
crossref_primary_10_3389_fphar_2022_1068855
crossref_primary_10_1016_j_ecoenv_2024_116661
crossref_primary_10_4103_2311_8571_392881
crossref_primary_10_1002_cph4_70041
crossref_primary_10_3390_molecules28135082
crossref_primary_10_1016_j_heliyon_2024_e34030
crossref_primary_10_1177_15353702231179961
crossref_primary_10_12991_jrespharm_1661047
crossref_primary_10_3389_fphar_2023_1257450
crossref_primary_10_3390_biomedicines12112632
crossref_primary_10_1016_j_ejmech_2024_116123
crossref_primary_10_1097_CU9_0000000000000259
crossref_primary_10_1016_j_ejmech_2023_115774
crossref_primary_10_1016_j_plaphy_2023_107794
crossref_primary_10_3389_fvets_2025_1557198
crossref_primary_10_1016_j_livres_2024_11_006
crossref_primary_10_1016_j_prmcm_2023_100326
crossref_primary_10_1016_j_phrs_2024_107167
crossref_primary_10_3389_fpls_2023_1220062
crossref_primary_10_1016_j_canlet_2024_217019
crossref_primary_10_1038_s41598_024_81196_2
crossref_primary_10_3389_fcell_2022_887688
crossref_primary_10_3390_ijms24119544
crossref_primary_10_1002_ptr_8066
crossref_primary_10_3389_fphar_2025_1551141
crossref_primary_10_1016_j_eujim_2025_102545
crossref_primary_10_1007_s12672_025_02570_8
crossref_primary_10_1016_j_cbi_2024_110940
crossref_primary_10_3390_molecules28041785
crossref_primary_10_1016_j_neuroscience_2024_03_032
crossref_primary_10_3390_life12122116
crossref_primary_10_3390_biom15050725
crossref_primary_10_3390_ph16020160
crossref_primary_10_1002_tox_23655
crossref_primary_10_1007_s44211_025_00786_w
crossref_primary_10_1177_0976500X241259577
crossref_primary_10_3390_molecules27072128
crossref_primary_10_1038_s41598_022_17586_1
crossref_primary_10_3390_ijms25116099
crossref_primary_10_1093_ijfood_vvaf041
crossref_primary_10_3390_pharmaceutics17091204
crossref_primary_10_3390_ph15121477
crossref_primary_10_1002_tox_24150
crossref_primary_10_1038_s41598_024_60859_0
crossref_primary_10_1002_cbdv_202403022
crossref_primary_10_1080_10667857_2025_2521788
crossref_primary_10_2147_DDDT_S466470
crossref_primary_10_1038_s41598_023_47757_7
crossref_primary_10_1371_journal_pone_0321556
crossref_primary_10_1016_j_brainresbull_2025_111202
crossref_primary_10_1002_tox_23907
crossref_primary_10_1016_j_bcp_2025_116928
crossref_primary_10_3390_ijms231810965
crossref_primary_10_1016_j_phymed_2024_155423
crossref_primary_10_1016_j_intimp_2025_115308
crossref_primary_10_3389_fphar_2024_1407891
crossref_primary_10_3389_fphar_2025_1546285
crossref_primary_10_3390_antiox12091665
crossref_primary_10_3389_fcimb_2025_1627863
crossref_primary_10_1002_jbt_70390
crossref_primary_10_3390_ph16020302
crossref_primary_10_1007_s13346_024_01652_4
crossref_primary_10_1016_j_ins_2025_122115
crossref_primary_10_1016_j_jep_2022_115516
Cites_doi 10.3390/ijms17050676
10.1142/9789813208575_0004
10.1142/9789813208575_0007
10.3389/fphar.2020.583200
10.2174/1389450115666141224125117
10.1142/9789813208575_0003
10.31557/APJCP.2019.20.11.3437
10.1371/journal.pone.0050811
10.1016/j.semcancer.2020.06.014
10.3892/ijo.2014.2320
10.1016/j.canlet.2006.01.011
10.1007/s00109-019-01863-0
10.1177/1535370219839163
10.1177/1534735414550036
10.1016/j.lfs.2012.10.023
10.1074/jbc.M111.286526
10.1016/s0090-4295(00)00467-2
10.1016/j.jep.2020.113198
10.1248/bpb.29.1132
10.4014/jmb.1305.05001
10.1139/o09-060
10.3892/ijo.2011.1027
10.1002/bmc.4264
10.1111/j.1349-7006.2008.00728.x
10.18632/oncotarget.2340
10.1186/s12885-017-3145-4
10.2147/Ijn.S28089
10.1002/ijc.22402
10.1142/9789813208575_0005
10.1016/j.phymed.2009.06.001
10.1038/cddis.2017.367
10.1007/s10565-010-9176-0
10.1016/j.toxlet.2013.07.013
10.1016/j.fct.2017.07.023
10.3109/10715762.2014.897342
10.1016/j.tox.2011.01.018
10.1111/j.1476-5381.2009.00245.x
10.1016/s0006-2952(01)00876-0
10.1007/s10565-013-9251-4
10.1055/s-2002-20246
10.1007/s10059-011-0041-7
10.1007/s00280-010-1396-8
10.1016/j.jep.2011.08.005
10.3892/mmr.2012.1085
10.1111/j.1749-6632.2009.04722.x
10.1007/s11060-010-0221-x
10.3892/ijo.2013.1777
10.1002/ptr.2062
10.1016/j.phymed.2017.12.019
10.1002/mc.22321
10.1371/journal.pone.0079201
10.1016/j.semcancer.2016.03.005
10.1016/j.lfs.2020.118475
10.3390/molecules24040734
10.7314/apjcp.2013.14.12.7179
10.3389/fphar.2018.01356
10.1093/abbs/gmx054
10.3892/etm.2019.7469
10.1007/s11033-020-05972-9
10.1007/s00262-011-1130-3
10.1016/j.phrs.2018.07.011
10.1111/bph.13621
10.1016/j.cellsig.2012.07.019
10.2174/1381612825666190708173108
10.3390/ijms20174101
10.1016/j.phymed.2009.07.003
10.1142/9789813208575_0013
10.1007/s00280-010-1552-1
10.1177/0300060520934288
10.2147/IJN.S32065
10.1007/s10495-013-0808-8
10.1021/jf051506
10.2147/DDDT.S250991
10.3978/j.issn.1000-9604.2013.08.14
10.1016/j.crphar.2020.100008
10.3390/nano8030159
10.18632/oncotarget.8332
10.12659/Msm.917823
10.1016/j.bcp.2017.03.004
10.1016/j.etap.2014.12.002
10.1080/17425255.2019.1650914
10.1007/s12253-018-0491-8
10.1016/j.jep.2009.04.031
10.1016/j.toxlet.2010.05.019
10.1002/bdd.2179
10.3390/cells9061451
10.3390/molecules25102278
10.1002/mc.22052
10.1142/9789813208575_0019
10.1111/j.1527-3458.2005.tb00266.x
10.3892/etm.2018.7023
10.1515/jbcpp-2019-0162
10.1016/j.bbrc.2006.10.064
10.1142/9789813208575_0011
10.1590/S0102-695x2011005000161
10.1615/CritRevImmunol.2020033210
10.1016/j.jds.2013.02.024
10.4274/balkanmedj.galenos.2019.2019.7.75
10.1182/blood-2006-03-011973
10.1016/j.tranon.2018.08.015
10.3390/biomedicines8080236
10.1016/j.phymed.2012.10.016
10.1016/j.yrtph.2011.03.008
10.1111/j.1872-034X.2007.00003.x
10.1016/S1875-5364(17)30005-5
10.1182/blood-2007-06-096198
10.1007/s11434-016-1136-5
10.1186/s13046-017-0574-5
10.1016/j.neuroscience.2006.02.028
10.1016/j.clbc.2017.07.013
10.3324/haematol.2017.177808
10.1016/j.jff.2018.12.020
10.1002/jcb.21528
10.1002/mc.21921
10.3109/07357900902744486
10.1016/j.intimp.2011.12.004
10.12659/Msm.913829
10.1016/j.bioorg.2018.08.028
10.1002/jcp.22226
10.1016/j.taap.2013.04.031
10.1248/bpb.26.911
10.1016/j.phymed.2009.06.005
10.1016/j.fct.2020.111517
10.2174/1573412911666150707182742
10.1016/j.canlet.2017.12.014
10.1016/j.ijpharm.2017.06.068
10.1371/journal.pone.0106458
10.1007/s00204-013-1085-6
10.1042/CS20160935
10.3322/caac.21492
10.1159/000443404
10.1016/j.ejphar.2008.06.024
10.1002/ijc.29009
10.1016/j.bcp.2008.02.023
10.4314/ahs.v13i3.3
10.3892/or.2012.1841
10.1016/j.phrs.2018.02.017
10.3390/ijms19082362
10.3390/ijms13089877
10.1055/s-0028-1088364
10.1615/CritRevImmunol.2020033205
10.1016/j.jpba.2018.10.028
10.3892/ijmm.2018.3776
10.3389/fphar.2018.00686
10.1016/j.bmcl.2016.12.076
10.3109/10717544.2013.853850
10.3390/ijms19102974
10.1002/mc.22182
10.1142/9789813208575_0014
10.1080/17425247.2017.1266333
10.1038/cddis.2011.66
10.1016/j.jep.2016.10.069
10.1002/mnfr.200700329
10.1016/j.lfs.2020.118372
10.3390/molecules19055538
10.1186/s12967-018-1381-2
10.1016/j.bmc.2017.03.007
10.1038/srep39950
10.1016/j.phymed.2020.153174
10.1016/j.ejmech.2019.06.024
10.1371/journal.pmed.1000100
10.1139/bcb-2012-0077
10.1002/cbdv.201400181
10.21873/invivo.11878
10.1016/j.jep.2003.11.014
10.1016/j.canlet.2018.06.017
10.18632/oncotarget.6796
10.1016/j.jep.2019.112260
10.1158/1078-0432.CCR-04-1974
10.1186/s13020-019-0270-9
10.4103/0366-6999.195466
10.3892/ol.2017.6059
10.7150/ijbs.33146
10.3390/cancers11020246
10.1016/j.ijbiomac.2017.01.080
10.1016/j.phrs.2019.04.004
10.1196/annals.1397.056
10.3892/or.2015.3896
10.1016/j.semcancer.2019.12.008
10.1002/ptr.2645
10.1016/j.jpba.2010.04.019
10.4103/0973-1482.183218
10.1007/s00232-018-0046-7
10.1016/j.cbi.2018.09.003
10.1155/2017/9381513
10.3892/ijmm.2016.2700
10.1111/j.1349-7006.2011.01874.x
10.5114/aoms.2018.73711
10.1002/jcb.24224
10.1016/j.semcancer.2020.05.015
10.3892/or.2013.2726
10.1038/cddis.2014.221
10.1016/j.vph.2014.01.010
10.1016/j.tox.2013.07.013
10.1142/S0192415X18500027
10.1097/Cji.0000000000000080
10.1097/01.cad.0000217431.64118.3f
10.1002/ijc.23182
10.1007/s12031-015-0530-9
10.1016/j.taap.2011.03.016
10.1186/s12906-017-1788-y
10.1211/0022357021778673
10.1016/j.ejpb.2018.04.023
10.1016/j.lfs.2020.118814
10.1007/s00204-002-0346-6
10.1016/j.jpba.2010.04.002
10.1016/j.bcp.2014.09.008
10.3390/ijms21093285
10.1007/s00204-020-02842-y
10.1007/s10495-016-1284-8
10.1016/j.jpba.2015.10.013
10.1016/j.biopha.2020.110917
10.1002/ijc.29726
10.12659/Msm.897621
10.3892/ol.2016.5367
10.3390/biom9120836
10.1055/s-2008-1034358
10.3390/cancers10070228
10.1371/journal.pone.0139147
10.3390/molecules23082046
10.1016/j.ctrv.2008.09.005
10.1016/j.bbcan.2013.12.005
10.1016/j.sjbs.2016.08.011
10.1016/j.pharep.2019.01.001
10.1016/j.lfs.2020.118182
10.3390/molecules23020384
10.1166/jnn.2016.10792
10.3390/molecules25092066
10.4103/0366-6999.225064
ContentType Journal Article
Copyright 2022 John Wiley & Sons Ltd.
2022 John Wiley & Sons, Ltd.
Copyright_xml – notice: 2022 John Wiley & Sons Ltd.
– notice: 2022 John Wiley & Sons, Ltd.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7QP
7QR
7TK
7TM
8FD
FR3
K9.
P64
RC3
7X8
7S9
L.6
DOI 10.1002/ptr.7386
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Biotechnology Research Abstracts
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Neurosciences Abstracts
Nucleic Acids Abstracts
Technology Research Database
Engineering Research Database
ProQuest Health & Medical Complete (Alumni)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Genetics Abstracts
Biotechnology Research Abstracts
Technology Research Database
Nucleic Acids Abstracts
ProQuest Health & Medical Complete (Alumni)
Chemoreception Abstracts
Engineering Research Database
Calcium & Calcified Tissue Abstracts
Neurosciences Abstracts
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList
CrossRef
Genetics Abstracts
MEDLINE - Academic
AGRICOLA
MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Pharmacy, Therapeutics, & Pharmacology
Botany
EISSN 1099-1573
EndPage 1883
ExternalDocumentID 35102626
10_1002_ptr_7386
PTR7386
Genre reviewArticle
Systematic Review
Journal Article
GroupedDBID ---
.3N
.GA
.GJ
.Y3
05W
0R~
10A
123
1L6
1OB
1OC
1ZS
31~
33P
3SF
3WU
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5VS
66C
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
AAESR
AAEVG
AAHBH
AAHHS
AAHQN
AAIPD
AAMNL
AANHP
AANLZ
AAONW
AASGY
AAWTL
AAXRX
AAYCA
AAYOK
AAZKR
ABCQN
ABCUV
ABEML
ABIJN
ABJNI
ABOCM
ABPVW
ABQWH
ABXGK
ACAHQ
ACBWZ
ACCFJ
ACCZN
ACGFO
ACGFS
ACGOF
ACIWK
ACMXC
ACPOU
ACPRK
ACRPL
ACSCC
ACXBN
ACXQS
ACYXJ
ADBBV
ADBTR
ADEOM
ADIZJ
ADKYN
ADMGS
ADNMO
ADOZA
ADXAS
ADZMN
AEEZP
AEGXH
AEIGN
AEIMD
AENEX
AEQDE
AEUQT
AEUYR
AFBPY
AFFPM
AFGKR
AFPWT
AFRAH
AFWVQ
AFZJQ
AHBTC
AHMBA
AIACR
AIAGR
AITYG
AIURR
AIWBW
AJBDE
ALAGY
ALMA_UNASSIGNED_HOLDINGS
ALUQN
ALVPJ
AMBMR
AMYDB
ASPBG
ATUGU
AVWKF
AZBYB
AZFZN
AZVAB
BAFTC
BDRZF
BFHJK
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CS3
D-6
D-7
D-E
D-F
DCZOG
DPXWK
DR2
DRFUL
DRMAN
DRSTM
EBD
EBS
ECGQY
EJD
EMOBN
F00
F01
F04
F5P
FEDTE
FUBAC
G-S
G.N
GNP
GODZA
GWYGA
H.X
HF~
HGLYW
HHY
HVGLF
HZ~
IX1
J0M
JPC
KBYEO
KQQ
LATKE
LAW
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
M6Q
MEWTI
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
O66
O9-
OIG
OVD
P2P
P2W
P2X
P2Z
P4B
P4D
PALCI
PQQKQ
Q.N
Q11
QB0
QRW
R.K
RIWAO
RJQFR
ROL
RWI
RX1
RYL
SAMSI
SUPJJ
SV3
TEORI
UB1
V2E
V8K
W8V
W99
WBKPD
WHWMO
WIB
WIH
WIJ
WIK
WOHZO
WQJ
WRC
WUP
WVDHM
WWP
WXI
WXSBR
XG1
XV2
YCJ
ZZTAW
~IA
~KM
~WT
AAMMB
AAYXX
AEFGJ
AEYWJ
AGHNM
AGQPQ
AGXDD
AGYGG
AIDQK
AIDYY
AIQQE
CITATION
O8X
CGR
CUY
CVF
ECM
EIF
NPM
7QO
7QP
7QR
7TK
7TM
8FD
FR3
K9.
