Niosomal hesperidin ameliorates depression-induced behavioral, histological, and molecular alterations in the rat hippocampus

Niosomal carriers offer a promising drug delivery in neurological disorders. This study evaluated the therapeutic effects of niosome-encapsulated hesperidin on reserpine-induced depression in rats, focusing on oxidative stress, transient receptor potential melastatin2 (TRPM2) and transient receptor...

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Vydané v:	Biomedicine & pharmacotherapy Ročník 191; s. 118473
Hlavní autori:	Otarkhani, Mahsa, Hatami, Homeira, panahi, Yousef, Jammal, Abdallah Al, Sadeghian, Reihaneh, Yavari, Sama
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	France Elsevier Masson SAS 01.10.2025
Predmet:	Animals Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacology Behavior, Animal - drug effects Depression Depression - chemically induced Depression - drug therapy Depression - metabolism Depression - pathology Disease Models, Animal Hesperidin - administration & dosage Hesperidin - pharmacology Hippocampus - drug effects Hippocampus - metabolism Hippocampus - pathology Internal Medicine Liposomes Male Nanoparticle Niosome-hesperidin Oxidative Stress - drug effects Rats Rats, Wistar Reserpine TRPC Cation Channels - genetics TRPC Cation Channels - metabolism TRPM Cation Channels - genetics TRPM Cation Channels - metabolism TRPM2 TRPMC1 Niosome-hesperidin TRPM2 Depression TRPMC1 Nanoparticle
ISSN:	0753-3322, 1950-6007, 1950-6007
On-line prístup:	Získať plný text
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