Insomnia and Telomere Length in Older Adults

Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age t...

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Published in:	Sleep (New York, N.Y.) Vol. 39; no. 3; p. 559
Main Authors:	Carroll, Judith E, Esquivel, Stephanie, Goldberg, Alyssa, Seeman, Teresa E, Effros, Rita B, Dock, Jeffrey, Olmstead, Richard, Breen, Elizabeth C, Irwin, Michael R
Format:	Journal Article
Language:	English
Published:	United States 01.03.2016
Subjects:	Aged Aged, 80 and over Aging - genetics Aging - pathology Case-Control Studies Cellular Senescence - genetics Chronic Disease Female Humans Leukocytes, Mononuclear - metabolism Male Middle Aged Real-Time Polymerase Chain Reaction Risk Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - genetics Sleep Initiation and Maintenance Disorders - pathology Telomere - genetics Telomere - metabolism sleep late life telomere cellular aging older adults aging insomnia
ISSN:	1550-9109, 1550-9109
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Abstract	Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology. In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44. Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.
AbstractList	Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology. In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44. Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging. Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging.STUDY OBJECTIVESInsomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging.A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology.METHODSA total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology.In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44.RESULTSIn the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44.Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.CONCLUSIONSInsomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.
Author	Dock, Jeffrey Breen, Elizabeth C Olmstead, Richard Esquivel, Stephanie Effros, Rita B Irwin, Michael R Carroll, Judith E Goldberg, Alyssa Seeman, Teresa E
Author_xml	– sequence: 1 givenname: Judith E surname: Carroll fullname: Carroll, Judith E organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 2 givenname: Stephanie surname: Esquivel fullname: Esquivel, Stephanie organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 3 givenname: Alyssa surname: Goldberg fullname: Goldberg, Alyssa organization: Children's National Medical Center, Department of Pediatrics, Washington, DC – sequence: 4 givenname: Teresa E surname: Seeman fullname: Seeman, Teresa E organization: University of California, Los Angeles, Department of Medicine, Division of Geriatrics, David Geffen School of Medicine, Los Angeles, CA – sequence: 5 givenname: Rita B surname: Effros fullname: Effros, Rita B organization: University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA – sequence: 6 givenname: Jeffrey surname: Dock fullname: Dock, Jeffrey organization: University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA – sequence: 7 givenname: Richard surname: Olmstead fullname: Olmstead, Richard organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 8 givenname: Elizabeth C surname: Breen fullname: Breen, Elizabeth C organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 9 givenname: Michael R surname: Irwin fullname: Irwin, Michael R organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA
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References	26140821 - Biol Psychiatry. 2016 Jul 1;80(1):40-52 24470696 - Sleep. 2014 Jan;37(1):65-70 23633749 - Sleep. 2013 May;36(5):671-9 18021748 - Free Radic Biol Med. 2008 Feb 1;44(3):235-46 20508208 - Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1649-56 17667954 - Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40 15680963 - FEBS Lett. 2005 Feb 7;579(4):859-62 19641160 - Diabetes Care. 2009 Nov;32(11):1980-5 20195384 - Aging (Albany NY). 2009 Jan;1(1):81-8 10911963 - Ann N Y Acad Sci. 2000 Jun;908:244-54 24072989 - Sleep Med Clin. 2013 Sep 1;8(3):309-322 12114022 - Trends Biochem Sci. 2002 Jul;27(7):339-44 25061767 - Annu Rev Psychol. 2015 Jan 3;66:143-72 16979422 - Metabolism. 2006 Oct;55(10 Suppl 2):S20-3 24833586 - J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9 24627273 - J Natl Cancer Inst. 2014 Apr;106(4):dju035 21853136 - PLoS One. 2011;6(8):e23462 16084689 - Brain Behav Immun. 2006 May;20(3):246-53 24699341 - PLoS One. 2014;9(4):e91965 20704891 - Discov Med. 2005 Jun;5(27):293-7 16448292 - Health Psychol. 2006 Jan;25(1):3-14 22046530 - J Aging Res. 2011;2011:721390 19036896 - J Appl Physiol (1985). 2009 Jan;106(1):326-32 19413143 - Sleep. 2009 Apr;32(4):491-7 25535858 - Brain Behav Immun. 2015 Jul;47:155-62 3558716 - J Chronic Dis. 1987;40(5):373-83 25714703 - PLoS One. 2015;10(2):e0118467 17942834 - Psychosom Med. 2007 Nov;69(8):756-61 25142571 - Sleep. 2014 Sep;37(9):1543-52 25006006 - BMJ. 2014;349:g4227 16459140 - Sleep Med. 2006 Mar;7(2):123-30 12531146 - Sleep Med Rev. 2002 Apr;6(2):97-111 9343003 - Arch Intern Med. 1997 Oct 27;157(19):2259-68 26336034 - Brain Behav Immun. 2016 Jan;51:223-9 12840146 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5 19131896 - J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):137-47 18209045 - J Immunol. 2008 Feb 1;180(3):1499-507 24663223 - Nat Rev Endocrinol. 2014 May;10(5):303-10 12000852 - Nucleic Acids Res. 2002 May 15;30(10):e47 21321098 - J Cell Biol. 2011 Feb 21;192(4):547-56 15734683 - Cell. 2005 Feb 25;120(4):513-22 19837074 - J Immunol Methods. 2010 Jan 31;352(1-2):71-80 22323897 - Nat Sci Sleep. 2010 Apr 1;2:47-61 10733687 - J Sleep Res. 2000 Mar;9(1):35-42 25317735 - Clin Sci (Lond). 2015 Mar;128(6):367-77 19007876 - Brain Behav Immun. 2009 Mar;23(3):351-4 23144701 - PLoS One. 2012;7(10):e47292 25325492 - Sleep. 2014 Dec;37(12):1929-40 21298072 - PLoS One. 2011;6(1):e16459 21587205 - EMBO J. 2011 Jul 6;30(13):2520-31 24470704 - Sleep. 2014 Jan;37(1):157-66 21307849 - Nature. 2011 Feb 17;470(7334):359-65 23167566 - Mol Ecol. 2013 Jan;22(1):249-59 25040775 - J Intern Med. 2015 Apr;277(4):478-87 20857861 - Sleep. 2010 Sep;33(9):1159-64 12077736 - Metabolism. 2002 Jul;51(7):887-92 24226807 - Circulation. 2014 Feb 18;129(7):737-46 17162986 - Sleep. 2006 Nov;29(11):1398-414 22705247 - Sleep Med. 2012 Dec;13(10):1217-25 23511462 - Nat Commun. 2013;4:1597 17943234 - Z Gerontol Geriatr. 2007 Oct;40(5):314-24 18328671 - Brain Behav Immun. 2008 Aug;22(6):960-8 24902894 - Aging (Albany NY). 2014 May;6(5):414-27
References_xml	– reference: 25325492 - Sleep. 2014 Dec;37(12):1929-40 – reference: 23167566 - Mol Ecol. 2013 Jan;22(1):249-59 – reference: 24902894 - Aging (Albany NY). 2014 May;6(5):414-27 – reference: 20195384 - Aging (Albany NY). 2009 Jan;1(1):81-8 – reference: 19007876 - Brain Behav Immun. 2009 Mar;23(3):351-4 – reference: 24470704 - Sleep. 2014 Jan;37(1):157-66 – reference: 24663223 - Nat Rev Endocrinol. 2014 May;10(5):303-10 – reference: 15680963 - FEBS Lett. 2005 Feb 7;579(4):859-62 – reference: 24699341 - PLoS One. 2014;9(4):e91965 – reference: 24226807 - Circulation. 2014 Feb 18;129(7):737-46 – reference: 26336034 - Brain Behav Immun. 2016 Jan;51:223-9 – reference: 18021748 - Free Radic Biol Med. 2008 Feb 1;44(3):235-46 – reference: 21298072 - PLoS One. 2011;6(1):e16459 – reference: 25317735 - Clin Sci (Lond). 