P64
RC3
7X8
7S9
L.6
ID FETCH-LOGICAL-c3826-675135f426e9fc4317a6fea012f16380c002082997e93c2744a009f51668d0183
IEDL.DBID DRFUL
ISICitedReferencesCount 117
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000748770300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0951-418X
1099-1573
IngestDate Fri Sep 05 17:31:52 EDT 2025
Fri Sep 05 13:35:39 EDT 2025
Sat Nov 29 14:20:34 EST 2025
Mon Jul 21 06:06:26 EDT 2025
Sat Nov 29 02:30:33 EST 2025
Tue Nov 18 21:11:12 EST 2025
Wed Jan 22 16:25:43 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords chemoprevention
Wogonin
therapy
in vitro
cancer
in vivo
molecular targets
Language English
License 2022 John Wiley & Sons Ltd.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c3826-675135f426e9fc4317a6fea012f16380c002082997e93c2744a009f51668d0183
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
content type line 14
ObjectType-Feature-3
ObjectType-Evidence Based Healthcare-1
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Undefined-4
ORCID 0000-0003-2497-8313
0000-0003-3529-7062
0000-0001-9159-960X
0000-0002-1050-3934
0000-0001-8190-3110
0000-0001-7854-2406
0000-0001-5882-6022
0000-0001-9121-6816
PMID 35102626
PQID 2667665935
PQPubID 1036338
PageCount 30
ParticipantIDs proquest_miscellaneous_2675585227
proquest_miscellaneous_2624657295
proquest_journals_2667665935
pubmed_primary_35102626
crossref_primary_10_1002_ptr_7386
crossref_citationtrail_10_1002_ptr_7386
wiley_primary_10_1002_ptr_7386_PTR7386
PublicationCentury 2000
PublicationDate May 2022
2022-05-00
2022-May
20220501
PublicationDateYYYYMMDD 2022-05-01
PublicationDate_xml – month: 05
  year: 2022
  text: May 2022
PublicationDecade 2020
PublicationPlace Chichester, UK
PublicationPlace_xml – name: Chichester, UK
– name: England
– name: Bognor Regis
PublicationSubtitle PTR
PublicationTitle Phytotherapy research
PublicationTitleAlternate Phytother Res
PublicationYear 2022
Publisher John Wiley & Sons, Ltd
Wiley Subscription Services, Inc
Publisher_xml – name: John Wiley & Sons, Ltd
– name: Wiley Subscription Services, Inc
References 2009; 87
2019; 11
2019b; 17
2019; 15
2019b; 15
2019; 14
2019; 17
2020; 14
2019b; 20
2008; 103
2020; 11
2012; 14
2012; 13
2012; 12
2016; 38
2019; 164
2017b; 10
2017b; 15
2007; 1095
2019; 20
2015; 136
2019; 24
2019a; 244
2019; 25
2013; 52
2010; 197
2012; 28
2018a; 130
2016; 40‐41
2008; 111
2012; 24
2007b; 37
2016a; 12
2012; 22
2011; 137
2011; 2
2020; 262
2019; 31
2020; 261
2020; 40
2020; 143
2002; 76
2020; 260
2018; 103
2013; 91
2008b; 99
2019c; 39
2020; 37
2016b; 61
2006; 351
2013; 92
2020; 34
2008; 122
2016; 17
2017; 135
2016; 16
2011; 254
2016; 7
2006; 108
2009; 75
2002; 63
2017a; 528
2002; 68
2016; 21
2020; 26
2020; 25
2020; 21
2016; 25
2016; 9
2016; 22
2013; 29
2010; 53
2013b; 14
2014; 737
2019; 53
2017; 49
2013; 23
2007a; 21
2013; 20
2002; 54
2018; 81
2008; 74
2008; 75
2017a; 131
2020; 8
2013; 18
2014; 5
2017; 36
2013; 13
2016; 118
2020; 9
2013; 312
2020; 48
2020; 47
2020; 254
2018b; 32
2014; 9
2016a; 55
2019; S1044‐579X
2008a; 52
2018b; 39
2014; 53
2007; 245
2019; 71
2014; 92
2017; 2017
2018c
2017; 25
2018b
2017; 27
2018a
2018a; 23
2016; 129
2007; 120
2019b; 40
2004; 91
2014; 88
2018; 68
2017; 108
2018a; 18
2011; 102
2013b; 25
2009b; 1171
2017; 14
2018a; 10
2017; 17
2020
2018a; 14
2017; 10
2017; 13
2013; 30
2006; 140
2018
2020; 68
2009; 6
2016; 138
2011; 101
2010; 17
2011; 60
2010; 225
2006b; 29
2008b; 32
2020; 98
2013; 8
2018; 42
2014; 21
2018; 46
2018a; 416
2018; 296
2018; 9
2018; 8
2010; 28
2020; 94
2009; 124
2007; 60
2011; 68
2011; 67
2014; 19
2015; 56
2021; 267
2011b; 27
2019a; 178
2014; 48
2021; 265
2018; 23
2017a; 17
2014; 1845
2014; 44
2018; 25
2019a; 25
2018; 19
2012; 113
2019a; 9
2015; 61
2013a; 27
2017b; 174
2015a; 55
2018b; 16
2003; 26
2021; 133
2018; 11
2005; 11
2012; 61
2017; 7
2015; 39
2012; 287
2015; 38
2018; 128
2013c; 222
2009a; 157
2015; 33
2006a; 17
2020; S1044‐579X
2018; 131
2018; 251
2013a; 42
2018; 135
2000; 55
2013; 271
2008a; 591
2016; 194
2009; 23
2015; 12
2015; 14
2015; 16
2011a; 282
2016b; 12
2015; 10
2011; 31
2011; 39
2019; 144
2017; 97
2009; 35
2018a; 432
2005; 53
2011; 46
2012; 6
2012; 7
2015b; 54
2018a; 9
1994; 54
e_1_2_13_120_1
e_1_2_13_143_1
e_1_2_13_166_1
Thakur K. K. (e_1_2_13_178_1) 2018
e_1_2_13_189_1
e_1_2_13_20_1
e_1_2_13_66_1
e_1_2_13_43_1
e_1_2_13_181_1
e_1_2_13_8_1
e_1_2_13_81_1
e_1_2_13_92_1
e_1_2_13_117_1
e_1_2_13_214_1
Choudhary H. (e_1_2_13_38_1) 2018
e_1_2_13_17_1
e_1_2_13_154_1
e_1_2_13_131_1
e_1_2_13_32_1
e_1_2_13_78_1
e_1_2_13_177_1
e_1_2_13_215_1
e_1_2_13_192_1
e_1_2_13_238_1
e_1_2_13_70_1
Monisha J. (e_1_2_13_132_1) 2018
Yano H. (e_1_2_13_217_1) 1994; 54
e_1_2_13_241_1
e_1_2_13_203_1
e_1_2_13_105_1
e_1_2_13_88_1
e_1_2_13_128_1
e_1_2_13_165_1
e_1_2_13_142_1
e_1_2_13_44_1
e_1_2_13_67_1
e_1_2_13_104_1
e_1_2_13_188_1
e_1_2_13_9_1
e_1_2_13_82_1
e_1_2_13_180_1
e_1_2_13_91_1
e_1_2_13_236_1
e_1_2_13_116_1
e_1_2_13_213_1
e_1_2_13_99_1
e_1_2_13_139_1
e_1_2_13_18_1
e_1_2_13_130_1
e_1_2_13_153_1
e_1_2_13_79_1
e_1_2_13_10_1
e_1_2_13_56_1
e_1_2_13_115_1
e_1_2_13_176_1
e_1_2_13_199_1
e_1_2_13_33_1
e_1_2_13_237_1
e_1_2_13_71_1
e_1_2_13_191_1
e_1_2_13_240_1
e_1_2_13_225_1
e_1_2_13_202_1
e_1_2_13_127_1
e_1_2_13_122_1
Lu X. (e_1_2_13_129_1) 2011; 46
e_1_2_13_68_1
e_1_2_13_45_1
e_1_2_13_145_1
e_1_2_13_168_1
e_1_2_13_205_1
e_1_2_13_22_1
e_1_2_13_60_1
e_1_2_13_83_1
e_1_2_13_183_1
e_1_2_13_228_1
e_1_2_13_6_1
e_1_2_13_160_1
e_1_2_13_90_1
e_1_2_13_231_1
e_1_2_13_98_1
e_1_2_13_119_1
e_1_2_13_19_1
e_1_2_13_133_1
e_1_2_13_179_1
e_1_2_13_57_1
Chen S. S. (e_1_2_13_30_1) 2012; 14
e_1_2_13_110_1
e_1_2_13_11_1
e_1_2_13_34_1
e_1_2_13_171_1
e_1_2_13_72_1
e_1_2_13_194_1
Broncel M. (e_1_2_13_21_1) 2007; 60
Sailo B. L. (e_1_2_13_157_1) 2018
e_1_2_13_220_1
e_1_2_13_243_1
Singh A. K. (e_1_2_13_163_1) 2018
Chen S. (e_1_2_13_29_1) 2008; 32
e_1_2_13_107_1
e_1_2_13_121_1
e_1_2_13_144_1
e_1_2_13_46_1
e_1_2_13_69_1
Tan H. (e_1_2_13_173_1) 2019; 24
e_1_2_13_23_1
e_1_2_13_167_1
e_1_2_13_204_1
e_1_2_13_84_1
e_1_2_13_182_1
e_1_2_13_227_1
e_1_2_13_61_1
e_1_2_13_230_1
Banik K. (e_1_2_13_7_1) 2018
e_1_2_13_97_1
e_1_2_13_118_1
e_1_2_13_155_1
e_1_2_13_35_1
e_1_2_13_58_1
e_1_2_13_216_1
e_1_2_13_12_1
e_1_2_13_170_1
e_1_2_13_193_1
e_1_2_13_73_1
e_1_2_13_239_1
e_1_2_13_50_1
Padmavathi G. (e_1_2_13_137_1) 2018
e_1_2_13_242_1
Lin C. C. (e_1_2_13_124_1) 2013; 27
e_1_2_13_106_1
e_1_2_13_24_1
e_1_2_13_47_1
e_1_2_13_185_1
e_1_2_13_207_1
e_1_2_13_101_1
e_1_2_13_147_1
e_1_2_13_85_1
e_1_2_13_62_1
e_1_2_13_162_1
e_1_2_13_233_1
e_1_2_13_96_1
e_1_2_13_210_1
e_1_2_13_13_1
e_1_2_13_36_1
e_1_2_13_59_1
e_1_2_13_219_1
e_1_2_13_112_1
e_1_2_13_158_1
e_1_2_13_196_1
e_1_2_13_135_1
e_1_2_13_51_1
e_1_2_13_74_1
e_1_2_13_150_1
e_1_2_13_222_1
e_1_2_13_245_1
e_1_2_13_4_1
e_1_2_13_109_1
e_1_2_13_25_1
e_1_2_13_48_1
e_1_2_13_100_1
e_1_2_13_169_1
e_1_2_13_206_1
e_1_2_13_123_1
e_1_2_13_86_1
e_1_2_13_40_1
e_1_2_13_63_1
Khwairakpam A. D. (e_1_2_13_94_1) 2018
e_1_2_13_184_1
e_1_2_13_161_1
Qi W. (e_1_2_13_146_1) 2016; 9
e_1_2_13_232_1
e_1_2_13_95_1
e_1_2_13_14_1
e_1_2_13_111_1
e_1_2_13_37_1
e_1_2_13_218_1
e_1_2_13_134_1
e_1_2_13_75_1
e_1_2_13_52_1
e_1_2_13_172_1
e_1_2_13_195_1
Fu P. (e_1_2_13_55_1) 2015; 61
e_1_2_13_221_1
e_1_2_13_5_1
e_1_2_13_244_1
e_1_2_13_108_1
e_1_2_13_49_1
e_1_2_13_141_1
e_1_2_13_164_1
e_1_2_13_209_1
e_1_2_13_26_1
e_1_2_13_126_1
e_1_2_13_87_1
e_1_2_13_187_1
e_1_2_13_64_1
e_1_2_13_103_1
e_1_2_13_41_1
Roy N. K. (e_1_2_13_152_1) 2018
Zhang H. W. (e_1_2_13_229_1) 2017; 10
e_1_2_13_235_1
e_1_2_13_138_1
e_1_2_13_212_1
e_1_2_13_15_1
Padmavathi G. (e_1_2_13_136_1) 2018
e_1_2_13_175_1
e_1_2_13_53_1
e_1_2_13_76_1
e_1_2_13_114_1
e_1_2_13_198_1
e_1_2_13_190_1
e_1_2_13_224_1
e_1_2_13_2_1
e_1_2_13_201_1
e_1_2_13_149_1
e_1_2_13_27_1
e_1_2_13_208_1
e_1_2_13_102_1
e_1_2_13_125_1
e_1_2_13_148_1
e_1_2_13_186_1
e_1_2_13_42_1
e_1_2_13_65_1
e_1_2_13_80_1
e_1_2_13_140_1
e_1_2_13_93_1
e_1_2_13_234_1
e_1_2_13_211_1
e_1_2_13_39_1
Sailo B. L. (e_1_2_13_156_1) 2018
e_1_2_13_16_1
e_1_2_13_113_1
e_1_2_13_159_1
e_1_2_13_174_1
e_1_2_13_197_1
e_1_2_13_31_1
e_1_2_13_77_1
e_1_2_13_54_1
e_1_2_13_151_1
e_1_2_13_223_1
e_1_2_13_3_1
Yu L. H. (e_1_2_13_226_1) 2017; 10
e_1_2_13_246_1
e_1_2_13_89_1
e_1_2_13_200_1
e_1_2_13_28_1
References_xml – volume: 9
  start-page: 172
  issue: 2
  year: 2014
  end-page: 177
  article-title: Inhibitory effects of wogonin on invasion by human oral cancer cells by decreasing the activity of matrix metalloproteinases and urokinase‐plasminogen activator
  publication-title: Journal of Dental Sciences
– volume: 140
  start-page: 477
  issue: 2
  year: 2006
  end-page: 489
  article-title: Lipopolysaccharide plus 12‐O‐tetradecanoylphorbol 13‐acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids
  publication-title: Neuroscience
– volume: 265
  year: 2021
  article-title: Traditional uses, ten‐years research progress on phytochemistry and pharmacology, and clinical studies of the genus Scutellaria
  publication-title: Journal of Ethnopharmacology
– volume: 128
  start-page: 156
  year: 2018
  end-page: 169
  article-title: Self‐assembled amphiphilic zein‐lactoferrin micelles for tumor targeted co‐delivery of rapamycin and wogonin to breast cancer
  publication-title: European Journal of Pharmaceutics and Biopharmaceutics
– volume: S1044‐579X
  start-page: 30150
  issue: 20
  year: 2020
  end-page: 4
  article-title: Phytochemicals in cancer cell chemosensitization: Current knowledge and future perspectives
  publication-title: Seminars in Cancer Biology
– volume: 39
  start-page: 168
  year: 2018b
  end-page: 175
  article-title: Wogonin exacerbates the cytotoxic effect of oxaliplatin by inducing nitrosative stress and autophagy in human gastric cancer cells
  publication-title: Phytomedicine
– volume: 38
  start-page: 167
  issue: 5
  year: 2015
  end-page: 184
  article-title: Wogonin inhibits tumor‐derived regulatory molecules by suppressing STAT3 signaling to promote tumor immunity
  publication-title: Journal of Immunotherapy
– volume: 27
  start-page: 733
  issue: 6
  year: 2013a
  end-page: 738
  article-title: Wogonin, a natural and biologically‐active flavonoid, influences a murine WEHI‐3 leukemia model in vivo through enhancing populations of T‐ and B‐cells
  publication-title: In Vivo
– volume: 131
  start-page: 1781
  issue: 15
  year: 2017a
  end-page: 1799
  article-title: Curcumin mediates anticancer effects by modulating multiple cell signaling pathways
  publication-title: Clinical Science (London, England)
– volume: 9
  start-page: 1451
  issue: 6
  year: 2020
  article-title: Targeting the JAK/STAT signaling pathway using Phytocompounds for cancer prevention and therapy
  publication-title: Cell
– volume: 13
  start-page: 551
  issue: 3
  year: 2013
  end-page: 555
  article-title: Probe substrate and enzyme source‐dependent inhibition of UDP‐glucuronosyltransferase (UGT) 1A9 by wogonin
  publication-title: African Health Sciences
– volume: 74
  start-page: 474
  issue: 4
