Diagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: A Meta-analysis
Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to c...
Uloženo v:
| Vydáno v: | Journal of molecular biomarkers & diagnosis Ročník 6; číslo 6 |
|---|---|
| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
01.11.2015
|
| Témata: | |
| ISSN: | 2155-9929 |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions. In this study we carried out a systematic electronic search on PubMed to retrieve all articles that have investigated circulating miRNAs for diagnosing obesity andT2DM in human. We also included lifestyle intervention studies known to be highly effective in delaying onset of diabetes, and studies analyzing the effect of bariatric surgery and anti-diabetic treatment. A total of 26 studies were enrolled in the global meta-analysis. Candidate miRNAs were defined as those reported in at least 2 studies with same direction of differential expression. Ten miRNAs altered in blood of patients suffering fromT2DM were identified (increased: miR-320a, miR-142-3p, miR-222, miR-29a, miR-27a, miR-375; decreased: miR-197, miR-20b, miR-17, miR-652) and 7 miRNAs in blood of obese subjects were identified (increased: miR-142-3p, miR-140-5p, miR-222; decreased:miR-21-5p, miR-221-3p, miR-125-5p, mir-103-5p). Both obese and T2DM patients had elevated concentrations of miR-142-3p and miR-222. MiRNAs target genes were predicted and their cellular functions are discussed in relation with the pathologies. Although a significant number of studies were taken into account in this review, we found a strong discrepancy between miRNA detection and quantification indicating that many of pre-analytical variables have yet to be normalized. Pre-analytical and analytical challenges are also discussed. |
|---|---|
| AbstractList | Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions. In this study we carried out a systematic electronic search on PubMed to retrieve all articles that have investigated circulating miRNAs for diagnosing obesity andT2DM in human. We also included lifestyle intervention studies known to be highly effective in delaying onset of diabetes, and studies analyzing the effect of bariatric surgery and anti-diabetic treatment. A total of 26 studies were enrolled in the global meta-analysis. Candidate miRNAs were defined as those reported in at least 2 studies with same direction of differential expression. Ten miRNAs altered in blood of patients suffering fromT2DM were identified (increased: miR-320a, miR-142-3p, miR-222, miR-29a, miR-27a, miR-375; decreased: miR-197, miR-20b, miR-17, miR-652) and 7 miRNAs in blood of obese subjects were identified (increased: miR-142-3p, miR-140-5p, miR-222; decreased:miR-21-5p, miR-221-3p, miR-125-5p, mir-103-5p). Both obese and T2DM patients had elevated concentrations of miR-142-3p and miR-222. MiRNAs target genes were predicted and their cellular functions are discussed in relation with the pathologies. Although a significant number of studies were taken into account in this review, we found a strong discrepancy between miRNA detection and quantification indicating that many of pre-analytical variables have yet to be normalized. Pre-analytical and analytical challenges are also discussed. Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions. In this study we carried out a systematic electronic search on PubMed to retrieve all articles that have investigated circulating miRNAs for diagnosing obesity andT2DM in human. We also included lifestyle intervention studies known to be highly effective in delaying onset of diabetes, and studies analyzing the effect of bariatric surgery and anti-diabetic treatment. A total of 26 studies were enrolled in the global meta-analysis. Candidate miRNAs were defined as those reported in at least 2 studies with same direction of differential expression. Ten miRNAs altered in blood of patients suffering fromT2DM were identified (increased: miR-320a, miR-142-3p, miR-222, miR-29a, miR-27a, miR-375; decreased: miR-197, miR-20b, miR-17, miR-652) and 7 miRNAs in blood of obese subjects were identified (increased: miR-142-3p, miR-140-5p, miR-222; decreased:miR-21-5p, miR-221-3p, miR-125-5p, mir-103-5p). Both obese and T2DM patients had elevated concentrations of miR-142-3p and miR-222. MiRNAs target genes were predicted and their cellular functions are discussed in relation with the pathologies. Although a significant number of studies were taken into account in this review, we found a strong discrepancy between miRNA detection and quantification indicating that many of pre-analytical variables have yet to be normalized. Pre-analytical and analytical challenges are also discussed.Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary lifestyles, the number of affected individuals is increasing at worrisome rates. While both environmental and genetic factors are known to contribute to the development of T2DM, continuous research is needed to identify specific biomarkers that could aid both in prevention of the disease and development of newer therapeutic options. Circulating miRNAs are considered as potential biomarkers because they are stable and resistant to degradation by blood RNAses and are modified under different pathophysiological conditions. In this study we carried out a systematic electronic search on PubMed to retrieve all articles that have investigated circulating miRNAs for diagnosing obesity andT2DM in human. We also included lifestyle intervention studies known to be highly effective in delaying onset of diabetes, and studies analyzing the effect of bariatric surgery and anti-diabetic treatment. A total of 26 studies were enrolled in the global meta-analysis. Candidate miRNAs were defined as those reported in at least 2 studies with same direction of differential expression. Ten miRNAs altered in blood of patients suffering fromT2DM were identified (increased: miR-320a, miR-142-3p, miR-222, miR-29a, miR-27a, miR-375; decreased: miR-197, miR-20b, miR-17, miR-652) and 7 miRNAs in blood of obese subjects were identified (increased: miR-142-3p, miR-140-5p, miR-222; decreased:miR-21-5p, miR-221-3p, miR-125-5p, mir-103-5p). Both obese and T2DM patients had elevated concentrations of miR-142-3p and miR-222. MiRNAs target genes were predicted and their cellular functions are discussed in relation with the pathologies. Although a significant number of studies were taken into account in this review, we found a strong discrepancy between miRNA detection and quantification indicating that many of pre-analytical variables have yet to be normalized. Pre-analytical and analytical challenges are also discussed. |
