Growth Hormone Treatment in Children With Prader-Willi Syndrome: Three Years of Longitudinal Data in Prepubertal Children and Adult Height Data From the KIGS Database

Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS). To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS. Data registered in KIGS from 1987 to 2012...

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Vydáno v:	The journal of clinical endocrinology and metabolism Ročník 102; číslo 5; s. 1702 - 1711
Hlavní autoři:	Bakker, Nienke E., Lindberg, Anders, Heissler, Joseph, Wollmann, Hartmut A., Camacho-Hübner, Cecilia, Hokken-Koelega, Anita C.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Oxford University Press 01.05.2017
Témata:	Body Height Body mass index Child Child, Preschool Children Cohort Studies Databases, Factual Dwarfism, Pituitary - drug therapy Dwarfism, Pituitary - etiology Dwarfism, Pituitary - metabolism Female Growth disorders Growth Disorders - drug therapy Growth Disorders - etiology Growth hormones Human Growth Hormone - therapeutic use Humans Infant Insulin-Like Growth Factor I - deficiency Insulin-Like Growth Factor I - metabolism Longitudinal Studies Male Physical growth Prader-Willi syndrome Prader-Willi Syndrome - complications Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - metabolism Puberty Recombinant Proteins - therapeutic use Retrospective Studies Safety Standard deviation
ISSN:	0021-972X, 1945-7197, 1945-7197
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Abstract	Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS). To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS. Data registered in KIGS from 1987 to 2012. Worldwide retrospective cohort study. Patients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment. Height standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS. In prepubertal children, mean (standard deviation) height SDS improved to -0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to -0.22 (1.31) (P < 0.05) but had a loss of -0.77 (0.81) during puberty, resulting in a mean adult height SDS of -1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports. GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment.
AbstractList	Abstract Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS). To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS. Data registered in KIGS from 1987 to 2012. Worldwide retrospective cohort study. Patients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment. Height standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS. In prepubertal children, mean (standard deviation) height SDS improved to -0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to -0.22 (1.31) (P < 0.05) but had a loss of -0.77 (0.81) during puberty, resulting in a mean adult height SDS of -1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports. GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment. This worldwide retrospective cohort study evaluates the efficacy and safety of GH treatment in a unique large group of children with PWS who were registered in the KIGS. Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS).ContextLongitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS).To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS.ObjectiveTo evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS.Data registered in KIGS from 1987 to 2012.DesignData registered in KIGS from 1987 to 2012.Worldwide retrospective cohort study.SettingWorldwide retrospective cohort study.Patients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment.PatientsPatients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment.Height standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS.Main outcome measureHeight standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS.In prepubertal children, mean (standard deviation) height SDS improved to -0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to -0.22 (1.31) (P < 0.05) but had a loss of -0.77 (0.81) during puberty, resulting in a mean adult height SDS of -1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports.ResultsIn prepubertal children, mean (standard deviation) height SDS improved to -0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to -0.22 (1.31) (P < 0.05) but had a loss of -0.77 (0.81) during puberty, resulting in a mean adult height SDS of -1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports.GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment.ConclusionsGH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment. Context:Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS).Objective:To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS.Design:Data registered in KIGS from 1987 to 2012.Setting:Worldwide retrospective cohort study.Patients:Patients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment.Main outcome measure:Height standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS.Results:In prepubertal children, mean (standard deviation) height SDS improved to −0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to −0.22 (1.31) (P < 0.05) but had a loss of −0.77 (0.81) during puberty, resulting in a mean adult height SDS of −1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports.Conclusions:GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment. Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS). To evaluate efficacy and safety of growth hormone (GH) treatment in a large group of children with PWS. Data registered in KIGS from 1987 to 2012. Worldwide retrospective cohort study. Patients included 522 prepubertal children treated with GH for three years and 173 children who had reached adult height. Safety analysis included 2332 children. Intervention involved GH treatment. Height standard deviation score (SDS), body mass index (BMI) SDS, occurrence of serious adverse events, and deaths reported in KIGS. In prepubertal children, mean (standard deviation) height SDS improved to -0.31 (1.34) (P < 0.05) during three years of GH treatment. In the adolescent group, height SDS improved until the start of puberty to -0.22 (1.31) (P < 0.05) but had a loss of -0.77 (0.81) during puberty, resulting in a mean adult height SDS of -1.19 (1.37). Total height gain was 0.95 (1.32) SDS. BMI SDS increased in the prepubertal group from 1.11 (2.09) to 1.53 (1.43) (P < 0.05) and did not significantly change in the adolescent group, who had a BMI SDS at an adult height of 1.78 (1.26). KIGS contained 12 death reports. GH treatment in children with PWS significantly improves linear growth. BMI remains on average below +2 SDS, in contrast to the natural course of increasing obesity in PWS. Safety should be closely monitored in children with PWS, with and without GH treatment.