  year: 2008
  end-page: 481
  article-title: Comparisons of Scutellaria baicalensis, Scutellaria lateriflora and Scutellaria racemosa: Genome size, antioxidant potential and phytochemistry
  publication-title: Planta Medica
– volume: 26
  start-page: 911
  issue: 7
  year: 2003
  end-page: 919
  article-title: Pharmacokinetic study on the multi‐constituents of Huangqin‐Tang decoction in rats
  publication-title: Biological & Pharmaceutical Bulletin
– volume: 68
  start-page: 128
  issue: 2
  year: 2002
  end-page: 132
  article-title: Different effects of baicalein, baicalin and wogonin on mitochondrial function, glutathione content and cell cycle progression in human hepatoma cell lines
  publication-title: Planta Medica
– volume: 14
  start-page: 48
  issue: 1
  year: 2019
  article-title: Naturally occurring anti‐cancer compounds: Shining from Chinese herbal medicine
  publication-title: Chinese Medicine
– volume: 10
  start-page: 228
  issue: 7
  year: 2018a
  article-title: NGAL is downregulated in Oral squamous cell carcinoma and leads to increased survival, proliferation, migration and chemoresistance
  publication-title: Cancers (Basel)
– volume: 13
  start-page: 5028
  issue: 6
  year: 2017
  end-page: 5034
  article-title: Combination of wogonin and sorafenib effectively kills human hepatocellular carcinoma cells through apoptosis potentiation and autophagy inhibition
  publication-title: Oncology Letters
– volume: 15
  start-page: 1056
  issue: 4
  year: 2019
  end-page: 1064
  article-title: Methylwogonin exerts anticancer effects in A375 human malignant melanoma cells through apoptosis induction, DNA damage, cell invasion inhibition and downregulation of the mTOR/PI3K/Akt signalling pathway
  publication-title: Archives of Medical Science
– volume: 28
  start-page: 220
  issue: 3
  year: 2010
  end-page: 229
  article-title: Effects of naturally occurring polymethyoxyflavonoids on cell growth, p‐glycoprotein function, cell cycle, and apoptosis of daunorubicin‐resistant T lymphoblastoid leukemia cells
  publication-title: Cancer Investigation
– volume: 222
  start-page: 212
  year: 2013c
  end-page: 223
  article-title: GSK3beta/beta‐catenin signaling is correlated with the differentiation of glioma cells induced by wogonin
  publication-title: Toxicology Letters
– volume: 25
  start-page: 8465
  year: 2019a
  end-page: 8471
  article-title: Anti‐proliferative effect of Wogonin on ovary cancer cells involves activation of apoptosis and cell cycle arrest
  publication-title: Medical Science Monitor
– volume: 35
  start-page: 57
  issue: 1
  year: 2009
  end-page: 68
  article-title: New therapeutic aspects of flavones: The anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin
  publication-title: Cancer Treatment Reviews
– volume: 53
  start-page: 723
  issue: 3
  year: 2010
  end-page: 728
  article-title: Secondary metabolite mapping identifies Scutellaria inhibitors of human lung cancer cells
  publication-title: Journal of Pharmaceutical and Biomedical Analysis
– volume: 1095
  start-page: 521
  year: 2007
  end-page: 526
  article-title: Wogonin, a plant flavone, potentiates etoposide‐induced apoptosis in cancer cells
  publication-title: Annals of the new York Academy of Sciences
– volume: 39
  start-page: 217
  issue: 1
  year: 2011
  end-page: 224
  article-title: Wogonin triggers apoptosis in human osteosarcoma U‐2 OS cells through the endoplasmic reticulum stress, mitochondrial dysfunction and caspase‐3‐dependent signaling pathways
  publication-title: International Journal of Oncology
– volume: 46
  start-page: 512
  year: 2011
  end-page: 517
  article-title: Inhibitory effect of wogonin on gastric cancer SGC7901 cell line in vitro
  publication-title: Chinese Pharmaceutical Journal
– volume: 54
  start-page: E81
  year: 2015b
  end-page: E93
  article-title: Wogonin suppresses human alveolar adenocarcinoma cell A549 migration in inflammatory microenvironment by modulating the IL‐6/STAT3 signaling pathway
  publication-title: Molecular Carcinogenesis
– start-page: 583
  year: 2018c
  end-page: 613
– volume: 21
  start-page: 3285
  issue: 9
  year: 2020
  article-title: Targeting AKT/mTOR in Oral cancer: Mechanisms and advances in clinical trials
  publication-title: International Journal of Molecular Sciences
– volume: 61
  start-page: 123
  issue: 7
  year: 2015
  end-page: 127
  article-title: Wogonin increases doxorubicin sensitivity by down‐regulation of IGF‐1R/AKT signaling pathway in human breast cancer
  publication-title: Cellular and Molecular Biology (Noisy‐le‐Grand, France)
– volume: 99
  start-page: 689
  issue: 4
  year: 2008b
  end-page: 695
  article-title: Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up‐regulates phospholipid scramblase 1 gene expression
  publication-title: Cancer Science
– volume: 68
  start-page: 394
  issue: 6
  year: 2018
  end-page: 424
  article-title: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
  publication-title: CA: A Cancer Journal for Clinicians
– volume: 67
  start-page: 1063
  issue: 5
  year: 2011
  end-page: 1072
  article-title: Wogonin potentiates the antitumor action of etoposide and ameliorates its adverse effects
  publication-title: Cancer Chemotherapy and Pharmacology
– volume: 11
  start-page: 246
  issue: 2
  year: 2019
  article-title: FBXW7 in cancer: What has been unraveled thus far?
  publication-title: Cancers (Basel)
– volume: 17
  start-page: 55
  issue: 1
  year: 2010
  end-page: 62
  article-title: In vitro anti‐leukemic activity of the ethno‐pharmacological plant Scutellaria orientalis ssp. carica endemic to western Turkey
  publication-title: Phytomedicine
– volume: 25
  start-page: 1639
  issue: 8
  year: 2018
  end-page: 1647
  article-title: Molecular characterization of flavonoid biosynthetic genes and accumulation of baicalin, baicalein, and wogonin in plant and hairy root of Scutellaria lateriflora
  publication-title: Saudi Journal of Biological Sciences
– volume: 18
  start-page: 618
  year: 2013
  end-page: 626
  article-title: Wogonin enhances antitumor activity of tumor necrosis factor‐related apoptosis‐inducing ligand in vivo through ROS‐mediated downregulation of cFLIPL and IAP proteins
  publication-title: Apoptosis
– volume: 60
  start-page: 212
  issue: 2
  year: 2011
  end-page: 217
  article-title: Developmental toxicity and genotoxicity studies of wogonin
  publication-title: Regulatory Toxicology and Pharmacology
– volume: 7
  start-page: 789
  year: 2012
  end-page: 798
  article-title: Effect of magnetic nanoparticles on apoptosis and cell cycle induced by wogonin in Raji cells
  publication-title: International Journal of Nanomedicine
– start-page: 107
  year: 2018
  end-page: 127
– start-page: 81
  year: 2018b
  end-page: 106
– volume: 120
  start-page: 2019
  issue: 9
  year: 2007
  end-page: 2027
  article-title: Reversal of inflammation‐associated dihydrodiol dehydrogenases (AKR1C1 and AKR1C2) overexpression and drug resistance in nonsmall cell lung cancer cells by wogonin and chrysin
  publication-title: International Journal of Cancer
– volume: 20
  start-page: 4101
  issue: 17
  year: 2019
  article-title: An update on pharmacological potential of Boswellic acids against chronic diseases
  publication-title: International Journal of Molecular Sciences
– volume: 8
  issue: 11
  year: 2013
  article-title: Wogonin has multiple anti‐cancer effects by regulating c‐Myc/SKP2/Fbw7alpha and HDAC1/HDAC2 pathways and inducing apoptosis in human lung adenocarcinoma cell line A549
  publication-title: PLoS One
– volume: 54
  start-page: 448
  year: 1994
  end-page: 454
  article-title: The herbal medicine Sho‐saiko‐to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase
  publication-title: Cancer Research
– volume: 10
  issue: 10
  year: 2015
  article-title: Food polyphenols fail to cause a biologically relevant reduction of COX‐2 activity
  publication-title: PLoS One
– volume: 11
  start-page: 583200
  year: 2020
  article-title: Regulatory mechanisms of Baicalin in cardiovascular diseases: A review
  publication-title: Frontiers in Pharmacology
– volume: 20
  start-page: 3437
  issue: 11
  year: 2019b
  end-page: 3446
  article-title: An investigation on the therapeutic potential of Butein, a Tretrahydroxychalcone against human Oral squamous cell carcinoma
  publication-title: Asian Pacific Journal of Cancer Prevention
– volume: 2017
  start-page: 9381513
  year: 2017
  article-title: Therapy effects of Wogonin on ovarian cancer cells
  publication-title: BioMed Research International
– volume: 9
  start-page: 686
  year: 2018a
  article-title: Googling the Guggul (Commiphora and Boswellia) for prevention of chronic diseases
  publication-title: Frontiers in Pharmacology
– volume: 245
  start-page: 269
  issue: 1–2
  year: 2007
  end-page: 274
  article-title: Difference of growth‐inhibitory effect of Scutellaria baicalensis‐producing flavonoid wogonin among human cancer cells and normal diploid cell
  publication-title: Cancer Letters
– volume: 46
  start-page: 25
  issue: 1
  year: 2018
  end-page: 54
  article-title: Scutellaria baicalensis and cancer treatment: Recent Progress and perspectives in biomedical and clinical studies
  publication-title: The American Journal of Chinese Medicine
– volume: 19
  start-page: 2362
  issue: 8
  year: 2018
  article-title: Magnolol: A Neolignan from the Magnolia family for the prevention and treatment of cancer
  publication-title: International Journal of Molecular Sciences
– volume: 32
  start-page: 405
  issue: 2
  year: 2008b
  end-page: 411
  article-title: Down‐regulation of androgen‐receptor and PSA by phytochemicals
  publication-title: International Journal of Oncology
– volume: 271
  start-page: 144
  issue: 2
  year: 2013
  end-page: 155
  article-title: Wogonin inhibits tumor angiogenesis via degradation of HIF‐1alpha protein
  publication-title: Toxicology and Applied Pharmacology
– volume: 7
  start-page: 5715
  issue: 5
  year: 2016
  end-page: 5727
  article-title: Wogonin inhibits multiple myeloma‐stimulated angiogenesis via c‐Myc/VHL/HIF‐1alpha signaling axis
  publication-title: Oncotarget
– volume: 53
  start-page: E107
  issue: Suppl 1
  year: 2014
  end-page: E118
  article-title: Wogonin reverses hypoxia resistance of human colon cancer HCT116 cells via downregulation of HIF‐1alpha and glycolysis, by inhibiting PI3K/Akt signaling pathway
  publication-title: Molecular Carcinogenesis
– volume: 178
  start-page: 782
  year: 2019a
  end-page: 801
  article-title: Design of wogonin‐inspired selective cyclin‐dependent kinase 9 (CDK9) inhibitors with potent in vitro and in vivo antitumor activity
  publication-title: European Journal of Medicinal Chemistry
– volume: 40
  start-page: 1
  issue: 1
  year: 2020
  end-page: 39
  article-title: Inflammation, NF‐kappaB, and chronic diseases: How are they linked?