| Author | Villard, Audrey Marchand, Lucien Thivolet, Charles Rome, Sophie |
| Author_xml | – sequence: 1 givenname: Audrey surname: Villard fullname: Villard, Audrey organization: CarMen laboratory (UMR INSERM 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France – sequence: 2 givenname: Lucien surname: Marchand fullname: Marchand, Lucien organization: Hospices Civils de Lyon, Service d'Endocrinologie Diabète Nutrition, Lyon, France – sequence: 3 givenname: Charles surname: Thivolet fullname: Thivolet, Charles organization: CarMen laboratory (UMR INSERM 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France; Hospices Civils de Lyon, Service d'Endocrinologie Diabète Nutrition, Lyon, France – sequence: 4 givenname: Sophie surname: Rome fullname: Rome, Sophie organization: CarMen laboratory (UMR INSERM 1060, INRA 1397, INSA), University of Lyon, Faculty of Medicine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27308097$$D View this record in MEDLINE/PubMed |
| BookMark | eNo9kD1rwzAURTWkNGmaH9ClaOziVHq2LKubcT8haaCkXY0kPwWBY6eWPfjf19C004HD5cK9V2TWtA0ScsPZOuES7oELESkFas0ZYyD4jCz-3ZysQvCGgRQcZBxfkvkEljElF6R69PrQtKH3ln7pekDaOlpgXUeuQ6SF7-xQ6943B7r1tms_3vNAXdvRncHg-5HqpqL78YQU6FRlsMfwQHO6xV5HutH1GHy4JhdO1wFXZy7J5_PTvniNNruXtyLfRDaWkkcWROqAWwFxholUMk20cLEVMmHGQOUSngoVo9RZJYBx0JNVaJ00ymSoYUnufntPXfs9YOjLow92GqMbbIdQ8gxSyQCSdIrenqODOWJVnjp_1N1Y_j0DPwlZZMU |
| CitedBy_id | crossref_primary_10_1038_s41598_019_55076_z crossref_primary_10_1038_s41598_023_46516_y crossref_primary_10_1016_j_atherosclerosis_2020_02_004 crossref_primary_10_1186_s12933_018_0767_z crossref_primary_10_1371_journal_pone_0247556 crossref_primary_10_1093_cvr_cvy049 crossref_primary_10_1210_endocr_bqab241 crossref_primary_10_1155_2021_6626845 crossref_primary_10_1007_s11010_022_04362_y crossref_primary_10_3390_nu14224889 crossref_primary_10_1111_cob_12192 crossref_primary_10_1007_s00592_019_01430_6 crossref_primary_10_3389_fendo_2021_750261 crossref_primary_10_1007_s12291_022_01069_1 crossref_primary_10_1016_j_semcancer_2023_05_001 crossref_primary_10_1016_j_numecd_2017_10_015 crossref_primary_10_1038_s41598_025_04062_9 crossref_primary_10_3390_cells9061557 crossref_primary_10_1038_s41598_018_32274_9 crossref_primary_10_1002_mnfr_70027 crossref_primary_10_3390_cells10123331 crossref_primary_10_3390_ijms21103485 crossref_primary_10_1177_1535370217731291 crossref_primary_10_3390_cells9112489 crossref_primary_10_3390_ijms20235998 crossref_primary_10_3389_fphys_2018_00883 crossref_primary_10_4093_dmj_2022_0226 crossref_primary_10_1172_JCI129187 crossref_primary_10_3390_cancers15174317 crossref_primary_10_1002_oby_23330 crossref_primary_10_7717_peerj_19221 crossref_primary_10_3389_fgene_2020_563166 crossref_primary_10_3389_fgene_2021_620744 crossref_primary_10_3389_fendo_2022_917041 crossref_primary_10_3390_ijms21186902 