Drug Standardization through Pharmacognostic Approaches and Estimation of Anticancer Potential of Chamomile ( Matricaria chamomilla L. ) using Prostate-Cancer cell lines: An In-vitro Study
Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. L., is one of the extensively used Unani medicament for the treatment of various t...
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| Published in: | Journal of Cancer Vol. 14; no. 3; pp. 490 - 504 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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01.01.2023
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| ISSN: | 1837-9664, 1837-9664 |
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| Abstract | Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers.
L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of
. Moreover, we analyzed the antioxidant and cytotoxic activity of
) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of
. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of
fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of
flowers could act as good source of natural anti-cancer compounds. |
|---|---|
| AbstractList | Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers.
L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of
. Moreover, we analyzed the antioxidant and cytotoxic activity of
) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of
. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of
fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of
flowers could act as good source of natural anti-cancer compounds. Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. Matricaria chamomilla L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. Moreover, we analyzed the antioxidant and cytotoxic activity of M. chamomilla (Gul-e Babuna) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of M. chamomilla fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of M. chamomilla flowers could act as good source of natural anti-cancer compounds.Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. Matricaria chamomilla L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. Moreover, we analyzed the antioxidant and cytotoxic activity of M. chamomilla (Gul-e Babuna) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of M. chamomilla fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of M. chamomilla flowers could act as good source of natural anti-cancer compounds. Cancer is the major challenge across world and the adenocarcinoma of prostate malignancy is the second most prevalent male cancer. Various medicinal plants are used for the treatment and management of various cancers. Matricaria chamomilla L., is one of the extensively used Unani medicament for the treatment of various type of diseases. In the current study we evaluated most of the parameters prescribed for drug standardization using pharmacognostic approaches. The 2,2 Diphenyl-1-picryl hydrazyl (DPPH) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. Moreover, we analyzed the antioxidant and cytotoxic activity of M. chamomilla (Gul-e Babuna) through in-vitro method. DPPH (2,2-diphenyl-1-picryl-hydrazl-hydrate) method was utilized for the analysis of antioxidant activity in the flower extracts of M. chamomilla. CFU and wound healing assay were performed to determine the anti-cancer activity. The results demonstrated that various extracts of M. chamomilla fulfilled most of the parameters of drug standardization and contained good antioxidant and anticancer activities. The ethyl acetate showed higher anticancer activity followed by aqueous, hydroalcoholic, petroleum benzene and methanol by CFU method. Also, the wound healing assay demonstrated that ethyl acetate extract has more significant effect followed by methanol and petroleum benzene extract on prostate cancer cell line (C4-2). The current study concluded that the extract of M. chamomilla flowers could act as good source of natural anti-cancer compounds. |
| Author | Kalam, Mohd Afsahul Butt, Tariq Ahmad Dar, Mohammad Yunis Masoodi, Khalid Z. Alam, Mohd Tauseef Showket, Wasia Wani, Shabir Hussain Khan, Shahanavaj Shilbayeh, Sireen Abdul Rahim Rudayni, Hassan Ahmed Binsaleh, Ammena Yahia El-Sheikh, Azza A. K. Haq, Syed Anam Ul Al-Zharani, Mohammed Dlamini, Zodwa Gani, Riehana Mushtaq, Waseem Chaudhary, Anis Ahmad Dar, Zahoor A. Rafiq, Nida Khan, Nida Akbar, Seema Rafeeqi, Towseef Amin Majeed, Uzma |
| AuthorAffiliation | 12 Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia 1 Department of Ilmul Advia (Pharmacology), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006 9 SMPU Unit RRIUM, Srinagar, University of Kashmir, J&K, India, 190006 2 Department of Moalajat (Medicine), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006 3 Transcriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025 6 Allelopathy Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, India 202002 17 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 11451 10 Division of Agricultural Statistics, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025 13 Basic Health Sciences Department, College of |
