A phenotype for the α7 nicotinic acetylcholine receptor null mutant
The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we r...
Gespeichert in:
| Veröffentlicht in: | Brain research Jg. 1023; H. 1; S. 41 - 47 |
|---|---|
| Hauptverfasser: | , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Elsevier B.V
01.10.2004
Amsterdam Elsevier New York, NY |
| Schlagworte: | |
| ISSN: | 0006-8993, 1872-6240 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin. |
|---|---|
| AbstractList | The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of functions, but it is not known if these molecular events translate into phenotypes. The null mutant mouse is viable and generally normal. Here, we report a phenotype for the α7 nAChR null mutant mouse. The α7 nAChR is obligatory for the synchronization of an important biological rhythm, the female estrous cycle. The female null mutant mouse has asynchronous estrous cycles and a reduced number of surviving pups. Female null mutants also demonstrate a reliable diversity in phenotype, suggesting an interaction between environment and gene expression. Real-time RT-PCR measurements of the α7 mRNA expression in reproductive tissues of wild-type mice suggest that the ovulatory dysfunction in null mutants is probably central in origin. |
| Author | Rodriguez-Sierra, Jorge F. Morley, Barbara J. |
| Author_xml | – sequence: 1 givenname: Barbara J. surname: Morley fullname: Morley, Barbara J. email: morley@boystown.org organization: Boys Town National Research Hospital, 555 North 30th St., Omaha, NE 68131, United States – sequence: 2 givenname: Jorge F. surname: Rodriguez-Sierra fullname: Rodriguez-Sierra, Jorge F. organization: University of Nebraska Medical Center, 98-6395 Nebraska Medical Center, Omaha, NE 68198-6395, United States |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16111627$$DView record in Pascal Francis |
| BookMark | eNqNkc9KAzEQxoNUsK2-guTicddkd5vdBRFL_QsFL3oO2eyEpqbZJYnCPpYv4jOZUvXQS73MMMP3fQO_maCR7SwgdE5JSglll-u0cUJbBz7NCClSUqaEsCM0plWZJSwryAiNSVwlVV3nJ2ji_TqOeV6TMbqd434FtgtDD1h1DocV4K_PElstu6BjxUJCGIxcdUZbwA4k9CEK7bsxePMehA2n6FgJ4-Hsp0_R6_3dy-IxWT4_PC3my0TmJQsJnbFZXQNrQdUqKwrVEqKqso0bJqFkolC5bKSq2wYqBUXUNCyroSlEQSvZ5lN0scvthZfCKCes1J73Tm-EGzhllFKWlVF3tdNJ13nvQHGpgwi6syGSMpwSviXH1_yXHN-S46TkEVO0sz3734VDxpudESKEDw2Oe6nBSmh1xBZ42-nDEdd7EdJsvyDMGwz_CfgGxdOmew |
| CODEN | BRREAP |
| CitedBy_id | crossref_primary_10_1111_j_1460_9568_2009_06919_x crossref_primary_10_1292_jvms_14_0350 crossref_primary_10_1007_s12576_016_0464_1 crossref_primary_10_1186_1471_2164_6_157 crossref_primary_10_2515_therapie_2008041 crossref_primary_10_1016_j_bcp_2007_06_010 crossref_primary_10_1016_j_neuropharm_2007_08_017 crossref_primary_10_1095_biolreprod_105_042184 crossref_primary_10_1016_j_biopsych_2006_02_024 crossref_primary_10_1002_mrd_20336 crossref_primary_10_1016_j_neuroscience_2006_12_036 crossref_primary_10_1113_jphysiol_2014_272054 |
| Cites_doi | 10.1016/0169-328X(96)00027-7 10.1095/biolreprod42.4.649 10.1016/S0306-4522(97)80196-0 10.1083/jcb.200206096 10.1530/jrf.0.0940261 10.1016/S0306-4522(02)00160-4 10.1016/0306-4522(83)90275-0 10.1101/lm.5.4.302 10.1016/S0166-4328(00)00195-9 10.1523/JNEUROSCI.20-17-06431.2000 10.1523/JNEUROSCI.22-12-05001.2002 10.1152/jn.2001.86.6.3043 10.1016/0006-8993(77)90935-0 10.1523/JNEUROSCI.19-10-03701.1999 10.1152/jn.00316.2001 10.1002/cne.901980405 10.1095/biolreprod19.4.807 10.1073/pnas.0308058101 10.1016/0006-8993(83)90250-0 10.1113/jphysiol.2001.013847 10.2527/jas1989.6771824x 10.1016/0006-8993(84)90736-4 10.1016/0361-9230(86)90139-5 10.1523/JNEUROSCI.17-23-09165.1997 10.1016/0006-8993(86)90030-2 10.1016/0006-8993(78)90025-2 10.1016/0361-9230(89)90072-5 10.1016/S0166-4328(00)00208-4 10.1007/BF00225412 10.1074/jbc.272.38.24024 10.1046/j.0022-3042.2002.00805.x |
