Detection and localization of surgically resectable cancers with a multi-analyte blood test
Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinical...
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| Vydáno v: | Science (American Association for the Advancement of Science) Ročník 359; číslo 6378; s. 926 |
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| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
23.02.2018
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| Témata: | |
| ISSN: | 1095-9203, 1095-9203 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
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| Abstract | Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients. |
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| AbstractList | Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients.Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients. Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels of circulating proteins and mutations in cell-free DNA. We applied this test, called CancerSEEK, to 1005 patients with nonmetastatic, clinically detected cancers of the ovary, liver, stomach, pancreas, esophagus, colorectum, lung, or breast. CancerSEEK tests were positive in a median of 70% of the eight cancer types. The sensitivities ranged from 69 to 98% for the detection of five cancer types (ovary, liver, stomach, pancreas, and esophagus) for which there are no screening tests available for average-risk individuals. The specificity of CancerSEEK was greater than 99%: only 7 of 812 healthy controls scored positive. In addition, CancerSEEK localized the cancer to a small number of anatomic sites in a median of 83% of the patients. |
| Author | Wang, Tian-Li Browne, James D Brand, Randall E Dal Molin, Marco Wong, Hui-Li Tie, Jeanne Thoburn, Christopher Falconi, Massimo Tomasetti, Cristian Cohen, Joshua D Schoen, Robert E Schaefer, Joy Roden, Richard Hanash, Samir M Ptak, Janine Papadopoulos, Nickolas Popoli, Maria Zhou, Shibin Wang, Yuxuan Dobbyn, Lisa Mattox, Austin Allen, Peter J Hruban, Ralph H Lennon, Anne Marie Douville, Christopher Vogelstein, Joshua T Silliman, Natalie Wong, Fay Gibbs, Peter Vogelstein, Bert Afsari, Bahman Goggins, Michael G Wolfgang, Christopher L Jen, Jin Bettegowda, Chetan Li, Lu Mansfield, Aaron S Diaz, Jr, Luis A Javed, Ammar A Klein, Alison P Danilova, Ludmila Kinzler, Kenneth W |
| Author_xml | – sequence: 1 givenname: Joshua D orcidid: 0000-0003-1158-5668 surname: Cohen fullname: Cohen, Joshua D organization: Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 2 givenname: Lu orcidid: 0000-0002-1920-4965 surname: Li fullname: Li, Lu organization: Department of Biostatistics, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA – sequence: 3 givenname: Yuxuan orcidid: 0000-0002-2932-6042 surname: Wang fullname: Wang, Yuxuan organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 4 givenname: Christopher orcidid: 0000-0001-7743-9183 surname: Thoburn fullname: Thoburn, Christopher organization: Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 5 givenname: Bahman surname: Afsari fullname: Afsari, Bahman organization: Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 6 givenname: Ludmila orcidid: 0000-0003-2813-3094 surname: Danilova fullname: Danilova, Ludmila organization: Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 7 givenname: Christopher orcidid: 0000-0002-2510-4151 surname: Douville fullname: Douville, Christopher organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 8 givenname: Ammar A orcidid: 0000-0002-5463-5250 surname: Javed fullname: Javed, Ammar A organization: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 9 givenname: Fay orcidid: 0000-0001-9759-3778 surname: Wong fullname: Wong, Fay organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 10 givenname: Austin orcidid: 0000-0002-7567-5542 surname: Mattox fullname: Mattox, Austin organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 11 givenname: Ralph H surname: Hruban fullname: Hruban, Ralph H organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 12 givenname: Christopher L orcidid: 0000-0002-8717-0373 surname: Wolfgang fullname: Wolfgang, Christopher L organization: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 13 givenname: Michael G surname: Goggins fullname: Goggins, Michael G organization: Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 14 givenname: Marco surname: Dal Molin fullname: Dal Molin, Marco organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 15 givenname: Tian-Li surname: Wang fullname: Wang, Tian-Li organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 16 givenname: Richard orcidid: 0000-0002-2506-0195 surname: Roden fullname: Roden, Richard organization: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 17 givenname: Alison P orcidid: 0000-0003-2737-8399 surname: Klein fullname: Klein, Alison P organization: Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA – sequence: 18 givenname: Janine orcidid: 0000-0003-1934-8739 surname: Ptak fullname: Ptak, Janine organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 19 givenname: Lisa orcidid: 0000-0002-3159-189X surname: Dobbyn fullname: Dobbyn, Lisa organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 20 givenname: Joy orcidid: 0000-0001-6788-8989 surname: Schaefer fullname: Schaefer, Joy organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 21 givenname: Natalie orcidid: 0000-0002-5198-9037 surname: Silliman fullname: Silliman, Natalie organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 22 givenname: Maria surname: Popoli fullname: Popoli, Maria organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 23 givenname: Joshua T surname: Vogelstein