Experimental thrombocytopenia does not affect acute kidney injury 24 hours after renal ischemia reperfusion in mice

The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Platelets (Edinburgh) Ročník 31; číslo 3; s. 383 - 391
Hlavní autoři: Jansen, Marcel. P.B., Huisman, Andras, Claessen, Nike, Florquin, Sandrine, Roelofs, Joris J.T.H.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Taylor & Francis 02.04.2020
Taylor & Francis Group
Témata:
Acute kidney injury
renal ischemia
renal ischemiareperfusion
reperfusion
thrombocytopenia
thrombocytopenia
renal ischemiareperfusion
Acute kidney injury
ISSN:0953-7104, 1369-1635, 1369-1635
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Abstract The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice.
AbstractList The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice.
The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice.The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice.
Author Roelofs, Joris J.T.H.
Jansen, Marcel. P.B.
Huisman, Andras
Florquin, Sandrine
Claessen, Nike
Author_xml – sequence: 1
  givenname: Marcel. P.B.
  surname: Jansen
  fullname: Jansen, Marcel. P.B.
  organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam
– sequence: 2
  givenname: Andras
  surname: Huisman
  fullname: Huisman, Andras
  organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam
– sequence: 3
  givenname: Nike
  surname: Claessen
  fullname: Claessen, Nike
  organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam
– sequence: 4
  givenname: Sandrine
  surname: Florquin
  fullname: Florquin, Sandrine
  organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam
– sequence: 5
  givenname: Joris J.T.H.
  surname: Roelofs
  fullname: Roelofs, Joris J.T.H.
  email: j.j.roelofs@amc.nl
  organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31364433$$D View this record in MEDLINE/PubMed
BookMark eNp9kU1vEzEQhi1URNPCTwDtkUvC-GO99g1UFVqpEhc4W157ljjs2sHeFc2_xyFpjz2NZD3vMxq_V-QipoiEvKewoaDgE-iWdxTEhgHVGyqFVFq_IivKpV5TydsLsjoy6yN0Sa5K2QFQBbJ9Qy55pYTgfEXK7eMec5gwznZs5m1OU5_cYU57jME2PmFpYpobOwzo6nDLjM3v4CMemhB3Sz40TDTbtORSmRlzkzFWUyhui1M1ZKz-YSkhxRpopuDwLXk92LHgu_O8Jj-_3v64uVs_fP92f_PlYe24gnnNnVcd2paBsrb32nUaUHqNEgWjTg9MdIPXrfad0Jz1LagWO6EoWuhZB_ya3J-8Ptmd2dcrbT6YZIP5_5DyL2PzHNyIxrLeMmlFi221AvTaopAalAeKQonq-nhy7XP6s2CZzVRPxHG0EdNSDGOyEyAVP679cEaXfkL_vPjp0yvQngCXUykZh2eEgjmWa57KNcdyzbncmvt8yoU4pDzZvymP3sz2MKY8ZBtdKHXJi4p_Prqq5Q
Cites_doi 10.1371/journal.pone.0177201
10.1056/NEJMoa1401105
10.1056/NEJMoa020798
10.1182/blood-2005-04-1530
10.1681/ASN.2012080800
