Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans

The induction of mitochondrial biogenesis could potentially alleviate mitochondrial and muscle disease. We show here that dimethyl fumarate (DMF) dose-dependently induces mitochondrial biogenesis and function dosed to cells in vitro, and also dosed in vivo to mice and humans. The induction of mitoch...

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Veröffentlicht in:	Human molecular genetics Jg. 26; H. 15; S. 2864
Hauptverfasser:	Hayashi, Genki, Jasoliya, Mittal, Sahdeo, Sunil, Saccà, Francesco, Pane, Chiara, Filla, Alessandro, Marsili, Angela, Puorro, Giorgia, Lanzillo, Roberta, Brescia Morra, Vincenzo, Cortopassi, Gino
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England 01.08.2017
Schlagworte:	Animals Cell Culture Techniques Dimethyl Fumarate - chemistry Dimethyl Fumarate - metabolism Fibroblasts Humans Mice Mitochondria - metabolism Multiple Sclerosis - metabolism Multiple Sclerosis - pathology Neuroprotective Agents - pharmacology NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Organelle Biogenesis
ISSN:	1460-2083, 1460-2083
Online-Zugang:	Weitere Angaben
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