Identification and functional analysis of senescent cells in the cardiovascular system using omics approaches

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and senescent cells have emerged as key contributors to its pathogenesis. Senescent cells exhibit cell cycle arrest and secrete a range of proinflammatory factors, termed the senescence-associated secretory phenoty...

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Bibliographic Details
Published in:American journal of physiology. Heart and circulatory physiology Vol. 325; no. 5; p. H1039
Main Authors: Mahoney, Sophia A, Dey, Amit K, Basisty, Nathan, Herman, Allison B
Format: Journal Article
Language:English
Published: United States 01.11.2023
Subjects:
Aging - genetics
Cardiovascular Diseases - genetics
Cardiovascular System
Cells, Cultured
Cellular Senescence - genetics
Humans
transcriptomics
cellular senescence
aging
proteomics
biomarkers
ISSN:1522-1539, 1522-1539
Online Access:Get more information
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Summary:Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and senescent cells have emerged as key contributors to its pathogenesis. Senescent cells exhibit cell cycle arrest and secrete a range of proinflammatory factors, termed the senescence-associated secretory phenotype (SASP), which promotes tissue dysfunction and exacerbates CVD progression. Omics technologies, specifically transcriptomics and proteomics, offer powerful tools to uncover and define the molecular signatures of senescent cells in cardiovascular tissue. By analyzing the comprehensive molecular profiles of senescent cells, omics approaches can identify specific genetic alterations, gene expression patterns, protein abundances, and metabolite levels associated with senescence in CVD. These omics-based discoveries provide insights into the mechanisms underlying senescence-induced cardiovascular damage, facilitating the development of novel diagnostic biomarkers and therapeutic targets. Furthermore, integration of multiple omics data sets enables a systems-level understanding of senescence in CVD, paving the way for precision medicine approaches to prevent or treat cardiovascular aging and its associated complications.
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ISSN:1522-1539
1522-1539
DOI:10.1152/ajpheart.00352.2023