Thyrotropin Receptor Structure—In the Crystal New Horizons Shine
The thyrotropin receptor (TSHR) expressed on the surface of the thyrocytes plays a key role in thyroid physiology and is also an important autoantibody target in patients with thyroid autoimmunity. Just over 50 years ago in 1956, Adams and Purves made their milestone observation that the immunoglobu...
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| Published in: | Endocrine practice Vol. 15; no. 1; pp. 56 - 60 |
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| Format: | Journal Article |
| Language: | English |
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01.01.2009
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| ISSN: | 1530-891X, 1934-2403, 1934-2403 |
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| Abstract | The thyrotropin receptor (TSHR) expressed on the surface of the thyrocytes plays a key role in thyroid physiology and is also an important autoantibody target in patients with thyroid autoimmunity. Just over 50 years ago in 1956, Adams and Purves made their milestone observation that the immunoglobulins from patients with Graves disease had the ability to stimulate the thyroid. Cloning of the TSHR complementary DNA sequence in 1989 was the next key development, which had considerable effect on studies of the TSHR. In particular, recombinant TSHRs could be expressed in different systems. The ability to produce recombinant TSHR enabled the development of animal antibodies to the TSHR that proved to be valuable tools for studying the structure and function of the receptor. After many years of efforts, the goal that was deemed by some as impossible was achieved when mouse and hamster thyroid-stimulating antibodies were produced. |
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| AbstractList | The thyrotropin receptor (TSHR) expressed on the surface of the thyrocytes plays a key role in thyroid physiology and is also an important autoantibody target in patients with thyroid autoimmunity. Just over 50 years ago in 1956, Adams and Purves made their milestone observation that the immunoglobulins from patients with Graves disease had the ability to stimulate the thyroid. Cloning of the TSHR complementary DNA sequence in 1989 was the next key development, which had considerable effect on studies of the TSHR. In particular, recombinant TSHRs could be expressed in different systems. The ability to produce recombinant TSHR enabled the development of animal antibodies to the TSHR that proved to be valuable tools for studying the structure and function of the receptor. After many years of efforts, the goal that was deemed by some as impossible was achieved when mouse and hamster thyroid-stimulating antibodies were produced. |
| Author | Furmaniak, Jadwiga Smith, Bernard Rees Sanders, Jane |
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| Cites_doi | 10.1006/jaut.2000.0499 10.1089/1050725041692918 10.1089/thy.2006.16.1195 10.1016/S0950-351X(97)80693-3 10.1172/JCI0216991 10.1677/JME-08-0040 10.1016/S0140-6736(74)91815-7 10.1038/nature03206 10.1089/105072502321085135 10.1089/thy.2006.16.1077 10.1016/S0140-6736(03)13866-4 10.1089/1050725042451248 10.1089/thy.2007.0034 10.1089/thy.2007.0331 10.1089/thy.2007.0327 10.1089/thy.2006.16.1085 10.1089/thy.2008.0140 10.1210/edrv-9-1-106 10.1089/thy.2007.0239 10.1073/pnas.0407869101 |