| ContentType | Journal Article |
| Copyright | 2004 Elsevier B.V. 2004 INIST-CNRS |
| Copyright_xml | – notice: 2004 Elsevier B.V. – notice: 2004 INIST-CNRS |
| DBID | AAYXX CITATION IQODW |
| DOI | 10.1016/j.brainres.2004.07.006 |
| DatabaseName | CrossRef Pascal-Francis |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology |
| EISSN | 1872-6240 |
| EndPage | 47 |
| ExternalDocumentID | 16111627 10_1016_j_brainres_2004_07_006 S0006899304010984 |
| GroupedDBID | --- --K --M -DZ -~X .1- .55 .FO .GJ .~1 0R~ 1B1 1P~ 1RT 1~. 1~5 23N 4.4 41~ 457 4G. 53G 5GY 5RE 5VS 6J9 7-5 71M 8P~ 9JM AABNK AAEDT AAEDW AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AATTM AAXKI AAXLA AAXUO AAYJJ AAYWO ABCQJ ABFNM ABFRF ABIVO ABJNI ABLJU ABMAC ABTEW ABUFD ABWVN ABXDB ACDAQ ACGFO ACGFS ACIUM ACLOT ACNCT ACRLP ACRPL ACVFH ADBBV ADCNI ADEZE ADIYS ADMUD ADNMO AEBSH AEFWE AEIPS AEKER AENEX AEUPX AEVXI AFJKZ AFPUW AFRHN AFTJW AFXIZ AGHFR AGQPQ AGUBO AGWIK AGYEJ AHHHB AI. AIEXJ AIGII AIIUN AIKHN AITUG AJUYK AKBMS AKRWK AKYEP ALMA_UNASSIGNED_HOLDINGS AMRAJ ANKPU APXCP ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC CS3 DU5 EBS EFJIC EFKBS EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HMQ HVGLF HZ~ IHE J1W K-O KOM L7B M2V M41 MO0 MOBAO MVM N9A O-L O9- OAUVE OP~ OZT P-8 P-9 P2P PC. Q38 R2- ROL RPZ SCC SDF SDG SES SEW SNS SPCBC SSN SSZ T5K VH1 WUQ X7M XPP Z5R ZGI ~G- ~HD AACTN AADPK AAIAV ABYKQ AFCTW AFKWA AFMIJ AHPSJ AJBFU AJOXV AMFUW RIG 9DU AAYXX CITATION IQODW |
| ID | FETCH-LOGICAL-c376t-156599e6def9f244fd00f87de6d6ce76a4f3cbcf9dbe8fe4f24b629eb4a418cd3 |
| ISSN | 0006-8993 |
| IngestDate | Mon Nov 03 04:57:17 EST 2025 Sat Nov 29 01:56:16 EST 2025 Tue Nov 18 22:35:32 EST 2025 Fri Feb 23 02:36:13 EST 2024 Tue Oct 14 19:36:59 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Endocrine Phenotype Mouse Neurotransmitters, modulators, transporters, receptors α7 Nicotinic acetylcholine receptor Vertebrata Mammalia Rodentia α7 nicotinic receptor Neurotransmitter Acetylcholine Mutation |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 CC BY 4.0 |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c376t-156599e6def9f244fd00f87de6d6ce76a4f3cbcf9dbe8fe4f24b629eb4a418cd3 |
| PageCount | 7 |
| ParticipantIDs | pascalfrancis_primary_16111627 crossref_citationtrail_10_1016_j_brainres_2004_07_006 crossref_primary_10_1016_j_brainres_2004_07_006 elsevier_sciencedirect_doi_10_1016_j_brainres_2004_07_006 elsevier_clinicalkey_doi_10_1016_j_brainres_2004_07_006 |
| PublicationCentury | 2000 |
| PublicationDate | 2004-10 |
| PublicationDateYYYYMMDD | 2004-10-01 |
| PublicationDate_xml | – month: 10 year: 2004 text: 2004-10 |
| PublicationDecade | 2000 |
| PublicationPlace | London Amsterdam New York, NY |
| PublicationPlace_xml | – name: Amsterdam – name: London – name: New York, NY |
| PublicationTitle | Brain research |
| PublicationYear | 2004 |
| Publisher | Elsevier B.V Elsevier |
| Publisher_xml | – name: Elsevier B.V – name: Elsevier |
