Gene silencing by EZH2 suppresses TGF-β activity within the decidua to avert pregnancy-adverse wound healing at the maternal-fetal interface

A little-appreciated feature of early pregnancy is that embryo implantation and placental outgrowth do not evoke wound-healing responses in the decidua, the specialized endometrial tissue that surrounds the conceptus. Here, we provide evidence that this phenomenon is partly due to an active program...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 38; no. 5; p. 110329
Main Authors:	Osokine, Ivan, Siewiera, Johan, Rideaux, Damon, Ma, Stephany, Tsukui, Tatsuya, Erlebacher, Adrian
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.02.2022
Subjects:	Animals Decidua - metabolism decidualization Embryo Implantation - physiology Embryo, Mammalian - metabolism Enhancer of Zeste Homolog 2 Protein - metabolism epigenetics EZH2 Female fibrosis Gene Expression - physiology Gene Silencing - physiology Histones - metabolism Humans Mice Mice, Inbred C57BL Placenta - metabolism PRC2 Pregnancy Stromal Cells - metabolism TGF-beta Transforming Growth Factor beta - genetics Transforming Growth Factor beta - metabolism wound healing Wound Healing - physiology TGF-beta wound healing PRC2 pregnancy fibrosis decidualization epigenetics EZH2
ISSN:	2211-1247, 2211-1247
Online Access:	Get full text
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