NF-kappa B and Oct-2 synergize to activate the human 3' Igh hs4 enhancer in B cells

In B cells, the Igh gene locus contains several DNase I-hypersensitive (hs) sites with enhancer activity. These include the 3' Igh enhancers, which are located downstream of the Calpha gene(s) in both mouse and human. In vivo experiments have implicated murine 3' enhancers, hs3B and/or hs4...

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Vydáno v:	The Journal of immunology (1950) Ročník 172; číslo 2; s. 1054
Hlavní autoři:	Sepulveda, Manuel A, Emelyanov, Alexander V, Birshtein, Barbara K
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.01.2004
Témata:	3' Untranslated Regions - immunology Animals B-Lymphocytes - chemistry B-Lymphocytes - immunology B-Lymphocytes - metabolism Chromatin - metabolism DNA-Binding Proteins - metabolism DNA-Binding Proteins - physiology Electrophoretic Mobility Shift Assay Enhancer Elements, Genetic - immunology Host Cell Factor C1 Humans Immunoglobulin Heavy Chains - genetics Immunoglobulin Heavy Chains - metabolism Mice NF-kappa B - metabolism NF-kappa B - physiology Nuclear Proteins Octamer Transcription Factor-1 Octamer Transcription Factor-2 PAX5 Transcription Factor Precipitin Tests Protein Binding - genetics Protein Binding - immunology Proteins - isolation & purification Proteins - metabolism Proto-Oncogene Proteins - isolation & purification Trans-Activators - metabolism Trans-Activators - physiology Transcription Factor RelB Transcription Factors - isolation & purification Transcription Factors - metabolism Transcription Factors - physiology Transfection
ISSN:	0022-1767
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