WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms

RNA-binding proteins (RBPs) are involved in mRNA splicing, maturation, transport, translation, storage and turnover. Here, we identified ACOT7 mRNA as a novel target of human WIG1. ACOT7 mRNA decay was triggered by the microRNA miR-9 in a WIG1-dependent manner via classic recruitment of Argonaute 2...

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Vydáno v:	Nucleic acids research Ročník 45; číslo 11; s. 6894 - 6910
Hlavní autoři:	Lee, Hyung Chul, Jung, Seung Hee, Hwang, Hyun Jung, Kang, Donghee, De, Supriyo, Dudekula, Dawood B., Martindale, Jennifer L., Park, Byungkyu, Park, Seung Kuk, Lee, Eun Kyung, Lee, Jeong-Hwa, Jeong, Sunjoo, Han, Kyungsook, Park, Heon Joo, Ko, Young-Gyu, Gorospe, Myriam, Lee, Jae-Seon
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Oxford University Press 20.06.2017
Témata:	3' Untranslated Regions Argonaute Proteins - physiology Base Sequence Binding Sites Carrier Proteins - physiology Eukaryotic Initiation Factors - metabolism HCT116 Cells HEK293 Cells Humans Inverted Repeat Sequences MCF-7 Cells MicroRNAs - physiology Nuclear Proteins - physiology Protein Binding Protein Biosynthesis Protein Domains RNA RNA Interference RNA Stability RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins
ISSN:	0305-1048, 1362-4962, 1362-4962
On-line přístup:	Získat plný text
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