10.1111/ijlh.12084
10.1182/blood-2014-05-573915
10.1038/ncomms3657
10.1111/j.1440-1746.2008.05497
10.1038/ki.2008.689
10.1160/THS10-11-0720
10.1371/journal.pone.0030094
10.1182/blood-2003-08-2804
10.1038/ki.2008.648
10.1164/rccm.201108-1533OC
10.1097/ALN.0000000000000959
10.1182/bloodadvances.2017010645
10.1681/ASN.2013070758
10.1681/ASN.2005010089
10.1093/bja/aes422
10.1182/blood-2013-05-468694
10.1084/jem.188.9.1751
10.1097/01.WCB.0000132690.96836.7F
10.1038/s41467-017-02402-6
10.1152/ajprenal.00462.2016
10.1681/ASN.2004090740
10.1172/JCI45161
10.1002/cphy.c110041
10.1371/journal.pone.0003596
10.1152/physiol.00046.2014
10.1161/CIRCINTERVENTIONS.115.003279
10.1093/ndt/gfm694
10.1016/j.kint.2016.08.006
10.1001/jama.2014.15284
10.1038/nm.2507
10.3109/09537104.2015.1064881
10.1038/nm.2290
10.1182/blood-2014-09-600312
10.1371/journal.pbio.1002459
10.1093/nar/gkp045
10.1182/blood-2017-06-788067
10.1152/ajpgi.2001.281.6.G1432
10.1038/ki.2008.500
10.1159/000444807
10.1097/CCM.0000000000001164
10.3109/09537101003637265
10.1096/fj.01-0199com
10.1152/japplphysiol.01086.2009
10.1152/ajpgi.00499.2011
10.1182/blood-2007-09-113837
10.1681/ASN.2010080793
10.1161/01.cir.90.4.1908
10.1016/S0002-9440(10)62503-5
ContentType Journal Article
Copyright 2019 Taylor & Francis Group, LLC 2019
Copyright_xml – notice: 2019 Taylor & Francis Group, LLC 2019
DBID AAYXX
CITATION
NPM
7X8
DOA
DOI 10.1080/09537104.2019.1646899
DatabaseName CrossRef
PubMed
MEDLINE - Academic
Open Access: DOAJ - Directory of Open Access Journals
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
MEDLINE - Academic

PubMed
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 1369-1635
EndPage 391
ExternalDocumentID oai_doaj_org_article_a2ba26a45e524700b9ae46908d01e484
31364433
10_1080_09537104_2019_1646899
1646899
Genre Article
Journal Article
GrantInformation_xml – fundername: The Netherlands Organisation for Health Research and Development Clinical Fellowship grant.
  grantid: #40-00703-97-12480
– fundername: Dutch Kidney Foundation
  grantid: #KJP10.017
GroupedDBID ---
00X
03L
0YH
123
29O
36B
4.4
AAGDL
AALUX
AAMIU
AAPUL
AAQRR
ABBKH
ABDBF
ABEIZ
ABJNI
ABLIJ
ABLKL
ABUPF
ABWVI
ABXYU
ACENM
ACGEJ
ACGFS
ACUHS
ADCVX
ADRBQ
ADXPE
AECIN
AENEX
AEOZL
AFKVX
AFRVT
AGDLA
AGFJD
AGRBW
AGYJP
AIJEM
AJWEG
AKBVH
ALMA_UNASSIGNED_HOLDINGS
ALQZU
ALYBC
AMDAE
AQTUD
BABNJ
BLEHA
BOHLJ
CCCUG
CS3
DKSSO
DU5
EAP
EBC
EBD
EBS
EMB
EMK
EMOBN
EPL
ESX
F5P
H13
HZ~
KRBQP
KSSTO
KWAYT
KYCEM
LJTGL
M4Z
O9-
RNANH
RVRKI
SV3
TBQAZ
TDBHL
TERGH
TFDNU
TFL
TFW
TUROJ
TUS
UEQFS
V1S
~1N
AAYXX
CITATION
53G
5VS
AALIY