Author	Hokken-Koelega, Anita C. Heissler, Joseph Lindberg, Anders Wollmann, Hartmut A. Bakker, Nienke E. Camacho-Hübner, Cecilia
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Cites_doi	10.1136/adc.44.235.291 10.1210/jc.2015-1410 10.1111/j.1365-2265.2008.03228.x 10.1210/jc.2009-0454 10.1210/jc.2008-1844 10.1054/ghir.2000.0175 10.1038/sj.ejhg.5201135 10.1002/ajmg.a.31824 10.1111/j.1651-2227.1991.tb11945.x 10.1002/ajmg.a.32131 10.1210/jc.2012-1595 10.1136/adc.45.239.13 10.1002/(SICI)1096-8628(19971231)73:4<437::AID-AJMG12>3.0.CO;2-S 10.1067/mpd.2003.81 10.1159/000145019 10.1136/adc.2007.123836 10.1210/jc.2012-1182 10.1210/jc.2013-2012 10.1210/jc.2011-1954 10.1210/jc.2009-1831 10.1111/j.1365-2265.2007.03126.x 10.1016/j.jpeds.2008.12.035 10.1038/ejhg.2008.165 10.1136/adc.73.1.17 10.1111/j.1365-2265.2011.03989.x 10.1111/j.1469-8749.1991.tb14950.x 10.1111/apa.12898 10.1111/j.1651-2227.2000.tb00755.x 10.1542/peds.91.2.398 10.1007/BF03349255 10.1210/jc.2006-0765 10.1080/1740028032000131396 10.1210/jc.2008-0649 10.1210/jc.2008-2808 10.1097/MPG.0b013e31805b82b5 10.1002/ajmg.a.31468 10.1136/jmg.38.11.792 10.1210/jcem.87.4.8414 10.1210/jc.2009-1389 10.1111/j.1651-2227.1997.tb18369.x 10.1210/jc.2007-2294 10.1210/jc.2012-3888 10.1111/j.1651-2227.2012.02638.x
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References	de Lind van Wijngaarden ( key 20180328151748_B22) 2009; 94 Siemensma ( key 20180328151748_B36) 2012; 97 de Lind van Wijngaarden ( key 20180328151748_B37) 2008; 93 Corrias ( key 20180328151748_B53) 2012; 76 de Lind van Wijngaarden ( key 20180328151748_B11) 2009; 94 Carrel ( key 20180328151748_B9) 2010; 95 Deal ( key 20180328151748_B38) 2013; 98 Vogels ( key 20180328151748_B2) 2003; 12 ( key 20180328151748_B43) 2001; 86 Grugni ( key 20180328151748_B8) 2011; 24 Whittington ( key 20180328151748_B26) 2001; 38 Feigerlová ( key 20180328151748_B49) 2010; 95 Greulich ( key 20180328151748_B32) Festen ( key 20180328151748_B10) 2008; 69 Eiholzer ( key 20180328151748_B23) 2000; 53 Tauber ( key 20180328151748_B12) 2009; 154 Marshall ( key 20180328151748_B28) 1969; 44 Clayton ( key 20180328151748_B44) 2000 de Lind van Wijngaarden ( key 20180328151748_B21) 2008; 93 Unanue ( key 20180328151748_B41) 2007; 67 Freeman ( key 20180328151748_B30) 1995; 73 Myers ( key 20180328151748_B39) 2007; 143A Gondoni ( key 20180328151748_B16) 2014; 31 Riis ( key 20180328151748_B33) 2003; 1 Angulo ( key 20180328151748_B42) 2007; 143A Davies ( key 20180328151748_B50) 2003; 142 Cassidy ( key 20180328151748_B1) 2008; 17 Eiholzer ( key 20180328151748_B20) 2005; 63 Bakker ( key 20180328151748_B25) 2013; 98 Bakker ( key 20180328151748_B48) 2015; 100 Stevenson ( key 20180328151748_B51) 2007; 45 Prader ( key 20180328151748_B29) 1989; 52 Wharton ( key 20180328151748_B52) 1997; 73 Tauber ( key 20180328151748_B19) 2008; 146A Carrel ( key 20180328151748_B24) 2002; 87 de Lind van Wijngaarden ( key 20180328151748_B46) 2009; 94 Siemensma ( key 20180328151748_B15) 2012; 97 Åkefeldt ( key 20180328151748_B3) 2008; 33 Niklasson ( key 20180328151748_B34) 1991; 80 key 20180328151748_B18 Holm ( key 20180328151748_B4) 1993; 91 Marshall ( key 20180328151748_B27) 1970; 45 Hoybye ( key 20180328151748_B47) 2015; 104 Lindgren ( key 20180328151748_B13) 2008; 70 Goldstone ( key 20180328151748_B5) 2008; 93 Swaab ( key 20180328151748_B6) 2012; 86 Katz-Salamon ( key 20180328151748_B17) 2012; 101 Siemensma ( key 20180328151748_B40) 2011; 75 Festen ( key 20180328151748_B45) 2006; 91 Festen ( key 20180328151748_B14) 2008; 68 Siemensma ( key 20180328151748_B35) 2012; 97 Driscoll ( key 20180328151748_B7) Hauffa ( key 20180328151748_B31) 2007; 89