  publication-title: Critical Reviews in Immunology
– volume: 97
  start-page: 598
  year: 2017
  end-page: 605
  article-title: Potent inhibition of monoamine oxidase a by decursin from Angelica gigas Nakai and by wogonin from Scutellaria baicalensis Georgi
  publication-title: International Journal of Biological Macromolecules
– volume: 122
  start-page: 816
  issue: 4
  year: 2008
  end-page: 822
  article-title: Anticancer effects of wogonin in both estrogen receptor‐positive and ‐negative human breast cancer cell lines in vitro and in nude mice xenografts
  publication-title: International Journal of Cancer
– volume: 25
  start-page: 2278
  issue: 10
  year: 2020
  article-title: Therapeutic emergence of Rhein as a potential anticancer drug: A review of its molecular targets and anticancer properties
  publication-title: Molecules
– volume: 52
  start-page: 1349
  issue: 11
  year: 2008a
  end-page: 1357
  article-title: Wogonin, a bioactive flavonoid in herbal tea, inhibits inflammatory cyclooxygenase‐2 gene expression in human lung epithelial cancer cells
  publication-title: Molecular Nutrition & Food Research
– volume: 17
  start-page: 304
  issue: 1
  year: 2017a
  article-title: Wogonin suppresses stem cell‐like traits of CD133 positive osteosarcoma cell via inhibiting matrix metallopeptidase‐9 expression
  publication-title: BMC Complementary and Alternative Medicine
– volume: 6
  start-page: 1443
  issue: 6
  year: 2012
  end-page: 1449
  article-title: Antitumor actions of baicalein and wogonin in HT‐29 human colorectal cancer cells
  publication-title: Molecular Medicine Reports
– volume: 135
  start-page: 49
  year: 2018
  end-page: 59
  article-title: Selective anti‐tumor activity of wogonin targeting the Warburg effect through stablizing p53
  publication-title: Pharmacological Research
– volume: 8
  start-page: 159
  issue: 3
  year: 2018
  article-title: Sustained cytotoxicity of Wogonin on breast cancer cells by encapsulation in solid lipid nanoparticles
  publication-title: Nanomaterials (Basel)
– start-page: 51
  year: 2018
  end-page: 80
– volume: 23
  start-page: 2046
  issue: 8
  year: 2018
  article-title: Combination effect of silver nanoparticles and histone deacetylases inhibitor in human alveolar basal epithelial cells
  publication-title: Molecules
– volume: 17
  start-page: 797
  issue: 7
  year: 2006a
  end-page: 805
  article-title: Involvement of bax/bcl‐2 in wogonin‐induced apoptosis of human hepatoma cell line SMMC‐7721
  publication-title: Anti‐Cancer Drugs
– volume: 61
  start-page: 1391
  year: 2016b
  end-page: 1398
  article-title: Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants
  publication-title: Science Bulletin
– volume: 9
  start-page: 836
  issue: 12
  year: 2019a
  article-title: TIPE2 induced the proliferation, survival, and migration of lung cancer cells through modulation of Akt/mTOR/NF‐kappaB signaling Cascade
  publication-title: Biomolecules
– volume: 11
  start-page: 1379
  issue: 6
  year: 2018
  end-page: 1389
  article-title: Sorcin a potential molecular target for cancer therapy
  publication-title: Translational Oncology
– volume: 55
  start-page: 778
  issue: 5
  year: 2016a
  end-page: 792
  article-title: LW‐213 induces G2/M cell cycle arrest through AKT/GSK3beta/beta‐catenin signaling pathway in human breast cancer cells
  publication-title: Molecular Carcinogenesis
– volume: 27
  start-page: 1012
  issue: 4
  year: 2017
  end-page: 1016
  article-title: Synthesis, evaluation and quantitative structure‐activity relationship (QSAR) analysis of Wogonin derivatives as cytotoxic agents
  publication-title: Bioorganic & Medicinal Chemistry Letters
– volume: 54
  start-page: 555
  issue: 4
  year: 2002
  end-page: 563
  article-title: Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats
  publication-title: The Journal of Pharmacy and Pharmacology
– volume: 144
  start-page: 192
  year: 2019
  end-page: 209
  article-title: Honokiol for cancer therapeutics: A traditional medicine that can modulate multiple oncogenic targets
  publication-title: Pharmacological Research
– volume: 53
  start-page: 8197
  issue: 21
  year: 2005
  end-page: 8204
  article-title: Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo
  publication-title: Journal of Agricultural and Food Chemistry
– year: 2018b
– start-page: 373
  year: 2018
  end-page: 398
– volume: S1044‐579X
  start-page: 30405
  issue: 19
  year: 2019
  end-page: 5
  article-title: Natural products targeting the PI3K‐Akt‐mTOR signaling pathway in cancer: A novel therapeutic strategy
  publication-title: Seminars in Cancer Biology
– volume: 25
  start-page: 2507
  issue: 8
  year: 2017
  end-page: 2517
  article-title: Novel platinum(IV) complexes conjugated with a wogonin derivative as multi‐targeted anticancer agents
  publication-title: Bioorganic & Medicinal Chemistry
– volume: 102
  start-page: 870
  issue: 4
  year: 2011
  end-page: 876
  article-title: Catalase suppression‐mediated H(2)O(2) accumulation in cancer cells by wogonin effectively blocks tumor necrosis factor‐induced NF‐kappaB activation and sensitizes apoptosis
  publication-title: Cancer Science
– volume: 138
  start-page: 507
  issue: 2
  year: 2016
  end-page: 514
  article-title: HTLV‐1‐associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression
  publication-title: International Journal of Cancer
– volume: 23
  start-page: 1422
  issue: 10
  year: 2013
  end-page: 1427
  article-title: Bioconversion of flavones during fermentation in Milk containing Scutellaria baicalensis extract by lactobacillus brevis
  publication-title: Journal of Microbiology and Biotechnology
– volume: 53
  start-page: 591
  issue: 3
  year: 2010
  end-page: 598
  article-title: Simultaneous determination of baicalin, baicalein, wogonin, berberine, palmatine and jatrorrhizine in rat plasma by liquid chromatography‐tandem mass spectrometry and application in pharmacokinetic studies after oral administration of traditional Chinese medicinal preparations containing scutellaria‐coptis herb couple
  publication-title: Journal of Pharmaceutical and Biomedical Analysis
– volume: 22
  start-page: 3737
  year: 2016
  end-page: 3745
  article-title: Characterization and bioavailability of Wogonin by different administration routes in beagles
  publication-title: Medical Science Monitor
– volume: 88
  start-page: 97
  issue: 1
  year: 2014
  end-page: 107
  article-title: V8, a newly synthetic flavonoid, induces apoptosis through ROS‐mediated ER stress pathway in hepatocellular carcinoma
  publication-title: Archives of Toxicology
– volume: 137
  start-page: 1373
  issue: 3
  year: 2011
  end-page: 1380
  article-title: Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC‐SD cells by inducing the expression of maspin
  publication-title: Journal of Ethnopharmacology
– volume: 21
  start-page: 553
  issue: 7
  year: 2014
  end-page: 559
  article-title: A wogonin‐loaded glycyrrhetinic acid‐modified liposome for hepatic targeting with anti‐tumor effects
  publication-title: Drug Delivery
– volume: 133
  year: 2021
  article-title: The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review
  publication-title: Biomedicine & Pharmacotherapy
– volume: 24
  start-page: 2216
  issue: 11
  year: 2012
  end-page: 2225
  article-title: Wogonin induces apoptosis by activating the AMPK and p53 signaling pathways in human glioblastoma cells
  publication-title: Cellular Signalling
– volume: 16
  start-page: 2499
  issue: 3
  year: 2016
  end-page: 2503
  article-title: Apoptosis induction and imaging of cadmium‐telluride quantum dots with Wogonin in multidrug‐resistant leukemia K562/A02 cell
  publication-title: Journal of Nanoscience and Nanotechnology
– volume: 19
  start-page: 2974
  issue: 10
  year: 2018
  article-title: TIPE family of proteins and its implications in different chronic diseases
  publication-title: International Journal of Molecular Sciences
– volume: 591
  start-page: 7
  year: 2008a
  end-page: 12
  article-title: Wogonin induced differentiation and G1 phase arrest of human U‐937 leukemia cells via PKCδ phosphorylation
  publication-title: European Journal of Pharmacology
– volume: 42
  start-page: 1018
  issue: 3
  year: 2013a
  end-page: 1026
  article-title: Hydrophobic flavonoids from Scutellaria baicalensis induce colorectal cancer cell apoptosis through a mitochondrial‐mediated pathway
  publication-title: International Journal of Oncology
– volume: 61
  start-page: 701
  issue: 5
  year: 2012
  end-page: 711
  article-title: Scutellaria extract and wogonin inhibit tumor‐mediated induction of T(reg) cells via inhibition of TGF‐beta1 activity
  publication-title: Cancer Immunology, Immunotherapy
– volume: 10
  start-page: 7553
  issue: 5
  year: 2017
  end-page: 7562
  article-title: Combination of icotinib and wogonin induces apoptosis and autophagy to overcome acquired resistance in lung cancer harbouring EGFR T790M mutation
  publication-title: International Journal of Clinical and Experimental Medicine
– volume: 262
  year: 2020
  article-title: Inflection of Akt/mTOR/STAT‐3 cascade in TNF‐alpha induced protein 8 mediated human lung carcinogenesis
  publication-title: Life Sciences
– start-page: 399
  year: 2018b
  end-page: 423
– volume: 8
  start-page: 236
  issue: 8
  year: 2020
  article-title: Targeting NF‐kappaB signaling by Calebin a, a compound of turmeric, in multicellular tumor microenvironment: Potential role of apoptosis induction in CRC cells
  publication-title: Biomedicine
– volume: 87
  start-page: 933
  year: 2009
  end-page: 942
  article-title: Wogonin induces G1 phase arrest through inhibiting Cdk4 and cyclin D1 concomitant with an elevation in p21Cip1 in human cervical carcinoma HeLa cells
  publication-title: Biochemistry and Cell Biology = Biochimie et Biologie Cellulaire
– volume: 48
  issue: 10
  year: 2020
  article-title: Effect of baicalin on gestational hypertension‐induced vascular endothelial cell damage
  publication-title: The Journal of International Medical Research
– volume: 53
  start-page: 248
  year: 2019
  end-page: 258
  article-title: Potential application of zerumbone in the prevention and therapy of chronic human diseases
  publication-title: Journal of Functional Foods
– volume: 254
  start-page: 221
  issue: 3
  year: 2011
  end-page: 228
  article-title: The ethanol extract of Scutellaria baicalensis and the active compounds induce cell cycle arrest and apoptosis including upregulation of p53 and Bax in human lung cancer cells
  publication-title: Toxicology and Applied Pharmacology
– volume: 14
  start-page: 7179
  issue: 12
  year: 2013b
  end-page: 7186
  article-title: Scutellaria extract decreases the proportion of side population cells in a myeloma cell line by down‐regulating the expression of ABCG2 protein
  publication-title: Asian Pacific Journal of Cancer Prevention
– volume: 42
  start-page: 1899
  issue: 4
  year: 2018
  end-page: 1908
  article-title: Wogonin suppresses the LPSenhanced invasiveness of MDAMB231 breast cancer cells by inhibiting the 5LO/BLT2 cascade
  publication-title: International Journal of Molecular Medicine
– volume: 101
  start-page: 15
  issue: 1
  year: 2011
  end-page: 24
  article-title: Delayed growth of glioma by Scutellaria flavonoids involve inhibition of Akt, GSK‐3 and NF‐kappaB signaling
  publication-title: Journal of Neuro‐Oncology
– volume: 14
  start-page: S594
  year: 2018a
  end-page: S599
  article-title: Deglycosylation of wogonoside enhances its anticancer potential
  publication-title: Journal of Cancer Research and Therapeutics
– volume: 7
  issue: 12
  year: 2012
  article-title: Wogonin induced Calreticulin/Annexin A1 exposure dictates the immunogenicity of cancer cells in a PERK/AKT dependent manner
  publication-title: PLoS One
– volume: 14
  start-page: 327
  issue: 78
  year: 2012
  end-page: 333
  article-title: Polyphenols inhibit indoleamine 3,5‐dioxygenase‐1 enzymatic activity‐‐a role of immunomodulation in chemoprevention
  publication-title: Discovery Medicine
– volume: 103
  start-page: 1394
  issue: 5
  year: 2008
  end-page: 1404
  article-title: Differential apoptotic effect of wogonin and nor‐wogonin via stimulation of ROS production in human leukemia cells
  publication-title: Journal of Cellular Biochemistry
– volume: 19
  start-page: 5538
  issue: 5
  year: 2014
  end-page: 5549
  article-title: Pharmacokinetics, tissue distribution, excretion and plasma protein binding studies of Wogonin in rats
  publication-title: Molecules
– volume: 37
  start-page: 29
  issue: 1
  year: 2020
  end-page: 33
  article-title: Inhibition of lung cancer proliferation by Wogonin is associated with activation of apoptosis and generation of reactive oxygen species
  publication-title: Balkan Medical Journal
– volume: 75
  start-page: 2020
  issue: 10
  year: 2008
  end-page: 2033
  article-title: Role of p53, PUMA, and Bax in wogonin‐induced apoptosis in human cancer cells
  publication-title: Biochemical Pharmacology
– volume: 28
  start-page: 601
  issue: 2
  year: 2012
  end-page: 605
  article-title: Wogonin potentiates cisplatin‐induced cancer cell apoptosis through accumulation of intracellular reactive oxygen species
  publication-title: Oncology Reports
– volume: 68
  start-page: 835
  issue: 4
  year: 2011
  end-page: 845
  article-title: Wogonin induced apoptosis in human nasopharyngeal carcinoma cells by targeting GSK‐3beta and DeltaNp63
  publication-title: Cancer Chemotherapy and Pharmacology
– volume: 23
  start-page: 417
  issue: 3
  year: 2009
  end-page: 422
  article-title: Toxicological studies of wogonin in experimental animals
  publication-title: Phytotherapy Research
– volume: 244
  start-page: 663
  issue: 8
  year: 2019a
  end-page: 689
  article-title: Cancer drug development: The missing links
  publication-title: Experimental Biology and Medicine (Maywood, N.J.)