crossref_primary_10_3389_fendo_2022_971354 crossref_primary_10_1139_cjpp_2016_0580 crossref_primary_10_3390_jcm12165265 crossref_primary_10_1007_s12013_020_00932_3 crossref_primary_10_3390_ijms24076186 crossref_primary_10_1080_07435800_2021_1914079 crossref_primary_10_2147_DMSO_S304055 crossref_primary_10_3389_fonc_2020_01567 crossref_primary_10_3390_diagnostics15020169 crossref_primary_10_1111_ijpo_12247 crossref_primary_10_3390_ijms231810635 crossref_primary_10_1111_cpr_12877 crossref_primary_10_1155_2016_1869082 crossref_primary_10_3390_jcm11185271 crossref_primary_10_1111_jcmm_14920 crossref_primary_10_3390_ijms20122922 crossref_primary_10_3390_ijms25094827 crossref_primary_10_1016_j_molmet_2017_08_007 crossref_primary_10_3390_pr10122551 crossref_primary_10_3390_ijms21249509 crossref_primary_10_1007_s13668_024_00549_5 crossref_primary_10_1111_jdi_14416 crossref_primary_10_33678_cor_2022_050 crossref_primary_10_3389_fgene_2020_00367 crossref_primary_10_3390_ijms22157855 crossref_primary_10_3390_ijms26136006 crossref_primary_10_1038_s41598_019_43793_4 crossref_primary_10_3390_cells11091553 crossref_primary_10_1016_j_yexcr_2017_03_060 crossref_primary_10_1371_journal_pone_0208131 crossref_primary_10_1016_j_genrep_2020_100954 crossref_primary_10_1016_j_jnutbio_2024_109714 crossref_primary_10_1210_endrev_bnac009 crossref_primary_10_3390_cimb46040212 crossref_primary_10_1016_j_gene_2019_05_012 crossref_primary_10_22270_jddt_v15i8_7336 crossref_primary_10_1111_jcmm_13885 crossref_primary_10_3390_ijms21072437 crossref_primary_10_1016_j_freeradbiomed_2021_05_004 crossref_primary_10_1016_j_crvi_2016_12_001 crossref_primary_10_1111_1753_0407_13431 crossref_primary_10_3390_biomedicines10061292 crossref_primary_10_1002_jcp_28649 |
| ContentType | Journal Article |
| DBID | NPM 7X8 |
| DOI | 10.4172/2155-9929.1000251 |
| DatabaseName | PubMed MEDLINE - Academic |
| DatabaseTitle | PubMed MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| ExternalDocumentID | 27308097 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIAID NIH HHS grantid: P01 AI042288 |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS KQ8 NPM 7X8 |
| ID | FETCH-LOGICAL-c3771-c256f21c5238e479764a5f3c5740bb2df416593e7a8d52012abb29ecf7b9b8ea2 |
| IEDL.DBID | 7X8 |
| ISSN | 2155-9929 |
| IngestDate | Fri Jul 11 08:44:27 EDT 2025 Sat Sep 18 05:37:59 EDT 2021 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | true |
| Issue | 6 |
| Keywords | Type 2 diabetes Obesity Circulating miRNAs Meta-analysis |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3771-c256f21c5238e479764a5f3c5740bb2df416593e7a8d52012abb29ecf7b9b8ea2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| OpenAccessLink | http://doi.org/10.4172/2155-9929.1000251 |
| PMID | 27308097 |
| PQID | 1826702246 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1826702246 pubmed_primary_27308097 |
| PublicationCentury | 2000 |
| PublicationDate | 2015-Nov |
| PublicationDateYYYYMMDD | 2015-11-01 |
| PublicationDate_xml | – month: 11 year: 2015 text: 2015-Nov |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Journal of molecular biomarkers & diagnosis |
