Polymorphism of the dopamine D4 receptor (DRD4) and serotonin transporter (5-HTTL) gene promoter regions in african tribes of Hadza and Datoga

Molecular genetic analysis of the allelic variants of the DRD4 and 5-HTTL gene promoter regions was performed in African tribes of Hadza and Datoga, characterized by different levels of socially acceptable aggression. It was demonstrated that Hadza and Datoga people differed in the structural organi...

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Veröffentlicht in:Russian journal of genetics Jg. 47; H. 2; S. 226 - 229
Hauptverfasser: Vasilyev, V. A, Martirosyan, I. A, Shibaev, D. V, Kulikov, A. M, Lazebny, O. E, Burkova, V. N, Ryskov, A. P, Butovskaya, M. L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Dordrecht Dordrecht : SP MAIK Nauka/Interperiodica 01.02.2011
SP MAIK Nauka/Interperiodica
Schlagworte:
aggression
alleles
Animal Genetics
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
dopamine
gene frequency
genetic techniques and protocols
genotype
Human Genetics
loci
Microbial Genetics and Genomics
promoter regions
receptors
serotonin
single nucleotide polymorphism
transporters
Poly Merase Chain Reaction
Allele Repeat
Active Allele
Obsessive Compulsive Disorder
Serotonin Transporter Gene
ISSN:1022-7954, 1608-3369
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Zusammenfassung:Molecular genetic analysis of the allelic variants of the DRD4 and 5-HTTL gene promoter regions was performed in African tribes of Hadza and Datoga, characterized by different levels of socially acceptable aggression. It was demonstrated that Hadza and Datoga people differed in the structural organization of one of the 5-HTTL alleles (extra long allele xL). Analysis of the allele length polymorphism of both genes showed that in the Hadza and Datoga samples examined, variation parameters, as well as the genotype and allele frequency distribution pattern were almost the same. At the same time, analysis of the SNP polymorphism at the A/G substitutions of the 5-HTTL locus revealed a substantial decrease of the active allele L A frequency in the population of Hadza compared to the population of Datoga (χ² = 3.77; d.f. = 1; p = 0.052).
Bibliographie:http://dx.doi.org/10.1134/S1022795411020190
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ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795411020190