Microfabricated mammalian organ systems and their integration into models of whole animals and humans
While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnol...
Saved in:
| Published in: | Lab on a chip Vol. 13; no. 7; p. 1201 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
07.04.2013
|
| Subjects: | |
| ISSN: | 1473-0189, 1473-0189 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry. |
|---|---|
| AbstractList | While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry. While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry.While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between the in vitro and in vivo systems has been a bottleneck in drug development process and biological sciences. The recent progress in microtechnology has enabled manipulation of cellular environment at a physiologically relevant length scale, which has led to the development of novel in vitro organ systems, often termed 'organ-on-a-chip' systems. By mimicking the cellular environment of in vivo tissues, various organ-on-a-chip systems have been reported to reproduce target organ functions better than conventional in vitro model systems. Ultimately, these organ-on-a-chip systems will converge into multi-organ 'body-on-a-chip' systems composed of functional tissues that reproduce the dynamics of the whole-body response. Such microscale in vitro systems will open up new possibilities in medical science and in the pharmaceutical industry. |
| Author | Long, Christopher J Sung, Jong H Smith, Alec Shuler, Michael L Prot, Jean-Matthieu Esch, Mandy B Hickman, James J |
| Author_xml | – sequence: 1 givenname: Jong H surname: Sung fullname: Sung, Jong H organization: Chemical Engineering, Hongik University, Seoul, Korea – sequence: 2 givenname: Mandy B surname: Esch fullname: Esch, Mandy B – sequence: 3 givenname: Jean-Matthieu surname: Prot fullname: Prot, Jean-Matthieu – sequence: 4 givenname: Christopher J surname: Long fullname: Long, Christopher J – sequence: 5 givenname: Alec surname: Smith fullname: Smith, Alec – sequence: 6 givenname: James J surname: Hickman fullname: Hickman, James J – sequence: 7 givenname: Michael L surname: Shuler fullname: Shuler, Michael L |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23388858$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkEtPwzAQhC1URB9w4QcgH7kE_Ihd54gqXlIRFzhHG3vTukrsEidC_fcEtUhcdkerb0ajnZNJiAEJuebsjjNZ3FvZ2JwzvtydkRnPlzJj3BSTf3pK5intGOMq1-aCTIWUxhhlZgTfvO1iDVXnLfToaAttC42HQGO3GWc6pB7bRCE42m_Rd9SHHjcd9D6GXx1pGx02icaafm9jgyPqx4ijZTu0ENIlOa_HC16d9oJ8Pj1-rF6y9fvz6-phnVm5NH1WK6GdEEY5bRygAA45FqJWSwGGaUCwtbROqwoMr1hVgRPKVEZrbgs0TCzI7TF338WvAVNftj5ZbBoIGIdUcslzU-RSqxG9OaFD1aIr991YujuUf68RP_GhaRo |
| CitedBy_id | crossref_primary_10_1016_j_biomaterials_2013_10_052 crossref_primary_10_1016_j_stem_2018_02_011 crossref_primary_10_1007_s00432_019_02973_5 crossref_primary_10_3390_bioengineering12060562 crossref_primary_10_1007_s10565_015_9302_0 crossref_primary_10_1002_bit_26087 crossref_primary_10_1080_17425255_2019_1700950 crossref_primary_10_1088_1758_5090_abfca8 crossref_primary_10_1002_btpr_3121 crossref_primary_10_1016_j_bios_2022_114626 crossref_primary_10_1186_scrt370 crossref_primary_10_1002_btpr_2160 crossref_primary_10_1002_bit_26919 crossref_primary_10_1186_s12918_019_0686_y crossref_primary_10_1038_nprot_2013_137 