Experimental thrombocytopenia does not affect acute kidney injury 24 hours after renal ischemia reperfusion in mice
The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what...
Gespeichert in:
| Veröffentlicht in: | Platelets (Edinburgh) Jg. 31; H. 3; S. 383 - 391 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
Taylor & Francis
02.04.2020
Taylor & Francis Group |
| Schlagworte: | |
| ISSN: | 0953-7104, 1369-1635, 1369-1635 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice. |
|---|---|
| AbstractList | The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice.The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice. The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by abnormal renal tissue repair, resulting in renal injury and function loss. Platelets are important actors in these processes, however to what extent platelets contribute to the pathophysiology of renal I/R injury still needs to be elucidated. In the current study, we treated wild-type mice with a platelet depleting antibody, which caused thrombocytopenia. We then investigated the role of platelets during the pathophysiology of renal I/R by subjecting control wild-type mice with normal platelet counts and thrombocytopenic wild-type mice to renal I/R injury. Our results showed that in the early phase of renal I/R injury, thrombocytopenia 24 hours after ischemia reperfusion does not influence renal injury, neutrophil infiltration and accumulation of inflammatory chemokines (e.g. keratinocyte chemoattractant, monocyte chemoattractant protein 1, tumor necrosis factor alpha). In the recovery and regeneration phase of I/R injury, respectively 5 and 10 days post-ischemia, thrombocytopenia did also not affect the accumulation of intra-renal neutrophils and macrophages, renal injury, and renal fibrosis. Together, these results imply that lowering platelet counts do not impact the pathogenesis of I/R injury in mice. |
| Author | Roelofs, Joris J.T.H. Jansen, Marcel. P.B. Huisman, Andras Florquin, Sandrine Claessen, Nike |
| Author_xml | – sequence: 1 givenname: Marcel. P.B. surname: Jansen fullname: Jansen, Marcel. P.B. organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam – sequence: 2 givenname: Andras surname: Huisman fullname: Huisman, Andras organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam – sequence: 3 givenname: Nike surname: Claessen fullname: Claessen, Nike organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam – sequence: 4 givenname: Sandrine surname: Florquin fullname: Florquin, Sandrine organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam – sequence: 5 givenname: Joris J.T.H. surname: Roelofs fullname: Roelofs, Joris