The association between the NAT2 genetic polymorphisms and risk of DILI during anti‐TB treatment: a systematic review and meta‐analysis

Aims The aim of this study is to evaluate the potential association between N‐acetyltransferase type 2 (NAT2) polymorphisms and drug‐induced liver injury during anti‐TB treatment (AT‐DILI). Methods We conducted a systematic review and performed a meta‐analysis to clarify the role of NAT2 polymorphis...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 84; no. 12; pp. 2747 - 2760
Main Authors:	Zhang, Min, Wang, Shuqiang, Wilffert, Bob, Tong, Rongsheng, Soolingen, Dick, Hof, Susan, Alffenaar, Jan‐Willem
Format:	Journal Article
Language:	English
Published:	England John Wiley and Sons Inc 01.12.2018
Subjects:	Antitubercular Agents - adverse effects antituberculosis drug‐induced liver injury Arylamine N-Acetyltransferase - genetics Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - genetics Genetic Predisposition to Disease Genotype Humans meta‐analysis NAT2 polymorphism Polymorphism, Genetic Review antituberculosis drug-induced liver injury meta-analysis polymorphism NAT2
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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