crossref_primary_10_1039_C4LC01252F crossref_primary_10_1016_j_colsurfb_2014_08_026 crossref_primary_10_1007_s10544_017_0156_5 crossref_primary_10_1016_S1872_2040_16_60920_9 crossref_primary_10_1007_s11705_015_1550_2 crossref_primary_10_1210_endocr_bqab078 crossref_primary_10_1007_s10544_017_0242_8 crossref_primary_10_1063_5_0230800 crossref_primary_10_1007_s10847_025_01283_3 crossref_primary_10_1002_admt_201800663 crossref_primary_10_1063_1_4948507 crossref_primary_10_1002_bit_26778 crossref_primary_10_1088_2516_1091_ab7cc4 crossref_primary_10_3390_mi7120233 crossref_primary_10_1016_j_addr_2013_11_010 crossref_primary_10_1039_D4BM00005F crossref_primary_10_3390_bioengineering4020046 crossref_primary_10_1016_j_drudis_2018_01_036 crossref_primary_10_1016_j_addr_2013_08_009 crossref_primary_10_1002_adhm_201600351 crossref_primary_10_2478_joeb_2018_0019 crossref_primary_10_1002_bit_26370 crossref_primary_10_3389_fbioe_2022_846230 crossref_primary_10_1002_btpr_2457 crossref_primary_10_1016_j_addr_2013_12_003 crossref_primary_10_1002_bit_27231 crossref_primary_10_1016_j_jbiotec_2014_05_029 crossref_primary_10_1039_C7LC00952F crossref_primary_10_1007_s40259_017_0258_x crossref_primary_10_1002_adma_202003558 crossref_primary_10_1007_s10544_015_9966_5 crossref_primary_10_3233_JCB_179004 crossref_primary_10_1016_j_jconrel_2014_04_030 crossref_primary_10_1038_nrm4041 crossref_primary_10_1002_adbi_202000526 crossref_primary_10_1186_s12938_020_0752_0 crossref_primary_10_1016_j_tibtech_2016_06_012 crossref_primary_10_1002_bit_26793 crossref_primary_10_1517_17460441_2015_1001736 crossref_primary_10_1016_j_actbio_2020_02_015 crossref_primary_10_1088_1758_5090_ad6599 crossref_primary_10_1186_scrt363 crossref_primary_10_1002_bit_25989 crossref_primary_10_1007_s13206_014_8206_z crossref_primary_10_1016_j_jpha_2018_12_001 crossref_primary_10_1007_s10847_025_01282_4 crossref_primary_10_1089_aivt_2015_0029 crossref_primary_10_1007_s10544_017_0179_y crossref_primary_10_1007_s13206_017_1307_8 crossref_primary_10_1007_s12035_019_01653_2 crossref_primary_10_1152_japplphysiol_00612_2014 crossref_primary_10_1002_smll_202006012 crossref_primary_10_1002_bit_26045 crossref_primary_10_1007_s00018_016_2258_2 crossref_primary_10_3390_ijms23052662 crossref_primary_10_1177_1535370217694101 crossref_primary_10_1007_s11626_013_9647_8 crossref_primary_10_1063_5_0179281 crossref_primary_10_1002_adma_201603483 crossref_primary_10_1002_adma_201606596 crossref_primary_10_1002_btpr_2512 crossref_primary_10_1007_s10439_013_0902_7 crossref_primary_10_1038_nrd4539 crossref_primary_10_1016_j_snb_2019_05_030 crossref_primary_10_2174_1381612825666190308150055 crossref_primary_10_1177_1535370214564534 crossref_primary_10_1016_j_dmpk_2018_01_003 crossref_primary_10_3390_bioengineering9110685 crossref_primary_10_1002_adhm_201700419 crossref_primary_10_3390_jmmp9090300 crossref_primary_10_1002_adhm_201701000 crossref_primary_10_1177_1535370214542068 crossref_primary_10_1016_S1672_6529_14_60025_1 crossref_primary_10_1016_j_biomaterials_2015_04_035 crossref_primary_10_1016_j_coche_2013_11_004 crossref_primary_10_1177_2211068214557812 crossref_primary_10_1016_j_addr_2018_05_001 crossref_primary_10_1007_s13206_014_8207_y crossref_primary_10_21595_jve_2016_17520 crossref_primary_10_3390_bioengineering5020036 