Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations

To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis). Eighty eyes...

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Published in:Retina (Philadelphia, Pa.) Vol. 32; no. 8; p. 1581
Main Authors: Garcia-Martin, Elena, Pinilla, Isabel, Sancho, Eva, Almarcegui, Carmen, Dolz, Isabel, Rodriguez-Mena, Diego, Fuertes, Isabel, Cuenca, Nicolas
Format: Journal Article
Language:English
Published: United States 01.09.2012
Subjects:
Adult
Aged
Cross-Sectional Studies
Female
Fourier Analysis
Humans
Macula Lutea - pathology
Male
Middle Aged
Nerve Fibers - pathology
Organ Size
Prospective Studies
Reproducibility of Results
Retinal Ganglion Cells - pathology
Retinitis Pigmentosa - diagnosis
Time Factors
Tomography, Optical Coherence - instrumentation
Tomography, Optical Coherence - standards
Visual Acuity - physiology
ISSN:1539-2864, 1539-2864
Online Access:Get more information
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Summary:To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis). Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation. Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes. Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients.
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ISSN:1539-2864
1539-2864
DOI:10.1097/IAE.0b013e318242b838