– volume: 76
  start-page: 351
  issue: 5–6
  year: 2002
  end-page: 359
  article-title: Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK‐HEP‐1
  publication-title: Archives of Toxicology
– volume: 98
  start-page: 71
  issue: 1
  year: 2020
  end-page: 95
  article-title: The vital role of ATP citrate lyase in chronic diseases
  publication-title: Journal of Molecular Medicine (Berlin, Germany)
– volume: 49
  start-page: 1045
  issue: 11
  year: 2017
  end-page: 1045
  article-title: Response of human non‐small‐cell lung cancer cells to the influence of Wogonin with SGK1 dynamics (vol 49, pg 302, 2017)
  publication-title: Acta Biochimica et Biophysica Sinica
– volume: 24
  start-page: 1143
  issue: 3
  year: 2019
  end-page: 1149
  article-title: A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways
  publication-title: Journal of BUON
– volume: 32
  year: 2018b
  article-title: Pharmacokinetic properties of wogonin and its herb‐drug interactions with docetaxel in rats with mammary tumors
  publication-title: Biomedical Chromatography
– volume: 40‐41
  start-page: 35
  year: 2016
  end-page: 47
  article-title: Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds
  publication-title: Seminars in Cancer Biology
– volume: 17
  start-page: 147
  year: 2017
  article-title: Wogonin as a targeted therapeutic agent for EBV (+) lymphoma cells involved in LMP1/NF‐kB/miR‐155/PU.1 pathway
  publication-title: BMC Cancer
– volume: 12
  start-page: 334
  issue: 2
  year: 2012
  end-page: 341
  article-title: Wogonin induces apoptosis and down‐regulates survivin in human breast cancer MCF‐7 cells by modulating PI3K‐AKT pathway
  publication-title: International Immunopharmacology
– volume: 9
  start-page: 684
  year: 2016
  end-page: 694
  article-title: Wogonin attenuates high glucose‐induced human breast cancer cell MCF‐7 viability, migration and invasion via the expression of AKT, PKCδ and p38 MAPK
  publication-title: International Journal of Clinical Pathology
– start-page: 163
  year: 2018b
  end-page: 179
– volume: 12
  start-page: 259
  issue: 2
  year: 2015
  end-page: 272
  article-title: Activities of Wogonin analogs and other flavones against Flavobacterium columnare
  publication-title: Chemistry & Biodiversity
– volume: 131
  start-page: 495
  year: 2018
  end-page: 497
  article-title: Wogonin inhibits growth of mantle cell lymphoma cells through nuclear factor‐κB signaling pathway
  publication-title: Chinese Medical Journal
– volume: 52
  start-page: 824
  issue: 10
  year: 2013
  end-page: 834
  article-title: Drug resistance associates with activation of Nrf2 in MCF‐7/DOX cells, and Wogonin reverses it by Down‐regulating Nrf2‐mediated cellular defense response
  publication-title: Molecular Carcinogenesis
– volume: 2
  year: 2011
  article-title: Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl‐1
  publication-title: Cell Death & Disease
– volume: 15
  start-page: 15
  issue: 1
  year: 2017b
  end-page: 40
  article-title: Anti‐tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways
  publication-title: Chinese Journal of Natural Medicines
– volume: 130
  start-page: 259
  year: 2018a
  end-page: 272
  article-title: Tocotrienols: The promising analogues of vitamin E for cancer therapeutics
  publication-title: Pharmacological Research
– volume: 75
  start-page: 41
  issue: 1
  year: 2009
  end-page: 48
  article-title: In vitro antitumor mechanisms of various Scutellaria extracts and constituent flavonoids
  publication-title: Planta Medica
– volume: 108
  start-page: 104
  issue: Pt A
  year: 2017
  end-page: 119
  article-title: Antiulcer properties of fruits and vegetables: A mechanism based perspective
  publication-title: Food and Chemical Toxicology
– volume: 1171
  start-page: 132
  year: 2009b
  end-page: 136
  article-title: Inhibition of P‐glycoprotein by wogonin is involved with the potentiation of etoposide‐induced apoptosis in cancer cells
  publication-title: Annals of the new York Academy of Sciences
– volume: 25
  start-page: 2066
  issue: 9
  year: 2020
  article-title: Flavonoids distinctly stabilize lymph endothelial‐ or blood endothelial disintegration induced by colon cancer spheroids SW620
  publication-title: Molecules
– volume: 21
  start-page: 817
  issue: 9
  year: 2007a
  end-page: 822
  article-title: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents
  publication-title: Phytotherapy Research
– volume: 40
  start-page: 151
  issue: 3–4
  year: 2019b
  end-page: 161
  article-title: Mechanistic study of absorption and first‐pass metabolism of GL‐V9, a derivative of wogonin
  publication-title: Biopharmaceutics & Drug Disposition
– volume: 113
  start-page: 3476
  issue: 11
  year: 2012
  end-page: 3485
  article-title: Wogonin induces cross‐regulation between autophagy and apoptosis via a variety of Akt pathway in human nasopharyngeal carcinoma cells
  publication-title: Journal of Cellular Biochemistry
– volume: 296
  start-page: 26
  year: 2018
  end-page: 33
  article-title: 4 '‐hydroxywogonin inhibits colorectal cancer angiogenesis by disrupting PI3K/AKT signaling
  publication-title: Chemico‐Biological Interactions
– volume: 26
  start-page: 3
  issue: 1
  year: 2020
  end-page: 15
  article-title: Cholangiocarcinoma: Classification, histopathology and molecular carcinogenesis
  publication-title: Pathology Oncology Research
– volume: 29
  start-page: 259
  issue: 4
  year: 2013
  end-page: 272
  article-title: Wogonin induces apoptosis by suppressing E6 and E7 expressions and activating intrinsic signaling pathways in HPV‐16 cervical cancer cells
  publication-title: Cell Biology and Toxicology
– volume: 136
  start-page: 688
  issue: 3
  year: 2015
  end-page: 698
  article-title: Targeting CDK9 by wogonin and related natural flavones potentiates the anti‐cancer efficacy of the Bcl‐2 family inhibitor ABT‐263
  publication-title: International Journal of Cancer
– volume: 56
  start-page: 652
  issue: 3
  year: 2015
  end-page: 662
  article-title: Wogonin induced mitochondrial dysfunction and endoplasmic reticulum stress in human malignant neuroblastoma cells via IRE1alpha‐dependent pathway
  publication-title: Journal of Molecular Neuroscience
– volume: 39
  start-page: 307
  issue: 1
  year: 2015
  end-page: 312
  article-title: Growth inhibition and apoptosis induction by Scutellaria pinnatifida a. ham. On HL‐60 and K562 leukemic cell lines
  publication-title: Environmental Toxicology and Pharmacology
– volume: 48
  start-page: 607
  issue: 5
  year: 2014
  end-page: 621
  article-title: Wogonin‐enhanced reactive oxygen species‐induced apoptosis and potentiated cytotoxic effects of chemotherapeutic agents by suppression Nrf2‐mediated signaling in HepG2 cells
  publication-title: Free Radical Research
– volume: 15
  start-page: 1500
  issue: 7
  year: 2019b
  end-page: 1513
  article-title: Scutellaria flavonoids effectively inhibit the malignant phenotypes of non‐small cell lung cancer in an Id1‐dependent manner
  publication-title: International Journal of Biological Sciences
– volume: 25
  start-page: 41
  issue: Suppl 2
  year: 2016
  end-page: 59
  article-title: Natural products as a vital source for the discovery of cancer chemotherapeutic and Chemopreventive agents
  publication-title: Medical Principles and Practice
– volume: 34
  start-page: 1077
  issue: 3
  year: 2020
  end-page: 1084
  article-title: Wogonin influences osteosarcoma stem cell stemness through ROS‐dependent signaling
  publication-title: In Vivo
– volume: 108
  start-page: 3700
  issue: 12
  year: 2006
  end-page: 3706
  article-title: Wogonin sensitizes resistant malignant cells to TNFalpha‐ and TRAIL‐induced apoptosis
  publication-title: Blood
– volume: 63
  start-page: 225
  issue: 2
  year: 2002
  end-page: 236
  article-title: Wogonin and fisetin induce apoptosis in human promyeloleukemic cells, accompanied by a decrease of reactive oxygen species, and activation of caspase 3 and ca(2+)‐dependent endonuclease
  publication-title: Biochemical Pharmacology
– volume: 91
  start-page: 65
  issue: 1
  year: 2004
  end-page: 68
  article-title: Cytotoxic activities of flavonoids from two Scutellaria plants in Chinese medicine
  publication-title: Journal of Ethnopharmacology
– volume: 12
  start-page: 91
  issue: 2
  year: 2016b
  end-page: 95
  article-title: Preparation of Wogonin from radix Scutellariae and its inhibitory effects on the growth of HepG2 cells
  publication-title: Current Pharmaceutical Analysis
– volume: 197
  start-page: 201
  issue: 3
  year: 2010
  end-page: 210
  article-title: Wogonin potentiates the antitumor effects of low dose 5‐fluorouracil against gastric cancer through induction of apoptosis by down‐regulation of NF‐kappaB and regulation of its metabolism
  publication-title: Toxicology Letters
– volume: 11
  start-page: 3905
  issue: 10
  year: 2005
  end-page: 3914
  article-title: Characterization of chemical constituents in Scutellaria baicalensis with antiandrogenic and growth‐inhibitory activities toward prostate carcinoma
  publication-title: Clinical Cancer Research
– volume: 103
  start-page: 688
  issue: 4
  year: 2018
  end-page: 697
  article-title: Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin
  publication-title: Haematologica
– volume: 13
  start-page: 9877
  issue: 8
  year: 2012
  end-page: 9892
  article-title: Wogonin induces reactive oxygen species production and cell apoptosis in human glioma cancer cells
  publication-title: International Journal of Molecular Sciences
– volume: 9
  start-page: e106458
  issue: 9
  year: 2014
  article-title: Wogonin suppresses melanoma cell B16‐F10 invasion and migration by inhibiting Ras‐medicated pathways
  publication-title: PLoS One
– volume: 225
  start-page: 472
  issue: 2
  year: 2010
  end-page: 481
  article-title: 12‐O‐tetradecanoylphorbol‐13‐acetate‐induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF‐kappaB‐dependent MMP‐9 expression
  publication-title: Journal of Cellular Physiology
– start-page: 267
  year: 2018a
  end-page: 319
– volume: 7
  start-page: 24436
  issue: 17
  year: 2016
  end-page: 24454
  article-title: BM microenvironmental protection of CML cells from imatinib through Stat5/NF‐kappaB signaling and reversal by Wogonin
  publication-title: Oncotarget
– volume: 94
  start-page: 3433
  issue: 10
  year: 2020
  end-page: 3447
  article-title: Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression
  publication-title: Archives of Toxicology
– volume: 12
  start-page: 5059
  issue: 6
  year: 2016a
  end-page: 5067
  article-title: Wogonin induces Beclin‐1/PI3K and reactive oxygen species‐mediated autophagy in human pancreatic cancer cells
  publication-title: Oncology Letters
– volume: 7
  start-page: 2843
  year: 2012
  end-page: 2852
  article-title: Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line
  publication-title: International Journal of Nanomedicine
– volume: 14
  start-page: 1059
  issue: 9
  year: 2017
  end-page: 1075
  article-title: Use of nanotechnology for improved pharmacokinetics and activity of immunogenic cell death inducers used in cancer chemotherapy
  publication-title: Expert Opinion on Drug Delivery
– volume: 129
  start-page: 2958
  issue: 24
  year: 2016
  end-page: 2966
  article-title: Apoptotic mechanism of human leukemia K562/A02 cells induced by magnetic Ferroferric oxide nanoparticles loaded with Wogonin
  publication-title: Chinese Medical Journal
– volume: 92
  start-page: 55
  issue: 1
  year: 2013
  end-page: 62
  article-title: Wogonin induces apoptosis in RPMI 8226, a human myeloma cell line, by downregulating phospho‐Akt and overexpressing Bax
  publication-title: Life Sciences
– volume: 261
  year: 2020
  article-title: Orai‐1 and Orai‐2 regulate oral cancer cell migration and colonisation by suppressing Akt/mTOR/NF‐kappaB signalling
  publication-title: Life Sciences
– volume: 157
  start-page: 1189
  issue: 7
  year: 2009a
  end-page: 1202
  article-title: Reactive oxygen species up‐regulate p53 and Puma; a possible mechanism for apoptosis during combined treatment with TRAIL and wogonin
  publication-title: British Journal of Pharmacology
– volume: 60
  start-page: 294
  issue: 5–6
  year: 2007
  end-page: 297
  article-title: Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi
  publication-title: Wiadomości Lekarskie
– start-page: 100008
  year: 2020
  publication-title: Emerging roles of cardamonin, a multitargeted nutraceutical in the prevention and treatment of chronic diseases
– volume: 111
  start-page: 2354
  issue: 4
  year: 2008
  end-page: 2363
  article-title: Wogonin preferentially kills malignant lymphocytes and suppresses T‐cell tumor growth by inducing PLCgamma1‐ and Ca2+‐dependent apoptosis
  publication-title: Blood
– volume: 14
  start-page: 75
  issue: 1
  year: 2015
  end-page: 85
  article-title: A Chinese medicine formula Gegen Qinlian decoction suppresses expansion of human renal carcinoma with inhibition of matrix metalloproteinase‐2
  publication-title: Integrative Cancer Therapies
– volume: 27
  start-page: 133
  issue: 2
  year: 2011b
  end-page: 147
  article-title: Combined activity of oridonin and wogonin in advanced‐stage ovarian cancer cells: Sensitivity of ovarian cancer cells to phyto‐active chemicals
  publication-title: Cell Biology and Toxicology
– volume: 71
  start-page: 289
  issue: 2
  year: 2019
  end-page: 298
  article-title: Anticancer effect of nor‐wogonin (5, 7, 8‐trihydroxyflavone) on human triple‐negative breast cancer cells via downregulation of TAK1, NF‐kappaB, and STAT3
  publication-title: Pharmacological Reports
– volume: 81
  start-page: 373
  year: 2018
  end-page: 381
  article-title: Discovery of Wogonin‐based PROTACs against CDK9 and capable of achieving antitumor activity
  publication-title: Bioorganic Chemistry
– volume: 29
  start-page: 1132
  issue: 6
  year: 2006b
  end-page: 1137
  article-title: The anticancer activities of wogonin in murine sarcoma S180 both in vitro and in vivo
  publication-title: Biological & Pharmaceutical Bulletin
– volume: 22
  start-page: 268
  issue: 2
  year: 2012
  end-page: 276
  article-title: Wogonin and neobaicalein from Scutellaria litwinowii roots are apoptotic for HeLa cells
  publication-title: Revista Brasileira De Farmacognosia‐Brazilian Journal of Pharmacognosy
– volume: 254
  year: 2020
  article-title: A review of the ethnopharmacology, phytochemistry, pharmacology, and quality control of Scutellaria barbata D. Don
  publication-title: Journal of Ethnopharmacology
– volume: 31
  start-page: 327
  issue: 4
  year: 2011
  end-page: 335
  article-title: Wogonin induces apoptosis by activation of ERK and p38 MAPKs signaling pathways and generation of reactive oxygen species in human breast cancer cells
  publication-title: Molecules and Cells
– volume: 10
  start-page: 4764
  issue: 3
  year: 2017b
  end-page: 4771
  article-title: Assessing the interactions between p53 gene and three types of flavonoid therapeutic compound in ovarian cancer cell line
  publication-title: International Journal of Clinical and Experimental Medicine
– volume: 143
  year: 2020
  article-title: Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV‐429‐mediated regulation of AR‐AKT‐HK2 signaling network
  publication-title: Food and Chemical Toxicology
– volume: 312
  start-page: 36
  year: 2013
  end-page: 47
  article-title: Wogonin induced G1 cell cycle arrest by regulating Wnt/beta‐catenin signaling pathway and inactivating CDK8 in human colorectal cancer carcinoma cells
  publication-title: Toxicology
– volume: 37
  start-page: 68
  issue: 1
  year: 2007b
  end-page: 76
  article-title: Changes in mitochondrial membrane potential and reactive oxygen species during wogonin‐induced cell death in human hepatoma cells
  publication-title: Hepatology Research
– volume: 7
  start-page: 39950
  year: 2017
  article-title: Wogonin reversed resistant human myelogenous leukemia cells via inhibiting Nrf2 signaling by Stat3/NF‐κB inactivation
  publication-title: Scientific Reports
– volume: 91
  start-page: 221
  issue: 4
  year: 2013
  end-page: 229
  article-title: Enhanced 5‐fluorouracil cytotoxicity in high COX‐2 expressing hepatocellular carcinoma cells by wogonin via the PI3K/Akt pathway
  publication-title: Biochemistry and Cell Biology
– volume: 14
  start-page: 2725
  year: 2020
  end-page: 2740
  article-title: Network pharmacology‐based prediction and verification of the active ingredients and potential targets of Zuojinwan for treating colorectal cancer
  publication-title: Drug Design, Development and Therapy
– volume: 38
  start-page: 1250
  issue: 4
  year: 2016
  end-page: 1256
  article-title: Wogonin inhibits the proliferation and invasion, and induces the apoptosis of HepG2 and Bel7402 HCC cells through NFkappaB/Bcl‐2, EGFR and EGFR downstream ERK/AKT signaling
  publication-title: International Journal of Molecular Medicine
– volume: 21
  start-page: 1265
  issue: 11
  year: 2016
  end-page: 1278
  article-title: Targeting Nrf2 with wogonin overcomes cisplatin resistance in head and neck cancer
  publication-title: Apoptosis
– volume: 174
  start-page: 1325
  issue: 11
  year: 2017b
  end-page: 1348
  article-title: Curcumin, the golden nutraceutical: Multitargeting for multiple chronic diseases
  publication-title: British Journal of Pharmacology
– volume: 25
  start-page: 2171
  issue: 19
  year: 2019
  end-page: 2177
  article-title: Can Wogonin be used in controlling diabetic cardiomyopathy?
