Glucocorticoids promote a TH2 cytokine response by CD4+ T cells in vitro

Purified rat CD4+ T cells were activated in vitro in the presence or absence of the glucocorticoid dexamethasone. They were then expanded in IL-2 and subsequently restimulated, this time in the absence of the hormone. The results indicate that the exposure of the cells to dexamethasone in the primar...

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Bibliographic Details
Published in:	The Journal of immunology (1950) Vol. 156; no. 7; p. 2406
Main Authors:	Ramírez, F, Fowell, D J, Puklavec, M, Simmonds, S, Mason, D
Format:	Journal Article
Language:	English
Published:	United States 01.04.1996
Subjects:	Animals Antibodies, Monoclonal - biosynthesis Base Sequence CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - immunology Concanavalin A - pharmacology Cytokines - biosynthesis Cytokines - genetics Dexamethasone - pharmacology DNA Primers - genetics Glucocorticoids - pharmacology In Vitro Techniques Interferon-gamma - biosynthesis Interferon-gamma - genetics Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-13 - biosynthesis Interleukin-13 - genetics Interleukin-4 - biosynthesis Interleukin-4 - genetics Lymphocyte Activation Mice Molecular Sequence Data Rats RNA, Messenger - genetics RNA, Messenger - metabolism Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics
ISSN:	0022-1767
Online Access:	Get more information
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