AAORF
AAPXX
ABWCV
ABZEW
ACKZS
ACOPL
ADFOM
ADFZZ
ADYSH
AEIIZ
AFLEI
AJVHN
AWYRJ
BRMBE
CAG
COF
CYYVM
CZDIS
DRXRE
DWTOO
EJD
GROUPED_DOAJ
JENTW
M44
NPM
NUSFT
QQXMO
7X8
ID FETCH-LOGICAL-c380t-3cd87ea5208aabd9c790e6d9e6e421c9f247fd959d74932b5085e7481ea0b2703
IEDL.DBID DOA
ISICitedReferencesCount 3
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000479487900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0953-7104
1369-1635
IngestDate Mon Nov 10 04:35:27 EST 2025
Thu Sep 04 19:44:50 EDT 2025
Thu Apr 03 07:02:33 EDT 2025
Sat Nov 29 06:10:54 EST 2025
Mon Oct 20 23:48:50 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 3
Keywords thrombocytopenia
renal ischemiareperfusion
Acute kidney injury
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c380t-3cd87ea5208aabd9c790e6d9e6e421c9f247fd959d74932b5085e7481ea0b2703
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
OpenAccessLink https://doaj.org/article/a2ba26a45e524700b9ae46908d01e484
PMID 31364433
PQID 2267406830
PQPubID 23479
PageCount 9
ParticipantIDs crossref_primary_10_1080_09537104_2019_1646899
pubmed_primary_31364433
informaworld_taylorfrancis_310_1080_09537104_2019_1646899
proquest_miscellaneous_2267406830
doaj_primary_oai_doaj_org_article_a2ba26a45e524700b9ae46908d01e484
PublicationCentury 2000
PublicationDate 2020-04-02
PublicationDateYYYYMMDD 2020-04-02
PublicationDate_xml – month: 04
  year: 2020
  text: 2020-04-02
  day: 02
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
PublicationTitle Platelets (Edinburgh)
PublicationTitleAlternate Platelets
PublicationYear 2020
Publisher Taylor & Francis
Taylor & Francis Group
Publisher_xml – name: Taylor & Francis
– name: Taylor & Francis Group
References CIT0030
CIT0032
CIT0031
CIT0034
CIT0033
CIT0036
CIT0035
CIT0037
CIT0039
CIT0041
CIT0040
CIT0043
CIT0042
CIT0001
CIT0045
CIT0044
CIT0003
CIT0047
CIT0002
CIT0046
CIT0005
CIT0049
CIT0004
CIT0048
CIT0007
CIT0006
CIT0009
CIT0008
CIT0050
CIT0052
CIT0051
CIT0010
CIT0054
CIT0053
CIT0012
CIT0011
CIT0055
Hamburger SA (CIT0038) 1990; 75
Chintala MS (CIT0013) 1995; 271
CIT0014
CIT0016
CIT0015
CIT0018
CIT0017
CIT0019
CIT0021
CIT0020
CIT0023
CIT0022
CIT0025
CIT0024
CIT0027
CIT0026
CIT0029
CIT0028
References_xml – ident: CIT0044
  doi: 10.1371/journal.pone.0177201
– ident: CIT0046
  doi: 10.1056/NEJMoa1401105
– ident: CIT0042
  doi: 10.1056/NEJMoa020798
– ident: CIT0032
  doi: 10.1182/blood-2005-04-1530
– ident: CIT0003
  doi: 10.1681/ASN.2012080800
– ident: CIT0015
  doi: 10.1111/ijlh.12084
– ident: CIT0051
  doi: 10.1182/blood-2014-05-573915
– ident: CIT0052