crossref_primary_10_1016_j_jbiosc_2018_10_019 crossref_primary_10_1007_s10404_020_02347_1 crossref_primary_10_2174_1381612825666190206195304 crossref_primary_10_1016_j_addr_2014_02_011 crossref_primary_10_1002_smll_201503208 crossref_primary_10_1007_s10544_016_0143_2 crossref_primary_10_1038_srep25022 crossref_primary_10_1016_j_drudis_2016_11_009 crossref_primary_10_1039_C4AN00056K crossref_primary_10_1016_j_joule_2018_11_015 crossref_primary_10_3390_mi11080730 crossref_primary_10_1016_j_bios_2016_07_015 crossref_primary_10_1038_s41378_023_00579_z crossref_primary_10_1063_5_0046376 crossref_primary_10_1177_2211068215619126 crossref_primary_10_1517_17460441_2014_886562 crossref_primary_10_1039_c4ib00157e crossref_primary_10_1007_s10404_019_2261_7 crossref_primary_10_1007_s10439_013_0966_4 crossref_primary_10_1007_s10404_014_1341_y crossref_primary_10_1088_1361_6439_aa96bd crossref_primary_10_1088_2057_1976_aa7400 crossref_primary_10_1155_2018_1021969 crossref_primary_10_1007_s13206_025_00191_5 crossref_primary_10_1016_j_scitotenv_2022_159306 crossref_primary_10_1038_ncomms14584 crossref_primary_10_1016_j_biomaterials_2019_119367 crossref_primary_10_1177_1535370214529386 crossref_primary_10_3390_mi7090162 crossref_primary_10_1039_C6LC01236A crossref_primary_10_1016_j_fct_2022_113012 crossref_primary_10_1038_s41598_017_17382_2 crossref_primary_10_1007_s11626_021_00548_8 crossref_primary_10_1007_s12274_023_5651_9 crossref_primary_10_1002_btpr_2701 crossref_primary_10_3390_mi7080130 crossref_primary_10_1002_psp4_12042 crossref_primary_10_1016_j_biomaterials_2018_07_062 crossref_primary_10_1016_j_biotechadv_2016_12_002 crossref_primary_10_1177_1535370214539228 crossref_primary_10_1002_biot_201300086 crossref_primary_10_1002_biot_201500551 crossref_primary_10_1016_j_drudis_2019_08_001 crossref_primary_10_1039_c3ib40040a crossref_primary_10_1063_5_0011583 crossref_primary_10_1177_1535370214529397 crossref_primary_10_1038_srep20030 crossref_primary_10_1098_rsos_150031 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1039/c3lc41017j |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Engineering Chemistry Biology |
| EISSN | 1473-0189 |
| ExternalDocumentID | 23388858 |
| Genre | Review Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NINDS NIH HHS grantid: R01 NS050452 – fundername: NINDS NIH HHS grantid: R01NS050452 – fundername: NIBIB NIH HHS grantid: R01 EB009429 – fundername: NIBIB NIH HHS grantid: R01EB009429 |
| GroupedDBID | --- 0-7 0R~ 0VX 29L 4.4 5GY 705 70~ 7~J AAEMU AAIWI AAJAE AAMEH AANOJ AAWGC AAXHV AAXPP ABASK ABDVN ABEMK ABJNI ABPDG ABRYZ ABXOH ACGFS ACIWK ACLDK ADMRA ADSRN AEFDR AENEX AENGV AESAV AETIL AFLYV AFOGI AFRZK AFVBQ AGEGJ AGKEF AGRSR AHGCF ALMA_UNASSIGNED_HOLDINGS ANBJS ANUXI APEMP ASKNT AUDPV BLAPV BSQNT C6K CGR CS3 CUY CVF DU5 EBS ECGLT ECM EE0 EF- EIF EJD F5P GGIMP GNO H13 HZ~ H~N IDZ J3G J3H J3I M4U N9A NPM O9- R7B RAOCF RCNCU RNS ROL RPMJG RRA RRC RSCEA SKA SLH VH6 7X8 AKMSF R56 |
| ID | FETCH-LOGICAL-c378t-f526d2285d68dae2a1a4e92f572a806aeacf3cd65ba81b0bbad258b8661c9e802 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 188 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000315688500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1473-0189 |