References_xml	– volume: 44 start-page: 291 issue: 235 year: 1969 ident: key 20180328151748_B28 article-title: Variations in pattern of pubertal changes in girls publication-title: Arch Dis Child doi: 10.1136/adc.44.235.291 – volume: 63 start-page: 33 issue: 1 year: 2005 ident: key 20180328151748_B20 article-title: Deaths in children with Prader-Willi syndrome: a contribution to the debate about the safety of growth hormone treatment in children with PWS publication-title: Horm Res – volume: 100 start-page: 3041 issue: 8 year: 2015 ident: key 20180328151748_B48 article-title: IGF-1 levels, complex formation, and IGF bioactivity in growth hormone–treated children with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-1410 – volume: 69 start-page: 443 issue: 3 year: 2008 ident: key 20180328151748_B10 article-title: Randomized controlled GH trial: effects on anthropometry, body composition and body proportions in a large group of children with Prader-Willi syndrome publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2008.03228.x – volume: 53 start-page: 200 issue: 4 year: 2000 ident: key 20180328151748_B23 article-title: Body composition abnormalities in children with Prader-Willi syndrome and long-term effects of growth hormone therapy publication-title: Horm Res – volume: 94 start-page: 4205 issue: 11 year: 2009 ident: key 20180328151748_B11 article-title: Efficacy and safety of long-term continuous growth hormone treatment in children with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-0454 – volume: 76 start-page: 843 year: 2012 ident: key 20180328151748_B53 article-title: Study Group for Genetic Obesity of the Italian Society of Pediatric Endocrinology and Diabetology (SIEDP/ISPED). Assessment of central adrenal insufficiency in children and adolescents with Prader-Willi syndrome publication-title: Horumon To Rinsho – volume: 94 start-page: 1274 issue: 4 year: 2009 ident: key 20180328151748_B46 article-title: Randomized controlled trial to investigate the effects of growth hormone treatment on scoliosis in children with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-1844 – year: 2000 ident: key 20180328151748_B44 article-title: Safety issues in children and adolescents during growth hormone therapy—a review publication-title: Growth Hormone IGF Res doi: 10.1054/ghir.2000.0175 – volume: 12 start-page: 238 issue: 3 year: 2003 ident: key 20180328151748_B2 article-title: Minimum prevalence, birth incidence and cause of death for Prader-Willi syndrome in Flanders publication-title: Eur J Hum Genet doi: 10.1038/sj.ejhg.5201135 – volume: 86 start-page: 1868 issue: 5 year: 2001 ident: key 20180328151748_B43 article-title: Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society publication-title: J Clin Endocrinol Metab – volume: 143A start-page: 1456 issue: 13 year: 2007 ident: key 20180328151748_B42 article-title: Final adult height in children with Prader-Willi syndrome with and without human growth hormone treatment publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.31824 – volume: 80 start-page: 756 issue: 8 year: 1991 ident: key 20180328151748_B34 article-title: An update of the Swedish reference standards for weight, length and head circumference at birth for given gestational age (1977–1981) publication-title: Acta Paediatr Scand doi: 10.1111/j.1651-2227.1991.tb11945.x – volume: 146A start-page: 881 issue: 7 year: 2008 ident: key 20180328151748_B19 article-title: Review of 64 cases of death in children with