| PublicationTitleAlternate | J Mol Biomark Diagn |
| PublicationYear | 2015 |
| References | 26233309 - Genes Nutr. 2015 Sep;10(5):483 22510765 - Nat Rev Genet. 2012 Apr 18;13(5):358-69 24361879 - Biochem Biophys Res Commun. 2014 Jan 17;443(3):980-6 20615901 - Nucleic Acids Res. 2010 Nov;38(20):7248-59 22265214 - Lancet Neurol. 2012 Feb;11(2):189-200 21609964 - Nucleic Acids Res. 2011 Sep 1;39(16):7223-33 19246379 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4402-7 22224773 - Annu Rev Immunol. 2012;30:295-312 25976503 - Tumour Biol. 2015 Sep;36(10):8065-73 19745058 - Clin Chem. 2009 Nov;55(11):1977-83 22155483 - Exp Neurol. 2012 Jun;235(2):491-6 22293113 - J Genet Genomics. 2012 Jan;39(1):11-8 24455723 - Biomed Res Int. 2013;2013:761617 22958478 - BMC Mol Biol. 2012 Sep 07;13:27 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 24037889 - J Clin Endocrinol Metab. 2013 Nov;98(11):E1835-44 24478399 - Diabetes Care. 2014;37(5):1375-83 23928666 - J Clin Endocrinol Metab. 2013 Oct;98(10):E1655-60 22652795 - Front Biosci (Landmark Ed). 2012 Jun 01;17:2508-40 22158052 - Cancer Prev Res (Phila). 2012 Mar;5(3):492-7 23635652 - Mol Cancer Ther. 2013 Jul;12(7):1266-75 23834149 - Curr Drug Targets. 2013 Sep;14(10):1110-7 21829658 - PLoS One. 2011;6(8):e22839 24927146 - Int J Mol Sci. 2014 Jun 12;15(6):10567-77 16969338 - Mol Syst Biol. 2006;2:46 25677225 - Diabetologia. 2015 May;58(5):900-11 18773077 - PLoS One. 2008 Sep 05;3(9):e3148 23150891 - Eur J Prev Cardiol. 2014 Apr;21(4):484-91 26271186 - Anal Biochem. 2015 Nov 1;488:28-35 25726255 - Metabolism. 2015 Apr;64(4):489-97 24955210 - Oxid Med Cell Longev. 2014;2014:729194 20651284 - Circ Res. 2010 Sep 17;107(6):810-7 21887347 - PLoS One. 2011;6(8):e23925 24937531 - J Clin Endocrinol Metab. 2014 Sep;99(9):E1681-5 14744438 - Cell. 2004 Jan 23;116(2):281-97 19800254 - Trends Endocrinol Metab. 2009 Nov;20(9):452-9 25532038 - J Clin Endocrinol Metab. 2015 Mar;100(3):E407-15 26136647 - Front Neurosci. 2015 Jun 16;9:204 17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9 25597340 - Eur J Neurol. 2015 Nov;22(11):1419-20 26116273 - Mol Aspects Med. 2015 Jun-Oct;43-44:66-76 22859996 - PLoS One. 2012;7(7):e41561 24363306 - Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H557-63 24385703 - Chin J Cancer Res. 2013 Dec;25(6):743-8 25923429 - PLoS One. 2015 Apr 29;10(4):e0122991 18318758 - Br J Haematol. 2008 May;141(5):672-5 18766170 - Cell Res. 2008 Oct;18(10):997-1006 23680784 - Nucleic Acids Res. 2013 Jul;41(Web Server issue):W169-73 23472110 - PLoS One. 2013;8(3):e57841 24436293 - J Appl Physiol (1985). 2014 Mar 1;116(5):522-31 26020947 - PLoS One. 2015 May 28;10(5):e0128372 20587728 - Diabetes Care. 2010 Jul;33(7):1674-85 24023848 - PLoS One. 2013 Sep 02;8(9):e73272 21367929 - J Clin Endocrinol Metab. 2011 May;96(5):E846-50 25977294 - Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6 23032062 - J Clin Endocrinol Metab. 2012 Dec;97(12):E2271-6 23036329 - Methods. 2013 Jan;59(1):S1-6 20370587 - Expert Rev Mol Diagn. 2010 Apr;10(3):297-308 24497980 - PLoS One. 2014 Jan 30;9(1):e86792 22064828 - Aging (Albany NY). 