2015 Mar;128(6):367-77 – reference: 12114022 - Trends Biochem Sci. 2002 Jul;27(7):339-44 – reference: 19837074 - J Immunol Methods. 2010 Jan 31;352(1-2):71-80 – reference: 26140821 - Biol Psychiatry. 2016 Jul 1;80(1):40-52 – reference: 16459140 - Sleep Med. 2006 Mar;7(2):123-30 – reference: 12531146 - Sleep Med Rev. 2002 Apr;6(2):97-111 – reference: 20508208 - Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1649-56 – reference: 25061767 - Annu Rev Psychol. 2015 Jan 3;66:143-72 – reference: 25006006 - BMJ. 2014;349:g4227 – reference: 21853136 - PLoS One. 2011;6(8):e23462 – reference: 17667954 - Nat Rev Mol Cell Biol. 2007 Sep;8(9):729-40 – reference: 12000852 - Nucleic Acids Res. 2002 May 15;30(10):e47 – reference: 17942834 - Psychosom Med. 2007 Nov;69(8):756-61 – reference: 19413143 - Sleep. 2009 Apr;32(4):491-7 – reference: 16448292 - Health Psychol. 2006 Jan;25(1):3-14 – reference: 23633749 - Sleep. 2013 May;36(5):671-9 – reference: 9343003 - Arch Intern Med. 1997 Oct 27;157(19):2259-68 – reference: 22046530 - J Aging Res. 2011;2011:721390 – reference: 19036896 - J Appl Physiol (1985). 2009 Jan;106(1):326-32 – reference: 23144701 - PLoS One. 2012;7(10):e47292 – reference: 3558716 - J Chronic Dis. 1987;40(5):373-83 – reference: 25142571 - Sleep. 2014 Sep;37(9):1543-52 – reference: 20857861 - Sleep. 2010 Sep;33(9):1159-64 – reference: 12840146 - Proc Natl Acad Sci U S A. 2003 Jul 22;100(15):9090-5 – reference: 23511462 - Nat Commun. 2013;4:1597 – reference: 24470696 - Sleep. 2014 Jan;37(1):65-70 – reference: 25714703 - PLoS One. 2015;10(2):e0118467 – reference: 10733687 - J Sleep Res. 2000 Mar;9(1):35-42 – reference: 22705247 - Sleep Med. 2012 Dec;13(10):1217-25 – reference: 21307849 - Nature. 2011 Feb 17;470(7334):359-65 – reference: 16084689 - Brain Behav Immun. 2006 May;20(3):246-53 – reference: 24627273 - J Natl Cancer Inst. 2014 Apr;106(4):dju035 – reference: 21321098 - J Cell Biol. 2011 Feb 21;192(4):547-56 – reference: 16979422 - Metabolism. 2006 Oct;55(10 Suppl 2):S20-3 – reference: 10911963 - Ann N Y Acad Sci. 2000 Jun;908:244-54 – reference: 25040775 - J Intern Med. 2015 Apr;277(4):478-87 – reference: 12077736 - Metabolism. 2002 Jul;51(7):887-92 – reference: 20704891 - Discov Med. 2005 Jun;5(27):293-7 – reference: 18328671 - Brain Behav Immun. 2008 Aug;22(6):960-8 – reference: 17162986 - Sleep. 2006 Nov;29(11):1398-414 – reference: 19131896 - J Acquir Immune Defic Syndr. 2009 Feb 1;50(2):137-47 – reference: 24072989 - Sleep Med Clin. 2013 Sep 1;8(3):309-322 – reference: 18209045 - J Immunol. 2008 Feb 1;180(3):1499-507 – reference: 15734683 - Cell. 2005 Feb 25;120(4):513-22 – reference: 22323897 - Nat Sci Sleep. 2010 Apr 1;2:47-61 – reference: 24833586 - J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9 – reference: 21587205 - EMBO J. 2011 Jul 6;30(13):2520-31 – reference: 19641160 - Diabetes Care. 2009 Nov;32(11):1980-5 – reference: 25535858 - Brain Behav Immun. 2015 Jul;47:155-62 – reference: 17943234 - Z Gerontol Geriatr. 2007 Oct;40(5):314-24
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SubjectTerms	Aged Aged, 80 and over Aging - genetics Aging - pathology Case-Control Studies Cellular Senescence - genetics Chronic Disease Female Humans Leukocytes, Mononuclear - metabolism Male Middle Aged Real-Time Polymerase Chain Reaction Risk Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - genetics Sleep Initiation and Maintenance Disorders - pathology Telomere - genetics Telomere - metabolism
Title	Insomnia and Telomere Length in Older Adults
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