  publication-title: Current Pharmaceutical Design
– volume: 267
  year: 2021
  article-title: Rationalizing the therapeutic potential of apigenin against cancer
  publication-title: Life Sciences
– volume: 351
  start-page: 521
  issue: 2
  year: 2006
  end-page: 527
  article-title: Oroxylin a induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity
  publication-title: Biochemical and Biophysical Research Communications
– volume: 92
  start-page: 220
  issue: 2
  year: 2014
  end-page: 234
  article-title: Wogonin reverses multi‐drug resistance of human myelogenous leukemia K562/A02 cells via downregulation of MRP1 expression by inhibiting Nrf2/ARE signaling pathway
  publication-title: Biochemical Pharmacology
– volume: 33
  start-page: 3146
  issue: 6
  year: 2015
  end-page: 3154
  article-title: Wogonin induces apoptosis and endoplasmic reticulum stress in HL‐60 leukemia cells through inhibition of the PI3K‐AKT signaling pathway
  publication-title: Oncology Reports
– volume: 20
  start-page: 328
  issue: 3–4
  year: 2013
  end-page: 336
  article-title: Anti‐tumor and anti‐metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti‐lymphangiogenesis
  publication-title: Phytomedicine
– volume: 194
  start-page: 861
  year: 2016
  end-page: 876
  article-title: Autophagy modulators from traditional Chinese medicine: Mechanisms and therapeutic potentials for cancer and neurodegenerative diseases
  publication-title: Journal of Ethnopharmacology
– volume: 287
  start-page: 641
  issue: 1
  year: 2012
  end-page: 649
  article-title: Wogonin and related natural flavones overcome tumor necrosis factor‐related apoptosis‐inducing ligand (TRAIL) protein resistance of tumors by down‐regulation of c‐FLIP protein and up‐regulation of TRAIL receptor 2 expression
  publication-title: The Journal of Biological Chemistry
– volume: 432
  start-page: 260
  year: 2018a
  end-page: 271
  article-title: Novel tumor necrosis factor‐alpha induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression
  publication-title: Cancer Letters
– volume: 17
  start-page: 47
  issue: 1
  year: 2010
  end-page: 54
  article-title: Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL‐60 leukemia cells
  publication-title: Phytomedicine
– volume: 23
  start-page: 384
  issue: 2
  year: 2018a
  article-title: Wogonin suppresses the activity of matrix Metalloproteinase‐9 and inhibits migration and invasion in human hepatocellular carcinoma
  publication-title: Molecules
– volume: 5
  start-page: e1283
  year: 2014
  article-title: NF‐κB and Nrf2 signaling pathways contribute to wogonin‐mediated inhibition of inflammation‐associated colorectal carcinogenesis
  publication-title: Cell Death & Disease
– volume: 16
  start-page: 14
  issue: 1
  year: 2018b
  article-title: Chronic diseases, inflammation, and spices: How are they linked?
  publication-title: Journal of Translational Medicine
– volume: 39
  start-page: 439
  issue: 6
  year: 2019c
  end-page: 479
  article-title: Upside and downside of tumor necrosis factor blockers for treatment of immune/inflammatory diseases
  publication-title: Critical Reviews in Immunology
– start-page: 557
  year: 2018c
  end-page: 581
– volume: 9
  start-page: 1356
  year: 2018
  article-title: Prevention of Wogonin on colorectal cancer tumorigenesis by regulating p53 nuclear translocation
  publication-title: Frontiers in Pharmacology
– volume: 118
  start-page: 27
  year: 2016
  end-page: 33
  article-title: On‐line comprehensive two‐dimensional HepG2 cell membrane chromatographic analysis system for charactering anti‐hepatoma components from rat serum after oral administration of radix scutellariae: A strategy for rapid screening active compounds in vivo
  publication-title: Journal of Pharmaceutical and Biomedical Analysis
– volume: 124
  start-page: 257
  issue: 2
  year: 2009
  end-page: 262
  article-title: Subchronic toxicity and plasma pharmacokinetic studies on wogonin, a natural flavonoid in Beagle dogs
  publication-title: Journal of Ethnopharmacology
– volume: S1044‐579X
  start-page: 30111
  issue: 20
  year: 2020
  end-page: 5
  article-title: Natural compounds modulate the crosstalk between apoptosis‐ and autophagy‐regulated signaling pathways: Controlling the uncontrolled expansion of tumor cells
  publication-title: Seminars in Cancer Biology
– volume: 31
  start-page: 0162
  issue: 3
  year: 2019
  article-title: Vietnamese coriander inhibits cell proliferation, survival and migration via suppression of Akt/mTOR pathway in oral squamous cell carcinoma
  publication-title: Journal of Basic and Clinical Physiology and Pharmacology
– volume: 24
  start-page: 734
  issue: 4
  year: 2019
  article-title: Potential of Zerumbone as an anti‐cancer agent
  publication-title: Molecules
– volume: 55
  start-page: 951
  issue: 6
  year: 2000
  end-page: 955
  article-title: Antitumor effects of Scutellariae radix and its components baicalein, baicalin, and wogonin on bladder cancer cell lines
  publication-title: Urology
– volume: 16
  start-page: 156
  issue: 2
  year: 2015
  end-page: 163
  article-title: ATP citrate lyase (ACLY): A promising target for cancer prevention and treatment
  publication-title: Current Drug Targets
– volume: 260
  year: 2020
  article-title: Diosgenin, a steroidal saponin, and its analogs: Effective therapies against different chronic diseases
  publication-title: Life Sciences
– volume: 528
  start-page: 602
  issue: 1–2
  year: 2017a
  end-page: 610
  article-title: Enhancement of solubility and dissolution rate of baicalein, wogonin and oroxylin A extracted from radix scutellariae
  publication-title: International Journal of Pharmaceutics
– volume: 15
  start-page: 705
  issue: 9
  year: 2019b
  end-page: 733
  article-title: Is curcumin bioavailability a problem in humans: Lessons from clinical trials
  publication-title: Expert Opinion on Drug Metabolism & Toxicology
– volume: 25
  start-page: 505
  issue: 5
  year: 2013b
  end-page: 513
  article-title: Synergistic inhibitory effect of wogonin and low‐dose paclitaxel on gastric cancer cells and tumor xenografts
  publication-title: Chinese Journal of Cancer Research
– volume: 18
  start-page: E393
  issue: 3
  year: 2018a
  end-page: E399
  article-title: Alarming burden of triple‐negative breast cancer in India
  publication-title: Clinical Breast Cancer
– volume: 6
  issue: 7
  year: 2009
  article-title: The PRISMA statement for reporting systematic reviews and meta‐analyses of studies that evaluate health care interventions: Explanation and elaboration
  publication-title: PLoS Medicine
– volume: 416
  start-page: 75
  year: 2018a
  end-page: 86
  article-title: Therapeutic potential of gambogic acid, a caged xanthone, to target cancer
  publication-title: Cancer Letters
– volume: 251
  start-page: 695
  issue: 5–6
  year: 2018
  end-page: 704
  article-title: The influence of 6‐prenylnaringenin and selected non‐prenylated flavonoids on the activity of Kv1.3 channels in human Jurkat T cells
  publication-title: Journal of Membrane Biology
– volume: 11
  start-page: 141
  issue: 2
  year: 2005
  end-page: 150
  article-title: Therapeutic potential of wogonin: A naturally occurring flavonoid
  publication-title: CNS Drug Reviews
– volume: 17
  start-page: 911
  issue: 1
  year: 2019b
  end-page: 918
  article-title: Wogonin affects proliferation and the energy metabolism of SGC‐7901 and A549 cells
  publication-title: Experimental and Therapeutic Medicine
– volume: 17
  start-page: 4748
  issue: 6
  year: 2019
  end-page: 4756
  article-title: Anti‐diarrheal effect of Scutellaria baicalensis is associated with suppression of smooth muscle in the rat colon
  publication-title: Experimental and Therapeutic Medicine
– volume: 55
  start-page: 778
  year: 2015a
  end-page: 792
  article-title: LW‐213 induces G2/M cell cycle arrest through AKT/GSK3/−catenin signaling pathway in human breast cancer cells
  publication-title: Molecular Carcinogenesis
– volume: 17
  start-page: 676
  issue: 5
  year: 2016
  article-title: A novel prostate‐specific membrane‐antigen (PSMA) targeted micelle‐encapsulating Wogonin inhibits prostate cancer cell proliferation via inducing intrinsic apoptotic pathway
  publication-title: International Journal of Molecular Sciences
– volume: 30
  start-page: 2411
  issue: 5
  year: 2013
  end-page: 2418
  article-title: Pretreatment of baicalin and wogonoside with glycoside hydrolase: A promising approach to enhance anticancer potential
  publication-title: Oncology Reports
– volume: 8
  issue: 1
  year: 2018
  article-title: Influence of c‐Src on hypoxic resistance to paclitaxel in human ovarian cancer cells and reversal of FV‐429
  publication-title: Cell Death & Disease
– volume: 44
  start-page: 1561
  issue: 5
  year: 2014
  end-page: 1570
  article-title: Flavonoid components in Scutellaria baicalensis inhibit nicotine‐induced proliferation, metastasis and lung cancer‐associated inflammation in vitro
  publication-title: International Journal of Oncology
– volume: 135
  start-page: 50
  year: 2017
  end-page: 68
  article-title: Reversal of cisplatin resistance in human gastric cancer cells by a wogonin‐conjugated Pt(IV) prodrug via attenuating casein kinase 2‐mediated nuclear factor‐kappaB pathways
  publication-title: Biochemical Pharmacology
– volume: 68
  year: 2020
  article-title: Wogonin inhibits cell cycle progression by activating the glycogen synthase kinase‐3 beta in hepatocellular carcinoma
  publication-title: Phytomedicine
– volume: 5
  start-page: 8188
  issue: 18
  year: 2014
  end-page: 8201
  article-title: Wogonin induces cell cycle arrest and erythroid differentiation in imatinib‐resistant K562 cells and primary CML cells
  publication-title: Oncotarget
– volume: 25
  start-page: 6007
  year: 2019a
  end-page: 6014
  article-title: Wogonin increases cisplatin sensitivity in ovarian cancer cells through inhibition of the phosphatidylinositol 3‐kinase (PI3K)/Akt pathway
  publication-title: Medical Science Monitor
– volume: 737
  start-page: 110
  year: 2014
  end-page: 119
  article-title: Wogonin inhibits LPS‐induced tumor angiogenesis via suppressing PI3K/Akt/NF‐κB signaling
  publication-title: Vascular Pharmacology
– volume: 47
  start-page: 9779
  issue: 12
  year: 2020
  end-page: 9789
  article-title: Potential therapeutic and pharmacological effects of Wogonin: An updated review
  publication-title: Molecular Biology Reports
– volume: 17
  start-page: 63
  issue: 1
  year: 2010
  end-page: 68
  article-title: Selective fraction of Scutellaria baicalensis and its chemopreventive effects on MCF‐7 human breast cancer cells
  publication-title: Phytomedicine
– volume: 164
  start-page: 550
  year: 2019
  end-page: 556
  article-title: Comparative two‐dimensional HepG2 and L02/ cell membrane chromatography/ C18/ time‐of‐flight mass spectrometry for screening selective anti‐hepatoma components from Scutellariae radix
  publication-title: Journal of Pharmaceutical and Biomedical Analysis
– volume: 1845
  start-page: 136
  issue: 2
  year: 2014
  end-page: 154
  article-title: Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
  publication-title: Biochimica et Biophysica Acta‐Reviews on Cancer
– volume: 36
  start-page: 103
  year: 2017
  article-title: Wogonoside inhibits invasion and migration through suppressing TRAF2/4 expression in breast cancer
  publication-title: Journal of Experimental & Clinical Cancer Research
– volume: 282
  start-page: 122
  issue: 3
  year: 2011a
  end-page: 128
  article-title: Inhibitory effects of wogonin on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase‐9
  publication-title: Toxicology
– volume-title: 20: Therapeutic strategies for chemosensitization of renal cancer
  year: 2018
  ident: e_1_2_13_156_1
– volume: 27
  start-page: 733
  issue: 6
  year: 2013