| IngestDate | Fri Jul 11 08:01:23 EDT 2025 Thu Apr 03 07:00:33 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c378t-f526d2285d68dae2a1a4e92f572a806aeacf3cd65ba81b0bbad258b8661c9e802 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3593746 |
| PMID | 23388858 |
| PQID | 1314894365 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1314894365 pubmed_primary_23388858 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-04-07 |
| PublicationDateYYYYMMDD | 2013-04-07 |
| PublicationDate_xml | – month: 04 year: 2013 text: 2013-04-07 day: 07 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Lab on a chip |
| PublicationTitleAlternate | Lab Chip |
| PublicationYear | 2013 |
| References | 18693260 - Bioessays. 2008 Sep;30(9):811-21 8750092 - J Neurosci Methods. 1995 Nov;62(1-2):111-9 22065201 - Ann Biomed Eng. 2012 Jun;40(6):1211-27 20739175 - Curr Opin Neurobiol. 2010 Oct;20(5):640-7 18006663 - Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18886-91 19484389 - Biomed Microdevices. 2009 Oct;11(5):1081-9 19865724 - Lab Chip. 2009 Nov 21;9(22):3185-92 17383103 - Neuroscience. 2007 May 11;146(2):481-8 17305308 - Anal Chem. 2007 Mar 15;79(6):2249-58 17046235 - Curr Opin Biotechnol. 2006 Dec;17(6):619-27 21079286 - Biofabrication. 2010 Dec;2(4):045004 17710264 - Analyst. 2007 Sep;132(9):892-8 19249356 - Cell Signal. 2009 Aug;21(8):1237-44 18030398 - Lab Chip. 2007 Dec;7(12):1759-66 21385587 - J Mol Cell Cardiol. 2011 Jun;50(6):940-50 21609734 - J Neurosci Methods. 2011 Aug 15;199(2):223-9 22422217 - Lab Chip. 2012 Apr 24;12(10):1784-92 20126684 - Lab Chip. 2010 Feb 21;10(4):446-55 5454145 - Science. 1970 Sep 25;169(3952):1331-3 19417905 - Lab Chip. 2009 May 21;9(10):1385-94 15961304 - Biosens Bioelectron. 2006 Jan 15;21(7):1093-100 16305581 - Br J Clin Pharmacol. 2005 Dec;60(6):581-3 22729031 - Nat Biotechnol. 2012 Aug;30(8):783-91 9700689 - J Neurosci Methods. 1998 Aug 1;82(2):167-73 10774777 - Drug Metab Rev. 2000 May;32(2):219-40 22271245 - Ann Biomed Eng. 2012 Jun;40(6):1255-67 15890712 - Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1105-9 20576885 - Science. 2010 Jun 25;328(5986):1662-8 12931155 - Nature. 2003 Aug 21;424(6951):870-2 22092374 - Tissue Eng Part C Methods. 2012 May;18(5):349-57 20024050 - Lab Chip. 2010 Jan 7;10(1):51-8 20193719 - J Biotechnol. 2010 Jul 1;148(1):64-9 17906630 - Nat Mater. 2007 Nov;6(11):908-15 19718695 - Biotechnol Bioeng. 2010 Jan 1;105(1):184-94 18236465 - Muscle Nerve. 2008 Apr;37(4):438-47 20548775 - PLoS One. 2010;5(6):e11042 11259831 - Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):27-43 19924460 - Med Biol Eng Comput. 2010 Jan;48(1):59-65 16522058 - Nano Lett. 2006 Mar;6(3):537-42 22521339 - J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):126-35 19137589 - Biotechnol Bioeng. 2009 May 1;103(1):187-98 21090751 - Anal Chem. 2010 Dec 15;82(24):9983-8 17958443 - Biotechnol Prog. 2007 Nov-Dec;23(6):1485-91 8959392 - Drug Metab Rev. 1996 Nov;28(4):591-623 17637504 - Toxicol In Vitro. 2007 Dec;21(8):1581-91 20676620 - Anal Bioanal Chem. 2011 Mar;399(7):2313-29 20346499 - Biomaterials. 2010 Jun;31(18):4880-8 22318426 - Lab Chip. 2012 Apr 7;12(7):1224-37 21372121 - Ther Adv Respir Dis. 2011 Aug;5(4):255-73 20835427 - Lab Chip. 2010 Oct 21;10(20):2778-86 20447685 - Biomaterials. 2010 Jul;31(21):5491-7 4374100 - Anat Rec. 1974 Dec;180(4):645-61 10205607 - Int J Pharm. 