| References | Hunt, Schmidt (bib12) 1985; 157 Khiroug, Harkness, Lamb, Sudweeks, Khiroug, Millar, Yakel (bib13) 2002; 540 Holinka, Tseng, Finch (bib11) 1978; 19 Levy, Aoki (bib14) 2002; 22 vom Saal (bib31) 1989; 67 Miller, Silver, Billiar (bib18) 1984; 290 Papka, Cotton, Traurig (bib25) 1985; 242 Marchi, Risso, Viola, Cavazzani, Raiteri (bib15) 2002; 80 Pauly, Stitzel, Marks, Collins (bib26) 1989; 22 Alkondon, Albuquerque (bib2) 2001; 86 Buhler, Dunwiddie (bib6) 2001; 87 Miller, Billiar (bib17) 1986; 16 Arredondo, Nguyen, Chernyavsky, Bercovich, Orr-Urtreger, Kummer, Lips, Vetter, Grando (bib5) 2002; 159 Nelson, Karelus, Felicio, Johnson (bib22) 1990; 42 Arimatsu (bib3) 1983; 9 Franceschini, Orr-Urtreger, Yu, Mackey, Bond, Armstrong, Patrick, Beaudet, De Biasi (bib10) 2000; 113 Paylor, Nguyen, Crawley, Patrick, Beaudet, Orr-Urtreger (bib27) 1998; 5 Ross, Wong, Clifford, Kinsella, Massalas, Horne, Scheffer, Kola, Waddington, Berkovic, Drago (bib28) 2000; 20 Albuquerque, Pereira, Mike, Eisenberg, Maelicke, Alkondon (bib1) 2000; 113 Egozi, Kloog, Sokolovsky (bib9) 1986; 383 Mitsushima, Shwe, Funabashi, Shinohara, Kimura (bib19) 2002; 113 Chen, Patrick (bib8) 1997; 272 Orr-Urtreger, Goldner, Saeki, Lorenzo, Goldberg, Dani, Patrick, Beaudet (bib24) 1997; 17 Marks, Pauly, Grun, Collins (bib16) 1996; 39 Chang, Berg (bib7) 1999; 19 Schafer, Eiden, Weihe (bib29) 1998; 84 Morley, Lorden, Bradley, Brown, Kemp (bib20) 1977; 134 Arimatsu, Seto, Amano (bib4) 1981; 198 Morley, Rodriguez-Sierra, Clough (bib21) 1983; 278 Nelson, Karelus, Felicio, Johnson (bib23) 1992; 94 Sullivan, Moenter (bib30) 2004; 101 Arimatsu (10.1016/j.brainres.2004.07.006_bib4) 1981; 198 Alkondon (10.1016/j.brainres.2004.07.006_bib2) 2001; 86 Chen (10.1016/j.brainres.2004.07.006_bib8) 1997; 272 Papka (10.1016/j.brainres.2004.07.006_bib25) 1985; 242 Arimatsu (10.1016/j.brainres.2004.07.006_bib3) 1983; 9 Ross (10.1016/j.brainres.2004.07.006_bib28) 2000; 20 Khiroug (10.1016/j.brainres.2004.07.006_bib13) 2002; 540 Morley (10.1016/j.brainres.2004.07.006_bib21) 1983; 278 Buhler (10.1016/j.brainres.2004.07.006_bib6) 2001; 87 Holinka (10.1016/j.brainres.2004.07.006_bib11) 1978; 19 Arredondo (10.1016/j.brainres.2004.07.006_bib5) 2002; 159 Paylor (10.1016/j.brainres.2004.07.006_bib27) 1998; 5 Morley (10.1016/j.brainres.2004.07.006_bib20) 1977; 134 Pauly (10.1016/j.brainres.2004.07.006_bib26) 1989; 22 Chang (10.1016/j.brainres.2004.07.006_bib7) 1999; 19 Orr-Urtreger (10.1016/j.brainres.2004.07.006_bib24) 1997; 17 Nelson (10.1016/j.brainres.2004.07.006_bib23) 1992; 94 vom Saal (10.1016/j.brainres.2004.07.006_bib31) 1989; 67 Hunt (10.1016/j.brainres.2004.07.006_bib12) 1985; 157 Marchi (10.1016/j.brainres.2004.07.006_bib15) 2002; 80 Mitsushima (10.1016/j.brainres.2004.07.006_bib19) 2002; 113 Miller (10.1016/j.brainres.2004.07.006_bib17) 1986; 16 Franceschini (10.1016/j.brainres.2004.07.006_bib10) 2000; 113 Egozi (10.1016/j.brainres.2004.07.006_bib9) 1986; 383 Levy (10.1016/j.brainres.2004.07.006_bib14) 2002; 22 Albuquerque (10.1016/j.brainres.2004.07.006_bib1) 2000; 113 Miller (10.1016/j.brainres.2004.07.006_bib18) 1984; 290 Sullivan (10.1016/j.brainres.2004.07.006_bib30) 2004; 101 Schafer (10.1016/j.brainres.2004.07.006_bib29) 1998; 84 Marks (10.1016/j.brainres.2004.07.006_bib16) 1996; 39 Nelson (10.1016/j.brainres.2004.07.006_bib22) 1990; 42 |