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| References | Adams (10.4158/EP.15.1.56_bb0010) 1956; 34 Sanders (10.4158/EP.15.1.56_bb0035) 2002; 12 Duntas (10.4158/EP.15.1.56_bb0080) 2008; 18 Sanders (10.4158/EP.15.1.56_bb0095) 2006; 16 Sanders (10.4158/EP.15.1.56_bb0060) 2007; 17 Smith (10.4158/EP.15.1.56_bb0070) 2004; 14 Rees Smith (10.4158/EP.15.1.56_bb0005) 1988; 9 Nakatake (10.4158/EP.15.1.56_bb0075) 2006; 16 Núñez Miguel (10.4158/EP.15.1.56_bb0105) 2008; 41 Wucherpfennig (10.4158/EP.15.1.56_bb0115) 2001; 16 Rapoport (10.4158/EP.15.1.56_bb0085) 2008; 18 Smith (10.4158/EP.15.1.56_bb0015) 1974; 2 Felding-Habermann (10.4158/EP.15.1.56_bb0120) 2004; 101 Sanders (10.4158/EP.15.1.56_bb0020) 1997; 11 Sanders (10.4158/EP.15.1.56_bb0090) 2008 Fan (10.4158/EP.15.1.56_bb0100) 2005; 433 Núñez Miguel (10.4158/EP.15.1.56_bb0110) 2008; 7 Ando (10.4158/EP.15.1.56_bb0040) 2002; 110 Sanders (10.4158/EP.15.1.56_bb0050) 2004; 14 Rapoport (10.4158/EP.15.1.56_bb0025) 1998; 19 Smith (10.4158/EP.15.1.56_bb0030) 2007; 17 Sanders (10.4158/EP.15.1.56_bb0045) 2003; 362 Sanders (10.4158/EP.15.1.56_bb0055) 2008; 18 Tonacchera (10.4158/EP.15.1.56_bb0065) 2006; 16 19507306 - Endocr Pract. 2009 May-Jun;15(4):383-4; author reply 384-5 |
| References_xml | – volume: 16 start-page: 293 year: 2001 ident: 10.4158/EP.15.1.56_bb0115 article-title: Structural basis of molecular mimicry publication-title: J Autoimmun. doi: 10.1006/jaut.2000.0499 – year: 2008 ident: 10.4158/EP.15.1.56_bb0090 – volume: 14 start-page: 560 year: 2004 ident: 10.4158/EP.15.1.56_bb0050 article-title: Characteristics of a human monoclonal autoantibody to the thyrotropin receptor: sequence structure and function publication-title: Thyroid. doi: 10.1089/1050725041692918 – volume: 16 start-page: 1195 year: 2006 ident: 10.4158/EP.15.1.56_bb0095 article-title: Effects of TSH receptor mutations on binding and biological activity of monoclonal antibodies and TSH [erratum in Thyroid. 2007;17:188] publication-title: Thyroid. doi: 10.1089/thy.2006.16.1195 – volume: 11 start-page: 451 year: 1997 ident: 10.4158/EP.15.1.56_bb0020 article-title: Understanding the thyrotropin receptor function-structure relationship publication-title: Baillieres Clin Endocrinol Metab. doi: 10.1016/S0950-351X(97)80693-3 – volume: 110 start-page: 1667 year: 2002 ident: 10.4158/EP.15.1.56_bb0040 article-title: A monoclonal thyroid-stimulating antibody publication-title: J Clin Invest. doi: 10.1172/JCI0216991 – volume: 41 start-page: 145 year: 2008 ident: 10.4158/EP.15.1.56_bb0105 article-title: FSH and TSH binding to their respective receptors: similarities, differences and implication for glycoprotein hormone specificity publication-title: J Mol Endocrinol. doi: 10.1677/JME-08-0040 – volume: 2 start-page: 427 year: 1974 ident: 10.4158/EP.15.1.56_bb0015 article-title: Thyroid-stimulating immunoglobulins in Graves’ disease publication-title: Lancet. doi: 10.1016/S0140-6736(74)91815-7 – volume: 433 start-page: 269 year: 2005 ident: 10.4158/EP.15.1.56_bb0100 article-title: Structure of human folliclestimulating hormone in complex with its receptor publication-title: Nature. doi: 10.1038/nature03206 – volume: 34 start-page: 11 year: 1956 ident: 10.4158/EP.15.1.56_bb0010 article-title: Abnormal responses in the assay of thyrotropin publication-title: Proc Univ Otago Sch Med. – volume: 12 start-page: 1043 year: 2002 ident: 10.4158/EP.15.1.56_bb0035 article-title: Thyroid-stimulating monoclonal antibodies publication-title: Thyroid. doi: 10.1089/105072502321085135 – volume: 16 start-page: 1077 year: 2006 ident: 10.4158/EP.15.1.56_bb0075 article-title: Estimation of serum TSH receptor autoantibody concentration and affinity publication-title: Thyroid. doi: 