Insomnia and Telomere Length in Older Adults

Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age t...

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Vydáno v:	Sleep (New York, N.Y.) Ročník 39; číslo 3; s. 559
Hlavní autoři:	Carroll, Judith E, Esquivel, Stephanie, Goldberg, Alyssa, Seeman, Teresa E, Effros, Rita B, Dock, Jeffrey, Olmstead, Richard, Breen, Elizabeth C, Irwin, Michael R
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.03.2016
Témata:	Aged Aged, 80 and over Aging - genetics Aging - pathology Case-Control Studies Cellular Senescence - genetics Chronic Disease Female Humans Leukocytes, Mononuclear - metabolism Male Middle Aged Real-Time Polymerase Chain Reaction Risk Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - genetics Sleep Initiation and Maintenance Disorders - pathology Telomere - genetics Telomere - metabolism sleep late life telomere cellular aging older adults aging insomnia
ISSN:	1550-9109, 1550-9109
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Abstract	Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology. In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44. Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.
AbstractList	Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging. A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology. In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44. Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging. Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging.STUDY OBJECTIVESInsomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study examines the effects of insomnia on telomere length, a measure of cellular aging, and tests whether insomnia interacts with chronological age to increase cellular aging.A total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology.METHODSA total of 126 males and females (60-88 y) were assessed for insomnia using the Diagnostic and Statistical Manual IV criterion for primary insomnia and the International Classification of Sleep Disorders, Second Edition for general insomnia (45 insomnia cases; 81 controls). Telomere length in peripheral blood mononuclear cells (PBMC) was determined using real-time quantitative polymerase chain reaction (qPCR) methodology.In the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44.RESULTSIn the analysis of covariance model adjusting for body mass index and sex, age (60-69 y versus 70-88 y) and insomnia diagnosis interacted to predict shorter PBMC telomere length (P = 0.04). In the oldest age group (70-88 y), PBMC telomere length was significantly shorter in those with insomnia, mean (standard deviation) M(SD) = 0.59(0.2) compared to controls with no insomnia M(SD) = 0.78(0.4), P = 0.04. In the adults aged 60-69 y, PBMC telomere length was not different between insomnia cases and controls, P = 0.44.Insomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.CONCLUSIONSInsomnia is associated with shorter PBMC telomere length in adults aged 70-88 y, but not in those younger than 70 y, suggesting that clinically severe sleep disturbances may increase cellular aging, especially in the later years of life. These findings highlight insomnia as a vulnerability factor in later life, with implications for risk for diseases of aging.
Author	Dock, Jeffrey Breen, Elizabeth C Olmstead, Richard Esquivel, Stephanie Effros, Rita B Irwin, Michael R Carroll, Judith E Goldberg, Alyssa Seeman, Teresa E
Author_xml	– sequence: 1 givenname: Judith E surname: Carroll fullname: Carroll, Judith E organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 2 givenname: Stephanie surname: Esquivel fullname: Esquivel, Stephanie organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 3 givenname: Alyssa surname: Goldberg fullname: Goldberg, Alyssa organization: Children's National Medical Center, Department of Pediatrics, Washington, DC – sequence: 4 givenname: Teresa E surname: Seeman fullname: Seeman, Teresa E organization: University of California, Los Angeles, Department of Medicine, Division of Geriatrics, David Geffen School of Medicine, Los Angeles, CA – sequence: 5 givenname: Rita B surname: Effros fullname: Effros, Rita B organization: University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA – sequence: 6 givenname: Jeffrey surname: Dock fullname: Dock, Jeffrey organization: University of California, Los Angeles, Department of Pathology and Laboratory Medicine, Los Angeles, CA – sequence: 7 givenname: Richard surname: Olmstead fullname: Olmstead, Richard organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 8 givenname: Elizabeth C surname: Breen fullname: Breen, Elizabeth C organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA – sequence: 9 givenname: Michael R surname: Irwin fullname: Irwin, Michael R organization: University of California, Los Angeles, Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA
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Snippet	Insomnia, particularly in later life, may raise the risk for chronic diseases of aging and mortality through its effect on cellular aging. The current study...
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SubjectTerms	Aged Aged, 80 and over Aging - genetics Aging - pathology Case-Control Studies Cellular Senescence - genetics Chronic Disease Female Humans Leukocytes, Mononuclear - metabolism Male Middle Aged Real-Time Polymerase Chain Reaction Risk Sleep Initiation and Maintenance Disorders - diagnosis Sleep Initiation and Maintenance Disorders - genetics Sleep Initiation and Maintenance Disorders - pathology Telomere - genetics Telomere - metabolism
Title	Insomnia and Telomere Length in Older Adults
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