Prader-Willi syndrome (PWS) publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.32131 – volume: 97 start-page: E1766 issue: 9 year: 2012 ident: key 20180328151748_B36 article-title: Ovarian function and reproductive hormone levels in girls with Prader-Willi syndrome: a longitudinal study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-1595 – volume: 45 start-page: 13 issue: 239 year: 1970 ident: key 20180328151748_B27 article-title: Variations in the pattern of pubertal changes in boys publication-title: Arch Dis Child doi: 10.1136/adc.45.239.13 – volume: 73 start-page: 437 issue: 4 year: 1997 ident: key 20180328151748_B52 article-title: Acute idiopathic gastric dilation with gastric necrosis in individuals with Prader-Willi syndrome publication-title: Am J Med Genet doi: 10.1002/(SICI)1096-8628(19971231)73:4<437::AID-AJMG12>3.0.CO;2-S – volume: 142 start-page: 174 issue: 2 year: 2003 ident: key 20180328151748_B50 article-title: Myeloid leukemia in Prader-Willi syndrome publication-title: J Pediatr doi: 10.1067/mpd.2003.81 – volume-title: Radiographic Atlas of Skeletal Development of Hand and Wrist ident: key 20180328151748_B32 – volume-title: GeneReviews ident: key 20180328151748_B7 article-title: Prader-Willi Syndrome – volume: 70 start-page: 182 issue: 3 year: 2008 ident: key 20180328151748_B13 article-title: Growth hormone treatment completely normalizes adult height and improves body composition in Prader-Willi syndrome: experience from KIGS (Pfizer International Growth Database) publication-title: Horm Res doi: 10.1159/000145019 – volume: 93 start-page: 1012 issue: 12 year: 2008 ident: key 20180328151748_B37 article-title: Scoliosis in Prader-Willi syndrome: prevalence, effects of age, gender, body mass index, lean body mass and genotype publication-title: Arch Dis Child doi: 10.1136/adc.2007.123836 – volume: 97 start-page: 2307 issue: 7 year: 2012 ident: key 20180328151748_B15 article-title: Beneficial effects of growth hormone treatment on cognition in children with Prader-Willi syndrome: a randomized controlled trial and longitudinal study publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-1182 – volume: 98 start-page: 4013 issue: 10 year: 2013 ident: key 20180328151748_B25 article-title: Eight years of growth hormone treatment in children with Prader-Willi syndrome: maintaining the positive effects publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2013-2012 – volume: 97 start-page: E452 issue: 3 year: 2012 ident: key 20180328151748_B35 article-title: Testicular failure in boys with Prader-Willi syndrome: longitudinal studies of reproductive hormones publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2011-1954 – volume: 95 start-page: 4600 issue: 10 year: 2010 ident: key 20180328151748_B49 article-title: Elevated insulin-like growth factor-I values in children with Prader-Willi syndrome compared with growth hormone (GH) deficiency children over two years of GH treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-1831 – volume: 68 start-page: 919 issue: 6 year: 2008 ident: key 20180328151748_B14 article-title: Mental and motor development before and during growth hormone treatment in infants and toddlers with Prader-Willi syndrome publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2007.03126.x – volume: 154 start-page: 778 issue: 5 year: 2009 ident: key 20180328151748_B12 article-title: About the benefits of growth hormone treatment in children with Prader-Willi syndrome publication-title: J Pediatr doi: 10.1016/j.jpeds.2008.12.035 – volume: 17 start-page: 3 issue: 1 