Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus

Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Theref...

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Bibliographic Details
Published in:	Metabolic brain disease Vol. 35; no. 4; pp. 637 - 647
Main Authors:	Keshk, Walaa A., Elseady, Walaa S., Sarhan, Naglaa I., Zineldeen, Doaa H.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.04.2020 Springer Nature B.V
Subjects:	Activating transcription factor 4 Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Animals Anticancer properties Antioxidants Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Bcl-x protein Biochemistry Biomedical and Life Sciences Biomedicine Blood Glucose - metabolism CCAAT/enhancer-binding protein Cellular stress response Central nervous system Cerebrovascular diseases Cerebrovascular system Choline Choline O-Acetyltransferase - genetics Choline O-Acetyltransferase - metabolism Cholinergics Cognition Complications Curcumin Curcumin - pharmacology Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Gene expression Glucose Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism Homology HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Inflammation Interferon Interferon-gamma - metabolism Male Metabolic Diseases Neurodegeneration Neurology Neurosciences Oncology Original Article Oxidants Oxidizing agents Peritoneum Protective Agents - pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Streptozocin Transcription Factor CHOP - metabolism γ-Interferon CCAAT-enhancer-binding protein homologous protein (CHOP) Neurodegeneration Glucose-regulated proteins78 (GRP78) Diabetes mellitus Activating transcription factor 4 (ATF-4) Choline acetyl transferase (ChAT)
ISSN:	0885-7490, 1573-7365, 1573-7365
Online Access:	Get full text
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