  ident: e_1_2_13_124_1
  article-title: Wogonin, a natural and biologically‐active flavonoid, influences a murine WEHI‐3 leukemia model in vivo through enhancing populations of T‐ and B‐cells
  publication-title: In Vivo
– ident: e_1_2_13_228_1
  doi: 10.3390/ijms17050676
– start-page: 81
  volume-title: Mechanism of chemoresistance in bone cancer and different chemosensitization approaches. Cancer cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_136_1
  doi: 10.1142/9789813208575_0004
– start-page: 163
  volume-title: Potential of different chemosensitizers to overcome chemoresistance in cervical cancer. Cancer cell Chemoresistance and Chemosensitization
  year: 2018
  ident: e_1_2_13_7_1
  doi: 10.1142/9789813208575_0007
– ident: e_1_2_13_203_1
  doi: 10.3389/fphar.2020.583200
– ident: e_1_2_13_95_1
  doi: 10.2174/1389450115666141224125117
– start-page: 51
  volume-title: Bladder cancer: Chemoresistance and chemosensitization. Cancer cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_152_1
  doi: 10.1142/9789813208575_0003
– ident: e_1_2_13_17_1
  doi: 10.31557/APJCP.2019.20.11.3437
– ident: e_1_2_13_216_1
  doi: 10.1371/journal.pone.0050811
– ident: e_1_2_13_92_1
  doi: 10.1016/j.semcancer.2020.06.014
– ident: e_1_2_13_63_1
  doi: 10.3892/ijo.2014.2320
– ident: e_1_2_13_72_1
  doi: 10.1016/j.canlet.2006.01.011
– ident: e_1_2_13_93_1
  doi: 10.1007/s00109-019-01863-0
– ident: e_1_2_13_105_1
  doi: 10.1177/1535370219839163
– ident: e_1_2_13_191_1
  doi: 10.1177/1534735414550036
– ident: e_1_2_13_231_1
  doi: 10.1016/j.lfs.2012.10.023
– ident: e_1_2_13_48_1
  doi: 10.1074/jbc.M111.286526
– ident: e_1_2_13_86_1
  doi: 10.1016/s0090-4295(00)00467-2
– ident: e_1_2_13_160_1
  doi: 10.1016/j.jep.2020.113198
– ident: e_1_2_13_197_1
  doi: 10.1248/bpb.29.1132
– ident: e_1_2_13_206_1
  doi: 10.4014/jmb.1305.05001
– ident: e_1_2_13_214_1
  doi: 10.1139/o09-060
– ident: e_1_2_13_123_1
  doi: 10.3892/ijo.2011.1027
– ident: e_1_2_13_195_1
  doi: 10.1002/bmc.4264
– ident: e_1_2_13_230_1
  doi: 10.1111/j.1349-7006.2008.00728.x
– ident: e_1_2_13_212_1
  doi: 10.18632/oncotarget.2340
– ident: e_1_2_13_201_1
  doi: 10.1186/s12885-017-3145-4
– ident: e_1_2_13_190_1
  doi: 10.2147/Ijn.S28089
– ident: e_1_2_13_187_1
  doi: 10.1002/ijc.22402
– start-page: 107
  volume-title: Chemoresistance in brain cancer and different chemosensitization approaches. Cancer Cell Chemoresistance and Chemosensitization
  year: 2018
  ident: e_1_2_13_94_1
  doi: 10.1142/9789813208575_0005
– ident: e_1_2_13_134_1
  doi: 10.1016/j.phymed.2009.06.001
– ident: e_1_2_13_65_1
  doi: 10.1038/cddis.2017.367
– ident: e_1_2_13_28_1
  doi: 10.1007/s10565-010-9176-0
– ident: e_1_2_13_198_1
  doi: 10.1016/j.toxlet.2013.07.013
– ident: e_1_2_13_68_1
  doi: 10.1016/j.fct.2017.07.023
– ident: e_1_2_13_147_1
  doi: 10.3109/10715762.2014.897342
– ident: e_1_2_13_27_1
  doi: 10.1016/j.tox.2011.01.018
– ident: e_1_2_13_112_1
  doi: 10.1111/j.1476-5381.2009.00245.x
– ident: e_1_2_13_116_1
  doi: 10.1016/s0006-2952(01)00876-0
– ident: e_1_2_13_98_1
  doi: 10.1007/s10565-013-9251-4
– ident: e_1_2_13_23_1
  doi: 10.1055/s-2002-20246
– ident: e_1_2_13_225_1
  doi: 10.1007/s10059-011-0041-7
– ident: e_1_2_13_51_1
  doi: 10.1007/s00280-010-1396-8
– ident: e_1_2_13_49_1
  doi: 10.1016/j.jep.2011.08.005
– ident: e_1_2_13_99_1
  doi: 10.3892/mmr.2012.1085
– ident: e_1_2_13_113_1
  doi: 10.1111/j.1749-6632.2009.04722.x
– ident: e_1_2_13_138_1
  doi: 10.1007/s11060-010-0221-x
– ident: e_1_2_13_183_1
  doi: 10.3892/ijo.2013.1777
– ident: e_1_2_13_223_1
  doi: 10.1002/ptr.2062
– ident: e_1_2_13_76_1
  doi: 10.1016/j.phymed.2017.12.019
– ident: e_1_2_13_235_1
  doi: 10.1002/mc.22321
– ident: e_1_2_13_32_1
  doi: 10.1371/journal.pone.0079201
– ident: e_1_2_13_159_1
  doi: 10.1016/j.semcancer.2016.03.005
– ident: e_1_2_13_16_1
  doi: 10.1016/j.lfs.2020.118475
– ident: e_1_2_13_60_1
  doi: 10.3390/molecules24040734
– ident: e_1_2_13_126_1
  doi: 10.7314/apjcp.2013.14.12.7179
– ident: e_1_2_13_54_1
  doi: 10.3389/fphar.2018.01356
– volume: 61
  start-page: 123
  issue: 7
  year: 2015
  ident: e_1_2_13_55_1
  article-title: Wogonin increases doxorubicin sensitivity by down‐regulation of IGF‐1R/AKT signaling pathway in human breast cancer
  publication-title: Cellular and Molecular Biology (Noisy‐le‐Grand, France)
– ident: e_1_2_13_162_1
  doi: 10.1093/abbs/gmx054
– ident: e_1_2_13_97_1
  doi: 10.3892/etm.2019.7469
– ident: e_1_2_13_84_1
  doi: 10.1007/s11033-020-05972-9
– ident: e_1_2_13_46_1
  doi: 10.1007/s00262-011-1130-3
– ident: e_1_2_13_220_1
  doi: 10.1016/j.phrs.2018.07.011
– ident: e_1_2_13_104_1
  doi: 10.1111/bph.13621
– ident: e_1_2_13_111_1
  doi: 10.1016/j.cellsig.2012.07.019
– ident: e_1_2_13_91_1
  doi: 10.2174/1381612825666190708173108
– ident: e_1_2_13_151_1
  doi: 10.3390/ijms20174101
– ident: e_1_2_13_184_1
  doi: 10.1016/j.phymed.2009.07.003
– volume: 46
  start-page: 512
  year: 2011
  ident: e_1_2_13_129_1
  article-title: Inhibitory effect of wogonin on gastric cancer SGC7901 cell line in vitro
  publication-title: Chinese Pharmaceutical Journal
– start-page: 373
  volume-title: Different methods to inhibit chemoresistance in hepatocellular carcinoma. Cancer Cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_163_1
  doi: 10.1142/9789813208575_0013
– ident: e_1_2_13_40_1
  doi: 10.1007/s00280-010-1552-1
– ident: e_1_2_13_128_1
  doi: 10.1177/0300060520934288
– ident: e_1_2_13_35_1
  doi: 10.2147/IJN.S32065
– ident: e_1_2_13_213_1
  doi: 10.1007/s10495-013-0808-8
– ident: e_1_2_13_62_1
  doi: 10.1021/jf051506
– ident: e_1_2_13_81_1
  doi: 10.2147/DDDT.S250991
– ident: e_1_2_13_194_1
  doi: 10.3978/j.issn.1000-9604.2013.08.14
– ident: e_1_2_13_45_1
  doi: 10.1016/j.crphar.2020.100008
– ident: e_1_2_13_4_1
  doi: 10.3390/nano8030159
– ident: e_1_2_13_208_1
  doi: 10.18632/oncotarget.8332
– ident: e_1_2_13_239_1
  doi: 10.12659/Msm.917823
– ident: e_1_2_13_24_1
  doi: 10.1016/j.bcp.2017.03.004
– ident: e_1_2_13_13_1
  doi: 10.1016/j.etap.2014.12.002
– ident: e_1_2_13_106_1
  doi: 10.1080/17425255.2019.1650914
– ident: e_1_2_13_117_1
  doi: 10.1007/s12253-018-0491-8
– ident: e_1_2_13_141_1
  doi: 10.1016/j.jep.2009.04.031
– ident: e_1_2_13_238_1
  doi: 10.1016/j.toxlet.2010.05.019
– ident: e_1_2_13_205_1
  doi: 10.1002/bdd.2179
– ident: e_1_2_13_18_1
  doi: 10.3390/cells9061451
– ident: e_1_2_13_71_1
  doi: 10.3390/molecules25102278
– ident: e_1_2_13_186_1
  doi: 10.1002/mc.22052
– start-page: 583
  volume-title: Different chemosensitization approaches to overcome chemoresistance in prostate cancer. Cancer cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_137_1
  doi: 10.1142/9789813208575_0019
– ident: e_1_2_13_170_1
  doi: 10.1111/j.1527-3458.2005.tb00266.x
– ident: e_1_2_13_193_1
  doi: 10.3892/etm.2018.7023
– ident: e_1_2_13_47_1
  doi: 10.1515/jbcpp-2019-0162
– ident: e_1_2_13_78_1
  doi: 10.1016/j.bbrc.2006.10.064
– ident: e_1_2_13_37_1
  doi: 10.1142/9789813208575_0011
– ident: e_1_2_13_174_1
  doi: 10.1590/S0102-695x2011005000161
– ident: e_1_2_13_108_1
  doi: 10.1615/CritRevImmunol.2020033210
– ident: e_1_2_13_73_1
  doi: 10.1016/j.jds.2013.02.024
– ident: e_1_2_13_182_1
  doi: 10.4274/balkanmedj.galenos.2019.2019.7.75
– ident: e_1_2_13_52_1
  doi: 10.1182/blood-2006-03-011973
– ident: e_1_2_13_158_1
  doi: 10.1016/j.tranon.2018.08.015
– ident: e_1_2_13_22_1
  doi: 10.3390/biomedicines8080236
– ident: e_1_2_13_100_1
  doi: 10.1016/j.phymed.2012.10.016
– ident: e_1_2_13_234_1
  doi: 10.1016/j.yrtph.2011.03.008
– ident: e_1_2_13_224_1
  doi: 10.1111/j.1872-034X.2007.00003.x
– ident: e_1_2_13_85_1
  doi: 10.1016/S1875-5364(17)30005-5
– ident: e_1_2_13_8_1
  doi: 10.1182/blood-2007-06-096198
– ident: e_1_2_13_240_1
  doi: 10.1007/s11434-016-1136-5
– ident: e_1_2_13_219_1
  doi: 10.1186/s13046-017-0574-5
– ident: e_1_2_13_161_1
  doi: 10.1016/j.neuroscience.2006.02.028
– ident: e_1_2_13_177_1
  doi: 10.1016/j.clbc.2017.07.013
– volume: 10
  start-page: 4764
  issue: 3
  year: 2017
  ident: e_1_2_13_226_1
  article-title: Assessing the interactions between p53 gene and three types of flavonoid therapeutic compound in ovarian cancer cell line
  publication-title: International Journal of Clinical and Experimental Medicine
– ident: e_1_2_13_50_1
  doi: 10.3324/haematol.2017.177808
– ident: e_1_2_13_165_1
  doi: 10.1016/j.jff.2018.12.020
– ident: e_1_2_13_39_1
  doi: 10.1002/jcb.21528
– volume: 32
  start-page: 405
  issue: 2
  year: 2008
  ident: e_1_2_13_29_1
  article-title: Down‐regulation of androgen‐receptor and PSA by phytochemicals
  publication-title: International Journal of Oncology
– ident: e_1_2_13_243_1
  doi: 10.1002/mc.21921
– ident: e_1_2_13_87_1
  doi: 10.3109/07357900902744486
– ident: e_1_2_13_80_1
  doi: 10.1016/j.intimp.2011.12.004
– ident: e_1_2_13_204_1
  doi: 10.12659/Msm.913829
– ident: e_1_2_13_11_1
  doi: 10.1016/j.bioorg.2018.08.028
– ident: e_1_2_13_125_1
  doi: 10.1002/jcp.22226
– ident: e_1_2_13_167_1
  doi: 10.1016/j.taap.2013.04.031
– ident: e_1_2_13_246_1
  doi: 10.1248/bpb.26.911
– volume: 60
  start-page: 294
  issue: 5
  year: 2007
  ident: e_1_2_13_21_1
  article-title: Antiatherosclerotic properties of flavones from the roots of Scutellaria baicalensis Georgi
  publication-title: Wiadomości Lekarskie
– ident: e_1_2_13_82_1
  doi: 10.1016/j.phymed.2009.06.005
– ident: e_1_2_13_31_1
  doi: 10.1016/j.fct.2020.111517
– ident: e_1_2_13_120_1
  doi: 10.2174/1573412911666150707182742
– start-page: 557
  volume-title: Molecular alterations involved in pancreatic cancer chemoresistance and chemosensitization strategies. Cancer cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_157_1
– ident: e_1_2_13_5_1
  doi: 10.1016/j.canlet.2017.12.014
– ident: e_1_2_13_222_1
  doi: 10.1016/j.ijpharm.2017.06.068
– ident: e_1_2_13_233_1
  doi: 10.1371/journal.pone.0106458
– ident: e_1_2_13_232_1
  doi: 10.1007/s00204-013-1085-6
– volume: 14
  start-page: 327
  issue: 78
  year: 2012
  ident: e_1_2_13_30_1
  article-title: Polyphenols inhibit indoleamine 3,5‐dioxygenase‐1 enzymatic activity‐‐a role of immunomodulation in chemoprevention
  publication-title: Discovery Medicine
– ident: e_1_2_13_103_1
  doi: 10.1042/CS20160935
– ident: e_1_2_13_20_1
  doi: 10.3322/caac.21492
– ident: e_1_2_13_44_1
  doi: 10.1159/000443404
– ident: e_1_2_13_227_1
  doi: 10.1016/j.ejphar.2008.06.024
– ident: e_1_2_13_236_1
  doi: 10.1002/mc.22321
– ident: e_1_2_13_144_1
  doi: 10.1002/ijc.29009
– ident: e_1_2_13_110_1
  doi: 10.1016/j.bcp.2008.02.023
– volume: 54
  start-page: 448
  year: 1994
  ident: e_1_2_13_217_1
  article-title: The herbal medicine Sho‐saiko‐to inhibits proliferation of cancer cell lines by inducing apoptosis and arrest at the G0/G1 phase
  publication-title: Cancer Research
– ident: e_1_2_13_36_1
  doi: 10.4314/ahs.v13i3.3
– ident: e_1_2_13_69_1
  doi: 10.3892/or.2012.1841
– ident: e_1_2_13_155_1
  doi: 10.1016/j.phrs.2018.02.017
– ident: e_1_2_13_149_1
  doi: 10.3390/ijms19082362
– ident: e_1_2_13_180_1
  doi: 10.3390/ijms13089877
– ident: e_1_2_13_139_1
  doi: 10.1055/s-0028-1088364
– ident: e_1_2_13_109_1
  doi: 10.1615/CritRevImmunol.2020033205
– ident: e_1_2_13_64_1
  doi: 10.1016/j.jpba.2018.10.028
– ident: e_1_2_13_61_1
  doi: 10.3892/ijmm.2018.3776
– ident: e_1_2_13_102_1
  doi: 10.3389/fphar.2018.00686
– ident: e_1_2_13_10_1
  doi: 10.1016/j.bmcl.2016.12.076
– ident: e_1_2_13_179_1
  doi: 10.3109/10717544.2013.853850
– ident: e_1_2_13_15_1
  doi: 10.3390/ijms19102974
– ident: e_1_2_13_241_1
  doi: 10.1002/mc.22182
– start-page: 399
  volume-title: Different chemosensitization approaches for the effective management of HNSCC. Cancer cell chemoresistance and chemosensitization
  year: 2018
  ident: e_1_2_13_178_1
  doi: 10.1142/9789813208575_0014
– ident: e_1_2_13_88_1
  doi: 10.1080/17425247.2017.1266333
– volume-title: 16: Chemoresistance and Chemosensitization in melanoma.
