A Myc–microRNA network promotes exit from quiescence by suppressing the interferon response and cell-cycle arrest genes

The transition of mammalian cells from quiescence to proliferation is accompanied by the differential expression of several microRNAs (miRNAs) and transcription factors. However, the interplay between transcription factors and miRNAs in modulating gene regulatory networks involved in human cell prol...

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Veröffentlicht in:	Nucleic acids research Jg. 41; H. 4; S. 2239 - 2254
Hauptverfasser:	Polioudakis, Damon, Bhinge, Akshay A., Killion, Patrick J., Lee, Bum-Kyu, Abell, Nathan S., Iyer, Vishwanath R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 01.02.2013
Schlagworte:	Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors Cell Cycle Checkpoints - genetics Cell Proliferation Cells, Cultured Down-Regulation Gene Regulation, Chromatin and Epigenetics Gene Regulatory Networks Genes, cdc HeLa Cells Humans Interferons - biosynthesis Interferons - genetics MicroRNAs - biosynthesis MicroRNAs - metabolism Oligonucleotide Array Sequence Analysis Proto-Oncogene Proteins c-myc - metabolism Repressor Proteins - antagonists & inhibitors
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
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