  doi: 10.1038/ncomms3657
– ident: CIT0022
  doi: 10.1111/j.1440-1746.2008.05497
– ident: CIT0010
  doi: 10.1038/ki.2008.689
– ident: CIT0036
  doi: 10.1160/THS10-11-0720
– ident: CIT0043
  doi: 10.1371/journal.pone.0030094
– volume: 75
  start-page: 550
  year: 1990
  ident: CIT0038
  publication-title: Am Soc Hematol
– ident: CIT0016
  doi: 10.1182/blood-2003-08-2804
– ident: CIT0037
  doi: 10.1038/ki.2008.648
– ident: CIT0039
  doi: 10.1164/rccm.201108-1533OC
– ident: CIT0041
  doi: 10.1097/ALN.0000000000000959
– ident: CIT0021
  doi: 10.1182/bloodadvances.2017010645
– ident: CIT0029
  doi: 10.1681/ASN.2013070758
– ident: CIT0026
  doi: 10.1681/ASN.2005010089
– ident: CIT0048
  doi: 10.1093/bja/aes422
– ident: CIT0033
  doi: 10.1182/blood-2013-05-468694
– ident: CIT0040
  doi: 10.1084/jem.188.9.1751
– ident: CIT0031
  doi: 10.1097/01.WCB.0000132690.96836.7F
– ident: CIT0017
  doi: 10.1038/s41467-017-02402-6
– ident: CIT0007
  doi: 10.1152/ajprenal.00462.2016
– ident: CIT0001
  doi: 10.1681/ASN.2004090740
– ident: CIT0004
  doi: 10.1172/JCI45161
– ident: CIT0005
  doi: 10.1002/cphy.c110041
– ident: CIT0025
  doi: 10.1371/journal.pone.0003596
– ident: CIT0011
  doi: 10.1152/physiol.00046.2014
– ident: CIT0047
  doi: 10.1161/CIRCINTERVENTIONS.115.003279
– ident: CIT0009
  doi: 10.1093/ndt/gfm694
– ident: CIT0049
  doi: 10.1016/j.kint.2016.08.006
– ident: CIT0045
  doi: 10.1001/jama.2014.15284
– ident: CIT0006
  doi: 10.1038/nm.2507
– ident: CIT0014
  doi: 10.3109/09537104.2015.1064881
– ident: CIT0028
  doi: 10.1038/nm.2290
– ident: CIT0023
  doi: 10.1182/blood-2014-09-600312
– ident: CIT0012
  doi: 10.1371/journal.pbio.1002459
– ident: CIT0027
  doi: 10.1093/nar/gkp045
– ident: CIT0018
  doi: 10.1182/blood-2017-06-788067
– ident: CIT0020
  doi: 10.1152/ajpgi.2001.281.6.G1432
– ident: CIT0008
  doi: 10.1038/ki.2008.500
– ident: CIT0054
  doi: 10.1159/000444807
– ident: CIT0053
  doi: 10.1097/CCM.0000000000001164
– ident: CIT0030
  doi: 10.3109/09537101003637265
– ident: CIT0050
  doi: 10.1096/fj.01-0199com
– ident: CIT0002
  doi: 10.1152/japplphysiol.01086.2009
– ident: CIT0019
  doi: 10.1152/ajpgi.00499.2011
– ident: CIT0024
  doi: 10.1182/blood-2007-09-113837
– ident: CIT0035
  doi: 10.1681/ASN.2010080793
– ident: CIT0055
  doi: 10.1161/01.cir.90.4.1908
– ident: CIT0034
  doi: 10.1016/S0002-9440(10)62503-5
– volume: 271
  start-page: 1203
  issue: 273
  year: 1995
  ident: CIT0013
  publication-title: J Pharmacol Exp Ther
SSID ssj0018065
Score 2.2467692
Snippet The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by...
