Inflammatory bowel disease in Turkish children

Background This study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey. Methods We analyzed the medical records of 127 children diagnosed with IBD (under 18 years old) between January 2004 a...

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Vydáno v:World journal of pediatrics : WJP Ročník 11; číslo 4; s. 331 - 337
Hlavní autoři: Cakir, Murat, Unal, Fatih, Dinler, Gonul, Baran, Masallah, Yuksekkaya, Hasan Ali, Tumgor, Gokhan, Kasirga, Erhun, Kalayci, Ayhan Gazi, Aydogdu, Sema
Médium: Journal Article
Jazyk:angličtina
Vydáno: Hangzhou Childrens Hospital, Zhejiang University School of Medicine 01.11.2015
Témata:
Adolescent
Biopsy
Child
Child, Preschool
Colonoscopy
Critical Care Medicine
Female
Humans
Imaging
Infant
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - diagnosis
Inflammatory Bowel Diseases - epidemiology
Inflammatory Bowel Diseases - therapy
Intensive
Male
Maternal and Child Health
Medicine
Medicine & Public Health
Original Article
Pediatric Surgery
Pediatrics
Radiology
Retrospective Studies
Surgery
Turkey - epidemiology
Turkey
ulcerative colitis
associated diseases
inflammatory bowel disease
outcome
Crohn’s disease
Crohn's disease
infl ammatory bowel disease
ISSN:1708-8569, 1867-0687
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Shrnutí:Background This study was undertaken to evaluate demographics, clinical manifestations, laboratory findings and outcomes of children with inflammatory bowel disease (IBD) in Turkey. Methods We analyzed the medical records of 127 children diagnosed with IBD (under 18 years old) between January 2004 and January 2012 in 8 pediatric gastroenterology centers. Results Of the 127 patients, 90 (70.9%) suffered from ulcerative colitis (UC), 29 (22.8%) from Crohn’s disease (CD), and 8 (6.3%) from IBD unclassified. The mean age of the 127 patients was 11.6±4.1 years, and 11.8% of the patients were below 5 years old. Of the patients, 49.6% were male, and males were more predominant in patients with CD than in those with UC (72.4% vs . 42.2%, P =0.008; a male/female ratio of 2.62 in CD, P =0.0016). Approximately one fifth of the patients had extra-intestinal manifestations and 13.3% of the patients had associated diseases. Extraintestinal manifestations and associated diseases were more common in early onset disease [ P =0.017, odds ratio (OR)=4.02; P =0.03, OR=4.1]. Of the patients, 15% had normal laboratory parameters including anemia, high platelet count, hypoalbuminemia, hypoferritinemia, and high sedimentation rate. Area under receiver operation characteristics was used to predict pancolitis in patients with UC. The values of C-reactive protein, sedimentation rate and pediatric ulcerative colitis activity were 0.61 ( P =0.06), 0.66 ( P =0.01) and 0.76 ( P =0.0001), respectively. Four (4.4%) patients with UC underwent colectomy, and finally two (1.5%, 95% confidence interval: 0-3.7%) patients died from primary disease or complications. Conclusions IBD is an increasing clinical entity in Turkey. Features of IBD are similar to those in other populations, but prospective multicenter studies are needed to analyze the true incidence of IBD in Turkish children.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1708-8569
1867-0687
DOI:10.1007/s12519-015-0042-2