J.T.H. email: j.j.roelofs@amc.nl organization: Department of Pathology, Amsterdam Cardiovascular Sciences, Amsterdam Infection & Immunity, Amsterdam UMC, University of Amsterdam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31364433$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kU1vEzEQhi1URNPCTwDtkUvC-GO99g1UFVqpEhc4W157ljjs2sHeFc2_xyFpjz2NZD3vMxq_V-QipoiEvKewoaDgE-iWdxTEhgHVGyqFVFq_IivKpV5TydsLsjoy6yN0Sa5K2QFQBbJ9Qy55pYTgfEXK7eMec5gwznZs5m1OU5_cYU57jME2PmFpYpobOwzo6nDLjM3v4CMemhB3Sz40TDTbtORSmRlzkzFWUyhui1M1ZKz-YSkhxRpopuDwLXk92LHgu_O8Jj-_3v64uVs_fP92f_PlYe24gnnNnVcd2paBsrb32nUaUHqNEgWjTg9MdIPXrfad0Jz1LagWO6EoWuhZB_ya3J-8Ptmd2dcrbT6YZIP5_5DyL2PzHNyIxrLeMmlFi221AvTaopAalAeKQonq-nhy7XP6s2CZzVRPxHG0EdNSDGOyEyAVP679cEaXfkL_vPjp0yvQngCXUykZh2eEgjmWa57KNcdyzbncmvt8yoU4pDzZvymP3sz2MKY8ZBtdKHXJi4p_Prqq5Q |
| Cites_doi | 10.1371/journal.pone.0177201 10.1056/NEJMoa1401105 10.1056/NEJMoa020798 10.1182/blood-2005-04-1530 10.1681/ASN.2012080800 10.1111/ijlh.12084 10.1182/blood-2014-05-573915 10.1038/ncomms3657 10.1111/j.1440-1746.2008.05497 10.1038/ki.2008.689 10.1160/THS10-11-0720 10.1371/journal.pone.0030094 10.1182/blood-2003-08-2804 10.1038/ki.2008.648 10.1164/rccm.201108-1533OC 10.1097/ALN.0000000000000959 10.1182/bloodadvances.2017010645 10.1681/ASN.2013070758 10.1681/ASN.2005010089 10.1093/bja/aes422 10.1182/blood-2013-05-468694 10.1084/jem.188.9.1751 10.1097/01.WCB.0000132690.96836.7F 10.1038/s41467-017-02402-6 10.1152/ajprenal.00462.2016 10.1681/ASN.2004090740 10.1172/JCI45161 10.1002/cphy.c110041 10.1371/journal.pone.0003596 10.1152/physiol.00046.2014 10.1161/CIRCINTERVENTIONS.115.003279 10.1093/ndt/gfm694 10.1016/j.kint.2016.08.006 10.1001/jama.2014.15284 10.1038/nm.2507 10.3109/09537104.2015.1064881 10.1038/nm.2290 10.1182/blood-2014-09-600312 10.1371/journal.pbio.1002459 10.1093/nar/gkp045 10.1182/blood-2017-06-788067 10.1152/ajpgi.2001.281.6.G1432 10.1038/ki.2008.500 10.1159/000444807 10.1097/CCM.0000000000001164 10.3109/09537101003637265 10.1096/fj.01-0199com 10.1152/japplphysiol.01086.2009 10.1152/ajpgi.00499.2011 10.1182/blood-2007-09-113837 10.1681/ASN.2010080793 10.1161/01.cir.90.4.1908 10.1016/S0002-9440(10)62503-5 |
| ContentType | Journal Article |
| Copyright | 2019 Taylor & Francis Group, LLC 2019 |
| Copyright_xml | – notice: 2019 Taylor & Francis Group, LLC 2019 |
| DBID | AAYXX CITATION NPM 7X8 DOA |
| DOI | 10.1080/09537104.2019.1646899 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic DOAJ Directory of Open Access Journals (WRLC) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1369-1635 |
| EndPage | 391 |
| ExternalDocumentID | oai_doaj_org_article_a2ba26a45e524700b9ae46908d01e484 31364433 10_1080_09537104_2019_1646899 1646899 |
