The Combination of Cystatin C and Serum Creatinine Improves the Monitoring of Kidney Function in Patients with Diabetes and Chronic Kidney Disease

Better GFR estimations are required for those patients considered to have chronic kidney disease (CKD) according to the new American Diabetes Association recommendations, particularly to assess the progression of their CKD, which may not be accurately estimated by the CG and MDRD equations (2). GFR...

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Veröffentlicht in:Clinical chemistry (Baltimore, Md.) Jg. 53; H. 11; S. 1988 - 1989
Hauptverfasser: Rigalleau, Vincent, Beauvieux, Marie-Christine, Lasseur, Catherine, Chauveau, Philippe, Raffaitin, Christelle, Perlemoine, Caroline, Barthe, Nicole, Combe, Christian, Gin, Henri
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Oxford University Press 01.11.2007
Schlagworte:
Aged
Chronic Disease
Chronic illnesses
Creatinine - blood
Cystatin C
Cystatins - blood
Diabetes
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - physiopathology
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - physiopathology
Disease
Female
Glomerular Filtration Rate
Humans
Kidney - physiopathology
Kidney diseases
Kidney Diseases - physiopathology
Kidneys
Male
ROC Curve
ISSN:0009-9147, 1530-8561
Online-Zugang:Volltext
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Zusammenfassung:Better GFR estimations are required for those patients considered to have chronic kidney disease (CKD) according to the new American Diabetes Association recommendations, particularly to assess the progression of their CKD, which may not be accurately estimated by the CG and MDRD equations (2). GFR was measured by ^sup 51^Cr-EDTA clearance [i-GFR, 33.2 (14.8) mL * min^sup -1^ * (1.73 m^sup 2^)^sup -1^], and compared to the recommended and new composite estimations by use of correlations, paired t tests, Bland-Altman procedures, and absolute percentage difference with i-GFR. sCr was quantified on an Olympus AU 640 analyzer by use of the Jaffé method with bichromatic measurements according to the manufacturer's specifications.
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ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2007.092171