Oleuropein Protects Against Cerebral Ischemia Injury in Rats: Molecular Docking, Biochemical and Histological Findings

This study was designed to evaluate the underlying protective mechanisms of oleuropein involved in alleviating brain damage in a rat model of ischemic stroke. Male Wistar rats were divided into four groups; Control, stroke (MCAO), MCAO + clopidogrel (Clop) and MCAO + oleuropein (Ole). Results showed...

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Bibliographic Details
Published in:	Neurochemical research Vol. 46; no. 8; pp. 2131 - 2142
Main Authors:	Mnafgui, Kais, Ghazouani, Lakhdar, Hajji, Raouf, Tlili, Abir, Derbali, Fatma, da Silva, Francisco Ivan, Araújo, Joabe Lima, de Oliveira Schinoff, Bianca, Bachega, José Fernando Ruggiero, da Silva Santos, Antônia Laíres, Allouche, Noureddine
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.08.2021 Springer Nature B.V
Subjects:	Acetylcholinesterase - metabolism Angiotensin Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain Brain - pathology Brain damage Brain Edema - pathology Brain Edema - prevention & control Brain injury Catalase Cell Biology Clopidogrel Clopidogrel - therapeutic use Creatine Creatine kinase Edema Fibrinogen Free Radical Scavengers - metabolism Free Radical Scavengers - therapeutic use Glutathione Glutathione peroxidase Humans Hyponatremia Hyponatremia - prevention & control Infarction, Middle Cerebral Artery - drug therapy Infarction, Middle Cerebral Artery - pathology Iridoid Glucosides - metabolism Iridoid Glucosides - therapeutic use Ischemia Kinases Lactic acid Male Molecular docking Molecular Docking Simulation Neurochemistry Neurology Neuroprotection Neuroprotective Agents - metabolism Neuroprotective Agents - therapeutic use Neurosciences Oleuropein Original Paper Oxidative stress Oxidative Stress - drug effects Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Peroxidase Protein Binding Protein disulfide-isomerase Protein Disulfide-Isomerases - metabolism Rats Rats, Wistar Rodents Stroke Superoxide dismutase Thiobarbituric acid Thiobarbituric Acid Reactive Substances - metabolism Tissue analysis Transforming growth factor-b1 Protein disulfide isomerase Oxidative stress Stroke ACE Oleuropein
ISSN:	0364-3190, 1573-6903, 1573-6903
Online Access:	Get full text
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