| Genre | Article Journal Article |
| GrantInformation_xml | – fundername: The Netherlands Organisation for Health Research and Development Clinical Fellowship grant. grantid: #40-00703-97-12480 – fundername: Dutch Kidney Foundation grantid: #KJP10.017 |
| GroupedDBID | --- 00X 03L 0YH 123 29O 36B 4.4 AAGDL AALUX AAMIU AAPUL AAQRR ABBKH ABDBF ABEIZ ABJNI ABLIJ ABLKL ABUPF ABWVI ABXYU ACENM ACGEJ ACGFS ACUHS ADCVX ADRBQ ADXPE AECIN AENEX AEOZL AFKVX AFRVT AGDLA AGFJD AGRBW AGYJP AIJEM AJWEG AKBVH ALMA_UNASSIGNED_HOLDINGS ALQZU ALYBC AMDAE AQTUD BABNJ BLEHA BOHLJ CCCUG CS3 DKSSO DU5 EAP EBC EBD EBS EMB EMK EMOBN EPL ESX F5P H13 HZ~ KRBQP KSSTO KWAYT KYCEM LJTGL M4Z O9- RNANH RVRKI SV3 TBQAZ TDBHL TERGH TFDNU TFL TFW TUROJ TUS UEQFS V1S ~1N AAYXX CITATION 53G 5VS AALIY AAORF AAPXX ABWCV ABZEW ACKZS ACOPL ADFOM ADFZZ ADYSH AEIIZ AFLEI AJVHN AWYRJ BRMBE CAG COF CYYVM CZDIS DRXRE DWTOO EJD GROUPED_DOAJ JENTW M44 NPM NUSFT QQXMO 7X8 |
| ID | FETCH-LOGICAL-c380t-3cd87ea5208aabd9c790e6d9e6e421c9f247fd959d74932b5085e7481ea0b2703 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 3 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000479487900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0953-7104 1369-1635 |
| IngestDate | Mon Nov 10 04:35:27 EST 2025 Thu Sep 04 19:44:50 EDT 2025 Thu Apr 03 07:02:33 EDT 2025 Sat Nov 29 06:10:54 EST 2025 Mon Oct 20 23:48:50 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | thrombocytopenia renal ischemiareperfusion Acute kidney injury |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c380t-3cd87ea5208aabd9c790e6d9e6e421c9f247fd959d74932b5085e7481ea0b2703 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | https://doaj.org/article/a2ba26a45e524700b9ae46908d01e484 |
| PMID | 31364433 |
| PQID | 2267406830 |
| PQPubID | 23479 |
| PageCount | 9 |
| ParticipantIDs | crossref_primary_10_1080_09537104_2019_1646899 pubmed_primary_31364433 informaworld_taylorfrancis_310_1080_09537104_2019_1646899 proquest_miscellaneous_2267406830 doaj_primary_oai_doaj_org_article_a2ba26a45e524700b9ae46908d01e484 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-04-02 |
| PublicationDateYYYYMMDD | 2020-04-02 |
| PublicationDate_xml | – month: 04 year: 2020 text: 2020-04-02 day: 02 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Platelets (Edinburgh) |
| PublicationTitleAlternate | Platelets |
| PublicationYear | 2020 |
| Publisher | Taylor & Francis Taylor & Francis Group |
| Publisher_xml | – name: Taylor & Francis – name: Taylor & Francis Group |