| AuthorAffiliation_xml | – name: 1 Department of Ilmul Advia (Pharmacology), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006 – name: 3 Transcriptomics Laboratory (K-Lab), Division of Plant Biotechnology, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025 – name: 10 Division of Agricultural Statistics, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Shalimar, Srinagar, J&K, India, 190025 – name: 12 Department of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia – name: 11 Department of Biology, College of Science, Al-Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia – name: 15 Department of Biotechnology, University of Kashmir, Srinagar, J&K, India, 190006 – name: 16 Department of Medical Lab Technology, Indian Institute of Health and Technology (IIHT), Deoband, Saharanpur, UP, India, 247554 – name: 14 SAMRC Precision Oncology Research Unit (PORU), DSI/NRF SARChI Chair in Precision Oncology and Cancer Prevention (POCP), Pan African Cancer Research Institute (PACRI), University of Pretoria, Hatfield 0028, South Africa – name: 2 Department of Moalajat (Medicine), RRIUM, University of Kashmir, Srinagar, J&K, India, 190006 – name: 5 Division of Forest Products & Utilization, Faculty of Forestry, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Benhama, Ganderbal, J&K, India 191202 – name: 7 Biochemistry and Pathology Lab, RRIUM, Srinagar, University of Kashmir, J&K, India, 190006 – name: 6 Allelopathy Laboratory, Department of Botany, Aligarh Muslim University, Aligarh, India 202002 – name: 17 Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia, 11451 – name: 8 Phytochemistry lab, RRIUM, Srinagar, University of Kashmir, J&K, India, 190006 – name: 4 Mountain Research Centre for Field Crops, Khudwani, Anantnag, 192101, Sher-e-Kashmir University of Agricultural Sciences and Technology of Kashmir, Srinagar, J&K, India, 192102 – name: 9 SMPU Unit RRIUM, Srinagar, University of Kashmir, J&K, India, 190006 – name: 13 Basic Health Sciences Department, College of Medicine, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia |
| Author_xml | – sequence: 1 givenname: Nida surname: Khan fullname: Khan, Nida – sequence: 2 givenname: Mohd Afsahul surname: Kalam fullname: Kalam, Mohd Afsahul – sequence: 3 givenname: Mohd Tauseef surname: Alam fullname: Alam, Mohd Tauseef – sequence: 4 givenname: Syed Anam Ul surname: Haq fullname: Haq, Syed Anam Ul – sequence: 5 givenname: Wasia surname: Showket fullname: Showket, Wasia – sequence: 6 givenname: Zahoor A. surname: Dar fullname: Dar, Zahoor A. – sequence: 7 givenname: Nida surname: Rafiq fullname: Rafiq, Nida – sequence: 8 givenname: Waseem surname: Mushtaq fullname: Mushtaq, Waseem – sequence: 9 givenname: Towseef Amin surname: Rafeeqi fullname: Rafeeqi, Towseef Amin – sequence: 10 givenname: Mohammad Yunis surname: Dar fullname: Dar, Mohammad Yunis – sequence: 11 givenname: Seema surname: Akbar fullname: Akbar, Seema – sequence: 12 givenname: Tariq Ahmad surname: Butt fullname: Butt, Tariq Ahmad – sequence: 13 givenname: Riehana surname: Gani fullname: Gani, Riehana – sequence: 14 givenname: Uzma surname: Majeed fullname: Majeed, Uzma – sequence: 15 givenname: Anis Ahmad surname: Chaudhary fullname: Chaudhary, Anis Ahmad – sequence: 16 givenname: Hassan Ahmed surname: Rudayni fullname: Rudayni, Hassan Ahmed – sequence: 17 givenname: Mohammed surname: Al-Zharani fullname: Al-Zharani, Mohammed – sequence: 18 givenname: Sireen Abdul Rahim surname: Shilbayeh fullname: Shilbayeh, Sireen Abdul Rahim – sequence: 19 givenname: Ammena Yahia surname: Binsaleh fullname: Binsaleh, Ammena Yahia – sequence: 20 givenname: Azza A. K. surname: El-Sheikh fullname: El-Sheikh, Azza A. K. – sequence: 21 givenname: Zodwa surname: Dlamini fullname: Dlamini, Zodwa – sequence: 22 givenname: Shabir Hussain surname: Wani fullname: Wani, Shabir Hussain – sequence: 23 givenname: Shahanavaj surname: Khan fullname: Khan, Shahanavaj – sequence: 24 givenname: Khalid Z. surname: Masoodi fullname: Masoodi, Khalid Z. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/36860921$$D View this record in MEDLINE/PubMed |
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| Keywords | CFU DPPH TLC Anti-cancer Antioxidant phytomedicine Gul-e-Babuna Prostate cancer Saraṭān |
| Language | English |
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| Title | Drug Standardization through Pharmacognostic Approaches and Estimation of Anticancer Potential of Chamomile ( Matricaria chamomilla L. ) using Prostate-Cancer cell lines: An In-vitro Study |
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