Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations

To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis). Eighty eyes...

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Veröffentlicht in:	Retina (Philadelphia, Pa.) Jg. 32; H. 8; S. 1581
Hauptverfasser:	Garcia-Martin, Elena, Pinilla, Isabel, Sancho, Eva, Almarcegui, Carmen, Dolz, Isabel, Rodriguez-Mena, Diego, Fuertes, Isabel, Cuenca, Nicolas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.09.2012
Schlagworte:	Adult Aged Cross-Sectional Studies Female Fourier Analysis Humans Macula Lutea - pathology Male Middle Aged Nerve Fibers - pathology Organ Size Prospective Studies Reproducibility of Results Retinal Ganglion Cells - pathology Retinitis Pigmentosa - diagnosis Time Factors Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - standards Visual Acuity - physiology
ISSN:	1539-2864, 1539-2864
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Abstract	To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis). Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation. Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes. Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients.
AbstractList	To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis).PURPOSETo evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis).Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation.METHODSEighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation.Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes.RESULTSMacular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes.Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients.CONCLUSIONDifferences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients. To evaluate the ability of time-domain and Fourier-domain optical coherence tomographies (OCTs) to detect macular and retinal nerve fiber layer atrophies in retinitis pigmentosa (RP). To test the intrasession reproducibility using three OCT instruments (Stratus, Cirrus, and Spectralis). Eighty eyes of 80 subjects (40 RP patients and 40 healthy subjects) underwent a visual field examination, together with 3 macular scans and 3 optic disk evaluations by the same experienced examiner using 3 OCT instruments. Differences between healthy and RP eyes were compared. The relationship between measurements with each OCT instrument was evaluated. Repeatability was studied by intraclass correlation coefficients and coefficients of variation. Macular and retinal nerve fiber layer atrophies were detected in RP patients for all OCT parameters. Macular and retinal nerve fiber layer thicknesses, as determined by the different OCTs, were correlated but significantly different (P < 0.05). Reproducibility was moderately high using Stratus, good using Cirrus and Spectralis, and excellent using the Tru-track technology of Spectralis. In RP eyes, measurements showed higher variability compared with healthy eyes. Differences in thickness measurements existed between OCT instruments, despite there being a high degree of correlation. Fourier-domain OCT can be considered a valid and repeatability technique to detect retinal nerve fiber layer atrophy in RP patients.
Author	Sancho, Eva Cuenca, Nicolas Pinilla, Isabel Rodriguez-Mena, Diego Almarcegui, Carmen Garcia-Martin, Elena Fuertes, Isabel Dolz, Isabel
Author_xml	– sequence: 1 givenname: Elena surname: Garcia-Martin fullname: Garcia-Martin, Elena email: egmvivax@yahoo.com organization: Department of Ophthalmology, Miguel Servet University Hospital, Zaragoza, Spain. egmvivax@yahoo.com – sequence: 2 givenname: Isabel surname: Pinilla fullname: Pinilla, Isabel – sequence: 3 givenname: Eva surname: Sancho fullname: Sancho, Eva – sequence: 4 givenname: Carmen surname: Almarcegui fullname: Almarcegui, Carmen – sequence: 5 givenname: Isabel surname: Dolz fullname: Dolz, Isabel – sequence: 6 givenname: Diego surname: Rodriguez-Mena fullname: Rodriguez-Mena, Diego – sequence: 7 givenname: Isabel surname: Fuertes fullname: Fuertes, Isabel – sequence: 8 givenname: Nicolas surname: Cuenca fullname: Cuenca, Nicolas
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SubjectTerms	Adult Aged Cross-Sectional Studies Female Fourier Analysis Humans Macula Lutea - pathology Male Middle Aged Nerve Fibers - pathology Organ Size Prospective Studies Reproducibility of Results Retinal Ganglion Cells - pathology Retinitis Pigmentosa - diagnosis Time Factors Tomography, Optical Coherence - instrumentation Tomography, Optical Coherence - standards Visual Acuity - physiology
Title	Optical coherence tomography in retinitis pigmentosa: reproducibility and capacity to detect macular and retinal nerve fiber layer thickness alterations
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