The COVID-19 Pandemic Affects Seasonality, With Increasing Cases of New-Onset Type 1 Diabetes in Children, From the Worldwide SWEET Registry

To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally. We analyzed data on 17,280 cases of T1D diagnosed during 2018-2021 from 92 worldwide centers part...

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Vydané v:Diabetes care Ročník 45; číslo 11; s. 2594
Hlavní autori: Reschke, Felix, Lanzinger, Stefanie, Herczeg, Vivien, Prahalad, Priya, Schiaffini, Riccardo, Mul, Dick, Clapin, Helen, Zabeen, Bedowra, Pelicand, Julie, Phillip, Moshe, Limbert, Catarina, Danne, Thomas
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: United States 01.11.2022
Predmet:
Adolescent
Child
Communicable Disease Control
COVID-19
Diabetes Mellitus, Type 1 - epidemiology
Glycated Hemoglobin
Humans
Pandemics
Registries
ISSN:1935-5548, 1935-5548
On-line prístup:Zistit podrobnosti o prístupe
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Shrnutí:To analyze whether the coronavirus disease 2019 (COVID-19) pandemic increased the number of cases or impacted seasonality of new-onset type 1 diabetes (T1D) in large pediatric diabetes centers globally. We analyzed data on 17,280 cases of T1D diagnosed during 2018-2021 from 92 worldwide centers participating in the SWEET registry using hierarchic linear regression models. The average number of new-onset T1D cases per center adjusted for the total number of patients treated at the center per year and stratified by age-groups increased from 11.2 (95% CI 10.1-12.2) in 2018 to 21.7 (20.6-22.8) in 2021 for the youngest age-group, <6 years; from 13.1 (12.2-14.0) in 2018 to 26.7 (25.7-27.7) in 2021 for children ages 6 to <12 years; and from 12.2 (11.5-12.9) to 24.7 (24.0-25.5) for adolescents ages 12-18 years (all P < 0.001). These increases remained within the expected increase with the 95% CI of the regression line. However, in Europe and North America following the lockdown early in 2020, the typical seasonality of more cases during winter season was delayed, with a peak during the summer and autumn months. While the seasonal pattern in Europe returned to prepandemic times in 2021, this was not the case in North America. Compared with 2018-2019 (HbA1c 7.7%), higher average HbA1c levels (2020, 8.1%; 2021, 8.6%; P < 0.001) were present within the first year of T1D during the pandemic. The slope of the rise in pediatric new-onset T1D in SWEET centers remained unchanged during the COVID-19 pandemic, but a change in the seasonality at onset became apparent.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1935-5548
1935-5548
DOI:10.2337/dc22-0278