| References_xml | – volume: 198 start-page: 603 year: 1981 end-page: 631 ident: bib4 article-title: At atlas of α-bungarotoxin binding sites and structures containing acetylcholinesterase in the mouse central nervous system publication-title: J. Comp. Neurol. – volume: 94 start-page: 261 year: 1992 end-page: 268 ident: bib23 article-title: Genetic influences on oestrous cyclicity in mice: evidence that cycle length and frequency are differentially regulated publication-title: Reprod. Fertil. – volume: 20 start-page: 6431 year: 2000 end-page: 6441 ident: bib28 article-title: Phenotypic characterization of an α publication-title: J. Neurosci. – volume: 157 start-page: 213 year: 1985 end-page: 222 ident: bib12 article-title: Some observations on the binding pattern of α-bungarotoxin in the central nervous system of the rat publication-title: Brain Res. – volume: 383 start-page: 310 year: 1986 end-page: 313 ident: bib9 article-title: Acetylcholine rhythm in the preoptic area of the rat hypothalamus is synchronized with the estrous cycle publication-title: Brain Res. – volume: 242 start-page: 475 year: 1985 end-page: 490 ident: bib25 article-title: Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive and noradrenergic nerve in the reproductive tract of the female rat publication-title: Cell Tissue Res. – volume: 22 start-page: 453 year: 1989 end-page: 459 ident: bib26 article-title: An autoradiographic analysis of cholinergic receptors in mouse brain publication-title: Brain Res. Bull. – volume: 113 start-page: 3 year: 2000 end-page: 10 ident: bib10 article-title: Altered baroreflex responses in α7 deficient mice publication-title: Behav. Brain Res. – volume: 19 start-page: 3701 year: 1999 end-page: 3710 ident: bib7 article-title: Nicotinic acetylcholine receptors containing α7 subunits are required for reliable synaptic transmission in situ publication-title: J. Neurosci. – volume: 17 start-page: 9165 year: 1997 end-page: 9171 ident: bib24 article-title: Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents publication-title: J. Neurosci. – volume: 113 start-page: 131 year: 2000 end-page: 141 ident: bib1 article-title: Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance publication-title: Behav. Brain Res. – volume: 16 start-page: 681 year: 1986 end-page: 688 ident: bib17 article-title: A quantitative and morphometric evaluation of publication-title: Brain Res. Bull. – volume: 113 start-page: 109 year: 2002 end-page: 114 ident: bib19 article-title: GABA release in the medial preoptic area of cyclic female rats publication-title: Neuroscience – volume: 19 start-page: 807 year: 1978 end-page: 816 ident: bib11 article-title: Prolonged gestation, elevated preparturitional plasma progesterone and reproductive aging in C57BL/6J mice publication-title: Biol. Reprod. – volume: 101 start-page: 7129 year: 2004 end-page: 7134 ident: bib30 article-title: Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder publication-title: Proc. Natl. Acad. Sci. – volume: 134 start-page: 161 year: 1977 end-page: 166 ident: bib20 article-title: Regional distribution of nicotinic receptors in rat brain publication-title: Brain Res. – volume: 22 start-page: 5001 year: 2002 end-page: 5015 ident: bib14 article-title: α7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex publication-title: J. Neurosci. – volume: 39 start-page: 207 year: 1996 end-page: 222 ident: bib16 article-title: ST/b and DBA/2 mice differ in brain