Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus
Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Theref...
Gespeichert in:
| Veröffentlicht in: | Metabolic brain disease Jg. 35; H. 4; S. 637 - 647 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
New York
Springer US
01.04.2020
Springer Nature B.V |
| Schlagworte: | |
| ISSN: | 0885-7490, 1573-7365, 1573-7365 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the mechanistic insights of diabetes-induced hippocampal neurodegeneration in addition to shedding the light on the modulatory effect of curcumin. Twenty-eight male Wistar rats were randomly divided into four groups. Type I DM was induced by a single intra-peritoneal injection of streptozotocin (STZ) (65 mg/kg b.w.). Curcumin (100 mg/kg b.w.) was given to the diabetic group after the induction and for eight weeks. Hippocampal glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF-4), Bcl2 and choline acetyl transferase (ChAT) genes expression were assessed. Heat shock protein 70 (HSP70), Bcl-2-Associated X protein (Bax), Interferon-γ (INF-γ) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in the hippocampus were immunoassayed, in addition to the assessment of glycemic and redox status. Curcumin significantly improved blood glucose level, redox status, cellular stress, and decreased INF-γ and Bax levels, down-regulated GRP78 and ATF-4 expression, meanwhile, up-regulated Bcl2 and ChAT expression in hippocampus. Histological findings proved the biochemical and molecular findings. Our results support curcumin as a potential neuro-protective agent against diabetes induced hippocampal neurodegeneration. |
|---|---|
| AbstractList | Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the mechanistic insights of diabetes-induced hippocampal neurodegeneration in addition to shedding the light on the modulatory effect of curcumin. Twenty-eight male Wistar rats were randomly divided into four groups. Type I DM was induced by a single intra-peritoneal injection of streptozotocin (STZ) (65 mg/kg b.w.). Curcumin (100 mg/kg b.w.) was given to the diabetic group after the induction and for eight weeks. Hippocampal glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF-4), Bcl2 and choline acetyl transferase (ChAT) genes expression were assessed. Heat shock protein 70 (HSP70), Bcl-2-Associated X protein (Bax), Interferon-γ (INF-γ) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in the hippocampus were immunoassayed, in addition to the assessment of glycemic and redox status. Curcumin significantly improved blood glucose level, redox status, cellular stress, and decreased INF-γ and Bax levels, down-regulated GRP78 and ATF-4 expression, meanwhile, up-regulated Bcl2 and ChAT expression in hippocampus. Histological findings proved the biochemical and molecular findings. Our results support curcumin as a potential neuro-protective agent against diabetes induced hippocampal neurodegeneration. Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the mechanistic insights of diabetes-induced hippocampal neurodegeneration in addition to shedding the light on the modulatory effect of curcumin. Twenty-eight male Wistar rats were randomly divided into four groups. Type I DM was induced by a single intra-peritoneal injection of streptozotocin (STZ) (65 mg/kg b.w.). Curcumin (100 mg/kg b.w.) was given to the diabetic group after the induction and for eight weeks. Hippocampal glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF-4), Bcl2 and choline acetyl transferase (ChAT) genes expression were assessed. Heat shock protein 70 (HSP70), Bcl-2-Associated X protein (Bax), Interferon-γ (INF-γ) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in the hippocampus were immunoassayed, in addition to the assessment of glycemic and redox status. Curcumin significantly improved blood glucose level, redox status, cellular stress, and decreased INF-γ and Bax levels, down-regulated GRP78 and ATF-4 expression, meanwhile, up-regulated Bcl2 and ChAT expression in hippocampus. Histological findings proved the biochemical and molecular findings. Our results support curcumin as a potential neuro-protective agent against diabetes induced hippocampal neurodegeneration. Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the mechanistic insights of diabetes-induced hippocampal neurodegeneration in addition to shedding the light on the modulatory effect of curcumin. Twenty-eight male Wistar rats were randomly divided into four groups. Type I DM was induced by a single intra-peritoneal injection of streptozotocin (STZ) (65 mg/kg b.w.). Curcumin (100 mg/kg b.w.) was given to the diabetic group after the induction and for eight weeks. Hippocampal glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF-4), Bcl2 and choline acetyl transferase (ChAT) genes expression were assessed. Heat shock protein 70 (HSP70), Bcl-2-Associated X protein (Bax), Interferon-γ (INF-γ) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in the hippocampus were immunoassayed, in addition to the assessment of glycemic and redox status. Curcumin significantly improved blood glucose level, redox status, cellular stress, and decreased INF-γ and Bax levels, down-regulated GRP78 and ATF-4 expression, meanwhile, up-regulated Bcl2 and ChAT expression in hippocampus. Histological findings proved the biochemical and molecular findings. Our results support curcumin as a potential neuro-protective agent against diabetes induced hippocampal neurodegeneration.Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition, dementia and neurodegeneration. Curcumin is a polyphenol with anti-oxidant, anti-inflammatory, anti-hyperlipidemic, and anti-cancer effects. Therefore, the present study was aimed to focus on the mechanistic insights of diabetes-induced hippocampal neurodegeneration in addition to shedding the light on the modulatory effect of curcumin. Twenty-eight male Wistar rats were randomly divided into four groups. Type I DM was induced by a single intra-peritoneal injection of streptozotocin (STZ) (65 mg/kg b.w.). Curcumin (100 mg/kg b.w.) was given to the diabetic group after the induction and for eight weeks. Hippocampal glucose-regulated protein 78 (GRP78), activating transcription factor 4 (ATF-4), Bcl2 and choline acetyl transferase (ChAT) genes expression were assessed. Heat shock protein 70 (HSP70), Bcl-2-Associated X protein (Bax), Interferon-γ (INF-γ) and CCAAT-enhancer-binding protein homologous protein (CHOP) levels in the hippocampus were immunoassayed, in addition to the assessment of glycemic and redox status. Curcumin significantly improved blood glucose level, redox status, cellular stress, and decreased INF-γ and Bax levels, down-regulated GRP78 and ATF-4 expression, meanwhile, up-regulated Bcl2 and ChAT expression in hippocampus. Histological findings proved the biochemical and molecular findings. Our results support curcumin as a potential neuro-protective agent against diabetes induced hippocampal neurodegeneration. |
| Author | Sarhan, Naglaa I. Keshk, Walaa A. Zineldeen, Doaa H. Elseady, Walaa S. |
| Author_xml | – sequence: 1 givenname: Walaa A. orcidid: 0000-0002-1583-9277 surname: Keshk fullname: Keshk, Walaa A. email: walaa.keshk@med.tanta.edu.eg, walaaarafaa@gmail.com organization: Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Tanta University – sequence: 2 givenname: Walaa S. surname: Elseady fullname: Elseady, Walaa S. organization: Department of anatomy, Faculty of Medicine, Tanta University – sequence: 3 givenname: Naglaa I. surname: Sarhan fullname: Sarhan, Naglaa I. organization: Department of histology, Faculty of Medicine, Tanta University – sequence: 4 givenname: Doaa H. surname: Zineldeen fullname: Zineldeen, Doaa H. organization: Department of Medical Biochemistry & Molecular Biology, Faculty of Medicine, Tanta University, Suliman Alrajhi University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32172517$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kT1vFDEQhi0URC6BP0CBLNFQZIk_1ud1iU4QkCLRQG15bW_iaNdePHZxVf46Pi4npBSpZorneTWa9wKdxRQ9Qu8p-UwJkddAKaG0I4x0hAjRtldoQ4XkneRbcYY2ZBhEJ3tFztEFwAMhhAuq3qBzzqhkgsoNetzVbOsSIjal-FhN8YDtvqR1NrAEe-2jO-04-xJsneuCoWQPcIXNmtaSIAA20WF7n-YQfb5rrNvDVKMtIUXc0l0w48HG2RR8H9Y1WbOsFd6i15OZwb97mpfo97evv3bfu9ufNz92X247y6UonZdytHJwru8H5bzzyplplMYwoXrScyu3klC15WLq2WiYmyj1ShnhCB8Mm_gl-nTMXXP6Uz0UvQSwfp5N9KmCZly2CLWloqEfn6EPqebYrmuUYoM6_LpRH56oOi7e6TWHxeS9Pr22AcMRsDkBZD9pG4o5_KNkE2ZNiT60qI8t6tai_teiJk1lz9RT-osSP0rQ4Hjn8_-zX7D-AoSqsX0 |
| CitedBy_id | crossref_primary_10_1007_s00210_024_03231_3 crossref_primary_10_1155_2021_5570796 crossref_primary_10_3390_ijms24043367 crossref_primary_10_1039_D5RA00739A crossref_primary_10_1016_j_nbd_2023_106225 crossref_primary_10_1016_j_biopha_2022_113763 crossref_primary_10_3389_fphar_2022_893118 crossref_primary_10_1097_WNR_0000000000001853 crossref_primary_10_1016_j_neubiorev_2022_104818 crossref_primary_10_1007_s10753_021_01465_4 crossref_primary_10_1039_D5FO00988J crossref_primary_10_1016_j_expneurol_2023_114414 crossref_primary_10_1016_j_heliyon_2024_e32566 crossref_primary_10_1016_j_neubiorev_2023_105106 crossref_primary_10_3389_fphar_2020_585413 |
| Cites_doi | 10.1016/j.neulet.2016.04.066 10.4103/1673-5374.135314 10.1002/jbt.21562 10.1007/s12011-016-0668-5 10.1038/cddis.2015.183 10.3109/00207454.2012.657380 10.1080/10408398.2015.1077195 10.4172/2168-975X.1000139 10.1016/j.neuroscience.2011.11.058 10.3109/14756366.2015.1004061 10.3233/JAD-150872 10.1111/aos.12919 10.4049/jimmunol.171.11.6072 10.1016/j.ejphar.2013.01.012 10.1016/j.bcp.2017.07.009 10.1093/brain/awl044 10.1186/s12974-016-0774-5 10.1111/j.1582-4934.2011.01401.x 10.1007/s12640-009-9110-5 10.1016/0076-6879(90)86141-H 10.1155/2014/102158 10.1523/JNEUROSCI.1598-10.2010 10.18632/oncotarget.19448 10.3390/jcm4040715 10.1080/17512433.2017.1293521 10.1016/j.sbi.2009.11.001 10.1016/j.taap.2014.12.003 10.1038/nrm2199 10.1038/nmeth.2019 10.3109/10715762.2011.579121 10.3389/fnins.2017.00177 10.1074/jbc.M708373200 10.1007/978-1-61779-111-6_2 10.1016/j.biopha.2016.12.105 10.1007/s11011-017-0039-8 10.1038/nrn3689 10.1155/2018/8953015 10.1161/JAHA.117.005819 10.3390/ijms18122709 10.1016/j.lfs.2007.10.026 10.1016/j.etp.2015.11.002 10.3390/nu9050437 10.1016/j.nbd.2013.10.012 10.2174/1570159X11311040002 10.1016/j.jphs.2017.05.002 10.9734/IJBCRR/2016/31435 10.1038/protex.2013.097 10.1016/S0021-9258(19)52451-6 |
| ContentType | Journal Article |
| Copyright | Springer Science+Business Media, LLC, part of Springer Nature 2020 Springer Science+Business Media, LLC, part of Springer Nature 2020. |
| Copyright_xml | – notice: Springer Science+Business Media, LLC, part of Springer Nature 2020 – notice: Springer Science+Business Media, LLC, part of Springer Nature 2020. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7TK 7U7 7X7 7XB 88E 88G 8AO 8FI 8FJ 8FK ABUWG AFKRA AZQEC BENPR C1K CCPQU DWQXO FYUFA GHDGH GNUQQ K9. M0S M1P M2M PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS PSYQQ Q9U 7X8 |
