Wogonin and its analogs for the prevention and treatment of cancer: A systematic review

The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article i...

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Veröffentlicht in:Phytotherapy research Jg. 36; H. 5; S. 1854 - 1883
Hauptverfasser: Banik, Kishore, Khatoon, Elina, Harsha, Choudhary, Rana, Varsha, Parama, Dey, Thakur, Krishan Kumar, Bishayee, Anupam, Kunnumakkara, Ajaikumar B.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Chichester, UK John Wiley & Sons, Ltd 01.05.2022
Wiley Subscription Services, Inc
Schlagworte:
antineoplastic agents
Antitumor agents
Baicalin
Bioactive compounds
Biocompatibility
Biomedical materials
Bladder cancer
Bone cancer
Breast cancer
breast neoplasms
Cancer
Cell signaling
Cervical cancer
chemoprevention
Chemotherapy
Cholangiocarcinoma
Clinical trials
Colorectal cancer
Colorectal carcinoma
colorectal neoplasms
drug therapy
Drugs, Chinese Herbal - pharmacology
Flavanones - pharmacology
Flavanones - therapeutic use
Flavonoids
gall bladder
Gallbladder
Gallbladder cancer
Gastric cancer
Glioblastoma
Head & neck cancer
head and neck neoplasms
Herbal medicine
Humans
in vitro
in vivo
In vivo methods and tests
Kidney cancer
kidney neoplasms
Leukemia
Liver cancer
liver neoplasms
Lung cancer
lung neoplasms
Lymphoma
Male
margin of safety
Medicinal plants
Melanoma
molecular targets
Multiple myeloma
myeloma
Neoplasms - drug therapy
Neoplasms - prevention & control
Neuroblastoma
Osteosarcoma
Ovarian cancer
ovarian neoplasms
Pancreatic cancer
pancreatic neoplasms
phytotherapy
Plant Extracts - pharmacology
Prevention
Prostate cancer
prostatic neoplasms
Sarcoma
Scutellaria
Scutellaria baicalensis
Side effects
stomach neoplasms
systematic review
therapy
Toxicity
Traditional medicine
urinary bladder neoplasms
uterine cervical neoplasms
Wogonin
chemoprevention
Wogonin
therapy
in vitro
cancer
in vivo
molecular targets
ISSN:0951-418X, 1099-1573, 1099-1573
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Zusammenfassung:The medicinal plant Scutellaria baicalensis, commonly known as Chinese skullcap or Huang‐Qin, has been used as a traditional medicine for several thousand years. The roots of this plant contain bioactive compounds, such as wogonin (WOG), wogonoside, baicalein, and baicalin. The aim of this article is to evaluate the therapeutic potential and mechanisms of action of WOG against different cancers. Numerous in vitro and in vivo studies have revealed that WOG exerts immense therapeutic potential against bladder cancer, breast cancer, cholangiocarcinoma, cervical cancer, colorectal cancer, gallbladder cancer, gastric cancer, glioblastoma, head and neck cancer, hepatic cancer, leukemia, lung cancer, lymphoma, melanoma, multiple myeloma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and renal cancer by regulating various cell signaling pathways. WOG, in combination with established chemotherapeutic drugs, improves the efficacy of treatment and lowers toxicity. Nevertheless, human trials are warranted to validate these findings. Numerous preclinical studies, combined with an extensive margin of safety and no severe side effects, underscore WOG's therapeutic potential as an anticancer drug. These studies propound the use of WOG as a potential anticancer candidate; however, further high‐quality studies are required to firmly establish the clinical efficacy of WOG for the prevention and treatment of human malignancies.
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ObjectType-Evidence Based Healthcare-1
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ISSN:0951-418X
1099-1573
1099-1573
DOI:10.1002/ptr.7386