1999 Jan 15;177(1):103-15 22025913 - Front Neuroeng. 2011 Oct 19;4:13 21881168 - Biofabrication. 2011 Sep;3(3):034112 21324402 - Biomaterials. 2011 May;32(14):3575-83 21944471 - Biomaterials. 2011 Dec;32(36):9602-11 20643478 - Biomaterials. 2010 Oct;31(29):7586-98 17525324 - Science. 2007 May 25;316(5828):1133-4 18026090 - Nat Biotechnol. 2008 Jan;26(1):120-6 22435738 - Tissue Eng Part C Methods. 2012 Sep;18(9):667-76 14656152 - Biotechnol Prog. 2003 Nov-Dec;19(6):1756-61 14763858 - Biotechnol Prog. 2004 Jan-Feb;20(1):316-23 20337513 - Tissue Eng Part C Methods. 2010 Dec;16(6):1347-55 21617793 - Lab Chip. 2011 Jul 7;11(13):2175-81 15533919 - Biophys J. 2005 Feb;88(2):1489-95 19933413 - Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H719-25 16647113 - Biomaterials. 2006 Aug;27(24):4374-80 19418562 - Biotechnol Bioeng. 2009 Sep 1;104(1):193-205 22451356 - Anal Sci. 2012;28(3):197-9 19728786 - Tissue Eng Part B Rev. 2010 Feb;16(1):55-64 16790553 - Drug Metab Dispos. 2006 Sep;34(9):1600-5 16358255 - Electrophoresis. 2005 Dec;26(24):4751-8 15590888 - Toxicol Sci. 2005 Mar;84(1):110-9 15914466 - Pharmacol Rev. 2005 Jun;57(2):173-85 21453966 - Biomaterials. 2011 Jun;32(18):4267-74 22179505 - Lab Chip. 2012 Feb 7;12(3):515-45 22509346 - PLoS One. 2012;7(4):e34704 19107278 - Lab Chip. 2009 Jan 21;9(2):232-8 21157619 - Lab Chip. 2011 Feb 7;11(3):389-92 20024049 - Lab Chip. 2010 Jan 7;10(1):43-50 18803264 - J Pharm Sci. 2009 May;98(5):1885-904 16871208 - Nature. 2006 Jul 27;442(7101):403-11 22488418 - Biotechnol Bioeng. 2012 Sep;109(9):2173-8 22645376 - Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9342-7 6358460 - J Pharm Sci. 1983 Oct;72(10):1103-27 22072288 - Lab Chip. 2011 Dec 21;11(24):4165-73 21495015 - Biotechnol Bioeng. 2011 Sep;108(9):2129-40 20062810 - PLoS One. 2010;5(1):e8643 16450032 - Lab Chip. 2006 Feb;6(2):230-5 11534848 - IEEE Trans Biomed Eng. 2001 Sep;48(9):996-1006 21044031 - Mini Rev Med Chem. 2010 Oct;10(11):1071-6 17853866 - Nat Protoc. 2007;2(9):2111-9 22434367 - Lab Chip. 2012 Jun 21;12(12):2165-74 18644311 - J Biomech. 2008 Aug 7;41(11):2396-401 14763861 - Biotechnol Prog. 2004 Jan-Feb;20(1):338-45 22094544 - Lab Chip. 2012 Jan 7;12(1):219-26 18955083 - J Neurosci Methods. 2009 Feb 15;177(1):51-9 15286737 - Nat Rev Drug Discov. 2004 Aug;3(8):711-5 21569296 - BMC Neurosci. 2011;12:40 10234198 - Pharm Sci Technolo Today. 1999 Jan;2(1):7-12 17641647 - Nat Protoc. 2007;2(7):1795-801 10757876 - Microsc Res Tech. 2000 Apr 1;49(1):26-37 20178370 - Anal Chem. 2010 Mar 15;82(6):2505-11 10835251 - Biotechnol Prog. 2000 May-Jun;16(3):471-9 20540627 - Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1063-81 16379670 - Curr Drug Metab. 2005 Dec;6(6):569-91 20436574 - Opt Lett. 2010 May 1;35(9):1374-6 20708792 - Biomaterials. 2010 Nov;31(32):8218-27 15965465 - Nat Biotechnol. 2005 Jul;23(7):879-84 19575443 - Biotechnol Bioeng. 2009 Oct 15;104(3):516-25 22092279 - Tissue Eng Part A. 2012 May;18(9-10):910-9 21799718 - Biomicrofluidics. 2011 Jun;5(2):22212 22640811 - Chem Biol Interact. 2012 Jul 30;199(1):1-8 20399226 - Neurotoxicology. 2010 Aug;31(4):331-50 18586852 - Biophys J. 2008 Oct;95(7):3479-87 17269697 - Biotechnol Prog. 2007 Jan-Feb;23(1):265-8 12791308 - Toxicol Appl Pharmacol. 2003 Jun 15;189(3):233-46 20149449 - Biomaterials. 2010 May;31(13):3613-21 17707502 - Biomaterials. 2007 Dec;28(34):5087-92 17538713 - Lab Chip. 2007 Jun;7(6):720-5 21303256 - Tissue Eng Part A. 2011 Jun;17(11-12):1635-42 |