2011 Oct;3(10):985-1002 16337999 - Cell. 2005 Dec 16;123(6):1133-46 24586621 - PLoS One. 2014 Feb 19;9(2):e89237 21423178 - Nat Cell Biol. 2011 Apr;13(4):423-33 23317344 - Ann N Y Acad Sci. 2013 Apr;1281:51-63 26182553 - Nurs Times. 2015 Mar 18-24;111(12 ):17-9 25150024 - Mutagenesis. 2014 Sep;29(5):385-91 20857148 - Acta Diabetol. 2011 Mar;48(1):61-9 24498934 - Cardiovasc Diabetol. 2014 Feb 05;13:37 25815110 - Oxid Med Cell Longev. 2015;2015:985845 23716129 - J Cardiovasc Transl Res. 2013 Aug;6(4):458-70 23396142 - Clin Chem. 2013 May;59(5):781-92 24376572 - PLoS One. 2013 Dec 23;8(12):e82753 23619912 - J Mol Med (Berl). 2013 Aug;91(8):989-1000 26131326 - World J Diabetes. 2015 Jun 25;6(6):850-67 20847327 - Clin Chem. 2010 Nov;56(11):1733-41 25861754 - Tumour Biol. 2015 Sep;36(9):6985-90 24073250 - PLoS One. 2013 Sep 20;8(9):e75184 25515554 - Eur J Endocrinol. 2015 Mar;172(3):291-300 21383194 - Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8 25331995 - Sheng Li Xue Bao. 2014 Oct 25;66(5):497-510 23755214 - PLoS One. 2013 Jun 05;8(6):e65300 24093444 - J Biomed Sci. 2013 Oct 04;20:72 23358195 - Toxicol Sci. 2013 Apr;132(2):478-92 21909417 - PLoS One. 2011;6(9):e24145 25995320 - Circulation. 2015 Jun 23;131(25):2202-16 24803022 - Cell Physiol Biochem. 2014;33(5):1329-39 26084689 - Physiol Rev. 2015 Jul;95(3):727-48 21690193 - J Physiol. 2011 Aug 15;589(Pt 16):3983-94 26063956 - Dis Markers. 2015;2015:435656 22849433 - BMC Genomics. 2012 Aug 01;13:357 23923026 - PLoS One. 2013 Jul 29;8(7):e70823 21057646 - Commun Integr Biol. 2010 Sep;3(5):478-81 24204780 - PLoS One. 2013 Oct 15;8(10):e77251 21525457 - Diabetes Care. 2011 May;34 Suppl 2:S210-4 19996457 - Sci Signal. 2009 Dec 08;2(100):ra81 22783422 - Oncol Lett. 2012 Jun;3(6):1221-1226 |
| References_xml | – reference: 19745058 - Clin Chem. 2009 Nov;55(11):1977-83 – reference: 24363306 - Am J Physiol Heart Circ Physiol. 2014 Feb 15;306(4):H557-63 – reference: 20615901 - Nucleic Acids Res. 2010 Nov;38(20):7248-59 – reference: 24436293 - J Appl Physiol (1985). 2014 Mar 1;116(5):522-31 – reference: 22155483 - Exp Neurol. 2012 Jun;235(2):491-6 – reference: 16969338 - Mol Syst Biol. 2006;2:46 – reference: 24955210 - Oxid Med Cell Longev. 2014;2014:729194 – reference: 26116273 - Mol Aspects Med. 2015 Jun-Oct;43-44:66-76 – reference: 26020947 - PLoS One. 2015 May 28;10(5):e0128372 – reference: 24803022 - Cell Physiol Biochem. 2014;33(5):1329-39 – reference: 23635652 - Mol Cancer Ther. 2013 Jul;12(7):1266-75 – reference: 26271186 - Anal Biochem. 2015 Nov 1;488:28-35 – reference: 24455723 - Biomed Res Int. 2013;2013:761617 – reference: 24586621 - PLoS One. 2014 Feb 19;9(2):e89237 – reference: 23834149 - Curr Drug Targets. 2013 Sep;14(10):1110-7 – reference: 21525457 - Diabetes Care. 2011 May;34 Suppl 2:S210-4 – reference: 26233309 - Genes Nutr. 2015 Sep;10(5):483 – reference: 20651284 - Circ Res. 2010 Sep 17;107(6):810-7 – reference: 25726255 - Metabolism. 2015 Apr;64(4):489-97 – reference: 22783422 - Oncol Lett. 2012 Jun;3(6):1221-1226 – reference: 23150891 - Eur J Prev Cardiol. 2014 Apr;21(4):484-91 – reference: 23317344 - Ann N Y Acad Sci. 2013 Apr;1281:51-63 – reference: 23619912 - J Mol Med (Berl). 