fullname: Vogelstein, Joshua T organization: Institute for Computational Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 24 givenname: James D surname: Browne fullname: Browne, James D organization: Department of Computer Science, Johns Hopkins University Whiting School of Engineering, Baltimore, MD 21218, USA – sequence: 25 givenname: Robert E orcidid: 0000-0001-7153-2766 surname: Schoen fullname: Schoen, Robert E organization: Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15260, USA – sequence: 26 givenname: Randall E orcidid: 0000-0002-4136-3313 surname: Brand fullname: Brand, Randall E organization: Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA – sequence: 27 givenname: Jeanne orcidid: 0000-0001-9244-2057 surname: Tie fullname: Tie, Jeanne organization: Department of Medical Oncology, Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia – sequence: 28 givenname: Peter surname: Gibbs fullname: Gibbs, Peter organization: Department of Medical Oncology, Peter MacCallum Cancer Center, Melbourne, VIC 3000, Australia – sequence: 29 givenname: Hui-Li orcidid: 0000-0003-3803-2107 surname: Wong fullname: Wong, Hui-Li organization: Division of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia – sequence: 30 givenname: Aaron S orcidid: 0000-0002-9483-6903 surname: Mansfield fullname: Mansfield, Aaron S organization: Division of Medical Oncology, Department of Oncology, Mayo Clinic, Rochester, MN 55902, USA – sequence: 31 givenname: Jin orcidid: 0000-0002-8790-9836 surname: Jen fullname: Jen, Jin organization: Division of Experimental Pathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55902, USA – sequence: 32 givenname: Samir M surname: Hanash fullname: Hanash, Samir M organization: Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA – sequence: 33 givenname: Massimo surname: Falconi fullname: Falconi, Massimo organization: Division of Pancreatic Surgery, Department of Surgery, San Raffaele Scientific Institute Research Hospital, 20132 Milan, Italy – sequence: 34 givenname: Peter J surname: Allen fullname: Allen, Peter J organization: Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA – sequence: 35 givenname: Shibin orcidid: 0000-0003-1941-4425 surname: Zhou fullname: Zhou, Shibin organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 36 givenname: Chetan surname: Bettegowda fullname: Bettegowda, Chetan organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 37 givenname: Luis A orcidid: 0000-0002-7079-8914 surname: Diaz, Jr fullname: Diaz, Jr, Luis A organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 38 givenname: Cristian orcidid: 0000-0003-3277-4804 surname: Tomasetti fullname: Tomasetti, Cristian email: ctomasetti@jhu.edu, amlennon@jhmi.edu, kinzlke@jhmi.edu, bertvog@gmail.com, npapado1@jhmi.edu organization: Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 39 givenname: Kenneth W orcidid: 0000-0001-5591-1176 surname: Kinzler fullname: Kinzler, Kenneth W email: ctomasetti@jhu.edu, amlennon@jhmi.edu, kinzlke@jhmi.edu, bertvog@gmail.com, npapado1@jhmi.edu organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 40 givenname: Bert orcidid: 0000-0003-0766-3854 surname: Vogelstein fullname: Vogelstein, Bert email: ctomasetti@jhu.edu, amlennon@jhmi.edu, kinzlke@jhmi.edu, bertvog@gmail.com, npapado1@jhmi.edu organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA – sequence: 41 givenname: Anne Marie orcidid: 0000-0001-8957-3945 surname: Lennon fullname: Lennon, Anne Marie email: ctomasetti@jhu.edu, amlennon@jhmi.edu, kinzlke@jhmi.edu, bertvog@gmail.com, npapado1@jhmi.edu organization: Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA – sequence: 42 givenname: Nickolas orcidid: 0000-0001-7135-7451 surname: Papadopoulos fullname: Papadopoulos, Nickolas email: ctomasetti@jhu.edu, amlennon@jhmi.edu, kinzlke@jhmi.edu, bertvog@gmail.com, npapado1@jhmi.edu organization: Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29348365$$D View this record in MEDLINE/PubMed |
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| References | 29405203 - Nat Rev Clin Oncol. 2018 Mar;15(3):133. doi: 10.1038/nrclinonc.2018.21. 29951738 - Pathologe. 2018 Jul;39(4):328-329. doi: 10.1007/s00292-018-0454-6. 29472467 - Science. 2018 Feb 23;359(6378):866-867. doi: 10.1126/science.aas9102. 29769632 - Nat Rev Cancer. 2018 Jul;18(7):401. doi: 10.1038/s41568-018-0021-8. 30123550 - J Thorac Dis. 2018 Jul;10(Suppl 18):S2165-S2167. doi: 10.21037/jtd.2018.06.58. |
| References_xml | – reference: 29951738 - Pathologe. 2018 Jul;39(4):328-329. doi: 10.1007/s00292-018-0454-6. – reference: 29769632 - Nat Rev Cancer. 2018 Jul;18(7):401. doi: 10.1038/s41568-018-0021-8. – reference: 29405203 - Nat Rev Clin Oncol. 2018 Mar;15(3):133. doi: 10.1038/nrclinonc.2018.21. – reference: 30123550 - J Thorac Dis. 2018 Jul;10(Suppl 18):S2165-S2167. doi: 10.21037/jtd.2018.06.58. – reference: 29472467 - Science. 2018 Feb 23;359(6378):866-867. doi: 10.1126/science.aas9102. |
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| Snippet | Earlier detection is key to reducing cancer deaths. Here, we describe a blood test that can detect eight common cancer types through assessment of the levels... |
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| SubjectTerms | Circulating Tumor DNA - genetics Costs and Cost Analysis Early Detection of Cancer - economics Early Detection of Cancer - methods Hematologic Tests - economics Humans Mutation Neoplasm Proteins - blood Neoplasms - blood Neoplasms - diagnosis Neoplasms - genetics Neoplasms - surgery Polymerase Chain Reaction - methods |
| Title | Detection and localization of surgically resectable cancers with a multi-analyte blood test |
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