SourceID doaj
proquest
pubmed
crossref
informaworld
SourceType Open Website
Aggregation Database
Index Database
Publisher
StartPage 383
SubjectTerms Acute kidney injury
renal ischemia
renal ischemiareperfusion
reperfusion
thrombocytopenia
SummonAdditionalLinks – databaseName: Taylor & Francis Online Journals
  dbid: TFW
  link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELr_JYXjIS4paS-LG2jwV1xaniUERvlh8TCGiTKski7b9n7CSrglRxgGuU2I49M_5mPP6GkDfMCemdVIUEAYUIShW-1HXhogt10Kw20udiE-r8XF9emk9zNuEwp1UmH7qeiCKyrU7K7fywZMS9SxRpuDGmiEhlThJBFjoNaIUR2ScZv9h8OZwjpGPDiW2Pp6xDsdzhuamV33anTOL_B4XpzUA0b0ibe__hV-6TuzMapaeT-Dwgt6B9SI5PW_TEt3v6lub80Bx4PybD2bViADSVV9j6LuzHVH-rcTR2MNC2G6nLGSLUhd0I9EcTW9jTpv2Oa0eZoN-wy4HmyuS0h9R5g_41bLGFHrD9epfCd_gB3aIJe0Q-b84uPnws5pINReC6HAseolbgJCu1cz6aoEwJ62hgDYJVwdRMqDoaaaISiBw9wkMJSugKXOkZWp_H5KjtWnhKaAWmghhZ5FEKD9wruU7UQ4E7IxwLK3KyLJW9mpg5bLUQns7TatO02nlaV-R9WtDDy4lYOz_o-q921lPrmHdsjQIMEodalt44SBEEHcsKhBYrYq6Lgx1zXKWeiqBY_pcBvF5kx6ISp5MZ10K3GyxiYIXISvNyRZ5MQnUYJq84YlbOn_1Dz8_JHZbiBCnjiL0gR2O_g5fkdvg5NkP_KqvMLwlsE4A
  priority: 102
  providerName: Taylor & Francis
Title Experimental thrombocytopenia does not affect acute kidney injury 24 hours after renal ischemia reperfusion in mice
URI https://www.tandfonline.com/doi/abs/10.1080/09537104.2019.1646899
https://www.ncbi.nlm.nih.gov/pubmed/31364433
https://www.proquest.com/docview/2267406830
https://doaj.org/article/a2ba26a45e524700b9ae46908d01e484
Volume 31
WOSCitedRecordID wos000479487900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVAWR
  databaseName: Taylor & Francis Online Journals
  customDbUrl:
  eissn: 1369-1635
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0018065
  issn: 0953-7104
  databaseCode: TFW
  dateStart: 19900101
  isFulltext: true
  titleUrlDefault: https://www.tandfonline.com
  providerName: Taylor & Francis
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV07j9QwELbgREGDgOOxPE5GQnQ5EttZ2-WBbkV1ojjEdpYfE7GgTdAmi7T_nhknOVZI6BqaFFZiWzOT-Bt78n2MvRVe1cHXuqhBQaGi1kUoTVP45GMTjWhsHbLYhL66Muu1_Xwk9UU1YSM98Gi4914EL5bYI9RC6bIM1gOldCaVFSiTmUAR9czJ1HR-QMeFI8uepGpDNf-7Q6za2EZNVNZlz4ley2Ti1z-rUibv_4u69N8ANC9Eq4fswYQg-cU480fsDrSP2elFi9nz9sDf8VzTmTfLT1l_eUTgz0kSYRu6eBhIM2vjeeqg5203cJ-rOriP-wH4j01q4cA37Xe0NxeKf8Mhe57VxPkOaPAN5sSwxR52gP03e9pywwc4ads_YV9Wl9cfPxWTzEIRpSmHQsZkNPgazeh9SDZqW8IyWViCElW0Ddq9Sba2SStEewEhXQ1amQp8GQR-MZ6yk7Zr4TnjFdgKUhJJploFkEHXS6ILitJb5UVcsPPZzO7nyKbhqpmkdPKLI7-4yS8L9oGccXMzkWHnBgwRN4WIuy1EFsweu9INeS-kGYVLnLxlAm9mvzt88eg0xbfQ7XuHuFUjGjKyXLBnY0DcTFNWEnGmlC_-x_RfsvuCknwqFxKv2Mmw28Nrdi_-Gjb97ozd1WtzlqMfr9err78BwSwEOw
