Prospective Evaluation of Germline Alterations in Patients With Exocrine Pancreatic Neoplasms

Identification of pathogenic germline alterations (PGAs) has important clinical and therapeutic implications in pancreas cancer. We performed comprehensive germline testing (GT) in an unselected prospective cohort of patients with exocrine pancreatic neoplasms with genotype and phenotype association...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute Jg. 110; H. 10; S. 1067
Hauptverfasser:	Lowery, Maeve A, Wong, Winston, Jordan, Emmet J, Lee, Jonathan W, Kemel, Yelena, Vijai, Joseph, Mandelker, Diana, Zehir, Ahmet, Capanu, Marinela, Salo-Mullen, Erin, Arnold, Angela G, Yu, Kenneth H, Varghese, Anna M, Kelsen, David P, Brenner, Robin, Kaufmann, Erica, Ravichandran, Vignesh, Mukherjee, Semanti, Berger, Michael F, Hyman, David M, Klimstra, David S, Abou-Alfa, Ghassan K, Tjan, Catherine, Covington, Christina, Maynard, Hannah, Allen, Peter J, Askan, Gokce, Leach, Steven D, Iacobuzio-Donahue, Christine A, Robson, Mark E, Offit, Kenneth, Stadler, Zsofia K, O'Reilly, Eileen M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2018
Schlagworte:	Adult Aged Aged, 80 and over Alleles Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor Female Genetic Association Studies Genetic Predisposition to Disease Germ-Line Mutation Heterozygote Humans Kaplan-Meier Estimate Loss of Heterozygosity Male Middle Aged Pancreas, Exocrine - pathology Pancreatic Neoplasms - genetics Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - therapy
ISSN:	1460-2105, 1460-2105
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