| DOI | 10.1007/s11011-020-00551-0 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Neurosciences Abstracts Toxicology Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Psychology Database (Alumni) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central Environmental Sciences and Pollution Management ProQuest One ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database Psychology Database Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China ProQuest One Psychology ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest One Psychology ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic Toxicology Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Psychology Journals (Alumni) Neurosciences Abstracts ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest Psychology Journals ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest One Psychology MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1573-7365 |
| EndPage | 647 |
| ExternalDocumentID | 32172517 10_1007_s11011_020_00551_0 |
| Genre | Journal Article |
| GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C -~X .86 .GJ .VR 06C 06D 0R~ 0VY 123 1N0 1SB 2.D 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5QI 5RE 5VS 67N 67Z 6NX 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABIVO ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFGCZ AFKRA AFLOW AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ IWAJR IXC IXD IXE IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LLZTM M1P M2M M4Y MA- N2Q N9A NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P PF0 PQQKQ PROAC PSQYO PSYQQ PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RIG RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 YLTOR Z45 Z7U Z83 Z87 Z8O Z8W Z91 ZMTXR ZOVNA ZXP ~A9 ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ABRTQ ACSTC ADHKG AEZWR AFDZB AFFHD AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT PJZUB PPXIY CGR CUY CVF ECM EIF NPM 7TK 7U7 7XB 8FK C1K K9. PKEHL PQEST PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-c375t-e77bc78dd4489dede9dafb7aa2594043c767019635f42ba2df11e99a5d038a2f3 |
| IEDL.DBID | 7X7 |
| ISICitedReferencesCount | 18 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000528563800007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0885-7490 1573-7365 |
| IngestDate | Sun Nov 09 10:07:56 EST 2025 Tue Nov 04 22:15:26 EST 2025 Mon Jul 21 06:02:44 EDT 2025 Sat Nov 29 03:57:10 EST 2025 Tue Nov 18 22:24:57 EST 2025 Fri Feb 21 02:25:58 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 4 |
| Keywords | CCAAT-enhancer-binding protein homologous protein (CHOP) Neurodegeneration Glucose-regulated proteins78 (GRP78) Diabetes mellitus Activating transcription factor 4 (ATF-4) Choline acetyl transferase (ChAT) |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c375t-e77bc78dd4489dede9dafb7aa2594043c767019635f42ba2df11e99a5d038a2f3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-1583-9277 |
| PMID | 32172517 |
| PQID | 2392890551 |
| PQPubID | 37975 |
| PageCount | 11 |
| ParticipantIDs | proquest_miscellaneous_2377679615 proquest_journals_2392890551 pubmed_primary_32172517 crossref_citationtrail_10_1007_s11011_020_00551_0 crossref_primary_10_1007_s11011_020_00551_0 springer_journals_10_1007_s11011_020_00551_0 |
| PublicationCentury | 2000 |
| PublicationDate | 20200400 2020-04-00 20200401 |
| PublicationDateYYYYMMDD | 2020-04-01 |
| PublicationDate_xml | – month: 4 year: 2020 text: 20200400 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Metabolic brain disease |
| PublicationTitleAbbrev | Metab Brain Dis |
| PublicationTitleAlternate | Metab Brain Dis |
| PublicationYear | 2020 |
| Publisher | Springer US Springer Nature B.V |
| Publisher_xml | – name: Springer US – name: Springer Nature B.V |
| References | Chang, Chen, Lin, Chang, Liou, Chang, Chan, Chuang (CR7) 2014; 62 Lakshmanan, Watanabe, Thandavarayan, Sari, Meilei, Soetikno, Arumugam, Giridharan, Suzuki, Kodama (CR23) 2011; 45 Hetz, Mollereau (CR15) 2014; 15 Cunard (CR9) 2015; 4 Sherin, Anu, Peeyush, Smijin, Anitha, Roshni, Paulose (CR44) 2012; 202 CR35 Zou, Yuan, Tang, Wei, Zhu, Zhang, Gu, Wang, Tang (CR51) 2017; 8 Kanitkar, Bhonde (CR18) 2008; 82 Rashid, Sil (CR38) 2015; 282 Huang, Zheng, Guo, Zhao, Zhao, Ma, Jiang (CR16) 2016; 52 Lowry, Rosebrough, Farr, Randall (CR29) 1951; 193 Muriach, Flores-Bellver, Romero, Barcia (CR33) 2014; 2014 Schindelin, Arganda-Carreras, Frise, Kaynig, Longair, Pietzsch, Preibisch, Rueden, Saalfeld, Schmid, Tinevez, White, Hartenstein, Eliceiri, Tomancak, Cardona (CR43) 2012; 9 Mait, Manna (CR31) 2014; 3 Shukla, Shakya, Perez-Pinzon, Dave (CR45) 2017; 14 Liu, Su, Hao, Zhong, Zhong, Singhal, Liu (CR27) 2012; 16 CR4 Fujii, Mashimo, Moriwaki, Misawa, Ono, Horiguchi, Kawashima (CR11) 2017; 134 Gidalevitz, Kikis, Morimoto (CR13) 2010; 20 Lee, Loo, Bebawy, Luk, Mason, Rohanizadeh (CR24) 2013; 11 Luo, Huang, Yang, Yu (CR30) 2003; 41 Spijker, Li (CR46) 2011 Testa, Bonfigli, Prattichizzo, La Sala, De Nigris, Ceriello (CR47) 2017; 9 Abdel-Moneim, Yousef, Abd El-Twab, Abdel Reheim, Ashour (CR1) 2017; 32 Das, Razzaghi-Asl, Tikare, Di Santo, Costi, Messore, Pescatori, Crucitti, Jargar, Dhundasi, Saso (CR10) 2016; 