linkProvider Directory of Open Access Journals
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELZgQWIvvBaW8jQS4pYl8aOOjwvaahFLT0XszfJjAgE1QW2K1H-Px0mqgrTiANcosR17xjPzefwNIa-YFdJZqTIJAjLhlcpcXlaZDdZXvmSVli4Vm1DzeXl5qffvwmBaJcbQVU8UkfZqVG4Eo8eUuDfIkRYtI0IihT5BhqwYNVwnN2S0tZjWt5h93p0k4MFhz7fHMe9QjLd4rmrmN_uUaPz_IDG92hVNJml253_8zF1ye3BI6WkvQffINWjuk6PTJgbjyy19TVOKaMLej8j6bK8eAMUKC0vX-m2HJbhqS0MLa9q0HbUpSYRav-mAfq9DA1taN9_i8lEm6NfY5Zqm4uR0Bdh5HUNsWMYWVhDbrzaI4MUP6DLuYg_Ip9nZ4t15NlRtyDwv8y7jPpQKrGR5aa0L2iudwzRomIJghdcVE6oKWuqgRHQeXfQQJShRFmBzx-IG9JAcNG0DjwgtQBcQAgs8SOGAOyWnyD7kudXCMj8hJ-NamR89OYcpRs7TYVoNTqsZpnVC3uKK7l5Gbu30oF19MYOqGsucZdMowyDjUPPcaQsIIpQhL0CUYkL0vjyYLkErVV8HxfC_DODlKDwm6jEeztgG2s3aRDdYReeq5PmEHPdStRsmL3h0Wzl__A89vyC3zhcfL8zF-_mHJ-SQIWyACUjsKTnoVht4Rm76n129Xj1P-vMLUVUXoQ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELagIMSFV3ksTyMhbmkTP9bxsUBXINCqhyJ6s_yYQECbVEkWaf89Yye7KkgVB7iusrZjz9gz4y_fR8grZoV0VqpMgoBMeKUyl5dVZoP1lS9ZpaVLYhNquSzPzvTJhCbsJ1hlzKGrkSgi7dXRuc9DtUXEHUaKNDwYY0Wk0AeRIAuThqvkWiLHQpM-XXzZXSTEe8ORbo9H2KHYfsRzWTO_HU-Jxf8PDtPLI9F0Ii1u_4d3uUNuTeEoPRrt5y65As09sn_UYCq-2tDXNAFEU-V9n_THF9QAaNRXWLnWb4YowFVbGlroadMO1CaICLV-PQD9UYcGNrRuvuPiUSboN-yyp0manHYQO68xwYYVttABtl-tY_0O_0BXuIfdJ58Xx6dv32eTZkPmeZkPGfehVGAly0trXdBe6RzmQcMcBCu8rphQVdBSByUwdHQYH0pQoizA5o7h9vOA7DVtA48ILUAXEAILPEjhgDsl55F7yHOrhWV-Rg62S2XOR2oOU2wZT6dpNXFazTStM_ImLuju4cisnX5ou69mclRjmbNsjhYMEoea505biCWEMuQFiFLMiL5oDmZIhZVqVEEx_C8DeLm1HYNeHK9mbAPtujcYBCsMrUqez8jD0ah2w-QFx6CV88f_0PMLcuPk3cJ8-rD8-ITcZLFmENFH7CnZG7o1PCPX_c-h7rvnyXt-AcR9FkU
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Experimental+thrombocytopenia+does+not+affect+acute+kidney+injury+24+hours+after+renal+ischemia+reperfusion+in+mice&rft.jtitle=Platelets+%28Edinburgh%29&rft.au=Jansen%2C+Marcel.+P.B.&rft.au=Huisman%2C+Andras&rft.au=Claessen%2C+Nike&rft.au=Florquin%2C+Sandrine&rft.date=2020-04-02&rft.issn=0953-7104&rft.eissn=1369-1635&rft.volume=31&rft.issue=3&rft.spage=383&rft.epage=391&rft_id=info:doi/10.1080%2F09537104.2019.1646899&rft.externalDBID=n%2Fa&rft.externalDocID=10_1080_09537104_2019_1646899
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0953-7104&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0953-7104&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0953-7104&client=summon