Progress and challenges in bioinformatics approaches for enhancer identification

Enhancers are cis-acting DNA elements that play critical roles in distal regulation of gene expression. Identifying enhancers is an important step for understanding distinct gene expression programs that may reflect normal and pathogenic cellular conditions. Experimental identification of enhancers...

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Bibliographic Details

Published in:	Briefings in bioinformatics Vol. 17; no. 6; pp. 967 - 979
Main Authors:	Kleftogiannis, Dimitrios, Kalnis, Panos, Bajic, Vladimir B.
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.11.2016
Subjects:	Computational Biology Enhancer Elements, Genetic Histones chromatin signatures computer science enhancers gene regulation genome annotation bioinformatics histone modification marks machine learning
ISSN:	1467-5463, 1477-4054, 1477-4054
Online Access:	Get full text
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