2013 Aug;91(8):989-1000 – reference: 22224773 - Annu Rev Immunol. 2012;30:295-312 – reference: 21609964 - Nucleic Acids Res. 2011 Sep 1;39(16):7223-33 – reference: 24093444 - J Biomed Sci. 2013 Oct 04;20:72 – reference: 23680784 - Nucleic Acids Res. 2013 Jul;41(Web Server issue):W169-73 – reference: 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 – reference: 25532038 - J Clin Endocrinol Metab. 2015 Mar;100(3):E407-15 – reference: 23928666 - J Clin Endocrinol Metab. 2013 Oct;98(10):E1655-60 – reference: 20857148 - Acta Diabetol. 2011 Mar;48(1):61-9 – reference: 21909417 - PLoS One. 2011;6(9):e24145 – reference: 22064828 - Aging (Albany NY). 2011 Oct;3(10):985-1002 – reference: 20847327 - Clin Chem. 2010 Nov;56(11):1733-41 – reference: 16337999 - Cell. 2005 Dec 16;123(6):1133-46 – reference: 23032062 - J Clin Endocrinol Metab. 2012 Dec;97(12):E2271-6 – reference: 21383194 - Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5003-8 – reference: 21367929 - J Clin Endocrinol Metab. 2011 May;96(5):E846-50 – reference: 22859996 - PLoS One. 2012;7(7):e41561 – reference: 24937531 - J Clin Endocrinol Metab. 2014 Sep;99(9):E1681-5 – reference: 22265214 - Lancet Neurol. 2012 Feb;11(2):189-200 – reference: 22652795 - Front Biosci (Landmark Ed). 2012 Jun 01;17:2508-40 – reference: 24497980 - PLoS One. 2014 Jan 30;9(1):e86792 – reference: 21057646 - Commun Integr Biol. 2010 Sep;3(5):478-81 – reference: 25976503 - Tumour Biol. 2015 Sep;36(10):8065-73 – reference: 19800254 - Trends Endocrinol Metab. 2009 Nov;20(9):452-9 – reference: 22293113 - J Genet Genomics. 2012 Jan;39(1):11-8 – reference: 18766170 - Cell Res. 2008 Oct;18(10):997-1006 – reference: 26131326 - World J Diabetes. 2015 Jun 25;6(6):850-67 – reference: 24204780 - PLoS One. 2013 Oct 15;8(10):e77251 – reference: 25977294 - Nucleic Acids Res. 2015 Jul 1;43(W1):W460-6 – reference: 24023848 - PLoS One. 2013 Sep 02;8(9):e73272 – reference: 22158052 - Cancer Prev Res (Phila). 2012 Mar;5(3):492-7 – reference: 24498934 - Cardiovasc Diabetol. 2014 Feb 05;13:37 – reference: 21423178 - Nat Cell Biol. 2011 Apr;13(4):423-33 – reference: 18773077 - PLoS One. 2008 Sep 05;3(9):e3148 – reference: 20370587 - Expert Rev Mol Diagn. 2010 Apr;10(3):297-308 – reference: 24361879 - Biochem Biophys Res Commun. 2014 Jan 17;443(3):980-6 – reference: 25597340 - Eur J Neurol. 2015 Nov;22(11):1419-20 – reference: 26136647 - Front Neurosci. 2015 Jun 16;9:204 – reference: 25861754 - Tumour Biol. 2015 Sep;36(9):6985-90 – reference: 24073250 - PLoS One. 2013 Sep 20;8(9):e75184 – reference: 22849433 - BMC Genomics. 2012 Aug 01;13:357 – reference: 18318758 - Br J Haematol. 2008 May;141(5):672-5 – reference: 26182553 - Nurs Times. 2015 Mar 18-24;111(12 ):17-9 – reference: 19246379 - Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4402-7 – reference: 24037889 - J Clin Endocrinol Metab. 2013 Nov;98(11):E1835-44 – reference: 23923026 - PLoS One. 2013 Jul 29;8(7):e70823 – reference: 24478399 - Diabetes Care. 2014;37(5):1375-83 – reference: 23396142 - Clin Chem. 2013 May;59(5):781-92 – reference: 23755214 - PLoS One. 2013 Jun 05;8(6):e65300 – reference: 26063956 - Dis Markers. 