α-bungarotoxin binding and α7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis publication-title: Mol. Brain Res. – volume: 290 start-page: 67 year: 1984 end-page: 75 ident: bib18 article-title: Effects of gonadal steroids on the in vivo binding of [ publication-title: Brain Res. – volume: 272 start-page: 24024 year: 1997 end-page: 24029 ident: bib8 article-title: The α-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the α7 subunits publication-title: J. Biol. Chem. – volume: 5 start-page: 302 year: 1998 end-page: 316 ident: bib27 article-title: α7 Nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice publication-title: Learn. Mem. – volume: 87 start-page: 548 year: 2001 end-page: 557 ident: bib6 article-title: α7 nicotinic acetylcholine receptors on GABAergic interneurons evoke dendritic and somatic inhibition of hippocampal neurons publication-title: J. Neurophysiol. – volume: 80 start-page: 1071 year: 2002 end-page: 1078 ident: bib15 article-title: Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals publication-title: J. Neurochem. – volume: 278 start-page: 262 year: 1983 end-page: 265 ident: bib21 article-title: Increase in hypothalamic nicotinic acetylcholine receptors in prepuberal female rats administered estrogen publication-title: Brain Res. – volume: 86 start-page: 3043 year: 2001 end-page: 3055 ident: bib2 article-title: Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus publication-title: J. Neurophysiol. – volume: 42 start-page: 649 year: 1990 end-page: 655 ident: bib22 article-title: Genetic influences on the timing of puberty in mice publication-title: Biol. Reprod. – volume: 67 start-page: 1824 year: 1989 end-page: 1840 ident: bib31 article-title: Sexual differentiation in litter-bearing mammals: influence of sex of adjacent fetuses in utero publication-title: J. Anim. Sci. – volume: 159 start-page: 325 year: 2002 end-page: 336 ident: bib5 article-title: Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium publication-title: J. Cell Biol. – volume: 540 start-page: 425 year: 2002 end-page: 534 ident: bib13 article-title: Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels publication-title: J. Physiol. – volume: 9 start-page: 873 year: 1983 end-page: 877 ident: bib3 article-title: Short- and long-term influences of neonatal sex steroids on α-bungarotoxin binding capacity in the mouse amygdala publication-title: Neuroscience – volume: 84 start-page: 361 year: 1998 end-page: 376 ident: bib29 article-title: Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter: II. The peripheral nervous system publication-title: Neuroscience – volume: 39 start-page: 207 year: 1996 ident: 10.1016/j.brainres.2004.07.006_bib16 article-title: ST/b and DBA/2 mice differ in brain α-bungarotoxin binding and α7 nicotinic receptor subunit mRNA levels: a quantitative autoradiographic analysis publication-title: Mol. Brain Res. doi: 10.1016/0169-328X(96)00027-7 – volume: 42 start-page: 649 year: 1990 ident: 10.1016/j.brainres.2004.07.006_bib22 article-title: Genetic influences on the timing of puberty in mice publication-title: Biol. Reprod. doi: 10.1095/biolreprod42.4.649 – volume: 84 start-page: 361 year: 1998 ident: 10.1016/j.brainres.2004.07.006_bib29 article-title: Cholinergic neurons and terminal fields revealed by immunohistochemistry for the vesicular acetylcholine transporter: II. The peripheral nervous system publication-title: Neuroscience doi: 10.1016/S0306-4522(97)80196-0 – volume: 159 start-page: 325 year: 2002 ident: 10.1016/j.brainres.2004.07.006_bib5 article-title: Central role of α7 nicotinic receptor in differentiation of the stratified squamous epithelium publication-title: J. Cell Biol. doi: 10.1083/jcb.200206096 – volume: 94 start-page: 261 year: 1992 ident: 10.1016/j.brainres.2004.07.006_bib23 article-title: Genetic influences on oestrous cyclicity in mice: evidence that cycle length and frequency are differentially regulated publication-title: Reprod. Fertil. doi: 10.1530/jrf.0.0940261 – volume: 113 start-page: 109 year: 2002 ident: 10.1016/j.brainres.2004.07.006_bib19 article-title: GABA release in the medial preoptic area of cyclic female rats publication-title: Neuroscience doi: 10.1016/S0306-4522(02)00160-4 – volume: 9 start-page: 873 year: 1983 ident: 10.1016/j.brainres.2004.07.006_bib3 article-title: Short- and long-term influences of neonatal sex steroids on α-bungarotoxin binding capacity in the mouse amygdala publication-title: Neuroscience doi: 10.1016/0306-4522(83)90275-0 – volume: 5 start-page: 302 year: 1998 ident: 10.1016/j.brainres.2004.07.006_bib27 article-title: α7 Nicotinic receptor subunits are not necessary for hippocampal-dependent learning or sensorimotor gating: a behavioral characterization of Acra7-deficient mice publication-title: Learn. Mem. doi: 10.1101/lm.5.4.302 – volume: 113 start-page: 3 year: 2000 ident: 10.1016/j.brainres.2004.07.006_bib10 article-title: Altered baroreflex responses in α7 deficient mice publication-title: Behav. Brain Res. doi: 10.1016/S0166-4328(00)00195-9 – volume: 20 start-page: 6431 year: 2000 ident: 10.1016/j.brainres.2004.07.006_bib28 article-title: Phenotypic characterization of an α4 neuronal nicotinic acetylcholine receptor subunit knock-out mouse publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.20-17-06431.2000 – volume: 22 start-page: 5001 year: 2002 ident: 10.1016/j.brainres.2004.07.006_bib14 article-title: α7 nicotinic acetylcholine receptors occur at postsynaptic densities of AMPA receptor-positive and -negative excitatory synapses in rat sensory cortex publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.22-12-05001.2002 – volume: 86 start-page: 3043 year: 2001 ident: 10.1016/j.brainres.2004.07.006_bib2 article-title: Nicotinic acetylcholine receptor alpha7 and alpha4beta2 subtypes differentially control GABAergic input to CA1 neurons in rat hippocampus publication-title: J. Neurophysiol. doi: 10.1152/jn.2001.86.6.3043 – volume: 134 start-page: 161 year: 1977 ident: 10.1016/j.brainres.2004.07.006_bib20 article-title: Regional distribution of nicotinic receptors in rat brain publication-title: Brain Res. doi: 10.1016/0006-8993(77)90935-0 – volume: 19 start-page: 3701 year: 1999 ident: 10.1016/j.brainres.2004.07.006_bib7 article-title: Nicotinic acetylcholine receptors containing α7 subunits are required for reliable synaptic transmission in situ publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.19-10-03701.1999 – volume: 87 start-page: 548 year: 2001 ident: 10.1016/j.brainres.2004.07.006_bib6 article-title: α7 nicotinic acetylcholine receptors on GABAergic interneurons evoke dendritic and somatic inhibition of hippocampal neurons publication-title: J. Neurophysiol. doi: 10.1152/jn.00316.2001 – volume: 198 start-page: 603 year: 1981 ident: 10.1016/j.brainres.2004.07.006_bib4 