| References_xml | – reference: 21090751 - Anal Chem. 2010 Dec 15;82(24):9983-8 – reference: 19418562 - Biotechnol Bioeng. 2009 Sep 1;104(1):193-205 – reference: 19137589 - Biotechnol Bioeng. 2009 May 1;103(1):187-98 – reference: 14763858 - Biotechnol Prog. 2004 Jan-Feb;20(1):316-23 – reference: 16358255 - Electrophoresis. 2005 Dec;26(24):4751-8 – reference: 21044031 - Mini Rev Med Chem. 2010 Oct;10(11):1071-6 – reference: 15533919 - Biophys J. 2005 Feb;88(2):1489-95 – reference: 22179505 - Lab Chip. 2012 Feb 7;12(3):515-45 – reference: 19718695 - Biotechnol Bioeng. 2010 Jan 1;105(1):184-94 – reference: 8750092 - J Neurosci Methods. 1995 Nov;62(1-2):111-9 – reference: 22092279 - Tissue Eng Part A. 2012 May;18(9-10):910-9 – reference: 19865724 - Lab Chip. 2009 Nov 21;9(22):3185-92 – reference: 20399226 - Neurotoxicology. 2010 Aug;31(4):331-50 – reference: 4374100 - Anat Rec. 1974 Dec;180(4):645-61 – reference: 20447685 - Biomaterials. 2010 Jul;31(21):5491-7 – reference: 17958443 - Biotechnol Prog. 2007 Nov-Dec;23(6):1485-91 – reference: 18026090 - Nat Biotechnol. 2008 Jan;26(1):120-6 – reference: 22072288 - Lab Chip. 2011 Dec 21;11(24):4165-73 – reference: 21944471 - Biomaterials. 2011 Dec;32(36):9602-11 – reference: 20540627 - Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1063-81 – reference: 17269697 - Biotechnol Prog. 2007 Jan-Feb;23(1):265-8 – reference: 15286737 - Nat Rev Drug Discov. 2004 Aug;3(8):711-5 – reference: 17710264 - Analyst. 2007 Sep;132(9):892-8 – reference: 22488418 - Biotechnol Bioeng. 2012 Sep;109(9):2173-8 – reference: 19933413 - Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H719-25 – reference: 18586852 - Biophys J. 2008 Oct;95(7):3479-87 – reference: 16305581 - Br J Clin Pharmacol. 2005 Dec;60(6):581-3 – reference: 21609734 - J Neurosci Methods. 2011 Aug 15;199(2):223-9 – reference: 17707502 - Biomaterials. 2007 Dec;28(34):5087-92 – reference: 17383103 - Neuroscience. 2007 May 11;146(2):481-8 – reference: 20024050 - Lab Chip. 2010 Jan 7;10(1):51-8 – reference: 21495015 - Biotechnol Bioeng. 2011 Sep;108(9):2129-40 – reference: 8959392 - Drug Metab Rev. 1996 Nov;28(4):591-623 – reference: 21324402 - Biomaterials. 2011 May;32(14):3575-83 – reference: 20062810 - PLoS One. 2010;5(1):e8643 – reference: 18236465 - Muscle Nerve. 2008 Apr;37(4):438-47 – reference: 21617793 - Lab Chip. 2011 Jul 7;11(13):2175-81 – reference: 20835427 - Lab Chip. 2010 Oct 21;10(20):2778-86 – reference: 21453966 - Biomaterials. 2011 Jun;32(18):4267-74 – reference: 17637504 - Toxicol In Vitro. 2007 Dec;21(8):1581-91 – reference: 10835251 - Biotechnol Prog. 2000 May-Jun;16(3):471-9 – reference: 20676620 - Anal Bioanal Chem. 2011 Mar;399(7):2313-29 – reference: 20436574 - Opt Lett. 2010 May 1;35(9):1374-6 – reference: 18644311 - J Biomech. 2008 Aug 7;41(11):2396-401 – reference: 20739175 - Curr Opin Neurobiol. 2010 Oct;20(5):640-7 – reference: 16790553 - Drug Metab Dispos. 2006 Sep;34(9):1600-5 – reference: 19924460 - Med Biol Eng Comput. 2010 Jan;48(1):59-65 – reference: 20346499 - Biomaterials. 2010 Jun;31(18):4880-8 – reference: 16522058 - Nano Lett. 2006 Mar;6(3):537-42 – reference: 22640811 - Chem Biol Interact. 