2015;2015:435656 – reference: 26084689 - Physiol Rev. 2015 Jul;95(3):727-48 – reference: 20587728 - Diabetes Care. 2010 Jul;33(7):1674-85 – reference: 21829658 - PLoS One. 2011;6(8):e22839 – reference: 25995320 - Circulation. 2015 Jun 23;131(25):2202-16 – reference: 14744438 - Cell. 2004 Jan 23;116(2):281-97 – reference: 21887347 - PLoS One. 2011;6(8):e23925 – reference: 23358195 - Toxicol Sci. 2013 Apr;132(2):478-92 – reference: 17486113 - Nat Cell Biol. 2007 Jun;9(6):654-9 – reference: 19996457 - Sci Signal. 2009 Dec 08;2(100):ra81 – reference: 25923429 - PLoS One. 2015 Apr 29;10(4):e0122991 – reference: 23472110 - PLoS One. 2013;8(3):e57841 – reference: 24385703 - Chin J Cancer Res. 2013 Dec;25(6):743-8 – reference: 25815110 - Oxid Med Cell Longev. 2015;2015:985845 – reference: 23716129 - J Cardiovasc Transl Res. 2013 Aug;6(4):458-70 – reference: 22510765 - Nat Rev Genet. 2012 Apr 18;13(5):358-69 – reference: 25677225 - Diabetologia. 2015 May;58(5):900-11 – reference: 24376572 - PLoS One. 2013 Dec 23;8(12):e82753 – reference: 25331995 - Sheng Li Xue Bao. 2014 Oct 25;66(5):497-510 – reference: 24927146 - Int J Mol Sci. 2014 Jun 12;15(6):10567-77 – reference: 25515554 - Eur J Endocrinol. 2015 Mar;172(3):291-300 – reference: 22958478 - BMC Mol Biol. 2012 Sep 07;13:27 – reference: 21690193 - J Physiol. 2011 Aug 15;589(Pt 16):3983-94 – reference: 23036329 - Methods. 2013 Jan;59(1):S1-6 – reference: 25150024 - Mutagenesis. 2014 Sep;29(5):385-91 |
| SSID | ssib027512733 ssib005568854 |
| Score | 1.9276683 |
| Snippet | Type 2 diabetes mellitus (T2DM) is the most common metabolic disorder worldwide. Because of population aging and increasing trends toward obesity and sedentary... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| Title | Diagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: A Meta-analysis |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27308097 https://www.proquest.com/docview/1826702246 |
| Volume | 6 |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpZ1LSwMxEMeDWg9efOCrvhjBa2ib3W02XqRUi5cuRVR6K3mKUHZrt_XzO9lNrRdB8LKHWRZCMpv5JZnMn5AbZ7VTSmoqmNE05qpLFTOStgWTXaP927gSm-BZlo7HYhQ23MqQVrmaE6uJ2hTa75G3PAfzqvzZ3eyDetUof7oaJDQ2SSNClPFezcc_ylMl3TRdh0vGMbrxSl0eA11CBaJBfdAZYxhvfdt85oBH79-hswo-g73_Nnuf7AbshF7tJwdkw-aHxNzXeXZog1c5XVooHPTtdErd3Frov891Je6Vv8HQ5-09Zb0SEHIhqAmAzA34hSwwCJk15S30YGgXkspQ7eSIvAwenvuPNKguUB1x3qEaIcixjsYVampjjrgSy8RFOuFxW-E4OkS4RESWy9QkiA9MolXgoHIlVGolOyZbeZHbUwIiwhlBWt1WzsQdrQTXQkbOpCwyyBGqSa5XnTZBr_ZHFTK3xbKcrLutSU7qnp_M6vIbExxCxFzBz_7w9TnZwSYm9eXBC9Jw-E_bS7KtPxfv5fyqchd8ZqPhF9IMyAc |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Diagnostic+Value+of+Cell-free+Circulating+MicroRNAs+for+Obesity+and+Type+2+Diabetes%3A+A+Meta-analysis&rft.jtitle=Journal+of+molecular+biomarkers+%26+diagnosis&rft.au=Villard%2C+Audrey&rft.au=Marchand%2C+Lucien&rft.au=Thivolet%2C+Charles&rft.au=Rome%2C+Sophie&rft.date=2015-11-01&rft.issn=2155-9929&rft.volume=6&rft.issue=6&rft_id=info:doi/10.4172%2F2155-9929.1000251&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2155-9929&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2155-9929&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2155-9929&client=summon |