Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clinical failures and relapses after antibiotic therapy...

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Published in:	Nature (London) Vol. 527; no. 7578; pp. 323 - 328
Main Authors:	Lehar, Sophie M., Pillow, Thomas, Xu, Min, Staben, Leanna, Kajihara, Kimberly K., Vandlen, Richard, DePalatis, Laura, Raab, Helga, Hazenbos, Wouter L., Hiroshi Morisaki, J., Kim, Janice, Park, Summer, Darwish, Martine, Lee, Byoung-Chul, Hernandez, Hilda, Loyet, Kelly M., Lupardus, Patrick, Fong, Rina, Yan, Donghong, Chalouni, Cecile, Luis, Elizabeth, Khalfin, Yana, Plise, Emile, Cheong, Jonathan, Lyssikatos, Joseph P., Strandh, Magnus, Koefoed, Klaus, Andersen, Peter S., Flygare, John A., Wah Tan, Man, Brown, Eric J., Mariathasan, Sanjeev
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 19.11.2015 Nature Publishing Group
Subjects:	631/326/22/1290 631/326/41/2534 Animals Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Antibiotics Bacteremia - drug therapy Bacteremia - microbiology Bacteria Bacteriology Carrier State - drug therapy Carrier State - microbiology Drug Design Female Humanities and Social Sciences Immunoconjugates - chemistry Immunoconjugates - pharmacology Immunoconjugates - therapeutic use Intracellular Space - drug effects Intracellular Space - microbiology Methicillin-Resistant Staphylococcus aureus - drug effects Methicillin-Resistant Staphylococcus aureus - pathogenicity Mice Microbial Sensitivity Tests multidisciplinary Pathogens Phagosomes - drug effects Phagosomes - metabolism Phagosomes - microbiology Science Staphylococcal Infections - drug therapy Staphylococcal Infections - microbiology Staphylococcal Infections - pathology Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Staphylococcus infections Vancomycin - pharmacology Vancomycin - therapeutic use
ISSN:	0028-0836, 1476-4687, 1476-4687
Online Access:	Get full text
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