  year: 2018
  ident: e_1_2_13_132_1
– ident: e_1_2_13_143_1
  doi: 10.1038/cddis.2011.66
– ident: e_1_2_13_192_1
  doi: 10.1016/j.jep.2016.10.069
– volume: 10
  start-page: 7553
  issue: 5
  year: 2017
  ident: e_1_2_13_229_1
  article-title: Combination of icotinib and wogonin induces apoptosis and autophagy to overcome acquired resistance in lung cancer harbouring EGFR T790M mutation
  publication-title: International Journal of Clinical and Experimental Medicine
– ident: e_1_2_13_26_1
  doi: 10.1002/mnfr.200700329
– volume: 9
  start-page: 684
  year: 2016
  ident: e_1_2_13_146_1
  article-title: Wogonin attenuates high glucose‐induced human breast cancer cell MCF‐7 viability, migration and invasion via the expression of AKT, PKCδ and p38 MAPK
  publication-title: International Journal of Clinical Pathology
– ident: e_1_2_13_164_1
  doi: 10.1016/j.lfs.2020.118372
– ident: e_1_2_13_171_1
  doi: 10.3390/molecules19055538
– ident: e_1_2_13_107_1
  doi: 10.1186/s12967-018-1381-2
– ident: e_1_2_13_148_1
  doi: 10.1016/j.bmc.2017.03.007
– ident: e_1_2_13_209_1
  doi: 10.1038/srep39950
– ident: e_1_2_13_74_1
  doi: 10.1016/j.phymed.2020.153174
– ident: e_1_2_13_188_1
  doi: 10.1016/j.ejmech.2019.06.024
– ident: e_1_2_13_122_1
  doi: 10.1371/journal.pmed.1000100
– ident: e_1_2_13_237_1
  doi: 10.1139/bcb-2012-0077
– ident: e_1_2_13_172_1
  doi: 10.1002/cbdv.201400181
– ident: e_1_2_13_101_1
  doi: 10.21873/invivo.11878
– ident: e_1_2_13_168_1
  doi: 10.1016/j.jep.2003.11.014
– ident: e_1_2_13_135_1
  doi: 10.1016/j.canlet.2018.06.017
– ident: e_1_2_13_56_1
  doi: 10.18632/oncotarget.6796
– ident: e_1_2_13_189_1
  doi: 10.1016/j.jep.2019.112260
– ident: e_1_2_13_12_1
  doi: 10.1158/1078-0432.CCR-04-1974
– ident: e_1_2_13_130_1
  doi: 10.1186/s13020-019-0270-9
– ident: e_1_2_13_142_1
  doi: 10.4103/0366-6999.195466
– ident: e_1_2_13_150_1
  doi: 10.3892/ol.2017.6059
– ident: e_1_2_13_242_1
  doi: 10.7150/ijbs.33146
– ident: e_1_2_13_154_1
  doi: 10.3390/cancers11020246
– ident: e_1_2_13_115_1
  doi: 10.1016/j.ijbiomac.2017.01.080
– ident: e_1_2_13_6_1
  doi: 10.1016/j.phrs.2019.04.004
– ident: e_1_2_13_114_1
  doi: 10.1196/annals.1397.056
– ident: e_1_2_13_77_1
  doi: 10.3892/or.2015.3896
– ident: e_1_2_13_176_1
  doi: 10.1016/j.semcancer.2019.12.008
– ident: e_1_2_13_145_1
  doi: 10.1002/ptr.2645
– ident: e_1_2_13_58_1
  doi: 10.1016/j.jpba.2010.04.019
– ident: e_1_2_13_185_1
  doi: 10.4103/0973-1482.183218
– ident: e_1_2_13_175_1
  doi: 10.1007/s00232-018-0046-7
– ident: e_1_2_13_169_1
  doi: 10.1016/j.cbi.2018.09.003
– ident: e_1_2_13_90_1
  doi: 10.1155/2017/9381513
– ident: e_1_2_13_127_1
  doi: 10.3892/ijmm.2016.2700
– ident: e_1_2_13_215_1
  doi: 10.1111/j.1349-7006.2011.01874.x
– ident: e_1_2_13_25_1
  doi: 10.5114/aoms.2018.73711
– ident: e_1_2_13_41_1
  doi: 10.1002/jcb.24224
– ident: e_1_2_13_19_1
  doi: 10.1016/j.semcancer.2020.05.015
– volume: 24
  start-page: 1143
  issue: 3
  year: 2019
  ident: e_1_2_13_173_1
  article-title: A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways
  publication-title: Journal of BUON
– ident: e_1_2_13_221_1
  doi: 10.3892/or.2013.2726
– ident: e_1_2_13_218_1
  doi: 10.1038/cddis.2014.221
– ident: e_1_2_13_244_1
  doi: 10.1016/j.vph.2014.01.010
– ident: e_1_2_13_70_1
  doi: 10.1016/j.tox.2013.07.013
– ident: e_1_2_13_34_1
  doi: 10.1142/S0192415X18500027
– ident: e_1_2_13_202_1
  doi: 10.1097/Cji.0000000000000080
– ident: e_1_2_13_196_1
  doi: 10.1097/01.cad.0000217431.64118.3f
– ident: e_1_2_13_42_1
  doi: 10.1002/ijc.23182
– ident: e_1_2_13_59_1
  doi: 10.1007/s12031-015-0530-9
– ident: e_1_2_13_57_1
  doi: 10.1016/j.taap.2011.03.016
– ident: e_1_2_13_83_1
  doi: 10.1186/s12906-017-1788-y
– ident: e_1_2_13_133_1
  doi: 10.1211/0022357021778673
– ident: e_1_2_13_153_1
  doi: 10.1016/j.ejpb.2018.04.023
– ident: e_1_2_13_3_1
  doi: 10.1016/j.lfs.2020.118814
– ident: e_1_2_13_33_1
  doi: 10.1007/s00204-002-0346-6
– ident: e_1_2_13_53_1
  doi: 10.1016/j.jpba.2010.04.002
– ident: e_1_2_13_210_1
  doi: 10.1016/j.bcp.2014.09.008
– ident: e_1_2_13_67_1
  doi: 10.3390/ijms21093285
– ident: e_1_2_13_211_1
  doi: 10.1007/s00204-020-02842-y
– ident: e_1_2_13_96_1
  doi: 10.1007/s10495-016-1284-8
– ident: e_1_2_13_89_1
  doi: 10.1016/j.jpba.2015.10.013
– volume-title: 17: Strategies to overcome Chemoresistance in ovarian cancer
  year: 2018
  ident: e_1_2_13_38_1
– ident: e_1_2_13_121_1
  doi: 10.1016/j.biopha.2020.110917
– ident: e_1_2_13_200_1
  doi: 10.1002/ijc.29726
– ident: e_1_2_13_245_1
  doi: 10.12659/Msm.897621
– ident: e_1_2_13_119_1
  doi: 10.3892/ol.2016.5367
– ident: e_1_2_13_14_1
  doi: 10.3390/biom9120836
– ident: e_1_2_13_43_1
  doi: 10.1055/s-2008-1034358
– ident: e_1_2_13_131_1
  doi: 10.3390/cancers10070228
– ident: e_1_2_13_199_1
  doi: 10.1371/journal.pone.0139147
– ident: e_1_2_13_66_1
  doi: 10.3390/molecules23082046
– ident: e_1_2_13_118_1
  doi: 10.1016/j.ctrv.2008.09.005
– ident: e_1_2_13_166_1
  doi: 10.1016/j.bbcan.2013.12.005
– ident: e_1_2_13_181_1
  doi: 10.1016/j.sjbs.2016.08.011
– ident: e_1_2_13_2_1
  doi: 10.1016/j.pharep.2019.01.001
– ident: e_1_2_13_140_1
  doi: 10.1016/j.lfs.2020.118182
– ident: e_1_2_13_75_1
  doi: 10.3390/molecules23020384
– ident: e_1_2_13_79_1
  doi: 10.1166/jnn.2016.10792
– ident: e_1_2_13_9_1
  doi: 10.3390/molecules25092066
– ident: e_1_2_13_207_1
  doi: 10.4103/0366-6999.225064
SSID ssj0009204
Score 2.6317122
SecondaryResourceType review_article
Snippet The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand...
The medicinal plant Scutellaria baicalensis , commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand...
The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang-Qin, has been used as a traditional medicine for several thousand...
SourceID proquest
pubmed
crossref
wiley
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1854
SubjectTerms antineoplastic agents
Antitumor agents
Baicalin
Bioactive compounds
Biocompatibility
Biomedical materials
Bladder cancer
Bone cancer
Breast cancer
breast neoplasms
Cancer
Cell signaling
Cervical cancer
chemoprevention
Chemotherapy
Cholangiocarcinoma
Clinical trials
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
drug therapy
Drugs, Chinese Herbal - pharmacology
Flavanones - pharmacology
Flavanones - therapeutic use
Flavonoids
gall bladder
Gallbladder
Gallbladder cancer
Gastric cancer
Glioblastoma
Head & neck cancer
head and neck neoplasms
Herbal medicine
Humans
in vitro
in vivo
In vivo methods and tests
Kidney cancer
kidney neoplasms
Leukemia
Liver cancer
liver neoplasms
Lung cancer
lung neoplasms
Lymphoma
Male
margin of safety
Medicinal plants
Melanoma
molecular targets
Multiple myeloma
myeloma
Neoplasms - drug therapy
Neoplasms - prevention & control
Neuroblastoma
Osteosarcoma
Ovarian cancer
ovarian neoplasms
Pancreatic cancer
pancreatic neoplasms
phytotherapy
Plant Extracts - pharmacology
Prevention
Prostate cancer
prostatic neoplasms
Sarcoma
Scutellaria
Scutellaria baicalensis
Side effects
stomach neoplasms
systematic review
therapy
Toxicity
Traditional medicine
urinary bladder neoplasms
uterine cervical neoplasms
Wogonin
Title Wogonin and its analogs for the prevention and treatment of cancer: A systematic review
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fptr.7386
https://www.ncbi.nlm.nih.gov/pubmed/35102626
https://www.proquest.com/docview/2667665935
https://www.proquest.com/docview/2624657295
https://www.proquest.com/docview/2675585227
Volume 36
WOSCitedRecordID wos000748770300001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVWIB
  databaseName: Wiley Online Library Full Collection 2020
  customDbUrl:
  eissn: 1099-1573
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0009204
  issn: 0951-418X
  databaseCode: DRFUL
  dateStart: 19960101
  isFulltext: true
  titleUrlDefault: https://onlinelibrary.wiley.com
  providerName: Wiley-Blackwell
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3fT9swED6NghAvGytslAEy0lReCKSOnR-8wUbFA0MVKqJvkePYE9KUVE2Z1P-euyRNhGAIaU9-yCWx7Dvfd7bvO4DvKuV-YIV2ApkaR5iIO4nh2hEidVNXKyGSkmf2Ori5CSeTaFTfqqRcmIofotlwI8so12sycJUUpy1p6HQ-O6GKlSuwylFtZQdWf94O765byl1eFg8sC8mLQThZUs-6_HT57nNn9AJhPgespccZfvqfvm7CxxpnsvNKMT7DB5N1Ye0iRyy46ML6r_pIvQv9UUVevThm4zYXqzhmfTZqaa0XW3B_n_-mvVumspQ9zAtsaeOnYAh7GcJINq3ZoPJKpLnCznLLNCnX7Iyds5Y6mlVpM9twN7wc_7hy6rIMjvYwGHEwxBh40qJrN5HVBECUb41CT2cJ3Lm6LPyJbi4wkaeJgVDhZFg58P0wdXEJ-QKdLM_MDjDPInqSBqMoqUWYysiXNkH3yZUXJUEke3C0nJ9Y15zlVDrjT1yxLfMYRzamke3BYSM5rXg6XpHZW05xXFtqEXO65OvLyMOfHTaP0cbo4ERlJn8kGS58iWHImzKBxNCL86AHXyv1aTri4cKH38AO9Est-WcP49H4ltrd9wp-gw1O-RjlDcw96Mxnj2Yf1vTf-UMxO4CVYBIe1HbxBLEpDj8
linkProvider Wiley-Blackwell
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dT9swED8xQIMXYB0fBQZGmroXAqljJw08sY2KaaWqUBF9i1LHRkgoqZqC1P-eu3wKMaZJe_JDLoll3_l-d7Z_B_A1jLjrGaEsT0baEtrn1lhzZQkR2ZGtQiHGGc9sz-v3O6ORP1iA8_IuTM4PUSXcyDKy9ZoMnBLSpzVr6GQ2PaGSlR9gSaAWoXov_bzp3vZqzl2eVQ_MKsmLdmdUcs_a_LR897U3egMxXyPWzOV01_-rsxuwViBNdpGrxidY0HEDlr8niAbnDfh4XWyqN6A1yOmr58dsWN_GSo9Ziw1qYuv5Z7i7S-4pe8vCOGIPsxRbSv2kDIEvQyDJJgUfVJKLVIfYWWKYIvWanrELVpNHs_zizCbcdi-HP66sojCDpRwMRywMMtqONOjctW8UQZDQNTpEX2cI3tkqK_2Jjs7TvqOIgzDE2TCy7bqdyMZFZAsW4yTWO8Acg_hJaoyjpBKdSPquNGN0oDx0_LHnyyZ8KycoUAVrORXPeAxyvmUe4MgGNLJNOKokJzlTxx9k9ss5DgpbTQNOx3xd6Tv4s6PqMVoZbZ2EsU6eSIYLV2Ig8lcZT2LwxbnXhO1cf6qOOLj04TewA61MTd7tYTAY3lC7-6-Ch7ByNbzuBb1f_d97sMrpdkZ2HnMfFmfTJ_0FltXz7CGdHhTm8QJ-qRFH
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LT9tAEB7RgBAXoGkL4dEuUpVecHHWu3YMJyiNWjWNLBREbpaz3kVIyI7igJR_z4yfQtCqUk978Nge7c7sfLOPbwA-RzF3PSOU5clYW0L73JpqriwhYju2VSTENOeZHXqjUX8y8YMVOKvuwhT8EPWCG3lGPl-Tg-tZbE4a1tDZYv6VSla-gVVBNWRasHp5NbgeNpy7PK8emFeSF73-pOKetflJ9e7zaPQCYj5HrHnIGWz9l7LbsFkiTXZemMZbWNFJG9YuUkSDyzas_y431dvQDQr66uUxGze3sbJj1mVBQ2y9fAc3N-ktrd6yKInZ3SLDlpZ-MobAlyGQZLOSDyotROpD7Cw1TJF5zU_ZOWvIo1lxceY9XA--j7_9sMrCDJZyMB2xMMnoOdJgcNe-UQRBItfoCGOdIXhnq7z0JwY6T_uOIg7CCEfDyJ7r9mMbJ5EP0ErSRO8CcwziJ6kxj5JK9GMcR2mmGEB55PhTz5cd-FINUKhK1nIqnnEfFnzLPMSeDalnO3BUS84Kpo5XZA6qMQ5LX81CTsd8Xek7-LOj-jF6GW2dRIlOH0iGC1diIvJXGU9i8sW514Gdwn5qRRyc-vAbqEA3N5M_ahgG4ytq9_5V8BOsB5eDcPhz9GsfNjhdzsiPYx5AazF_0Iewph4Xd9n8Y-kdT-_oEMI
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Wogonin+and+its+analogs+for+the+prevention+and+treatment+of+cancer%3A+A+systematic+review&rft.jtitle=Phytotherapy+research&rft.au=Banik%2C+Kishore&rft.au=Khatoon%2C+Elina&rft.au=Harsha%2C+Choudhary&rft.au=Rana%2C+Varsha&rft.date=2022-05-01&rft.issn=1099-1573&rft.eissn=1099-1573&rft.volume=36&rft.issue=5&rft.spage=1854&rft_id=info:doi/10.1002%2Fptr.7386&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0951-418X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0951-418X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0951-418X&client=summon