31 Lin, Kemper, Dupree, Harding, Ron, Popko (CR26) 2006; 129 Samarghandian, Azimi-Nezhad, Farkhondeh, Samini (CR41) 2017; 87 Patel, Pandya, Clark, Parikh, Lau-Cam (CR36) 2016; 68 Ron, Walter (CR39) 2007; 8 Rozas, Bargsted, Martínez, Hetz, Medinas (CR40) 2017; 636 Ji, Zhang, Liu, Liu, Song, Dong, Jia, Zhou (CR17) 2014; 9 Kim, Park, Joe, Jou (CR19) 2003; 171 Kim, Son, Park, Park, Kim, Kim, Chung, Mattson, Lee (CR20) 2008; 283 Acar, Akil, Alp, Evliyaoglu, Kibrisli, Inal, Unan, Tasdemir (CR3) 2012; 122 Venkat, Chopp, Chen (CR48) 2017; 6 Bellini, Barutta, Mastrocola, Imperatore, Bruno, Gruden (CR5) 2017; 18 Liu, Lv, Zhao, Guan, Wang (CR28) 2015; 6 Casas (CR6) 2017; 11 Zhou, Hao, Zhao, Chen, Chen, Ying, Sun, Wang (CR49) 2013; 29 Zineldeen, Sarhan, Tahoon, Wasfy (CR50) 2016; 15 Abo-Salem, Harisa, Ali, El-Sayed El-S, Abou-Elnour (CR2) 2014; 28 Nakka, Gusain, Raghubir (CR34) 2010; 17 Hamed (CR14) 2017; 10 Kocaadam, Curcumin (CR21) 2017; 57 Matsuura, Otani, Takano, Kadoyama, Matsuyama (CR32) 2018; 2018 Rashid, Chowdhury, Ghosh, Sil (CR37) 2017; 143 Levine, Garland, Oliver, Amici, Climent, Lenz, Ahn, Shaltiel, Stadtman (CR25) 1990; 186 Kumar, George, Antony, Paulose (CR22) 2013; 702 Sayed, Mahmoud (CR42) 2016; 94 Cong, Piao, Li, Xie, Liu (CR8) 2016; 173 Galehdar, Swan, Fuerth, Callaghan, Park, Cregan (CR12) 2010; 30 JH Zhou (551_CR49) 2013; 29 S Spijker (551_CR46) 2011 T Gidalevitz (551_CR13) 2010; 20 PT Kumar (551_CR22) 2013; 702 S Bellini (551_CR5) 2017; 18 J Schindelin (551_CR43) 2012; 9 551_CR4 X Ji (551_CR17) 2014; 9 RL Levine (551_CR25) 1990; 186 KM Sayed (551_CR42) 2016; 94 SJ Kim (551_CR20) 2008; 283 XQ Cong (551_CR8) 2016; 173 R Cunard (551_CR9) 2015; 4 OH Lowry (551_CR29) 1951; 193 W Lin (551_CR26) 2006; 129 A Sherin (551_CR44) 2012; 202 T Fujii (551_CR11) 2017; 134 HY Kim (551_CR19) 2003; 171 V Shukla (551_CR45) 2017; 14 AP Lakshmanan (551_CR23) 2011; 45 C Hetz (551_CR15) 2014; 15 P Mait (551_CR31) 2014; 3 HC Huang (551_CR16) 2016; 52 R Testa (551_CR47) 2017; 9 SA Hamed (551_CR14) 2017; 10 S Samarghandian (551_CR41) 2017; 87 Z Galehdar (551_CR12) 2010; 30 551_CR35 G Liu (551_CR27) 2012; 16 CC Chang (551_CR7) 2014; 62 M Kanitkar (551_CR18) 2008; 82 C Casas (551_CR6) 2017; 11 WH Lee (551_CR24) 2013; 11 VP Nakka (551_CR34) 2010; 17 OM Abo-Salem (551_CR2) 2014; 28 B Kocaadam (551_CR21) 2017; 57 SN Patel (551_CR36) 2016; 68 F Luo (551_CR30) 2003; 41 K Rashid (551_CR38) 2015; 282 M Muriach (551_CR33) 2014; 2014 K Matsuura (551_CR32) 2018; 2018 KK Das (551_CR10) 2016; 31 Z Liu (551_CR28) 2015; 6 D Zineldeen (551_CR50) 2016; 15 P Venkat (551_CR48) 2017; 6 W Zou (551_CR51) 2017; 8 D Ron (551_CR39) 2007; 8 P Rozas (551_CR40) 2017; 636 K Rashid (551_CR37) 2017; 143 A Acar (551_CR3) 2012; 122 A Abdel-Moneim (551_CR1) 2017; 32 |
| References_xml | – volume: 636 start-page: 9 year: 2017 end-page: 15 ident: CR40 article-title: The ER proteostasis network in ALS: determining the differential motoneuron vulnerability publication-title: Neurosci Lett doi: 10.1016/j.neulet.2016.04.066 – ident: CR4 – volume: 9 start-page: 1122 issue: 11 year: 2014 end-page: 1128 ident: CR17 article-title: Potential targets for protecting against hippocampal cell apoptosis after transient cerebral ischemia-reperfusion injury in aged rats publication-title: Neural Regen Res doi: 10.4103/1673-5374.135314 – volume: 28 start-page: 263 issue: 6 year: 2014 end-page: 270 ident: CR2 article-title: Curcumin ameliorates streptozotocin-induced heart injury in rats publication-title: J Biochem Mol Toxicol doi: 10.1002/jbt.21562 – volume: 173 start-page: 390 issue: 2 year: 2016 end-page: 398 ident: CR8 article-title: Bis (maltolato) oxovanadium (IV) (BMOV) attenuates apoptosis in high glucose-treated cardiac cells and diabetic rat hearts by regulating the unfolded protein responses (UPRs) publication-title: Biol Trace Elem Res doi: 10.1007/s12011-016-0668-5 – volume: 6 year: 2015 ident: CR28 article-title: Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate publication-title: Cell Death and Disease doi: 10.1038/cddis.2015.183 – ident: CR35 – volume: 122 start-page: 367 issue: 7 year: 2012 end-page: 372 ident: CR3 article-title: Oxidative damage is ameliorated by curcumin treatment in brain and sciatic nerve of diabetic rats publication-title: Int J Neurosci doi: 10.3109/00207454.2012.657380 – volume: 57 start-page: 2889 issue: 13 year: 2017 end-page: 2895 ident: CR21 article-title: an active component of turmeric ( ), and its effects on health publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408398.2015.1077195 – volume: 3 start-page: 139 year: 2014 ident: CR31 article-title: Activation of heat shock proteins by Nanocurcumin to prevent neurodegenerative diseases publication-title: Brain Disord Ther doi: 10.4172/2168-975X.1000139 – volume: 41 start-page: 940 issue: 12 year: 2003 end-page: 944 ident: CR30 article-title: Protective effect and mechanism of pretreatment with curcumin on infectious brain edema in rats publication-title: Zhonghua Er Ke Za Zhi – volume: 202 start-page: 69 year: 2012 end-page: 76 ident: CR44 article-title: Cholinergic and GABAergic receptor functional deficit in the hippocampus of insulin-induced hypoglycemic and streptozotocin-induced diabetic rats publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.11.058 – volume: 31 start-page: 99 issue: 1 year: 2016 end-page: 105 ident: CR10 article-title: Hypoglycemic activity