Isorhamnetin exerts anti-proliferative effect on cancer-associated fibroblasts by inducing cell cycle arrest

Isorhamnetin (ISO), a dietary flavonoid, has been shown to possess antioxidant, anti-cancer, and anti-inflammatory properties. Cancer-associated fibroblasts (CAFs), found in the tumor microenvironment of several types of cancer including pancreatic ductal adenocarcinoma (PDAC) impact the tumor growt...

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Bibliographic Details
Published in:	Biomedicine & pharmacotherapy Vol. 185; p. 117954
Main Authors:	Ganbold, Munkhzul, Louphrasitthiphol, Pakavarin, Miyamoto, Takafumi, Miyazaki, Yoshihiro, Oda, Tatsuya, Tominaga, Kenichi, Isoda, Hiroko
Format:	Journal Article
Language:	English
Published:	France Elsevier Masson SAS 01.04.2025
Subjects:	Apoptosis - drug effects Cancer-associated fibroblast Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism Cancer-Associated Fibroblasts - pathology Carcinoma, Pancreatic Ductal - drug therapy Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - pathology Cell cycle arrest Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects G2/M cell cycle checkpoint Gene Expression Regulation, Neoplastic - drug effects Humans Isorhamnetin Membrane Potential, Mitochondrial - drug effects Microarray analysis Mitochondrial membrane potential Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - genetics Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Quercetin - analogs & derivatives Quercetin - pharmacology Tumor Microenvironment - drug effects Cell cycle arrest Isorhamnetin Cancer-associated fibroblast G2/M cell cycle checkpoint Mitochondrial membrane potential Microarray analysis
ISSN:	0753-3322, 1950-6007, 1950-6007
Online Access:	Get full text
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