A Boolean network model of the double-strand break repair pathway choice

•The Boolean network model (BNM) recapitulates HR pathway activity observed in response to DSBs.•The BNM recovers behaviors of BRCA1/FANCS mutants.•The BNM retrieves drug resistance mechanisms related to shifts in DNA repair pathway selections.•TIP60 complex and its corresponding histone acetylation...

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Bibliographic Details
Published in:	Journal of theoretical biology Vol. 573; p. 111608
Main Authors:	Ayala-Zambrano, Cecilia, Yuste, Mariana, Frias, Sara, Garcia-de-Teresa, Benilde, Mendoza, Luis, Azpeitia, Eugenio, Rodríguez, Alfredo, Torres, Leda
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 21.09.2023
Subjects:	DNA damage Mathematical modeling Single-strand annealing Synthetic lethality TIP60 Mathematical modeling Single-strand annealing Synthetic lethality DNA damage TIP60
ISSN:	0022-5193, 1095-8541, 1095-8541
Online Access:	Get full text
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