of curcumin synthetic analogues in alloxan-induced diabetic rats publication-title: J Enzyme Inhib Med Chem doi: 10.3109/14756366.2015.1004061 – volume: 52 start-page: 899 issue: 3 year: 2016 end-page: 911 ident: CR16 article-title: Antioxidative and Neuroprotective effects of Curcumin in an Alzheimer's disease rat model co-treated with Intracerebroventricular Streptozotocin and subcutaneous D-Galactose publication-title: J Alzheimers Dis doi: 10.3233/JAD-150872 – volume: 94 start-page: e361 issue: 5 year: 2016 end-page: e366 ident: CR42 article-title: Heat shock protein-70 and hypoxia inducible factor-1α in type 2 diabetes mellitus patients complicated with retinopathy publication-title: Acta Ophthalmol doi: 10.1111/aos.12919 – volume: 171 start-page: 6072 issue: 11 year: 2003 end-page: 6079 ident: CR19 article-title: Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia publication-title: J Immunol doi: 10.4049/jimmunol.171.11.6072 – volume: 702 start-page: 323 issue: 1–3 year: 2013 end-page: 331 ident: CR22 article-title: Curcumin restores diabetes induced neurochemical changes in the brain stem of Wistar rats publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2013.01.012 – volume: 29 start-page: 318 issue: 4 year: 2013 end-page: 323 ident: CR49 article-title: Effects of curcumin on pneumocyte apoptosis and CHOP in pulmonary ischemia/reperfusion injury of mice publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi – volume: 143 start-page: 140 year: 2017 end-page: 155 ident: CR37 article-title: Curcumin attenuates oxidative stress induced NFκB mediated inflammation and endoplasmic reticulum dependent apoptosis of splenocytes in diabetes publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2017.07.009 – volume: 129 start-page: 1306 issue: Pt 5 year: 2006 end-page: 1318 ident: CR26 article-title: Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress publication-title: Brain doi: 10.1093/brain/awl044 – volume: 14 start-page: 21 issue: 1 year: 2017 ident: CR45 article-title: Cerebral ischemic damage in diabetes: an inflammatory perspective publication-title: J Neuroinflammation doi: 10.1186/s12974-016-0774-5 – volume: 16 start-page: 1618 issue: 7 year: 2012 end-page: 1628 ident: CR27 article-title: Salermide up-regulates death receptor 5 expression through the ATF4-ATF3-CHOP axis and leads to apoptosis in human cancer cells publication-title: J Cell Mol Med doi: 10.1111/j.1582-4934.2011.01401.x – volume: 17 start-page: 189 issue: 2 year: 2010 end-page: 202 ident: CR34 article-title: Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia/reperfusion in rats publication-title: Neurotox Res doi: 10.1007/s12640-009-9110-5 – volume: 186 start-page: 464 year: 1990 end-page: 478 ident: CR25 article-title: Determination of carbonyl content in oxidatively modified proteins publication-title: Methods of Enzymology doi: 10.1016/0076-6879(90)86141-H – volume: 2014 start-page: 102158 year: 2014 ident: CR33 article-title: Diabetes and the brain: oxidative stress, inflammation, and autophagy publication-title: Oxidative Med Cell Longev doi: 10.1155/2014/102158 – volume: 30 start-page: 16938 issue: 50 year: 2010 end-page: 16948 ident: CR12 article-title: Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1598-10.2010 – volume: 8 start-page: 64203 issue: 38 year: 2017 end-page: 64216 ident: CR51 article-title: Hydrogen sulfide ameliorates cognitive dysfunction in streptozotocin-induced diabetic rats: involving suppression in hippocampal endoplasmic reticulum stress publication-title: Oncotarget doi: 10.18632/oncotarget.19448 – volume: 4 start-page: 715 issue: 4 year: 2015 end-page: 740 ident: CR9 article-title: Endoplasmic reticulum stress in the diabetic kidney, the good, the bad and the ugly publication-title: J Clin Med doi: 10.3390/jcm4040715 – volume: 10 start-page: 409 issue: 4 year: 2017 end-page: 428 ident: CR14 article-title: Brain injury with diabetes mellitus: evidence, mechanisms and treatment implications publication-title: Expert Rev Clin Pharmacol doi: 10.1080/17512433.2017.1293521 – volume: 193 start-page: 265 issue: 1 year: 1951 end-page: 275 ident: CR29 article-title: Protein measurement with the Folin phenol reagent publication-title: J Biol Chem – volume: 20 start-page: 23 issue: 1 year: 2010 end-page: 32 ident: CR13 article-title: A cellular perspective on conformational disease: the role of genetic background and proteostasis networks publication-title: Curr Opin Struct Biol doi: 10.1016/j.sbi.2009.11.001 – volume: 282 start-page: 297 issue: 3 year: 2015 end-page: 310 ident: CR38 article-title: Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats. Toxicol publication-title: Appl. Pharmacol doi: 10.1016/j.taap.2014.12.003 – volume: 8 start-page: 519 issue: 7 year: 2007 end-page: 529 ident: CR39 article-title: Signal integration in the endoplasmic reticulum unfolded protein response publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2199 – volume: 9 start-page: 676 issue: 7 year: 2012 end-page: 682 ident: CR43 article-title: Fiji: an open-source platform for biological-image analysis publication-title: Nat Methods doi: 10.1038/nmeth.2019 – volume: 45 start-page: 788 issue: 7 year: 2011 end-page: 795 ident: CR23 article-title: Curcumin attenuates hyperglycaemia-mediated AMPK activation and oxidative stress in cerebrum of streptozotocin-induced diabetic rat publication-title: Free Radic Res doi: 10.3109/10715762.2011.579121 – volume: 11 start-page: 177 year: 2017 ident: CR6 article-title: GRP78 at the Centre of the Stage in Cancer and Neuroprotection publication-title: Front Neurosci doi: 10.3389/fnins.2017.00177 – volume: 283 start-page: 14497 issue: 21 year: 2008 end-page: 14505 ident: CR20 article-title: Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus publication-title: J Biol Chem doi: 10.1074/jbc.M708373200 – start-page: 13 year: 2011 end-page: 26 ident: CR46 article-title: Dissection of rodent brain regions publication-title: Neuroproteomics. Neuromethods doi: 10.1007/978-1-61779-111-6_2 – volume: 87 start-page: 223 year: 2017 end-page: 229 ident: CR41 article-title: Anti-oxidative effects of curcumin on immobilization-induced oxidative stress in rat brain, liver and kidney publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.12.105 – volume: 32 start-page: 1279 issue: 4 year: 2017 end-page: 1286 ident: CR1 article-title: Gallic acid and p-coumaric acid attenuate type 2 diabetes-induced neurodegeneration in rats publication-title: Metab Brain Dis doi: 10.1007/s11011-017-0039-8 – volume: 15 start-page: 233 issue: 4 year: 2014 end-page: 249 ident: CR15 article-title: Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases publication-title: Nat Rev Neurosci doi: 10.1038/nrn3689 – volume: 2018 start-page: 8953015 year: 2018 ident: CR32 article-title: Proteomic analysis of Hippocampus and cortex in Streptozotocin-induced diabetic model mice showing dementia publication-title: J Diabetes Res doi: 10.1155/2018/8953015 – volume: 6 issue: 6 year: 2017 ident: CR48 article-title: Blood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke publication-title: Journal of the American Heart Association doi: 10.1161/JAHA.117.005819 – volume: 18 start-page: 2709 issue: 12 year: 2017 ident: CR5 article-title: Heat shock proteins in vascular diabetic complications: review and future perspective publication-title: Int J Mol Sci doi: 10.3390/ijms18122709 – volume: 82 start-page: 182 issue: 3–4 year: 2008 end-page: 189 ident: CR18 article-title: Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation publication-title: Life Sci doi: 10.1016/j.lfs.2007.10.026 – volume: 68 start-page: 103 issue: 2–3 year: 2016 end-page: 112 ident: CR36 article-title: Comparison of taurine and pantoyltaurine as antioxidants in vitro and in the central nervous system of diabetic rats publication-title: Exp Toxicol Pathol doi: 10.1016/j.etp.2015.11.002 – volume: 9 issue: 5 year: 2017 ident: CR47 article-title: The "metabolic memory" theory and the early treatment of hyperglycemia in prevention of diabetic complications publication-title: Nutrients doi: 10.3390/nu9050437 – volume: 62 start-page: 241 year: 2014 end-page: 249 ident: CR7 article-title: Heat shock protein 70 protects against seizure-induced neuronal cell death in the hippocampus following experimental status epilepticus via inhibition of nuclear factor-κB activation-induced nitric oxide synthase II expression publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2013.10.012 – volume: 11 start-page: 338 issue: 4 year: 2013 end-page: 378 ident: CR24 article-title: Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century publication-title: Curr Neuropharmacol doi: 10.2174/1570159X11311040002 – volume: 134 start-page: 1 issue: 1 year: 2017 end-page: 21 ident: CR11 article-title: Physiological functions of the cholinergic system in immune cells publication-title: J Pharmacol Sci doi: 10.1016/j.jphs.2017.05.002 – volume: 15 start-page: 1 year: 2016 end-page: 17 ident: CR50 article-title: Mechanistic insight of transient receptor potential Melastatin 8 role in Streptozotocin induced diabetic nephropathy publication-title: International journal of Biochemistry Research & Review doi: 10.9734/IJBCRR/2016/31435 – volume: 122 start-page: 367 issue: 7 year: 2012 ident: 551_CR3 publication-title: Int J Neurosci doi: 10.3109/00207454.2012.657380 – volume: 82 start-page: 182 issue: 3–4 year: 2008 ident: 551_CR18 publication-title: Life Sci doi: 10.1016/j.lfs.2007.10.026 – volume: 134 start-page: 1 issue: 1 year: 2017 ident: 551_CR11 publication-title: J Pharmacol Sci doi: 10.1016/j.jphs.2017.05.002 – volume: 68 start-page: 103 issue: 2–3 year: 2016 ident: 551_CR36 publication-title: Exp Toxicol Pathol doi: 10.1016/j.etp.2015.11.002 – start-page: 13 volume-title: Neuroproteomics. Neuromethods year: 2011 ident: 551_CR46 doi: 10.1007/978-1-61779-111-6_2 – volume: 29 start-page: 318 issue: 4 year: 2013 ident: 551_CR49 publication-title: Zhongguo Ying Yong Sheng Li Xue Za Zhi – volume: 4 start-page: 715 issue: 4 year: 2015 ident: 551_CR9 publication-title: J Clin Med doi: 10.3390/jcm4040715 – volume: 282 start-page: 297 issue: 3 year: 2015 ident: 551_CR38 publication-title: Appl. Pharmacol doi: 10.1016/j.taap.2014.12.003 – volume: 171 start-page: 6072 issue: 11 year: 2003 ident: 551_CR19 publication-title: J Immunol doi: 10.4049/jimmunol.171.11.6072 – volume: 9 start-page: 1122 issue: 11 year: 2014 ident: 551_CR17 publication-title: Neural Regen Res doi: 10.4103/1673-5374.135314 – volume: 15 start-page: 233 issue: 4 year: 2014 ident: 551_CR15 publication-title: Nat Rev Neurosci doi: 10.1038/nrn3689 – volume: 16 start-page: 1618 issue: 7 year: 2012 ident: 551_CR27 publication-title: J Cell Mol Med doi: 10.1111/j.1582-4934.2011.01401.x – volume: 702 