10.1089/thy.2006.16.1077 – volume: 19 start-page: 673 year: 1998 ident: 10.4158/EP.15.1.56_bb0025 article-title: The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies [erratum in Endocr Rev. 1999;20:100] publication-title: Endocr Rev. – volume: 362 start-page: 126 year: 2003 ident: 10.4158/EP.15.1.56_bb0045 article-title: Human monoclonal thyroid stimulating autoantibody publication-title: Lancet. doi: 10.1016/S0140-6736(03)13866-4 – volume: 14 start-page: 830 year: 2004 ident: 10.4158/EP.15.1.56_bb0070 article-title: A new assay for thyrotropin receptor autoantibodies publication-title: Thyroid. doi: 10.1089/1050725042451248 – volume: 7 start-page: 30 issue: Suppl 1 year: 2008 ident: 10.4158/EP.15.1.56_bb0110 article-title: Molecular mimicry between thyroid stimulating autoantibody and TSH binding to the TSH receptor publication-title: Hormones. – volume: 17 start-page: 395 year: 2007 ident: 10.4158/EP.15.1.56_bb0060 article-title: Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody publication-title: Thyroid. doi: 10.1089/thy.2007.0034 – volume: 18 start-page: 509 year: 2008 ident: 10.4158/EP.15.1.56_bb0080 article-title: Review on the occasion of a decade of recombinant human TSH: prospects and novel uses publication-title: Thyroid. doi: 10.1089/thy.2007.0331 – volume: 18 start-page: 735 year: 2008 ident: 10.4158/EP.15.1.56_bb0055 article-title: A human monoclonal autoantibody to the thyrotropin receptor with thyroidstimulating blocking activity publication-title: Thyroid. doi: 10.1089/thy.2007.0327 – volume: 16 start-page: 1085 year: 2006 ident: 10.4158/EP.15.1.56_bb0065 article-title: Effects of a thyroid-stimulating human monoclonal autoantibody (M22) on functional activity of LH and FSH receptors publication-title: Thyroid. doi: 10.1089/thy.2006.16.1085 – volume: 18 start-page: 695 year: 2008 ident: 10.4158/EP.15.1.56_bb0085 article-title: Whither TSH receptor blocking antibodies in the treatment of Graves’ disease? publication-title: Thyroid. doi: 10.1089/thy.2008.0140 – volume: 9 start-page: 106 year: 1988 ident: 10.4158/EP.15.1.56_bb0005 article-title: Autoantibodies to the thyrotropin receptor publication-title: Endocr Rev. doi: 10.1210/edrv-9-1-106 – volume: 17 start-page: 923 year: 2007 ident: 10.4158/EP.15.1.56_bb0030 article-title: TSH receptor antibodies publication-title: Thyroid. doi: 10.1089/thy.2007.0239 – volume: 101 start-page: 17210 year: 2004 ident: 10.4158/EP.15.1.56_bb0120 article-title: Combinatorial antibody libraries from cancer patients yield ligand-mimetic Arg-Gly-Asp-containing immunoglobulins that inhibit breast cancer metastasis publication-title: Proc Natl Acad Sci U S A. doi: 10.1073/pnas.0407869101 – reference: 19507306 - Endocr Pract. 2009 May-Jun;15(4):383-4; author reply 384-5 |
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| Snippet | The thyrotropin receptor (TSHR) expressed on the surface of the thyrocytes plays a key role in thyroid physiology and is also an important autoantibody target... |
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| SubjectTerms | Animals Antibodies, Monoclonal - metabolism Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Disease Models, Animal Graves Disease - drug therapy Humans Protein Binding Receptors, Thyrotropin - chemistry Receptors, Thyrotropin - drug effects Receptors, Thyrotropin - metabolism Thyroiditis, Autoimmune - drug therapy Thyrotropin - metabolism |
| Title | Thyrotropin Receptor Structure—In the Crystal New Horizons Shine |
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