article-title: At atlas of α-bungarotoxin binding sites and structures containing acetylcholinesterase in the mouse central nervous system publication-title: J. Comp. Neurol. doi: 10.1002/cne.901980405 – volume: 19 start-page: 807 year: 1978 ident: 10.1016/j.brainres.2004.07.006_bib11 article-title: Prolonged gestation, elevated preparturitional plasma progesterone and reproductive aging in C57BL/6J mice publication-title: Biol. Reprod. doi: 10.1095/biolreprod19.4.807 – volume: 101 start-page: 7129 year: 2004 ident: 10.1016/j.brainres.2004.07.006_bib30 article-title: Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder publication-title: Proc. Natl. Acad. Sci. doi: 10.1073/pnas.0308058101 – volume: 278 start-page: 262 year: 1983 ident: 10.1016/j.brainres.2004.07.006_bib21 article-title: Increase in hypothalamic nicotinic acetylcholine receptors in prepuberal female rats administered estrogen publication-title: Brain Res. doi: 10.1016/0006-8993(83)90250-0 – volume: 540 start-page: 425 year: 2002 ident: 10.1016/j.brainres.2004.07.006_bib13 article-title: Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels publication-title: J. Physiol. doi: 10.1113/jphysiol.2001.013847 – volume: 67 start-page: 1824 year: 1989 ident: 10.1016/j.brainres.2004.07.006_bib31 article-title: Sexual differentiation in litter-bearing mammals: influence of sex of adjacent fetuses in utero publication-title: J. Anim. Sci. doi: 10.2527/jas1989.6771824x – volume: 290 start-page: 67 year: 1984 ident: 10.1016/j.brainres.2004.07.006_bib18 article-title: Effects of gonadal steroids on the in vivo binding of [125I]-α-bungarotoxin (2.2 and 3.3) to the suprachiasmatic nucleus of the hypothalamus: an in vivo autoradiographic analysis publication-title: Brain Res. doi: 10.1016/0006-8993(84)90736-4 – volume: 16 start-page: 681 year: 1986 ident: 10.1016/j.brainres.2004.07.006_bib17 article-title: A quantitative and morphometric evaluation of 125I-alpha-bungarotoxin binding in the rat hypothalamus publication-title: Brain Res. Bull. doi: 10.1016/0361-9230(86)90139-5 – volume: 17 start-page: 9165 year: 1997 ident: 10.1016/j.brainres.2004.07.006_bib24 article-title: Mice deficient in the α7 neuronal nicotinic acetylcholine receptor lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.17-23-09165.1997 – volume: 383 start-page: 310 year: 1986 ident: 10.1016/j.brainres.2004.07.006_bib9 article-title: Acetylcholine rhythm in the preoptic area of the rat hypothalamus is synchronized with the estrous cycle publication-title: Brain Res. doi: 10.1016/0006-8993(86)90030-2 – volume: 157 start-page: 213 year: 1985 ident: 10.1016/j.brainres.2004.07.006_bib12 article-title: Some observations on the binding pattern of α-bungarotoxin in the central nervous system of the rat publication-title: Brain Res. doi: 10.1016/0006-8993(78)90025-2 – volume: 22 start-page: 453 year: 1989 ident: 10.1016/j.brainres.2004.07.006_bib26 article-title: An autoradiographic analysis of cholinergic receptors in mouse brain publication-title: Brain Res. Bull. doi: 10.1016/0361-9230(89)90072-5 – volume: 113 start-page: 131 year: 2000 ident: 10.1016/j.brainres.2004.07.006_bib1 article-title: Neuronal nicotinic receptors in synaptic functions in humans and rats: physiological and clinical relevance publication-title: Behav. Brain Res. doi: 10.1016/S0166-4328(00)00208-4 – volume: 242 start-page: 475 