Genetic polymorphism of cytochrome P450 2D6 determines oestrogen receptor activity of the major infertility drug clomiphene via its active metabolites

Clomiphene citrate is the most used drug for the treatment of female infertility, a common condition in western societies and developing countries. Despite dose escalation, up to 30% of women do not respond. Since clomiphene shares structural similarities with tamoxifen, which is predominantly bioac...

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Bibliographic Details
Published in:	Human molecular genetics Vol. 21; no. 5; p. 1145
Main Authors:	Mürdter, Thomas E, Kerb, Reinhold, Turpeinen, Miia, Schroth, Werner, Ganchev, Boian, Böhmer, Gabriele M, Igel, Svitlana, Schaeffeler, Elke, Zanger, Ulrich, Brauch, Hiltrud, Schwab, Matthias
Format:	Journal Article
Language:	English
Published:	England 01.03.2012
Subjects:	Biotransformation Clomiphene - analogs & derivatives Clomiphene - chemistry Clomiphene - metabolism Clomiphene - pharmacology Cytochrome P-450 CYP2D6 - genetics Cytochrome P-450 CYP2D6 - metabolism Estrogen Antagonists - metabolism Estrogen Antagonists - pharmacology Female Genotype Humans Microsomes, Liver - metabolism Molecular Structure Polymorphism, Genetic Receptors, Estrogen - antagonists & inhibitors Receptors, Estrogen - metabolism Recombinant Proteins - metabolism
ISSN:	1460-2083, 1460-2083
Online Access:	Get more information
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