year: 2008 ident: key 20180328151748_B1 article-title: Prader-Willi syndrome publication-title: Eur J Hum Genet doi: 10.1038/ejhg.2008.165 – volume: 73 start-page: 17 issue: 1 year: 1995 ident: key 20180328151748_B30 article-title: Cross sectional stature and weight reference curves for the UK, 1990 publication-title: Arch Dis Child doi: 10.1136/adc.73.1.17 – volume: 75 start-page: 83 year: 2011 ident: key 20180328151748_B40 article-title: Pubarche and serum dehydroepiandrosterone sulfate levels in children with Prader-Willi syndrome publication-title: Clin Endocrinol (Oxf) doi: 10.1111/j.1365-2265.2011.03989.x – volume: 33 start-page: 715 issue: 8 year: 2008 ident: key 20180328151748_B3 article-title: Prader-Willi syndrome in a Swedish rural county: epidemiological aspects publication-title: Dev Med Child Neurol doi: 10.1111/j.1469-8749.1991.tb14950.x – volume: 104 start-page: 422 issue: 4 year: 2015 ident: key 20180328151748_B47 article-title: Growth hormone treatment of Prader-Willi syndrome has long-term, positive effects on body composition publication-title: Acta Paediatr doi: 10.1111/apa.12898 – volume: 67 start-page: 152 issue: 3 year: 2007 ident: key 20180328151748_B41 article-title: Adrenarche in Prader-Willi syndrome appears not related to insulin sensitivity and serum adiponectin publication-title: Horm Res – volume: 89 start-page: 1302 issue: 11 year: 2007 ident: key 20180328151748_B31 article-title: Spontaneous growth in German children and adolescents with genetically confirmed Prader-Willi syndrome publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.2000.tb00755.x – volume: 91 start-page: 398 issue: 2 year: 1993 ident: key 20180328151748_B4 article-title: Prader-Willi syndrome: consensus diagnostic criteria publication-title: Pediatrics doi: 10.1542/peds.91.2.398 – volume: 31 start-page: 765 issue: 9 year: 2014 ident: key 20180328151748_B16 article-title: Growth hormone therapy improves exercise capacity in adult patients with Prader-Willi syndrome publication-title: J Endocrinol Invest doi: 10.1007/BF03349255 – volume: 52 start-page: 1 year: 1989 ident: key 20180328151748_B29 article-title: Physical growth of Swiss children from birth to 20 years of age: First Zurich longitudinal study of growth and development publication-title: Helv Paediatr Acta Suppl – volume: 91 start-page: 4911 issue: 12 year: 2006 ident: key 20180328151748_B45 article-title: Sleep-related breathing disorders in prepubertal children with Prader-Willi syndrome and effects of growth hormone treatment publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2006-0765 – volume: 1 start-page: 15 issue: 1 year: 2003 ident: key 20180328151748_B33 article-title: Thirty years of bioethics: the Helsinki Declaration 1964–2003 publication-title: New Rev Bioeth doi: 10.1080/1740028032000131396 – volume: 93 start-page: 4183 issue: 11 year: 2008 ident: key 20180328151748_B5 article-title: Recommendations for the diagnosis and management of Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-0649 – ident: key 20180328151748_B18 – volume: 94 start-page: 2387 issue: 7 year: 2009 ident: key 20180328151748_B22 article-title: The relationship between central adrenal insufficiency and sleep-related breathing disorders in children with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2008-2808 – volume: 45 start-page: 272 issue: 2 year: 2007 ident: key 20180328151748_B51 article-title: Gastric rupture and necrosis in Prader-Willi syndrome publication-title: J Pediatr Gastroenterol Nutr doi: 10.1097/MPG.0b013e31805b82b5 – volume: 143A