13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion

Naïve T cells remain in an actively maintained state of quiescence until activation by antigenic signals, upon which they start to proliferate and generate effector cells to initiate a functional immune response. Metabolic reprogramming is essential to meet the biosynthetic demands of the differenti...

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Bibliographic Details

Published in:	Frontiers in immunology Vol. 14; p. 1267816
Main Authors:	Kirchmair, Alexander, Nemati, Niloofar, Lamberti, Giorgia, Trefny, Marcel, Krogsdam, Anne, Siller, Anita, Hörtnagl, Paul, Schumacher, Petra, Sopper, Sieghart, Sandbichler, Adolf, Zippelius, Alfred, Ghesquière, Bart, Trajanoski, Zlatko
Format:	Journal Article
Language:	English
Published:	Frontiers Media S.A 19.10.2023
Subjects:	13C tracer analysis differentiation exhaustion Immunology immunometabolism RNA sequencing stem cell memory cells
ISSN:	1664-3224, 1664-3224
Online Access:	Get full text
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