| References | CIT0030 CIT0032 CIT0031 CIT0034 CIT0033 CIT0036 CIT0035 CIT0037 CIT0039 CIT0041 CIT0040 CIT0043 CIT0042 CIT0001 CIT0045 CIT0044 CIT0003 CIT0047 CIT0002 CIT0046 CIT0005 CIT0049 CIT0004 CIT0048 CIT0007 CIT0006 CIT0009 CIT0008 CIT0050 CIT0052 CIT0051 CIT0010 CIT0054 CIT0053 CIT0012 CIT0011 CIT0055 Hamburger SA (CIT0038) 1990; 75 Chintala MS (CIT0013) 1995; 271 CIT0014 CIT0016 CIT0015 CIT0018 CIT0017 CIT0019 CIT0021 CIT0020 CIT0023 CIT0022 CIT0025 CIT0024 CIT0027 CIT0026 CIT0029 CIT0028 |
| References_xml | – ident: CIT0044 doi: 10.1371/journal.pone.0177201 – ident: CIT0046 doi: 10.1056/NEJMoa1401105 – ident: CIT0042 doi: 10.1056/NEJMoa020798 – ident: CIT0032 doi: 10.1182/blood-2005-04-1530 – ident: CIT0003 doi: 10.1681/ASN.2012080800 – ident: CIT0015 doi: 10.1111/ijlh.12084 – ident: CIT0051 doi: 10.1182/blood-2014-05-573915 – ident: CIT0052 doi: 10.1038/ncomms3657 – ident: CIT0022 doi: 10.1111/j.1440-1746.2008.05497 – ident: CIT0010 doi: 10.1038/ki.2008.689 – ident: CIT0036 doi: 10.1160/THS10-11-0720 – ident: CIT0043 doi: 10.1371/journal.pone.0030094 – volume: 75 start-page: 550 year: 1990 ident: CIT0038 publication-title: Am Soc Hematol – ident: CIT0016 doi: 10.1182/blood-2003-08-2804 – ident: CIT0037 doi: 10.1038/ki.2008.648 – ident: CIT0039 doi: 10.1164/rccm.201108-1533OC – ident: CIT0041 doi: 10.1097/ALN.0000000000000959 – ident: CIT0021 doi: 10.1182/bloodadvances.2017010645 – ident: CIT0029 doi: 10.1681/ASN.2013070758 – ident: CIT0026 doi: 10.1681/ASN.2005010089 – ident: CIT0048 doi: 10.1093/bja/aes422 – ident: CIT0033 doi: 10.1182/blood-2013-05-468694 – ident: CIT0040 doi: 10.1084/jem.188.9.1751 – ident: CIT0031 doi: 10.1097/01.WCB.0000132690.96836.7F – ident: CIT0017 doi: 10.1038/s41467-017-02402-6 – ident: CIT0007 doi: 10.1152/ajprenal.00462.2016 – ident: CIT0001 doi: 10.1681/ASN.2004090740 – ident: CIT0004 doi: 10.1172/JCI45161 – ident: CIT0005 doi: 10.1002/cphy.c110041 – ident: CIT0025 doi: 10.1371/journal.pone.0003596 – ident: CIT0011 doi: 10.1152/physiol.00046.2014 – ident: CIT0047 doi: 10.1161/CIRCINTERVENTIONS.115.003279 – ident: CIT0009 doi: 10.1093/ndt/gfm694 – ident: CIT0049 doi: 10.1016/j.kint.2016.08.006 – ident: CIT0045 doi: 10.1001/jama.2014.15284 – ident: CIT0006 doi: 10.1038/nm.2507 – ident: CIT0014 doi: 10.3109/09537104.2015.1064881 – ident: CIT0028 doi: 10.1038/nm.2290 – ident: CIT0023 doi: 10.1182/blood-2014-09-600312 – ident: CIT0012 doi: 10.1371/journal.pbio.1002459 – ident: CIT0027 doi: 10.1093/nar/gkp045 – ident: CIT0018 doi: 10.1182/blood-2017-06-788067 – ident: CIT0020 doi: 10.1152/ajpgi.2001.281.6.G1432 – ident: CIT0008 doi: 10.1038/ki.2008.500 – ident: CIT0054 doi: 10.1159/000444807 – ident: CIT0053 doi: 10.1097/CCM.0000000000001164 – ident: CIT0030 doi: 10.3109/09537101003637265 – ident: CIT0050 doi: 10.1096/fj.01-0199com – ident: CIT0002 doi: 10.1152/japplphysiol.01086.2009 – ident: CIT0019 doi: 10.1152/ajpgi.00499.2011 – ident: CIT0024 doi: 10.1182/blood-2007-09-113837 – ident: CIT0035 doi: 10.1681/ASN.2010080793 – ident: CIT0055 doi: 10.1161/01.cir.90.4.1908 – ident: CIT0034 doi: 10.1016/S0002-9440(10)62503-5 – volume: 271 start-page: 1203 issue: 273 year: 1995 ident: CIT0013 publication-title: J Pharmacol Exp Ther |