start-page: 443 issue: 5 year: 2007 ident: key 20180328151748_B39 article-title: Two years of growth hormone therapy in young children with Prader-Willi syndrome: physical and neurodevelopmental benefits publication-title: Am J Med Genet A doi: 10.1002/ajmg.a.31468 – volume: 38 start-page: 792 issue: 11 year: 2001 ident: key 20180328151748_B26 article-title: Population prevalence and estimated birth incidence and mortality rate for people with Prader-Willi syndrome in one UK Health Region publication-title: J Med Genet doi: 10.1136/jmg.38.11.792 – volume: 87 start-page: 1581 issue: 4 year: 2002 ident: key 20180328151748_B24 article-title: Benefits of long-term GH therapy in Prader-Willi syndrome: a 4-year study publication-title: J Clin Endocrinol Metab doi: 10.1210/jcem.87.4.8414 – volume: 95 start-page: 1131 issue: 3 year: 2010 ident: key 20180328151748_B9 article-title: Long-term growth hormone therapy changes the natural history of body composition and motor function in children with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-1389 – volume: 86 start-page: 50 year: 2012 ident: key 20180328151748_B6 article-title: Prader-Willi syndrome and the hypothalamus publication-title: Acta Paediatr Suppl doi: 10.1111/j.1651-2227.1997.tb18369.x – volume: 93 start-page: 1649 issue: 5 year: 2008 ident: key 20180328151748_B21 article-title: High prevalence of central adrenal insufficiency in patients with Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2007-2294 – volume: 98 start-page: E1072 issue: 6 year: 2013 ident: key 20180328151748_B38 article-title: GrowthHormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3888 – volume: 24 start-page: 477 issue: 7 year: 2011 ident: key 20180328151748_B8 article-title: Growth hormone secretory pattern in non-obese children and adolescents with Prader-Willi syndrome publication-title: J Pediatr Endocrinol Metab – volume: 101 start-page: 643 issue: 6 year: 2012 ident: key 20180328151748_B17 article-title: The effect of growth hormone on sleep-related cardio-respiratory control in Prader-Willi syndrome publication-title: Acta Paediatr doi: 10.1111/j.1651-2227.2012.02638.x
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Snippet	Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database (KIGS). To... Abstract Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database... Context:Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database... Longitudinal data of children with Prader-Willi syndrome (PWS) treated with genotropin were registered in the Pfizer International Growth Database...
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SubjectTerms	Body Height Body mass index Child Child, Preschool Children Cohort Studies Databases, Factual Dwarfism, Pituitary - drug therapy Dwarfism, Pituitary - etiology Dwarfism, Pituitary - metabolism Female Growth disorders Growth Disorders - drug therapy Growth Disorders - etiology Growth hormones Human Growth Hormone - therapeutic use Humans Infant Insulin-Like Growth Factor I - deficiency Insulin-Like Growth Factor I - metabolism Longitudinal Studies Male Physical growth Prader-Willi syndrome Prader-Willi Syndrome - complications Prader-Willi Syndrome - drug therapy Prader-Willi Syndrome - metabolism Puberty Recombinant Proteins - therapeutic use Retrospective Studies Safety Standard deviation
Title	Growth Hormone Treatment in Children With Prader-Willi Syndrome: Three Years of Longitudinal Data in Prepubertal Children and Adult Height Data From the KIGS Database
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