year: 1985 ident: 10.1016/j.brainres.2004.07.006_bib25 article-title: Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive and noradrenergic nerve in the reproductive tract of the female rat publication-title: Cell Tissue Res. doi: 10.1007/BF00225412 – volume: 272 start-page: 24024 year: 1997 ident: 10.1016/j.brainres.2004.07.006_bib8 article-title: The α-bungarotoxin-binding nicotinic acetylcholine receptor from rat brain contains only the α7 subunits publication-title: J. Biol. Chem. doi: 10.1074/jbc.272.38.24024 – volume: 80 start-page: 1071 year: 2002 ident: 10.1016/j.brainres.2004.07.006_bib15 article-title: Direct evidence that release-stimulating alpha7* nicotinic cholinergic receptors are localized on human and rat brain glutamatergic axon terminals publication-title: J. Neurochem. doi: 10.1046/j.0022-3042.2002.00805.x |
| SSID | ssj0003390 |
| Score | 1.8338666 |
| Snippet | The α7 nicotinic acetylcholine receptor (nAChR) is heavily expressed in the mammalian brain. On a molecular level, the α7 nAChR may have a diversity of... |
| SourceID | pascalfrancis crossref elsevier |
| SourceType | Index Database Enrichment Source Publisher |
| StartPage | 41 |
| SubjectTerms | Biological and medical sciences Cell receptors Cell structures and functions Endocrine Fundamental and applied biological sciences. Psychology Molecular and cellular biology Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Mouse Phenotype α7 Nicotinic acetylcholine receptor |
| Title | A phenotype for the α7 nicotinic acetylcholine receptor null mutant |
| URI | https://www.clinicalkey.com/#!/content/1-s2.0-S0006899304010984 https://dx.doi.org/10.1016/j.brainres.2004.07.006 |
| Volume | 1023 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: ScienceDirect database customDbUrl: eissn: 1872-6240 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003390 issn: 0006-8993 databaseCode: AIEXJ dateStart: 19950109 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1bb9MwFLZg4wEJIWAgdpUfGC9RwLnUjh_DFqAINhQ2VPESJbGNmLa0ajO0_az9EX7TjmMnbWCo44GXqLLstvb5cm4-F4Re-Mz3SUkDV5KCuaH0By4vpOdSFXoikMpXTTTh14_s4CAajfhnm3sya9oJsKqKLi745L-SGsaA2Dp19h_I3X0pDMBnIDo8gezwvBXhY0eHbY0b32obQ7i7l-y-8ZhTAd1rnQrp5KWsL08179NqJrA9OQHr26nAInXOznVr4d51r24k4djCQJ0D-dNhCurtwq3F_I4pPdxPh--Ok2_ul2GSprFx1E-_SxtJ3PoZwi5izTq_rKTuMVPqgrkW9JgpMenDPdgY3mgKXFkpa8ps_sG_jSvh5FWhtwW7agz4proquaFg9m-CrAsvBC3W86jP7qJVnw04MLvVeJiMPnQiOgiM863dwULq-M2__Tet5cEkn8G7pEwTlAXN5OgRemhNChwbKDxGd2T1BK3FVV6Pzy7xS9wE-Ta3J2toP8YdOjCgAwM68K8rhjtk4B4ycIsMrJGBDTKeouO3ydHee9c20nBLkB-1CzY6nIKkQiquQJ9TghAVMQEjtJSM5qEKyqJUXBQyUjKEOQX1uSzCPPSiUgTP0Eo1ruRzhHORF7pkJMzKQa_xIioIE17uS06EiAbraNAeVFbaKvO62clp1oYTnmTtAesWqGFGdAAEXUevu3UTU2dl6QrW0iFrs4hB7mUApaUrebfS6plGf7zV2p0eyed_1mJuY9mETXR__nptoZV6ei630b3yZ_1jNt2xSL0GT8ypMQ |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+phenotype+for+the+%CE%B17+nicotinic+acetylcholine+receptor+null+mutant&rft.jtitle=Brain+research&rft.au=MORLEY%2C+Barbara+J&rft.au=RODRIGUEZ-SIERRA%2C+Jorge+F&rft.date=2004-10-01&rft.pub=Elsevier&rft.issn=0006-8993&rft.volume=1023&rft.issue=1&rft.spage=41&rft.epage=47&rft_id=info:doi/10.1016%2Fj.brainres.2004.07.006&rft.externalDBID=n%2Fa&rft.externalDocID=16111627 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0006-8993&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0006-8993&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0006-8993&client=summon |