start-page: 323 issue: 1–3 year: 2013 ident: 551_CR22 publication-title: Eur J Pharmacol doi: 10.1016/j.ejphar.2013.01.012 – ident: 551_CR4 – volume: 11 start-page: 177 year: 2017 ident: 551_CR6 publication-title: Front Neurosci doi: 10.3389/fnins.2017.00177 – volume: 10 start-page: 409 issue: 4 year: 2017 ident: 551_CR14 publication-title: Expert Rev Clin Pharmacol doi: 10.1080/17512433.2017.1293521 – volume: 202 start-page: 69 year: 2012 ident: 551_CR44 publication-title: Neuroscience doi: 10.1016/j.neuroscience.2011.11.058 – volume: 41 start-page: 940 issue: 12 year: 2003 ident: 551_CR30 publication-title: Zhonghua Er Ke Za Zhi – volume: 30 start-page: 16938 issue: 50 year: 2010 ident: 551_CR12 publication-title: J Neurosci doi: 10.1523/JNEUROSCI.1598-10.2010 – volume: 8 start-page: 519 issue: 7 year: 2007 ident: 551_CR39 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm2199 – volume: 143 start-page: 140 year: 2017 ident: 551_CR37 publication-title: Biochem Pharmacol doi: 10.1016/j.bcp.2017.07.009 – volume: 87 start-page: 223 year: 2017 ident: 551_CR41 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.12.105 – volume: 283 start-page: 14497 issue: 21 year: 2008 ident: 551_CR20 publication-title: J Biol Chem doi: 10.1074/jbc.M708373200 – ident: 551_CR35 doi: 10.1038/protex.2013.097 – volume: 11 start-page: 338 issue: 4 year: 2013 ident: 551_CR24 publication-title: Curr Neuropharmacol doi: 10.2174/1570159X11311040002 – volume: 8 start-page: 64203 issue: 38 year: 2017 ident: 551_CR51 publication-title: Oncotarget doi: 10.18632/oncotarget.19448 – volume: 6 year: 2015 ident: 551_CR28 publication-title: Cell Death and Disease doi: 10.1038/cddis.2015.183 – volume: 14 start-page: 21 issue: 1 year: 2017 ident: 551_CR45 publication-title: J Neuroinflammation doi: 10.1186/s12974-016-0774-5 – volume: 94 start-page: e361 issue: 5 year: 2016 ident: 551_CR42 publication-title: Acta Ophthalmol doi: 10.1111/aos.12919 – volume: 2014 start-page: 102158 year: 2014 ident: 551_CR33 publication-title: Oxidative Med Cell Longev doi: 10.1155/2014/102158 – volume: 62 start-page: 241 year: 2014 ident: 551_CR7 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2013.10.012 – volume: 52 start-page: 899 issue: 3 year: 2016 ident: 551_CR16 publication-title: J Alzheimers Dis doi: 10.3233/JAD-150872 – volume: 129 start-page: 1306 issue: Pt 5 year: 2006 ident: 551_CR26 publication-title: Brain doi: 10.1093/brain/awl044 – volume: 2018 start-page: 8953015 year: 2018 ident: 551_CR32 publication-title: J Diabetes Res doi: 10.1155/2018/8953015 – volume: 15 start-page: 1 year: 2016 ident: 551_CR50 publication-title: International journal of Biochemistry Research & Review doi: 10.9734/IJBCRR/2016/31435 – volume: 636 start-page: 9 year: 2017 ident: 551_CR40 publication-title: Neurosci Lett doi: 10.1016/j.neulet.2016.04.066 – volume: 186 start-page: 464 year: 1990 ident: 551_CR25 publication-title: Methods of Enzymology doi: 10.1016/0076-6879(90)86141-H – volume: 3 start-page: 139 year: 2014 ident: 551_CR31 publication-title: Brain Disord Ther doi: 10.4172/2168-975X.1000139 – volume: 173 start-page: 390 issue: 2 year: 2016 ident: 551_CR8 publication-title: Biol Trace Elem Res doi: 10.1007/s12011-016-0668-5 – volume: 57 start-page: 2889 issue: 13 year: 2017 ident: 551_CR21 publication-title: Critical Reviews in Food Science and Nutrition doi: 10.1080/10408398.2015.1077195 – volume: 28 start-page: 263 issue: 6 year: 2014 ident: 551_CR2 publication-title: J Biochem Mol Toxicol doi: 10.1002/jbt.21562 – volume: 45 start-page: 788 issue: 7 year: 2011 ident: 551_CR23 publication-title: Free Radic Res doi: 10.3109/10715762.2011.579121 – volume: 193 start-page: 265 issue: 1 year: 1951 ident: 551_CR29 publication-title: J Biol Chem doi: 10.1016/S0021-9258(19)52451-6 – volume: 18 start-page: 2709 issue: 12 year: 2017 ident: 551_CR5 publication-title: Int J Mol Sci doi: 10.3390/ijms18122709 – volume: 17 start-page: 189 issue: 2 year: 2010 ident: 551_CR34 publication-title: Neurotox Res doi: 10.1007/s12640-009-9110-5 – volume: 6 issue: 6 year: 2017 ident: 551_CR48 publication-title: Journal of the American Heart Association doi: 10.1161/JAHA.117.005819 – volume: 31 start-page: 99 issue: 1 year: 2016 ident: 551_CR10 publication-title: J Enzyme Inhib Med Chem doi: 10.3109/14756366.2015.1004061 – volume: 32 start-page: 1279 issue: 4 year: 2017 ident: 551_CR1 publication-title: Metab Brain Dis doi: 10.1007/s11011-017-0039-8 – volume: 9 start-page: 676 issue: 7 year: 2012 ident: 551_CR43 publication-title: Nat Methods doi: 10.1038/nmeth.2019 – volume: 9 issue: 5 year: 2017 ident: 551_CR47 publication-title: Nutrients doi: 10.3390/nu9050437 – volume: 20 start-page: 23 issue: 1 year: 2010 ident: 551_CR13 publication-title: Curr Opin Struct Biol doi: 10.1016/j.sbi.2009.11.001 |
| SSID | ssj0003519 |
| Score | 2.3370564 |
| Snippet | Diabetes mellitus (DM) is associated with the increased risk of the central nervous system complications as cerebrovascular disease, impaired cognition,... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 637 |
