Early Events in the Molecular Pathogenesis of Lung Cancer

The majority of cancer-related deaths in the United States and worldwide are attributed to lung cancer. There are more than 90 million smokers in the United States who represent a significant population at elevated risk for lung malignancy. In other epithelial tumors, it has been shown that if neopl...

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Bibliographic Details
Published in:Cancer prevention research (Philadelphia, Pa.) Vol. 9; no. 7; p. 518
Main Authors: Kadara, Humam, Scheet, Paul, Wistuba, Ignacio I, Spira, Avrum E
Format: Journal Article
Language:English
Published: United States 01.07.2016
Subjects:
Animals
Biomarkers, Tumor - analysis
Early Detection of Cancer - methods
Early Detection of Cancer - trends
Humans
Lung Neoplasms - diagnosis
Lung Neoplasms - genetics
Lung Neoplasms - pathology
Precancerous Conditions - diagnosis
Precancerous Conditions - genetics
Precancerous Conditions - pathology
ISSN:1940-6215, 1940-6215
Online Access:Get more information
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Summary:The majority of cancer-related deaths in the United States and worldwide are attributed to lung cancer. There are more than 90 million smokers in the United States who represent a significant population at elevated risk for lung malignancy. In other epithelial tumors, it has been shown that if neoplastic lesions can be detected and treated at their intraepithelial stage, patient prognosis is significantly improved. Thus, new strategies to detect and treat lung preinvasive lesions are urgently needed in order to decrease the overwhelming public health burden of lung cancer. Limiting these advances is a poor knowledge of the earliest events that underlie lung cancer development and that would constitute markers and targets for early detection and prevention. This review summarizes the state of knowledge of human lung cancer pathogenesis and the molecular pathology of premalignant lung lesions, with a focus on the molecular premalignant field that associates with lung cancer development. Lastly, we highlight new approaches and models to study genome-wide alterations in human lung premalignancy in order to facilitate the discovery of new markers for early detection and prevention of this fatal disease. Cancer Prev Res; 9(7); 518-27. ©2016 AACR.
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ISSN:1940-6215
1940-6215
DOI:10.1158/1940-6207.CAPR-15-0400