Detection and localization of surgically resectable cancers with a multi-analyte blood test

Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinical...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 359; no. 6378; p. 926
Main Authors:	Cohen, Joshua D, Li, Lu, Wang, Yuxuan, Thoburn, Christopher, Afsari, Bahman, Danilova, Ludmila, Douville, Christopher, Javed, Ammar A, Wong, Fay, Mattox, Austin, Hruban, Ralph H, Wolfgang, Christopher L, Goggins, Michael G, Dal Molin, Marco, Wang, Tian-Li, Roden, Richard, Klein, Alison P, Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Vogelstein, Joshua T, Browne, James D, Schoen, Robert E, Brand, Randall E, Tie, Jeanne, Gibbs, Peter, Wong, Hui-Li, Mansfield, Aaron S, Jen, Jin, Hanash, Samir M, Falconi, Massimo, Allen, Peter J, Zhou, Shibin, Bettegowda, Chetan, Diaz, Jr, Luis A, Tomasetti, Cristian, Kinzler, Kenneth W, Vogelstein, Bert, Lennon, Anne Marie, Papadopoulos, Nickolas
Format:	Journal Article
Language:	English
Published:	United States 23.02.2018
Subjects:	Circulating Tumor DNA - genetics Costs and Cost Analysis Early Detection of Cancer - economics Early Detection of Cancer - methods Hematologic Tests - economics Humans Mutation Neoplasm Proteins - blood Neoplasms - blood Neoplasms - diagnosis Neoplasms - genetics Neoplasms - surgery Polymerase Chain Reaction - methods
ISSN:	1095-9203, 1095-9203
Online Access:	Get more information
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Summary:	Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23
ISSN:	1095-9203 1095-9203
DOI:	10.1126/science.aar3247