| SubjectTerms | Activating transcription factor 4 Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Animals Anticancer properties Antioxidants Apoptosis Apoptosis - drug effects BAX protein Bcl-2 protein bcl-2-Associated X Protein - metabolism Bcl-x protein Biochemistry Biomedical and Life Sciences Biomedicine Blood Glucose - metabolism CCAAT/enhancer-binding protein Cellular stress response Central nervous system Cerebrovascular diseases Cerebrovascular system Choline Choline O-Acetyltransferase - genetics Choline O-Acetyltransferase - metabolism Cholinergics Cognition Complications Curcumin Curcumin - pharmacology Dementia disorders Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Endoplasmic reticulum Endoplasmic Reticulum Stress - drug effects Gene expression Glucose Heat shock proteins Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hippocampus Hippocampus - drug effects Hippocampus - metabolism Homology HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Inflammation Interferon Interferon-gamma - metabolism Male Metabolic Diseases Neurodegeneration Neurology Neurosciences Oncology Original Article Oxidants Oxidizing agents Peritoneum Protective Agents - pharmacology Proteins Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rats Rats, Wistar Streptozocin Transcription Factor CHOP - metabolism γ-Interferon |
| SummonAdditionalLinks | – databaseName: SpringerLink Journals dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS-QwEB9E5fBF78PTqndE8E2L269N8yhycg93IuiJbyWbDyy4bdm2wj75rzuTtruI58H5VuhkWpKZzG-SzC8ARykFFikm6EgxkWqbwEe7Ub5JQ6Niga0cqc_tL355md7diau-KKweTrsPW5Jupl4WuwVuOS-kSmiM8z4m6msJsc1Qjn59u5h_6cq5DjsmPo_FqC-V-buOl-HoFcZ8tT_qws7F1vt--CNs9jCTnXV28QlWTPEZPvzuN9K_wNN5O1PtNC8Y8WsWLSFOpuZNWSGanubq1BR6eGau0JFWCVlXWXLCZFVWTVnnNZOFZjSDuhpClNXzmkIlDTdD7d3SLumQDbvPqwpD57Rq6234c_Hj5vyn39_F4KuIJ41vOJ8onmqN6ZzQRhuhpZ1wKTF9IoIexcdE7I7wxcbhRIbaBoERQiZ6FKUytNFXWC3KwuwCs9JIo4RQqCYeG5Nam6iRjBDa2bGV2oNgGJJM9UTldF_GQ7akWKaezbBnM9ez2ciD40WbqqPp-Kf0wTDSWe-ydRYiUkwFCXhwuHiNzkY7KLIwZUsyRH4kEAV6sNNZyOJzEV31lQTcg5PBHJbK3_6Xvf8T34eN0FkUnR06gNVm1ppvsK4em7yefXeO8AwswgQR priority: 102 providerName: Springer Nature |
| Title | Curcumin attenuates cytoplasmic/endoplasmic reticulum stress, apoptosis and cholinergic dysfunction in diabetic rat hippocampus |
| URI | https://link.springer.com/article/10.1007/s11011-020-00551-0 https://www.ncbi.nlm.nih.gov/pubmed/32172517 https://www.proquest.com/docview/2392890551 https://www.proquest.com/docview/2377679615 |
| Volume | 35 |
| WOSCitedRecordID | wos000528563800007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: Springer LINK customDbUrl: eissn: 1573-7365 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003519 issn: 0885-7490 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB5BixAX3o9AqYzEjUbNcx2fEFStOLCrqkC1t8jrh4jEJmGTIPXEX2fGcXaFKnrhYiWKPbE0Y894xvMNwNuCFIsUK1xIGYFqmzhEuVGhKRKjMoGjHKjP5We-WBTLpTj3DrfOX6uc9kS3UetGkY_8OEFFXogIFfz79mdIVaMouupLaNyGfSqbTXLOl9sDFwXJxGhF5iHPROSTZsbUudg5BxPKq0aiYfS3YrpmbV6LlDoFdPbgf6f-EO5705N9GGXlEdwy9WO4O_fB9Sfw-2TYqGFd1YwwN-uBrFCmrvqmRQt7XaljU-vpmbnkR_IcsjHb5IjJtmn7pqs6JmvNaFd1eYXYV191pD5JBBhSH929REP27HvVtqhO1-3QPYVvZ6dfTz6Fvj5DqFKe96HhfKV4oTUe8YQ22ggt7YpLiUcqAu1RfEZg72jS2CxZyUTbODZCyFxHaSETmz6DvbqpzQtgVhpplBAKyWQzYwprcxXJFM09O7NSBxBPzCmVBy-nGho_yh3sMjG0RIaWjqFlFMC77Zh2hO64sffBxLzSL-Ou3HEugDfbz7gAKaoia9MM1IcAkQRahgE8H2Vl-7uUyn_lMQ_gaBKeHfF_z-XlzXN5BfcSJ7h0f-gA9vrNYF7DHfWrr7rNoVsCri0OYf_j6eL8At_myRzbiy-XfwBuMxLj |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9QwEB6VgoAL70doASPBiUZNnGQdHyqEClWr7q44FNRb6rUdEYlNwiah2lP_Eb-RmTx2hSp664FbpNiTOPk8D9vzDcDbmAyLkjOcSCGRalvfRdxo18bc6lBir5bU59tYTKfx6an8sgG_h1wYOlY56MRWUZtC0xr5LkdDHksPDfyH8qdLVaNod3UoodHB4tguzzFkq_aOPuH_fcf5weeT_UO3ryrg6kBEtWuFmGkRG4OBiTTWWGlUOhNKYSBAVDNajIiiHA1xGvKZ4ib1fSuliowXxIqnAcq9ATdDtIRUMWHCJyvNT8XuOq81ckUovT5Jp0vV89vFSE553DgI1_vbEF7ybi_tzLYG7-D-__apHsC93rVmH7u58BA2bP4Ibk_6wwOP4WK_WehmnuWMOEXzhrxsppd1UWIEMc_0rs3NcM3a5E5aGWVdNs0OU2VR1kWVVUzlhpHVaPMmsa1ZVuQeEMQZSu-Ws0mGqtn3rCzRXZiXTfUEvl7L8J_CZl7k9jmwVFlltZQaxYQja-M0jbSnAnRn01GqjAP-AIZE9-TsVCPkR7KmlSYAJQigpAVQ4jnwftWn7KhJrmy9PYAl6dVUlayR4sCb1W1UMLRrpHJbNNSGCJ8ker4OPOuwuXpcQOXNIl84sDOAdS383-_y4up3eQ13Dk8m42R8ND3egru8nTR0VmobNutFY1_CLf2rzqrFq3b6MTi7bhD_AXs7bFI |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEB6VFFVceD8MBRYJTtSKX8l6DxWCthFVSxQhQL2ZzT6EJWKb2AblxP_i13XGj0SoorceuFny7thrf7vz2J1vAF7GpFikmONEiohU2_gu4ka5Jg6MigT2akh9vpzy6TQ-OxOzLfjT58LQscp-TWwWap0ripEPA1TksfBQwQ9tdyxidjh5U_xwqYIU7bT25TRaiJyY1S9038r940P816-CYHL06eC921UYcFXIR5VrOJ8rHmuNTorQRhuhpZ1zKdEpINoZxcdEV45K2UbBXAba-r4RQo60F8YysCHKvQbbPESnZwDb746ms49rPUCl71obduTySHhdyk6buOc3ocmAsrpxSK73t1q8YOte2Kdt1N_k1v_84W7Dzc7oZm_bWXIHtkx2F3Y-dMcK7sHvg3qp6kWaMWIbzWqyv5laVXmBvsUiVUOT6f6aNWmfFDNlbZ7NHpNFXlR5mZZMZpqRPmkyKrGtXpVkOBD4GUpvA90kQ1bsW1oUaEgsirq8D5-vZPgPYJDlmXkEzEojjRJCoZhobExs7Uh5MkRD146t1A74PTAS1dG2U_WQ78mGcJrAlCCYkgZMiefA63WfoiUtubT1bg-cpFvAymSDGgderG_j0kP7STIzeU1tiApKoE3swMMWp-vHhVT4bORzB_Z64G6E__tdHl_-Ls9hB7GbnB5PT57AjaCZP3SIahcG1bI2T-G6-lml5fJZNxcZfL1qFJ8DXj92dQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Curcumin+attenuates+cytoplasmic%2Fendoplasmic+reticulum+stress%2C+apoptosis+and+cholinergic+dysfunction+in+diabetic+rat+hippocampus&rft.jtitle=Metabolic+brain+disease&rft.au=Keshk%2C+Walaa+A&rft.au=Elseady%2C+Walaa+S&rft.au=Sarhan%2C+Naglaa+I&rft.au=Zineldeen%2C+Doaa+H&rft.date=2020-04-01&rft.pub=Springer+Nature+B.V&rft.issn=0885-7490&rft.eissn=1573-7365&rft.volume=35&rft.issue=4&rft.spage=637&rft.epage=647&rft_id=info:doi/10.1007%2Fs11011-020-00551-0&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0885-7490&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0885-7490&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0885-7490&client=summon |