2012 Jul 30;199(1):1-8 – reference: 6358460 - J Pharm Sci. 1983 Oct;72(10):1103-27 – reference: 19484389 - Biomed Microdevices. 2009 Oct;11(5):1081-9 – reference: 18693260 - Bioessays. 2008 Sep;30(9):811-21 – reference: 16871208 - Nature. 2006 Jul 27;442(7101):403-11 – reference: 22435738 - Tissue Eng Part C Methods. 2012 Sep;18(9):667-76 – reference: 22318426 - Lab Chip. 2012 Apr 7;12(7):1224-37 – reference: 15590888 - Toxicol Sci. 2005 Mar;84(1):110-9 – reference: 22729031 - Nat Biotechnol. 2012 Aug;30(8):783-91 – reference: 21881168 - Biofabrication. 2011 Sep;3(3):034112 – reference: 17641647 - Nat Protoc. 2007;2(7):1795-801 – reference: 22065201 - Ann Biomed Eng. 2012 Jun;40(6):1211-27 – reference: 21303256 - Tissue Eng Part A. 2011 Jun;17(11-12):1635-42 – reference: 20126684 - Lab Chip. 2010 Feb 21;10(4):446-55 – reference: 10774777 - Drug Metab Rev. 2000 May;32(2):219-40 – reference: 16379670 - Curr Drug Metab. 2005 Dec;6(6):569-91 – reference: 12791308 - Toxicol Appl Pharmacol. 2003 Jun 15;189(3):233-46 – reference: 10234198 - Pharm Sci Technolo Today. 1999 Jan;2(1):7-12 – reference: 22645376 - Proc Natl Acad Sci U S A. 2012 Jun 12;109(24):9342-7 – reference: 15961304 - Biosens Bioelectron. 2006 Jan 15;21(7):1093-100 – reference: 15914466 - Pharmacol Rev. 2005 Jun;57(2):173-85 – reference: 18030398 - Lab Chip. 2007 Dec;7(12):1759-66 – reference: 19107278 - Lab Chip. 2009 Jan 21;9(2):232-8 – reference: 15890712 - Am J Physiol Gastrointest Liver Physiol. 2005 Jun;288(6):G1105-9 – reference: 19417905 - Lab Chip. 2009 May 21;9(10):1385-94 – reference: 16647113 - Biomaterials. 2006 Aug;27(24):4374-80 – reference: 20708792 - Biomaterials. 2010 Nov;31(32):8218-27 – reference: 5454145 - Science. 1970 Sep 25;169(3952):1331-3 – reference: 22451356 - Anal Sci. 2012;28(3):197-9 – reference: 20548775 - PLoS One. 2010;5(6):e11042 – reference: 15965465 - Nat Biotechnol. 2005 Jul;23(7):879-84 – reference: 11534848 - IEEE Trans Biomed Eng. 2001 Sep;48(9):996-1006 – reference: 19575443 - Biotechnol Bioeng. 2009 Oct 15;104(3):516-25 – reference: 18955083 - J Neurosci Methods. 2009 Feb 15;177(1):51-9 – reference: 14763861 - Biotechnol Prog. 2004 Jan-Feb;20(1):338-45 – reference: 10205607 - Int J Pharm. 1999 Jan 15;177(1):103-15 – reference: 20149449 - Biomaterials. 2010 May;31(13):3613-21 – reference: 20643478 - Biomaterials. 2010 Oct;31(29):7586-98 – reference: 19249356 - Cell Signal. 2009 Aug;21(8):1237-44 – reference: 20193719 - J Biotechnol. 2010 Jul 1;148(1):64-9 – reference: 21799718 - Biomicrofluidics. 2011 Jun;5(2):22212 – reference: 21079286 - Biofabrication. 2010 Dec;2(4):045004 – reference: 22509346 - PLoS One. 2012;7(4):e34704 – reference: 14656152 - Biotechnol Prog. 2003 Nov-Dec;19(6):1756-61 – reference: 11259831 - Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):27-43 – reference: 12931155 - Nature. 2003 Aug 21;424(6951):870-2 – reference: 20178370 - Anal Chem. 2010 Mar 15;82(6):2505-11 – reference: 17305308 - Anal Chem. 2007 Mar 15;79(6):2249-58 – reference: 21372121 - Ther Adv Respir Dis. 2011 Aug;5(4):255-73 – reference: 22271245 - Ann Biomed Eng. 2012 Jun;40(6):1255-67 – reference: 19728786 - Tissue Eng Part B Rev. 2010 Feb;16(1):55-64 – reference: 17525324 - Science. 