| SSID | ssj0018065 |
| Score | 2.2467692 |
| Snippet | The pathophysiology of renal ischemia/reperfusion (I/R) injury is characterized by excessive activation of inflammation and coagulation processes followed by... |
| SourceID | doaj proquest pubmed crossref informaworld |
| SourceType | Open Website Aggregation Database Index Database Publisher |
| StartPage | 383 |
| SubjectTerms | Acute kidney injury renal ischemia renal ischemiareperfusion reperfusion thrombocytopenia |
| SummonAdditionalLinks | – databaseName: Taylor & Francis Online Journals dbid: TFW link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQxYELr_JYCshIiFuKYzsb-1hQVxxQxaFAb5YfYwjVJijJIu2_79jJrgpSxQGuUWI79sz4m_H4G0Je11UIsQqikL5ShVxGV2jJZcFYZBp4iDEXg_nysT47UxcX-tOcTTjMaZXJh44TUUS21Um5rRt2GXFvE0UabowpIlLq40SQhU4DWmFE9knGz1df9-cI6dhwYtsTKetQ7u7w3NTKb7tTJvH_g8L0ZiCaN6TVvf_wK_fJ3RmN0pNJfB6QW9A-JIcnLXri6y19Q3N-aA68H5Lh9FoxAJrKK6xd57djqr_VWBo6GGjbjdTmDBFq_WYEetmEFra0aX_g2lEu6XfscqC5MjntIXXeoH8Na2yhB2w_blL4Dj-gazRhj8jn1en5-w_FXLKh8EKxsRA-qBpsxZmy1gXta81gGTQsQfLS68hlHYOudKglIkeH8LCCWqoSLHMcrc9jctB2LTwl1NqSB_QOnbRSehdVjEExz6IqJYK8uCDHu6UyPydmDlPuCE_naTVpWs08rQvyLi3o_uVErJ0fdP03M-upsdxZvrSyggqHypjTFlIEQQVWglRyQfR1cTBjjqvEqQiKEX8ZwKud7BhU4nQyY1voNoNBDFwjslKCLciTSaj2wxSlQMwqxLN_6PmI3OEpTpAyjvhzcjD2G3hBbvtfYzP0L7PKXAGRrBLk priority: 102 providerName: Taylor & Francis |
| Title | Experimental thrombocytopenia does not affect acute kidney injury 24 hours after renal ischemia reperfusion in mice |
| URI | https://www.tandfonline.com/doi/abs/10.1080/09537104.2019.1646899 https://www.ncbi.nlm.nih.gov/pubmed/31364433 https://www.proquest.com/docview/2267406830 https://doaj.org/article/a2ba26a45e524700b9ae46908d01e484 |
| Volume | 31 |
| WOSCitedRecordID | wos000479487900001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAWR databaseName: Taylor & Francis Online Journals customDbUrl: eissn: 1369-1635 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0018065 issn: 0953-7104 databaseCode: TFW dateStart: 19900101 isFulltext: true titleUrlDefault: https://www.tandfonline.com providerName: Taylor & Francis |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWg4sAFAeVjKVRGQtxSHNtZ28eCuuKAKg4F9mY59lgEtAnaZJH233fsJGWFhHrhkoOV2NbMJH5jT94j5I2qQohVEIX0lS7kMtaFkVwWjEVmgIcYsxjM10_q8lKv1-bzgdRXqgkb6YFHw71zvHZ86WQFFZeKsdo4SCmdDqwEqTMTKKKeOZmazg_SceHIsidStaGc_91JrNrYlppSWZc5S_RaOhO__lmVMnn_X9Sl_wageSFaPSQPJgRJz8eZPyJ3oH1Mjs9bzJ43e_qW5prOvFl-TPqLAwJ_miQRNnXn90PSzGocDR30tO0G6nJVB3V-NwD92YQW9rRpf6C9KZf0Ow7Z06wmTreQBm8wJ4YN9rAF7D_u0pYbPkCTtv0T8mV1cfXhYzHJLBReaDYUwgetwFVoRufqYLwyDJbBwBIkL72JaPcYTGWCkoj2aoR0FSipS3Cs5vjFeEqO2q6F54Q6V_KAGV0tnZS-jjrGoJlnUZcSgVlckLPZzPbXyKZhy5mkdPKLTX6xk18W5H1yxs3NiQw7N2CI2ClE7G0hsiDm0JV2yHshcRQuseKWCbye_W7xxUunKa6FbtdbxK0K0ZAWbEGejQFxM01RCsSZQrz4H9M_Ifd5SvJTuRB_SY6G7Q5ekXv-99D021NyV631aY5-vF6tvl0DdH8Dnw |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lj9MwELZgQYILr4WlPI2EuGXXsZ3GPi5oq0WUngrszXJiG8KqCUpSpP57ZpymKkgrDnCNEtuxZzzfjMffEPI6z5wLmROJLDOVyGkoEi25TBgLTHvuQojFYD7P88VCXVzo_bswmFaJPnQYiCLiXo3KjcHoMSXuBDnSwDJiSCTVx8iQBV7DdXIjA1uLaX3L2ZfdSQIeHA58ewLzDuV4i-eqZn6zT5HG_w8S06uhaDRJs7v_42fukTtbQEpPBwm6T675-gE5PK3BGV9t6BsaU0Rj7P2QdGd79QAoVlhYFU256bEEV2Wpa3xH66anNiaJUFuue08vK1f7Da3q77B8lEv6DbrsaCxOTluPnVfgYvsVtNB6aD-sMYIHH9AV7GIPyafZ2fLdebKt2pCUQrE-EaVTubcZZ8rawuky18xPnfZTL3la6sBlHpzOtMslgMcCEGLmc6lSb1nBYQN6RA7qpvaPCbU25Q4cxEJaKcsiqBCcYiULKpWA88KEHI9rZX4M5BwmHTlPt9NqcFrNdlon5C2u6O5l5NaOD5r2q9mqqrG8sHxqZeYzGCpjhbYegwjKsdRLJSdE78uD6WNoJQx1UIz4ywBejcJjQI_xcMbWvll3BmBwDuBKCTYhR4NU7YYpUgGwVYgn_9DzS3LrfPlxbubvFx-ektscwwaYgMSfkYO-Xfvn5Gb5s6-69kXUn1_QERcF |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELWgIMSFr0JZPo2EuKV1HGdjHwt0BaJa9VCgN8uxxxCqTaoki7T_nrGTrApSxQGuq6zt2DP2m_HkPUJeF7lzPndZImwuEzH3ZaIEFwljningzvsoBvPluFgu5dmZOhmrCbuxrDLE0H4gioh7dXDuC-eniriDQJGGB2PIiKRqPxBkYdBwndyI5Fho0qeLr9uLhHBvONDtZaHsUEwf8VzVzG_HU2Tx_4PD9GokGk-kxd3_8C73yJ0RjtLDwX7uk2tQPyC7hzWG4qsNfUNjgWjMvO-S7uiSGgAN-gqrsrGbPghwVYa6BjpaNz01sUSEGrvugZ5XroYNreofuHiUC_odu-xolCanLYTOKwywYYUttIDt-3XI3-Ef6Ar3sIfk8-Lo9N2HZNRsSGwmWZ9k1skCTM6ZNKZ0yhaKwdwpmIPgqVWei8I7lStXCISOJeLDHAohUzCs5Lj9PCI7dVPDY0KNSbnD8LAURghbeum9k8wyL1OBKM_PyP60VPpioObQ6cR4Ok6rDtOqx2mdkbdhQbcPB2bt-EPTftOjo2rDS8PnRuSQ41AZK5WBkEKQjqUgpJgRddkcdB8TK35QQdHZXwbwarIdjV4crmZMDc260wiCC4RWMmMzsjcY1XaYWZohaM2yJ__Q80ty6-T9Qh9_XH56Sm7zkDMI1Uf8Gdnp2zU8Jzftz77q2hfRe34BRVwVqQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Experimental+thrombocytopenia+does+not+affect+acute+kidney+injury+24+hours+after+renal+ischemia+reperfusion+in+mice&rft.jtitle=Platelets+%28Edinburgh%29&rft.au=Jansen%2C+Marcel+P+B&rft.au=Huisman%2C+Andras&rft.au=Claessen%2C+Nike&rft.au=Florquin%2C+Sandrine&rft.date=2020-04-02&rft.issn=1369-1635&rft.eissn=1369-1635&rft.volume=31&rft.issue=3&rft.spage=383&rft_id=info:doi/10.1080%2F09537104.2019.1646899&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0953-7104&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0953-7104&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0953-7104&client=summon |