2007 May 25;316(5828):1133-4 – reference: 16450032 - Lab Chip. 2006 Feb;6(2):230-5 – reference: 22094544 - Lab Chip. 2012 Jan 7;12(1):219-26 – reference: 10757876 - Microsc Res Tech. 2000 Apr 1;49(1):26-37 – reference: 21157619 - Lab Chip. 2011 Feb 7;11(3):389-92 – reference: 18803264 - J Pharm Sci. 2009 May;98(5):1885-904 – reference: 18006663 - Proc Natl Acad Sci U S A. 2007 Nov 27;104(48):18886-91 – reference: 17538713 - Lab Chip. 2007 Jun;7(6):720-5 – reference: 22092374 - Tissue Eng Part C Methods. 2012 May;18(5):349-57 – reference: 22521339 - J Pharmacol Toxicol Methods. 2012 May-Jun;65(3):126-35 – reference: 21569296 - BMC Neurosci. 2011;12:40 – reference: 20024049 - Lab Chip. 2010 Jan 7;10(1):43-50 – reference: 22434367 - Lab Chip. 2012 Jun 21;12(12):2165-74 – reference: 17906630 - Nat Mater. 2007 Nov;6(11):908-15 – reference: 9700689 - J Neurosci Methods. 1998 Aug 1;82(2):167-73 – reference: 20337513 - Tissue Eng Part C Methods. 2010 Dec;16(6):1347-55 – reference: 21385587 - J Mol Cell Cardiol. 2011 Jun;50(6):940-50 – reference: 22422217 - Lab Chip. 2012 Apr 24;12(10):1784-92 – reference: 22025913 - Front Neuroeng. 2011 Oct 19;4:13 – reference: 20576885 - Science. 2010 Jun 25;328(5986):1662-8 – reference: 17853866 - Nat Protoc. 2007;2(9):2111-9 – reference: 17046235 - Curr Opin Biotechnol. 2006 Dec;17(6):619-27 |
| SSID | ssj0015468 |
| Score | 2.5142913 |
| SecondaryResourceType | review_article |
| Snippet | While in vitro cell based systems have been an invaluable tool in biology, they often suffer from a lack of physiological relevance. The discrepancy between... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 1201 |
| SubjectTerms | Animal Structures - cytology Animal Structures - metabolism Animal Structures - physiology Animals Biomimetics - methods Humans Mammals Microtechnology - methods |
| Title | Microfabricated mammalian organ systems and their integration into models of whole animals and humans |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23388858 https://www.proquest.com/docview/1314894365 |
| Volume | 13 |
| WOSCitedRecordID | wos000315688500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1LS8QwEMcHdRX14GN9v4jgNWybJm1yEhEXLy4eFPa25AkrbqvWB357k7RFL4LgpfSQlDIZJtPM9P8DOMtVKphjGmtpJKZUKSwsLbBOuFCkSI1wJsImitGIj8fitj1wq9u2yi4mxkBtKh3OyAdp5hN3QbOcnT8940CNCtXVFqExD73MpzKhpasYf1cRGG1-haNF6BniopMnzcRAZ4-aBnd8-D21jFvMcP2_L7cBa21yiS4ab9iEOVv2YanBTX72Yfmyo7v1YfWHEOEW2JvQl-ekitAga9BMzmbxBARF7BNqBJ9rJEuDYm0BdToTfl3DfYUiU6dGlUMfgbnrh079I5opkQRYb8P98Oru8hq3AAass4K_YsdIbgjhzOTcSEtkKqkVxLGCSJ7k0gdtl2mTMyV99psoJQ1hXHG_52theUJ2YKGsSrsHyKqgJKYFIamlWdB998Odz04D-tjldh9OO8tOvCVC1UKWtnqrJ9-23YfdZnkmT40Sx4T4D2zOGT_4w-xDWCERZUFxUhxBz3kT2GNY1O-v0_rlJHqOv45ub74AlEPQVA |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Microfabricated+mammalian+organ+systems+and+their+integration+into+models+of+whole+animals+and+humans&rft.jtitle=Lab+on+a+chip&rft.au=Sung%2C+Jong+H&rft.au=Esch%2C+Mandy+B&rft.au=Prot%2C+Jean-Matthieu&rft.au=Long%2C+Christopher+J&rft.date=2013-04-07&rft.issn=1473-0189&rft.eissn=1473-0189&rft.volume=13&rft.issue=7&rft.spage=1201&rft_id=info:doi/10.1039%2Fc3lc41017j&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1473-0189&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1473-0189&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1473-0189&client=summon |